| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramachandran Balasubramanian, Bernard Robaye, Jean-Marie Boeynaems, Kenneth A Jacobso. Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists. PloS one. vol 9. issue 12. 2015-09-14. PMID:25549240. |
we previously demonstrated that p2y6 receptor (p2y6r) agonists protect pancreatic islet cells from apoptosis and stimulate glucose-dependent insulin release. |
2015-09-14 |
2023-08-13 |
mouse |
| Xia Sun, Yi Lin, Qiansheng Huang, Junpeng Shi, Ling Qiu, Mei Kang, Yajie Chen, Chao Fang, Ting Ye, Sijun Don. Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection. Journal of cellular and molecular medicine. vol 19. issue 3. 2015-09-10. PMID:25418486. |
the results showed that dehp decreased insulin secretion and content and induced apoptosis in ins-1 cells in a dose-dependent manner. |
2015-09-10 |
2023-08-13 |
rat |
| Yun-Ying Huang, Xiong-Qin Huang, Li-Yan Zhao, Fang-Yun Sun, Wen-Liang Chen, Jie-Yi Du, Feng Yuan, Jie Li, Xue-Lian Huang, Jie Liu, Xiao-Fei Lv, Yong-Yuan Guan, Jian-Wen Chen, Guan-Lei Wan. ClC-3 deficiency protects preadipocytes against apoptosis induced by palmitate in vitro and in type 2 diabetes mice. Apoptosis : an international journal on programmed cell death. vol 19. issue 11. 2015-09-04. PMID:25218423. |
moreover, the enhanced apoptosis was shown in preadipocytes from high-sucrose/fat, low-dose stz induced t2dm mouse model with hyperglycemia, hyperlipidemia (elevated serum tg and ffa levels) and insulin resistance. |
2015-09-04 |
2023-08-13 |
mouse |
| Ying-Ka Ingar Lau, Xing Du, Vinayak Rayannavar, Benjamin Hopkins, Jacquelyn Shaw, Eliana Bessler, Tiffany Thomas, Maira M Pires, Megan Keniry, Ramon E Parsons, Serge Cremers, Matthias Szabolcs, Matthew A Maure. Metformin and erlotinib synergize to inhibit basal breast cancer. Oncotarget. vol 5. issue 21. 2015-08-31. PMID:25361177. |
combined metformin and erlotinib led to partial regression of pten-null and egfr-amplified xenografted mda-mb-468 bbc tumors with evidence of significant apoptosis, reduction of egfr and akt signaling, and lack of altered plasma insulin levels. |
2015-08-31 |
2023-08-13 |
mouse |
| Giovanni Corsetti, Giuseppe D'Antona, Chiara Ruocco, Alessandra Stacchiotti, Claudia Romano, Laura Tedesco, Francesco Dioguardi, Rita Rezzani, Enzo Nisol. Dietary supplementation with essential amino acids boosts the beneficial effects of rosuvastatin on mouse kidney. Amino acids. vol 46. issue 9. 2015-08-28. PMID:24923264. |
mitochondrial biogenesis and function, apoptosis, and insulin signaling pathway events were studied, primarily in cortical proximal tubules. |
2015-08-28 |
2023-08-13 |
mouse |
| Lin Wang, Xiong Zhao, Bo-yuan Wei, Yi Liu, Xiang-yu Ma, Jian Wang, Peng-chong Cao, Yang Zhang, Ya-bo Yan, Wei Lei, Ya-fei Fen. Insulin improves osteogenesis of titanium implants under diabetic conditions by inhibiting reactive oxygen species overproduction via the PI3K-Akt pathway. Biochimie. vol 108. 2015-08-19. PMID:25308835. |
in contrast, treatment with insulin inhibited ros production, alleviated cell dysfunction, and decreased apoptosis of osteoblasts on the implants. |
2015-08-19 |
2023-08-13 |
rabbit |
| Catalina Carrasco-Pozo, Martin Gotteland, Rodrigo L Castillo, Chen Che. 3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol. Experimental cell research. vol 334. issue 2. 2015-08-10. PMID:25845496. |
es increased nrf2 translocation to the nucleus and protected pancreatic β-cells against impaired insulin secretion induced by cholesterol by preventing oxidative stress, apoptosis and mitochondrial dysfunction. |
2015-08-10 |
2023-08-13 |
Not clear |
| Antonia Diaz-Ganete, Gloria Baena-Nieto, Isabel M Lomas-Romero, Jose Francisco Lopez-Acosta, Irene Cozar-Castellano, Francisco Medina, Carmen Segundo, Alfonso M Lechuga-Sanch. Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on β-Cell Functionality. International journal of endocrinology. vol 2015. 2015-08-10. PMID:26257781. |
several proteins involved in survival pathways (erk 1/2 and akt/pkb) and apoptosis (caspases and bcl-2 protein family and endoplasmic reticulum stress markers) as well as insulin secretion were analyzed. |
2015-08-10 |
2023-08-13 |
rat |
| Michael Johns, Robert Fyalka, Jennifer A Shea, William L Neumann, Smita Rausaria, Eliwaza Naomi Msengi, Maryam Imani-Nejad, Harry Zollars, Timothy McPherson, Joseph Schober, Joshua Wooten, Guim Kwo. SR-135, a peroxynitrite decomposing catalyst, enhances β-cell function and survival in B6D2F1 mice fed a high fat diet. Archives of biochemistry and biophysics. vol 577-578. 2015-08-07. PMID:25935364. |
moreover, sr-135 increased insulin content, restored islet architecture, decreased islet size, and reduced tyrosine nitration and apoptosis. |
2015-08-07 |
2023-08-13 |
mouse |
| Erica D Louden, Kerri M Luzzo, Patricia T Jimenez, Tiffany Chi, Maggie Chi, Kelle H Mole. TallyHO obese female mice experience poor reproductive outcomes and abnormal blastocyst metabolism that is reversed by metformin. Reproduction, fertility, and development. vol 27. issue 1. 2015-08-06. PMID:25472042. |
blastocysts from tallyho mice exhibited increased apoptosis, decreased insulin sensitivity and decreased ampk. |
2015-08-06 |
2023-08-13 |
mouse |
| Chia-Yu Lin, Pei-Jane Huang, Che-Yi Cha. Chlorella protects against hydrogen peroxide-induced pancreatic β-cell damage. Journal of medicinal food. vol 17. issue 12. 2015-07-29. PMID:25250885. |
our results suggest that chlorella is effective in amelioration of cellular oxidative stress and destruction, and therefore protects ins-1 (832/13) cells from h2o2-induced apoptosis and increases insulin secretion. |
2015-07-29 |
2023-08-13 |
Not clear |
| Zodwa Dlamini, Patricia Ntlabati, Zukile Mbita, Lungile Shoba-Zikhal. Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance. Experimental and molecular pathology. vol 98. issue 3. 2015-07-27. PMID:25794976. |
pyruvate dehydrogenase kinase 4 (pdk4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance. |
2015-07-27 |
2023-08-13 |
Not clear |
| Zodwa Dlamini, Patricia Ntlabati, Zukile Mbita, Lungile Shoba-Zikhal. Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance. Experimental and molecular pathology. vol 98. issue 3. 2015-07-27. PMID:25794976. |
these findings were very interesting as pdk4 has not previously been associated with apoptosis and this could be the link between apoptosis and insulin resistance. |
2015-07-27 |
2023-08-13 |
Not clear |
| Nora Klöting, Matthias Blühe. Adipocyte dysfunction, inflammation and metabolic syndrome. Reviews in endocrine & metabolic disorders. vol 15. issue 4. 2015-07-23. PMID:25344447. |
importantly, an inability to increase at mass by adipocyte hyperplasia may lead to adipocyte hypertrophy and could induce dysfunction of adipose tissue characterized by decreased insulin sensitivity, hypoxia, increased parameters of intracellular stress, increased autophagy and apoptosis and tissue inflammation. |
2015-07-23 |
2023-08-13 |
Not clear |
| Ebubekir Dirican, Zehra Kaya, Gokce Gullu, Irem Peker, Tolga Ozmen, Bahadir M Gulluoglu, Handan Kaya, Ayse Ozer, Mustafa Akkipri. Detection of PIK3CA gene mutations with HRM analysis and association with IGFBP-5 expression levels in breast cancer. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 21. 2015-07-22. PMID:25422220. |
insulin growth factor binding protein-5 (igfbp-5) can show different effects on apoptosis, cell motility and survival in breast cancer. |
2015-07-22 |
2023-08-13 |
Not clear |
| Hong Yao, Xiangyang Han, Xiuzhen Ha. The cardioprotection of the insulin-mediated PI3K/Akt/mTOR signaling pathway. American journal of cardiovascular drugs : drugs, devices, and other interventions. vol 14. issue 6. 2015-07-17. PMID:25160498. |
activation of the pi3k/akt signaling pathway induced by insulin not only inhibits cardiomyocyte apoptosis but also substantially preserves and even improves regional and overall cardiac function. |
2015-07-17 |
2023-08-13 |
Not clear |
| Hong Yao, Xiangyang Han, Xiuzhen Ha. The cardioprotection of the insulin-mediated PI3K/Akt/mTOR signaling pathway. American journal of cardiovascular drugs : drugs, devices, and other interventions. vol 14. issue 6. 2015-07-17. PMID:25160498. |
insulin can protect cardiomyocytes from apoptosis by regulating a number of signaling molecules, such as enos, foxos, bad, gsk-3β, mtor, ndrg2, and nrf2, through activating pi3k and akt. |
2015-07-17 |
2023-08-13 |
Not clear |
| Lin Wang, Juxiang Huang, Minghu Jiang, Qingchun Chen, Zhenfu Jiang, Haitao Fen. CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24825433. |
our hypothesis was verified by camk1 functional regulation subnetwork containing positive regulation of calcium ion transport via voltage gated calcium channel, cell proliferation, dna repair, exocytosis, i-kappab kinase/nf-kappab cascade, immunoglobulin-mediated immune response, mast cell activation, natural killer cell-mediated cytotoxicity directed against tumor cell target, protein ubiquitination, sodium ion transport, survival gene product activity, t cell-mediated cytotoxicity, transcription, transcription from rna polymerase ii promoter, transcription initiation from rna polymerase ii promoter, transcription via serum response element binding, exit from mitosis, ubiquitin ligase activity during mitotic cell cycle, regulation of angiogenesis, apoptosis, cell growth, cell proliferation, cyclin-dependent protein kinase activity, gene expression, insulin secretion, steroid biosynthesis, transcription from rna polymerase ii promoter, transcription from rna polymerase iii promoter, cell cycle, cell migration, dna recombination, and protein metabolism; also by camk1 negative functional regulation subnetwork including negative regulation of apoptosis, cell proliferation, centriole replication, fatty acid biosynthesis, lipoprotein lipase activity, mapk activity, progression through cell cycle, transcription, transcription from rna polymerase ii promoter, cell growth, phosphorylation, and ubiquitin ligase activity during mitotic cell cycle in hcc. |
2015-07-02 |
2023-08-13 |
human |
| Chen Shao, Jianqiu Gu, Xin Meng, Hongzhi Zheng, Difei Wan. Systematic investigation into the role of intermittent high glucose in pancreatic beta-cells. International journal of clinical and experimental medicine. vol 8. issue 4. 2015-07-01. PMID:26131124. |
to determine how it induces beta-cell dysfunction, we systematically evaluated the effects of intermittent high glucose (ihg) in ins-1 rat pancreatic beta-cells on their proliferation activity, apoptosis, insulin secretion, reactive oxygen species (ros), intracellular concentration of ca(2+) ([ca(2+)]i), and the pten expression as well as akt phosphorylation. |
2015-07-01 |
2023-08-13 |
rat |
| Anson Snow, Biehuoy Shieh, Kun-Che Chang, Arttatrana Pal, Patricia Lenhart, David Ammar, Philip Ruzycki, Suryanarayana Palla, G Bhanuprakesh Reddy, J Mark Petras. Aldose reductase expression as a risk factor for cataract. Chemico-biological interactions. vol 234. 2015-06-29. PMID:25541468. |
these results indicate that high ar expression in the context of hyperglycemia and insulin deficiency may constitute a risk factor that could predispose the lens to disturbances in signaling through the erk and jnk pathways and thereby alter the balance of cell growth and apoptosis that is critical to lens transparency and homeostasis. |
2015-06-29 |
2023-08-13 |
mouse |