| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrizia Luppi, Peter Drai. Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress. Diabetes/metabolism research and reviews. vol 30. issue 7. 2015-06-22. PMID:24459093. |
recent evidence has shown that c-peptide, produced by beta cells and co-secreted with insulin in the circulation of healthy individuals, decreases ros and prevents apoptosis in dysfunctional vascular endothelial cells. |
2015-06-22 |
2023-08-12 |
Not clear |
| Tingting Sun, Jinghui Guo, Hui Chen, Jieting Zhang, Xiaohu Zhang, Xiaohua Jiang, Fuqiang Wang, Zhiyang Xu, Xiaoyan Huang, Jiahao Sha, Hsiao Chang Cha. Maternal caffeine exposure impairs insulin secretion by pancreatic β-cells and increases the risk of type II diabetes mellitus in offspring. Cell biology international. vol 38. issue 10. 2015-06-22. PMID:24890676. |
while basal insulin secretion of caffeine-treated cells was elevated, insulin secretion after glucose challenge in long-term caffeine-treated cells was significantly reduced, with increased apoptosis of β-cells. |
2015-06-22 |
2023-08-13 |
rat |
| Chun-Li Lu, Ying Wang, Li Yuan, Yang Li, Xiao-Ya L. The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects the function of pancreatic β cells by improving the function of islet microvascular endothelial cells. International journal of molecular medicine. vol 34. issue 5. 2015-06-17. PMID:25175177. |
ang(1-7) increased the activity of the akt/endothelial nos/nitric oxide (no) pathway in the ms-1 cells, protected min6 cells against palmitate-induced apoptosis, and improved min6 insulin secretory function in the co-culture system. |
2015-06-17 |
2023-08-13 |
mouse |
| Kannikar Wongdee, Narattaphol Charoenphandh. Update on type 2 diabetes-related osteoporosis. World journal of diabetes. vol 6. issue 5. 2015-06-13. PMID:26069716. |
hyperglycemia and insulin resistance in t2dm may further induce osteoblast apoptosis and uncoupling bone turnover. |
2015-06-13 |
2023-08-13 |
rat |
| Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Hideaki Tanaka, Chigusa Shimizu-Okabe, Shogo Ishiuchi, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui, Jun-ichi Miyazaki, Seiichi Oyadomari, Michio Shimabukuro, Hiroaki Masuzak. γ-Oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice. Endocrinology. vol 156. issue 4. 2015-06-11. PMID:25594697. |
in min6 cells with augmented er stress by tunicamycin, γ-oryzanol decreased exaggerated expression of er stress-related genes and phosphorylation of eukaryotic initiation factor-2α, resulting in restoration of glucose-stimulated insulin secretion and prevention of apoptosis. |
2015-06-11 |
2023-08-13 |
mouse |
| Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Hideaki Tanaka, Chigusa Shimizu-Okabe, Shogo Ishiuchi, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui, Jun-ichi Miyazaki, Seiichi Oyadomari, Michio Shimabukuro, Hiroaki Masuzak. γ-Oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice. Endocrinology. vol 156. issue 4. 2015-06-11. PMID:25594697. |
in islets from high-fat diet-fed diabetic mice, oral administration of γ-oryzanol improved glucose-stimulated insulin secretion on following reduction of exaggerated er stress and apoptosis. |
2015-06-11 |
2023-08-13 |
mouse |
| Maria Kasdagly, Sridhar Radhakrishnan, Lavanya Reddivari, D N Rao Veeramachaneni, Jairam Vanamal. Colon carcinogenesis: influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds. Nutrition (Burbank, Los Angeles County, Calif.). vol 30. issue 11-12. 2015-06-01. PMID:25280404. |
western diet-induced obesity elevates systemic insulin-like growth factor-1 and insulin levels, which could lead to elevated proliferation and suppressed apoptosis of cscs through pi3k/akt/wnt pathway. |
2015-06-01 |
2023-08-13 |
human |
| Yasar Colak, Atakan Yesil, Hasan Huseyin Mutlu, Ozge Telci Caklili, Celal Ulasoglu, Ebubekir Senates, Mumtaz Takir, Osman Kostek, Yusuf Yilmaz, Feruze Yilmaz Enc, Guralp Tasan, Ilyas Tunce. A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. Journal of gastrointestinal and liver diseases : JGLD. vol 23. issue 3. 2015-05-29. PMID:25267960. |
among the effects of sirt1 are: its healing activity on insulin sensitivity, thereby ameliorating glycemic regulation; its mimetic activity on calorie restriction; its antihyperlipidemic activity on lipid homeostasis via the liver, adipose tissues and skeletal muscles; its anti-inflammatory activities; its protective effects against cardiovascular events and endothelial dysfunction; its positive influence on autophagy, apoptosis and cancer; and finally, its anti-aging activity. |
2015-05-29 |
2023-08-13 |
Not clear |
| Ke Chen, Liling Zhao, Honghui He, Xinxing Wan, Fang Wang, Zhaohui M. Silibinin protects β cells from glucotoxicity through regulation of the Insig-1/SREBP-1c pathway. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25109869. |
exposure to high glucose may cause glucotoxicity, leading to pancreatic β cell dysfunction including cell apoptosis, impaired glucose‑stimulated insulin secretion (gsis) and intracellular lipid accumulation. |
2015-05-26 |
2023-08-13 |
rat |
| Eylul Harputlugil, Christopher Hine, Dorathy Vargas, Lauren Robertson, Brendan D Manning, James R Mitchel. The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo. Cell reports. vol 8. issue 4. 2015-05-26. PMID:25131199. |
pr improved hepatic insulin sensitivity in a tsc1-dependent manner prior to ischemia, facilitating increased prosurvival signaling and reduced apoptosis after reperfusion. |
2015-05-26 |
2023-08-13 |
Not clear |
| Nadine S Sauter, Constanze Thienel, Yuliya Plutino, Kapil Kampe, Erez Dror, Shuyang Traub, Katharina Timper, Benoit Bédat, Francois Pattou, Julie Kerr-Conte, Andreas W Jehle, Marianne Böni-Schnetzler, Marc Y Donat. Angiotensin II induces interleukin-1β-mediated islet inflammation and β-cell dysfunction independently of vasoconstrictive effects. Diabetes. vol 64. issue 4. 2015-05-22. PMID:25352639. |
here we show that exposure of human and mouse islets to angiotensin ii induces interleukin (il)-1-dependent expression of il-6 and mcp-1, enhances β-cell apoptosis, and impairs mitochondrial function and insulin secretion. |
2015-05-22 |
2023-08-13 |
mouse |
| Chun-Jiu Ren, Yao Zhang, Wei-Zheng Cui, Zhi-Mei M. [Progress in the role of oxidative stress in the pathogenesis of type 2 diabetes]. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 6. 2015-05-16. PMID:24343725. |
firstly oxidative stress damages the normal function of islet β cells, through the destruction of mitochondrial structure and inducing apoptosis, activation of nuclear transcription factor kappa b (nf-κb) signaling pathway, causing cell inflammatory response, and reducing insulin synthesis and secretion by inhibiting pancreatic and duodenal homeobox 1 (pdx-1) nuclear cytoplasm translocation as well as inhibiting energy metabolism; secondly, oxidative stress induces insulin resistance by interfering physiological activities related to insulin signaling including phosphorylation of insulin receptor (insr) and insulin receptor substrate (irs), the activation of phosphatidylinositol 3-kinase (pi3k) and the translocation of glucose transporter 4 (glut4), as well as injuring the cytoskeleton. |
2015-05-16 |
2023-08-12 |
Not clear |
| Jun-Jie Su, Ge-Yao Qi, Xiao-Zhi Dang, Nian Yang, Jun Zhan. [Progress in the physiological and pathophysiological functions of sodium calcium exchangers]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 2. 2015-05-16. PMID:24777416. |
moreover, abnormal activation of the reverse mode of ncx plays a vital role in many pathological processes including cell apoptosis, ischemia-reperfusion injury, insulin secretion, tumor etc. |
2015-05-16 |
2023-08-13 |
Not clear |
| Xu Sun, Meizhu Zheng, Maomin Song, Rixing Bai, Shi Cheng, Ying Xing, Huisheng Yuan, Pilin Wan. Ileal interposition reduces blood glucose levels and decreases insulin resistance in a type 2 diabetes mellitus animal model by up-regulating glucagon-like peptide-1 and its receptor. International journal of clinical and experimental pathology. vol 7. issue 7. 2015-05-14. PMID:25120793. |
it significantly reduces blood glucose and decreases insulin resistance by up-regulating glp-1 concentrations and glp-1r levels, which may contribute to insulin secretion of pancreatic β-cells and decreases apoptosis of pancreatic β-cell. |
2015-05-14 |
2023-08-13 |
rat |
| Yao Zhang, Chunjiu Ren, Guobing Lu, Zhimei Mu, Weizheng Cui, Huiju Gao, Yanwen Wan. Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats. International immunopharmacology. vol 22. issue 1. 2015-05-11. PMID:25023123. |
anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats. |
2015-05-11 |
2023-08-13 |
rat |
| Yao Zhang, Chunjiu Ren, Guobing Lu, Zhimei Mu, Weizheng Cui, Huiju Gao, Yanwen Wan. Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats. International immunopharmacology. vol 22. issue 1. 2015-05-11. PMID:25023123. |
in this study, we investigated the effect of mulberry leaf polysaccharide (mlpii) on pancreatic islet cell apoptosis and insulin secretory function in diabetic rats induced by a high fat diet and streptozotocin. |
2015-05-11 |
2023-08-13 |
rat |
| Yao Zhang, Chunjiu Ren, Guobing Lu, Zhimei Mu, Weizheng Cui, Huiju Gao, Yanwen Wan. Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats. International immunopharmacology. vol 22. issue 1. 2015-05-11. PMID:25023123. |
our results showed that mlpii treatment inhibited pancreatic islet cell apoptosis and ameliorated insulin secretory capacity of pancreatic β-cells in diabetic rats. |
2015-05-11 |
2023-08-13 |
rat |
| Yao Zhang, Chunjiu Ren, Guobing Lu, Zhimei Mu, Weizheng Cui, Huiju Gao, Yanwen Wan. Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats. International immunopharmacology. vol 22. issue 1. 2015-05-11. PMID:25023123. |
these findings suggested that mlpii might play a critical role in protecting pancreatic islet cell from apoptosis via elevation of bcl-2/bax ratio, and ameliorating insulin secretory capacity of pancreatic β-cells via restoration of pdx-1 nuclear localization and expression levels in diabetic rats. |
2015-05-11 |
2023-08-13 |
rat |
| Annika Sommerfeld, Roland Reinehr, Dieter Häussinge. Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25548285. |
as non-alcoholic steatohepatitis (nash) is associated with hyperinsulinemia and increased ffa-blood levels, the interplay between insulin and ffa was studied with regard to hepatocyte proliferation and apoptosis in isolated rat and mouse hepatocytes. |
2015-05-08 |
2023-08-13 |
mouse |
| Annika Sommerfeld, Roland Reinehr, Dieter Häussinge. Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25548285. |
saturated long chain ffas induced apoptosis and jnk activation in primary rat hepatocytes, but did not activate the cd95 (fas, apo-1) system, whereas insulin triggered egfr activation and hepatocyte proliferation. |
2015-05-08 |
2023-08-13 |
mouse |