| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Camilla Kappe, Liselotte Fransson, Petra Wolbert, Henrik Ortsäte. Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects. Clinical science (London, England : 1979). vol 129. issue 5. 2015-11-09. PMID:25853863. |
however, although defective glp-1 secretion has been correlated with insulin resistance, potential direct effects of gcs on glp-1-producing l-cell function in terms of glp-1 secretion and apoptosis have not been studied in any greater detail. |
2015-11-09 |
2023-08-13 |
rat |
| Carol J Fabian, Bruce F Kimle. Marine-derived omega-3 fatty acids: fishing for clues for cancer prevention. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 2015-11-04. PMID:23714467. |
mechanistic studies largely in preclinical models suggest epa and dha reduce synthesis of prostaglandin e2 and other inflammatory cytokines, decrease aromatase activity and proliferation, promote differentiation and apoptosis, and enhance insulin sensitivity. |
2015-11-04 |
2023-08-12 |
Not clear |
| Margo C Honeyman, David Laine, Yifan Zhan, Sarah Londrigan, Carl Kirkwood, Leonard C Harriso. Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice. PloS one. vol 9. issue 9. 2015-11-04. PMID:25181416. |
cell proliferation and apoptosis, and insulin expression, were analyzed by immunohistochemistry. |
2015-11-04 |
2023-08-13 |
mouse |
| Margo C Honeyman, David Laine, Yifan Zhan, Sarah Londrigan, Carl Kirkwood, Leonard C Harriso. Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice. PloS one. vol 9. issue 9. 2015-11-04. PMID:25181416. |
in the first phase, widespread apoptosis of pancreatic cells was associated with a decrease in pancreas mass and insulin production, without detectable virus in the pancreas. |
2015-11-04 |
2023-08-13 |
mouse |
| Zhipeng Li, Zhaoshui Shangguan, Yijie Liu, Jihua Wang, Xuejun Li, Shuyu Yang, Suhuan Li. Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. Journal of molecular endocrinology. vol 53. issue 1. 2015-10-26. PMID:24827001. |
pancreatic β-cell survival and function were assessed in diabetic mice by measuring β-cell apoptosis, β-cell mass, pancreatic insulin content, and glucose tolerance, and in cultured islets and clonial min6 β-cells by measuring β-cell viability and apoptosis and glucose-stimulated insulin secretion. |
2015-10-26 |
2023-08-13 |
mouse |
| Zhipeng Li, Zhaoshui Shangguan, Yijie Liu, Jihua Wang, Xuejun Li, Shuyu Yang, Suhuan Li. Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. Journal of molecular endocrinology. vol 53. issue 1. 2015-10-26. PMID:24827001. |
puerarin increased pancreatic β-cell mass via β-cell apoptosis inhibition in diabetic mice, and increased serum insulin, whereas it decreased blood glucose levels and improved glucose tolerance. |
2015-10-26 |
2023-08-13 |
mouse |
| Zhipeng Li, Zhaoshui Shangguan, Yijie Liu, Jihua Wang, Xuejun Li, Shuyu Yang, Suhuan Li. Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. Journal of molecular endocrinology. vol 53. issue 1. 2015-10-26. PMID:24827001. |
in cultured islets and min6 cells, puerarin protected β-cell from cobalt chloride (cocl2)-induced apoptosis and restored the impaired capacity of glucose-stimulated insulin secretion. |
2015-10-26 |
2023-08-13 |
mouse |
| Song-Yang Zhang, Juan Feng, Xian Wan. [ER stress and cardiometabolic disease: role of adipokines]. Sheng li ke xue jin zhan [Progress in physiology]. vol 44. issue 5. 2015-10-22. PMID:24475720. |
while prolonged er stress lead to inflammation, cell dysfunction and apoptosis, which takes part in the progression of insulin resistance and atherosclerosis. |
2015-10-22 |
2023-08-12 |
Not clear |
| Colette Galet, Ashley Gray, Jonathan W Said, Brandon Castor, Junxiang Wan, Pedro J Beltran, Franck J Calzone, David Elashoff, Pinchas Cohen, William J Aronso. Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts. International journal of molecular sciences. vol 14. issue 7. 2015-10-13. PMID:23823800. |
results showed that cr alone decreased final tumor weight, plasma insulin and igf-1 levels, and increased apoptosis. |
2015-10-13 |
2023-08-12 |
mouse |
| Colette Galet, Ashley Gray, Jonathan W Said, Brandon Castor, Junxiang Wan, Pedro J Beltran, Franck J Calzone, David Elashoff, Pinchas Cohen, William J Aronso. Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts. International journal of molecular sciences. vol 14. issue 7. 2015-10-13. PMID:23823800. |
the combination therapy (cr/ab) further decreased final tumor weight and proliferation, increased apoptosis in comparison to the ad-lib group, and lowered plasma insulin levels relative to the ad-lib and ad-lib/ab groups. |
2015-10-13 |
2023-08-12 |
mouse |
| Reza Meshkani, Asie Sadeghi, Gholamreza Taheripak, Maryam Zarghooni, Siavash Gerayesh-Nejad, Salar Bakhtiyar. Rosiglitazone, a PPARγ agonist, ameliorates palmitate-induced insulin resistance and apoptosis in skeletal muscle cells. Cell biochemistry and function. vol 32. issue 8. 2015-10-05. PMID:25431031. |
rosiglitazone, a pparγ agonist, ameliorates palmitate-induced insulin resistance and apoptosis in skeletal muscle cells. |
2015-10-05 |
2023-08-13 |
Not clear |
| Reza Meshkani, Asie Sadeghi, Gholamreza Taheripak, Maryam Zarghooni, Siavash Gerayesh-Nejad, Salar Bakhtiyar. Rosiglitazone, a PPARγ agonist, ameliorates palmitate-induced insulin resistance and apoptosis in skeletal muscle cells. Cell biochemistry and function. vol 32. issue 8. 2015-10-05. PMID:25431031. |
palmitate induces insulin resistance and apoptosis in insulin target tissues. |
2015-10-05 |
2023-08-13 |
Not clear |
| Xiao-Rong Ni, Zhou-Jun Sun, Guo-Hua Hu, Rong-Hui Wan. High concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular HMGB1. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 3. 2015-09-30. PMID:25228632. |
high concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular hmgb1. |
2015-09-30 |
2023-08-13 |
rat |
| Xiao-Rong Ni, Zhou-Jun Sun, Guo-Hua Hu, Rong-Hui Wan. High concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular HMGB1. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 3. 2015-09-30. PMID:25228632. |
furthermore, we discovered that high concentration of insulin, which mimics insulin resistance model, promoted apoptosis in primary cultured rat ovarian granulosa cells (gcs) via its effect on the increase in extracellular hmgb1. |
2015-09-30 |
2023-08-13 |
rat |
| Xiao-Rong Ni, Zhou-Jun Sun, Guo-Hua Hu, Rong-Hui Wan. High concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular HMGB1. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 3. 2015-09-30. PMID:25228632. |
our data presented the first evidence that increased hmgb1 induced by insulin resistance/hyperinsulinemia promoted apoptosis of ovarian gcs, which provided new molecular basis for the pcos pathogenesis. |
2015-09-30 |
2023-08-13 |
rat |
| Inmaculada Simón-Muela, Gemma Llauradó, Matilde Rodriguez Chacón, Montserrat Olona, Silvia Näf, Elsa Maymó-Masip, Pilar Gil, Miriam de la Flor, Jose Miguel Gonzalez Clemente, Joan Vendrell, Ana Megí. Reduced circulating levels of TWEAK are associated with gestational diabetes mellitus. European journal of clinical investigation. vol 45. issue 1. 2015-09-28. PMID:25443800. |
to evaluate the inflammatory axis mediated by tumour necrosis factor-like weak inducer of apoptosis (tweak) and its scavenger receptor cd163 during pregnancy and their influence on insulin sensitivity in normal pregnancy and in gestational diabetes mellitus (gdm). |
2015-09-28 |
2023-08-13 |
Not clear |
| Min Liu, Danqing Jing, Yan Wang, Yu Liu, Shinan Yi. Overexpression of angiotensin II type 2 receptor promotes apoptosis and impairs insulin secretion in rat insulinoma cells. Molecular and cellular biochemistry. vol 400. issue 1-2. 2015-09-21. PMID:25430897. |
overexpression of angiotensin ii type 2 receptor promotes apoptosis and impairs insulin secretion in rat insulinoma cells. |
2015-09-21 |
2023-08-13 |
rat |
| Min Liu, Danqing Jing, Yan Wang, Yu Liu, Shinan Yi. Overexpression of angiotensin II type 2 receptor promotes apoptosis and impairs insulin secretion in rat insulinoma cells. Molecular and cellular biochemistry. vol 400. issue 1-2. 2015-09-21. PMID:25430897. |
our findings suggested that at2r overexpression triggers the apoptosis of ins-1 cells and dysfunction in insulin secretion. |
2015-09-21 |
2023-08-13 |
rat |
| Yanqing Wu, Fang Wang, Mao Fu, Cheng Wang, Michael J Quon, Peixin Yan. Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy. Diabetes. vol 64. issue 7. 2015-09-15. PMID:25720389. |
dm dams treated with 200 mg/kg metformin in drinking water ameliorated fasting hyperglycemia, glucose intolerance, and insulin resistance with consequent reduction of cellular stress, apoptosis, and ntds in their embryos. |
2015-09-15 |
2023-08-13 |
mouse |
| Haiyan Ding, Tienian Zhu, Xiaomei Yin, Jiankun Liu, Lizhong Zhang, Michel Bernier, Ruijing Zha. Pyrrolidine dithiocarbamate protects pancreatic β-cells from oxidative damage through regulation of FoxO1 activity in type 2 diabetes rats. Acta biochimica et biophysica Sinica. vol 46. issue 7. 2015-09-14. PMID:24829401. |
pdtc treatment significantly reduced the oxidative damage and the β-cell apoptosis, and also increased the insulin production through down-regulating foxo1 acetylation and up-regulating nuclear pdx-1 level. |
2015-09-14 |
2023-08-13 |
rat |