| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun-Jung Lee, Conglin Liu, Mengyang Liao, Galina K Sukhova, Jun Shirakawa, Meriem Abdennour, Karine Iamarene, Sebastien Andre, Karen Inouye, Karine Clement, Rohit N Kulkarni, Alexander S Banks, Peter Libby, Guo-Ping Sh. Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. vol 156. issue 11. 2016-04-12. PMID:26295369. |
this study established two novel pathways of ige in reducing body weight gain in dio mice by suppressing adipogenesis and inducing adipocyte apoptosis while worsening glucose tolerance by reducing glut4 expression, glucose uptake, and insulin secretion. |
2016-04-12 |
2023-08-13 |
mouse |
| Avital Beck, Hadas Shatz-Azoulay, Yaron Vinik, Roi Isaac, Sigalit Boura-Halfon, Yehiel Zic. Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells. Biochemical and biophysical research communications. vol 465. issue 4. 2016-04-12. PMID:26319551. |
silencing of ndfip1 inhibited cytokine-induced apoptosis of mouse and human pancreatic islets and promoted glucose-stimulated insulin secretion. |
2016-04-12 |
2023-08-13 |
mouse |
| Chi Teng Vong, Hisa Hui Ling Tseng, Yiu Wa Kwan, Simon Ming-Yuen Lee, Maggie Pui Man Ho. Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Frontiers in pharmacology. vol 7. 2016-04-06. PMID:27047382. |
antrodia camphorata increases insulin secretion and protects from apoptosis in min6 cells. |
2016-04-06 |
2023-08-13 |
mouse |
| Chi Teng Vong, Hisa Hui Ling Tseng, Yiu Wa Kwan, Simon Ming-Yuen Lee, Maggie Pui Man Ho. Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Frontiers in pharmacology. vol 7. 2016-04-06. PMID:27047382. |
therefore, the aim of the present study was to examine the effects of a. camphorata on insulin secretion and er stress-induced apoptosis in a mouse β-cell line, min6, and their underlying mechanisms. |
2016-04-06 |
2023-08-13 |
mouse |
| Dongdong Sun, Shuang Li, Hao Wu, Mingming Zhang, Xiaotian Zhang, Liping Wei, Xing Qin, Erhe Ga. Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity. Journal of cellular and molecular medicine. vol 19. issue 6. 2016-04-01. PMID:25752217. |
oncostatin m (osm) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity. |
2016-04-01 |
2023-08-13 |
mouse |
| Dongdong Sun, Shuang Li, Hao Wu, Mingming Zhang, Xiaotian Zhang, Liping Wei, Xing Qin, Erhe Ga. Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity. Journal of cellular and molecular medicine. vol 19. issue 6. 2016-04-01. PMID:25752217. |
its mechanism on cardiomyocyte apoptosis, mitochondrial biogenesis and insulin sensitivity were further studied. |
2016-04-01 |
2023-08-13 |
mouse |
| Dongdong Sun, Shuang Li, Hao Wu, Mingming Zhang, Xiaotian Zhang, Liping Wei, Xing Qin, Erhe Ga. Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity. Journal of cellular and molecular medicine. vol 19. issue 6. 2016-04-01. PMID:25752217. |
on the contrary, osm receptor oβ knockout exacerbated cardiac i/r injury, increased ip7 production, enhanced cardiomyocyte apoptosis, impaired mitochondrial biogenesis, glucose homoeostasis and insulin sensitivity in cardiac i/r injured diabetic mice. |
2016-04-01 |
2023-08-13 |
mouse |
| Dongdong Sun, Shuang Li, Hao Wu, Mingming Zhang, Xiaotian Zhang, Liping Wei, Xing Qin, Erhe Ga. Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity. Journal of cellular and molecular medicine. vol 19. issue 6. 2016-04-01. PMID:25752217. |
osm protects against cardiac i/r injury by regulating apoptosis, insulin sensitivity and mitochondrial biogenesis in diabetic mice through inhibition of ip7 production. |
2016-04-01 |
2023-08-13 |
mouse |
| Hisanori Imai, Gauri P Misra, Linfeng Wu, Dileep R Janagam, Thomas W Gardner, Tao L Low. Subconjunctivally Implanted Hydrogels for Sustained Insulin Release to Reduce Retinal Cell Apoptosis in Diabetic Rats. Investigative ophthalmology & visual science. vol 56. issue 13. 2016-03-31. PMID:26658505. |
subconjunctivally implanted hydrogels for sustained insulin release to reduce retinal cell apoptosis in diabetic rats. |
2016-03-31 |
2023-08-13 |
rat |
| Mun-Wai Cheong, Li-Hua Kuo, Yi-Ning Cheng, Pei-Jane Tsai, Li-Chun Ho, Haw-Chih Tai, Wen-Tai Chiu, Shun-Hua Chen, Pei-Jung Lu, Yan-Shen Shan, Lee-Ming Chuang, Yau-Sheng Tsa. Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis. Journal of molecular medicine (Berlin, Germany). vol 93. issue 7. 2016-03-24. PMID:25737480. |
akt replenishment and insulin supplementation rescued pa-induced apoptosis in egr-1 knockdown cells. |
2016-03-24 |
2023-08-13 |
mouse |
| Antje Garten, Susanne Schuster, Melanie Penke, Theresa Gorski, Tommaso de Giorgis, Wieland Kies. Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nature reviews. Endocrinology. vol 11. issue 9. 2016-03-21. PMID:26215259. |
nampt is able to modulate processes involved in the pathogenesis of obesity and related disorders such as nonalcoholic fatty liver disease (nafld) and type 2 diabetes mellitus (t2dm) by influencing the oxidative stress response, apoptosis, lipid and glucose metabolism, inflammation and insulin resistance. |
2016-03-21 |
2023-08-13 |
human |
| Jie Zhang, Jideng Ma, Keren Long, Long Jin, Yihui Liu, Chaowei Zhou, Shilin Tian, Lei Chen, Zonggang Luo, Qianzi Tang, An'an Jiang, Xun Wang, Dawei Wang, Zhi Jiang, Jinyong Wang, Xuewei Li, Mingzhou L. Dynamic gene expression profiles during postnatal development of porcine subcutaneous adipose. PeerJ. vol 4. 2016-03-18. PMID:26989614. |
we identified 3,274 differential expressed genes associated with oxidative stress, immune processes, apoptosis, energy metabolism, insulin stimulus, cell cycle, angiogenesis and translation. |
2016-03-18 |
2023-08-13 |
human |
| Yi Lin, Zhongjie Su. Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes. Diabetes. vol 64. issue 12. 2016-03-15. PMID:26340932. |
in an autoimmune t1dm model (nod), we showed that in vivo β-cell-specific expression of mkl improved glucose tolerance, attenuated β-cell apoptosis, enhanced insulin storage in β-cells, and increased plasma insulin levels. |
2016-03-15 |
2023-08-13 |
mouse |
| Xiaoli Shi, Xiaokan Xiong, Zhe Dai, Haohua Deng, Li Sun, Xuemei Hu, Feng Zhou, Yancheng X. Nuclear orphan receptor TLX affects gene expression, proliferation and cell apoptosis in beta cells. Biochemical and biophysical research communications. vol 468. issue 1-2. 2016-03-15. PMID:26471300. |
we next examined the effects of tlx overexpression on proliferation, apoptosis and insulin secretion in min6 cells. |
2016-03-15 |
2023-08-13 |
Not clear |
| Manijheh Sabokdast, Mehran Habibi-Rezaei, Ali Akbar Moosavi-Movahedi, Maryam Ferdousi, Effat Azimzadeh-Irani, Najmeh Poursasa. Protection by beta-Hydroxybutyric acid against insulin glycation, lipid peroxidation and microglial cell apoptosis. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 23. 2016-03-09. PMID:26311627. |
protection by beta-hydroxybutyric acid against insulin glycation, lipid peroxidation and microglial cell apoptosis. |
2016-03-09 |
2023-08-13 |
Not clear |
| Xiangchen Kong, Longmei Zhang, Xianxin Hua, Xiaosong M. Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway. Journal of diabetes research. vol 2015. 2016-03-08. PMID:26167511. |
chronic hyperglycemia increases apoptosis and reduces glucose-stimulated insulin secretion. |
2016-03-08 |
2023-08-13 |
mouse |
| Xiangchen Kong, Longmei Zhang, Xianxin Hua, Xiaosong M. Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway. Journal of diabetes research. vol 2015. 2016-03-08. PMID:26167511. |
chronic culture of β-cells in 30 mm glucose caused progressive reduction of cell viability, accompanied with increased apoptosis and reduced insulin secretion. |
2016-03-08 |
2023-08-13 |
mouse |
| Xiangchen Kong, Longmei Zhang, Xianxin Hua, Xiaosong M. Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway. Journal of diabetes research. vol 2015. 2016-03-08. PMID:26167511. |
these effects on apoptosis and insulin were reversed by flz in a dose-dependent manner. |
2016-03-08 |
2023-08-13 |
mouse |
| Jingyi Qian, Bonnie Yeh, Kuntol Rakshit, Christopher S Colwell, Aleksey V Matveyenk. Circadian Disruption and Diet-Induced Obesity Synergize to Promote Development of β-Cell Failure and Diabetes in Male Rats. Endocrinology. vol 156. issue 12. 2016-03-07. PMID:26348474. |
in contrast, concomitant exposure to ll and hfd resulted in development of hyperglycemia characterized by loss of diurnal changes in insulin secretion, compromised β-cell function, and induction of β-cell apoptosis. |
2016-03-07 |
2023-08-13 |
rat |
| Jeremy A Lavine, Carly R Kibbe, Mieke Baan, Sirinart Sirinvaravong, Heidi M Umhoefer, Kimberly A Engler, Louise M Meske, Kaitlyn A Sacotte, Daniel P Erhardt, Dawn Belt Davi. Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis. American journal of physiology. Endocrinology and metabolism. vol 309. issue 10. 2016-03-07. PMID:26394663. |
while these agonists clearly have beneficial effects on body weight and insulin sensitivity in peripheral tissues, they may also directly protect β-cells from apoptosis. |
2016-03-07 |
2023-08-13 |
mouse |