| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunhui You, Shiqing Liu, Lijuan Peng, Mei Long, Hongxiang Deng, Hongjun Zha. Arg972 insulin receptor substrate-1 enhances tumor necrosis factor-α-induced apoptosis in osteoblasts. Molecular medicine reports. vol 12. issue 1. 2016-01-05. PMID:25760103. |
following stimulation with 10 nm insulin for 30 min, the stable overexpression of arg972 irs-1 and knock down of irs-1 significantly decreased irs-1-associated pi3k activity and akt activation/phosphorylation at serine 473 (ser473) and enhanced tnf-α-induced apoptosis in normal and in ra osteoblasts. |
2016-01-05 |
2023-08-13 |
human |
| Yunhui You, Shiqing Liu, Lijuan Peng, Mei Long, Hongxiang Deng, Hongjun Zha. Arg972 insulin receptor substrate-1 enhances tumor necrosis factor-α-induced apoptosis in osteoblasts. Molecular medicine reports. vol 12. issue 1. 2016-01-05. PMID:25760103. |
in conclusion, the present study provided the first evidence, to the best of our knowledge, that insulin stimulation of arg972 irs-1 and irs-1 enhanced and inhibited tnf-α-induced apoptosis, respectively in normal and ra osteoblasts by a pi3k‑dependent mechanism. |
2016-01-05 |
2023-08-13 |
human |
| Antonella Maffei, Ann Marie Segal, Juan Carlos Alvarez-Perez, Adolfo Garcia-Ocaña, Paul E Harri. Anti-incretin, Anti-proliferative Action of Dopamine on β-Cells. Molecular endocrinology (Baltimore, Md.). vol 29. issue 4. 2016-01-01. PMID:25751312. |
we found that there are similar excursions of incretins and da in rats, as those reported in humans, after a mixed meal challenge and that da counters incretin enhanced glucose-stimulated insulin secretion and intracellular signaling at multiple points from dampening calcium fluxes to inhibiting proliferation as well as apoptosis. |
2016-01-01 |
2023-08-13 |
human |
| Kenneth Maies. Programming apoptosis and autophagy with novel approaches for diabetes mellitus. Current neurovascular research. vol 12. issue 2. 2015-12-29. PMID:25742566. |
multiple treatment approaches are being entertained for dm with wnt1 inducible signaling pathway protein 1 (wisp1), mechanistic target of rapamycin (mtor), and silent mating type information regulation 2 homolog) 1 (s. cerevisiae) (sirt1) generating significant interest as target pathways that can address maintenance of glucose homeostasis as well as prevention of cellular pathology by controlling insulin resistance, stem cell proliferation, and the programmed cell death pathways of apoptosis and autophagy. |
2015-12-29 |
2023-08-13 |
Not clear |
| Yeong Sook Yoon, NaNa Keum, Xuehong Zhang, Eunyoung Cho, Edward L Giovannucc. Hyperinsulinemia, insulin resistance and colorectal adenomas: A meta-analysis. Metabolism: clinical and experimental. vol 64. issue 10. 2015-12-29. PMID:26169471. |
insulin stimulates cell proliferation and inhibits apoptosis. |
2015-12-29 |
2023-08-13 |
Not clear |
| Maren G Dietrich, Richard A Zuellig, Giatgen A Spinas, Roger Lehmann, Oliver Tschopp, Markus Niesse. Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets. Experimental cell research. vol 338. issue 1. 2015-12-29. PMID:26318486. |
in this study we have analysed proliferation, apoptosis, β cell size and glucose-stimulated insulin secretion in human islets overexpressing either pkbα or pkbβ. |
2015-12-29 |
2023-08-13 |
mouse |
| Dan-dan Yin, Er-bao Zhang, Liang-hui You, Ning Wang, Lin-tao Wang, Fei-yan Jin, Ya-nan Zhu, Li-hua Cao, Qing-xin Yuan, Wei De, Wei Tan. Downregulation of lncRNA TUG1 affects apoptosis and insulin secretion in mouse pancreatic β cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 5. 2015-12-28. PMID:25871529. |
downregulation of lncrna tug1 affects apoptosis and insulin secretion in mouse pancreatic β cells. |
2015-12-28 |
2023-08-13 |
mouse |
| Danalea V Skarra, Varykina G Thackra. FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes. Molecular and cellular endocrinology. vol 405. 2015-12-21. PMID:25676570. |
the growth factors, insulin and insulin-like growth factor i (igf1), function as key regulators of cell proliferation, metabolism and apoptosis in multiple cell types through the pi3k/akt signaling pathway. |
2015-12-21 |
2023-08-13 |
Not clear |
| K Tachibana, K Sakurai, H Yokoh, T Ishibashi, K Ishikawa, T Shirasawa, K Yokot. Mutation in insulin receptor attenuates oxidative stress and apoptosis in pancreatic beta-cells induced by nutrition excess: reduced insulin signaling and ROS. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 3. 2015-12-15. PMID:25295420. |
mutation in insulin receptor attenuates oxidative stress and apoptosis in pancreatic beta-cells induced by nutrition excess: reduced insulin signaling and ros. |
2015-12-15 |
2023-08-13 |
mouse |
| K Tachibana, K Sakurai, H Yokoh, T Ishibashi, K Ishikawa, T Shirasawa, K Yokot. Mutation in insulin receptor attenuates oxidative stress and apoptosis in pancreatic beta-cells induced by nutrition excess: reduced insulin signaling and ROS. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 3. 2015-12-15. PMID:25295420. |
here, we clarify the role of insulin signaling pathway in the beta-cell apoptosis using insulin resistant model mice. |
2015-12-15 |
2023-08-13 |
mouse |
| Jiayue Yang, Ling Li, Dimitri Raptis, Xiaoshan Li, Fengfei Li, Bijun Chen, Jiajia He, Rolf Graf, Zilin Su. Pancreatic stone protein/regenerating protein (PSP/reg): a novel secreted protein up-regulated in type 2 diabetes mellitus. Endocrine. vol 48. issue 3. 2015-12-14. PMID:25234740. |
type 2 diabetes mellitus (t2dm) has insulin resistance (ir) or reduced β-cell mass, partially due to an increased β-cell apoptosis rate. |
2015-12-14 |
2023-08-13 |
human |
| Ran Rostoker, Sagi Abelson, Keren Bitton-Worms, Inna Genkin, Sarit Ben-Shmuel, Maria Dakwar, Zila Shen Orr, Avishay Caspi, Maty Tzukerman, Derek LeRoit. Highly specific role of the insulin receptor in breast cancer progression. Endocrine-related cancer. vol 22. issue 2. 2015-12-01. PMID:25694511. |
the tumorigenic effects of insulin on the mvt-1 cells were also demonstrated using microarray analysis, which indicates alteration of genes and signaling pathways involved in proliferation, the cell cycle, and apoptosis following insulin stimulation. |
2015-12-01 |
2023-08-13 |
mouse |
| Kenneth Craig, Cristina d'Agostino, Daniel Poratt, Marjorie Walke. Original hypothesis: Extracorporeal shockwaves as a homeostatic autoimmune restorative treatment (HART) for Type 1 diabetes mellitus. Medical hypotheses. vol 83. issue 3. 2015-11-30. PMID:24947195. |
mononuclear invasion of langerhans islet and the ensuing insulitis triggers signal-transduction for the autoimmune mediated pancreatic beta-cell (β-cell) apoptosis that severely disrupts insulin production resulting in hyperglycemia associated with type-1 diabetes (t1dm). |
2015-11-30 |
2023-08-13 |
Not clear |
| Shuguo Zheng, Mengqiu Zhao, Younan Ren, Yuanjie Wu, Jieren Yan. Sesamin suppresses STZ induced INS-1 cell apoptosis through inhibition of NF-κB activation and regulation of Bcl-2 family protein expression. European journal of pharmacology. vol 750. 2015-11-24. PMID:25637086. |
sesamin effectively improved stz induced cell damage as determined by mtt [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-h-tetrazolium bromide] assay and insulin secretion capacity, and suppressed stz induced cell apoptosis as evaluated by flow cytometry using annexin v and propidium iodide double staining. |
2015-11-24 |
2023-08-13 |
Not clear |
| Federico Figliolini, Vincenzo Cantaluppi, Michela De Lena, Silvia Beltramo, Renato Romagnoli, Mauro Salizzoni, Raffaella Melzi, Rita Nano, Lorenzo Piemonti, Ciro Tetta, Luigi Biancone, Giovanni Camuss. Isolation, characterization and potential role in beta cell-endothelium cross-talk of extracellular vesicles released from human pancreatic islets. PloS one. vol 9. issue 7. 2015-11-23. PMID:25028931. |
on iecs, we evaluated ev-induced insulin mrna transfer, proliferation, resistance to apoptosis, in vitro angiogenesis, migration, gene and protein profiling. |
2015-11-23 |
2023-08-13 |
human |
| Federico Figliolini, Vincenzo Cantaluppi, Michela De Lena, Silvia Beltramo, Renato Romagnoli, Mauro Salizzoni, Raffaella Melzi, Rita Nano, Lorenzo Piemonti, Ciro Tetta, Luigi Biancone, Giovanni Camuss. Isolation, characterization and potential role in beta cell-endothelium cross-talk of extracellular vesicles released from human pancreatic islets. PloS one. vol 9. issue 7. 2015-11-23. PMID:25028931. |
purified evs were internalized into iecs inducing insulin mrna expression, protection from apoptosis and enhancement of angiogenesis. |
2015-11-23 |
2023-08-13 |
human |
| Yoon Sin O. Plant-Derived Compounds Targeting Pancreatic Beta Cells for the Treatment of Diabetes. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-11-20. PMID:26587047. |
published data suggest that natural compounds directly enhance insulin secretion, prevent pancreatic beta cell apoptosis, and modulate pancreatic beta cell differentiation and proliferation. |
2015-11-20 |
2023-08-13 |
Not clear |
| Rachel J Salisbury, Bing Han, Rachel E Jennings, Andrew A Berry, Adam Stevens, Zainab Mohamed, Sarah A Sugden, Ronald De Krijger, Sarah E Cross, Paul P V Johnson, Melanie Newbould, Karen E Cosgrove, Karen Piper Hanley, Indraneel Banerjee, Mark J Dunne, Neil A Hanle. Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel. Diabetes. vol 64. issue 9. 2015-11-17. PMID:25931474. |
increased β-cell proliferation observed in some cases was offset by an increase in apoptosis; this is in keeping with no difference in insulin expression or surface area stained for insulin between chi-d and control pancreas. |
2015-11-17 |
2023-08-13 |
Not clear |
| Myriam Chentouf, Caroline Guzman, Moustafa Hamze, René Gross, Anne Dominique Lajoix, Sylvie Peraldi-Rou. Possible protective effect of membrane lipid rafts against interleukin-1β-mediated anti-proliferative effect in INS-1 cells. PloS one. vol 9. issue 7. 2015-11-09. PMID:25068701. |
in the present study, using the ins-1 rat pancreatic β-cell line, we investigated the potential involvement of membrane-associated cholesterol-enriched lipid rafts in il-1β signaling and biological effects on insulin secretion, β-cell proliferation and apoptosis. |
2015-11-09 |
2023-08-13 |
rat |
| Myriam Chentouf, Caroline Guzman, Moustafa Hamze, René Gross, Anne Dominique Lajoix, Sylvie Peraldi-Rou. Possible protective effect of membrane lipid rafts against interleukin-1β-mediated anti-proliferative effect in INS-1 cells. PloS one. vol 9. issue 7. 2015-11-09. PMID:25068701. |
disruption of membrane lipid rafts markedly reduced glucose-stimulated insulin secretion but did not affect either cell apoptosis or proliferation rate, demonstrating that membrane lipid raft integrity is essential for β-cell secretory function. |
2015-11-09 |
2023-08-13 |
rat |