| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Zhang, Zhanjiang Yu, Fengchun Den. The role of noggin in regulation of high glucose-induced apoptosis and insulin secretion in INS-1 rat beta cells. Iranian journal of basic medical sciences. vol 18. issue 11. 2016-03-07. PMID:26949503. |
the role of noggin in regulation of high glucose-induced apoptosis and insulin secretion in ins-1 rat beta cells. |
2016-03-07 |
2023-08-13 |
rat |
| Wei Zhang, Zhanjiang Yu, Fengchun Den. The role of noggin in regulation of high glucose-induced apoptosis and insulin secretion in INS-1 rat beta cells. Iranian journal of basic medical sciences. vol 18. issue 11. 2016-03-07. PMID:26949503. |
the purpose of this study was to investigate the effects of noggin on high glucose-induced apoptosis and insulin secretion in pancreatic beta cells. |
2016-03-07 |
2023-08-13 |
rat |
| Joanne E Mallinson, Kanagaraj Marimuthu, Andrew Murton, Anna Selby, Kenneth Smith, Dumitru Constantin-Teodosiu, Michael J Rennie, Paul L Greenhaf. Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression. The Journal of physiology. vol 593. issue 5. 2016-03-04. PMID:25620655. |
statin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis. |
2016-03-04 |
2023-08-13 |
human |
| R Amini, R Yazdanparast, S H Ghaffar. Apigenin modulates the expression levels of pro-inflammatory mediators to reduce the human insulin amyloid-induced oxidant damages in SK-N-MC cells. Human & experimental toxicology. vol 34. issue 6. 2016-03-02. PMID:25304968. |
pretreatment of sk-n-mc neuroblastoma cells with apigenin increased cell viability and reduced the apoptosis induced by insulin fibrils. |
2016-03-02 |
2023-08-13 |
human |
| Parisa Shoae-Hagh, Mahban Rahimifard, Mona Navaei-Nigjeh, Maryam Baeeri, Mahdi Gholami, Azadeh Mohammadirad, Mohammad Abdollah. Zinc oxide nanoparticles reduce apoptosis and oxidative stress values in isolated rat pancreatic islets. Biological trace element research. vol 162. issue 1-3. 2016-02-23. PMID:25183395. |
islets of langerhans were isolated and assessed for viability, functionality (insulin secretion), cytosolic reactive oxygen species (ros), and apoptosis by flow cytometry. |
2016-02-23 |
2023-08-13 |
rat |
| Lídia Cedó, Anna Castell-Auví, Victor Pallarès, Mayte Blay, Anna Ardévol, Montserrat Pinen. Grape Seed Procyanidin Extract Improves Insulin Production but Enhances Bax Protein Expression in Cafeteria-Treated Male Rats. International journal of food science. vol 2013. 2016-02-23. PMID:26904613. |
in a previous study, the administration of a grape seed procyanidin extract (gspe) in female wistar rats improved insulin resistance, reduced insulin production, and modulated apoptosis biomarkers in the pancreas. |
2016-02-23 |
2023-08-13 |
rat |
| Lídia Cedó, Anna Castell-Auví, Victor Pallarès, Mayte Blay, Anna Ardévol, Montserrat Pinen. Grape Seed Procyanidin Extract Improves Insulin Production but Enhances Bax Protein Expression in Cafeteria-Treated Male Rats. International journal of food science. vol 2013. 2016-02-23. PMID:26904613. |
the results have confirmed that the cafeteria model is a robust model mimicking a prediabetic state, as these rats display insulin resistance, increased insulin synthesis and secretion, and increased apoptosis in the pancreas. |
2016-02-23 |
2023-08-13 |
rat |
| Jun-Ho Lee, Soo-Bong Choi, Mingli Jin, Ju-Han Lee, Sang-Don Han, Hyemi Bae, Inja Lim, Yun-Hee No. Euglycemia in Diabetic Rats Leads to Reduced Liver Weight via Increased Autophagy and Apoptosis through Increased AMPK and Caspase-3 and Decreased mTOR Activities. Journal of diabetes research. vol 2015. 2016-02-09. PMID:26060824. |
in conclusion, euglycemia achieved by calorie-control is deleterious in insulin deficiency due to increased autophagy and apoptosis in the liver via ampk and caspase-3 activation. |
2016-02-09 |
2023-08-13 |
human |
| Yasuhiro Kubota, Hirofumi Noguchi, Masayuki Seita, Takeshi Yuasa, Hiromi Sasamoto, Shuhei Nakaji, Teru Okitsu, Toshiyoshi Fujiwara, Naoya Kobayash. Maintenance of Viability and Function of Rat Islets With the Use of ROCK Inhibitor Y-27632. Cell medicine. vol 6. issue 1-2. 2016-02-09. PMID:26858876. |
for islet transplantation, y-27632 inhibited cell apoptosis in a graft and was also effective in promoting insulin secretion. |
2016-02-09 |
2023-08-13 |
rat |
| Patricia de Godoy Bueno, Juliana Navarro Ueda Yochite, Graziela Fernanda Derigge-Pisani, Kelen Cristina Ribeiro Malmegrim de Farias, Lucimar Retto da Silva de Avó, Júlio César Voltarelli, Ângela Merice de Oliveira Lea. Metabolic and pancreatic effects of bone marrow mesenchymal stem cells transplantation in mice fed high-fat diet. PloS one. vol 10. issue 4. 2016-02-08. PMID:25923733. |
the results demonstrate the ability of multiple infusions of mscs to promote prolonged decrease in hyperglycemia and apoptosis in pancreatic islets and increase in insulin sensitivity in hfd fed mice. |
2016-02-08 |
2023-08-13 |
mouse |
| Maria Jose Garcia Barrado, Maria Carmen Iglesias Osma, Enrique J Blanco, Marta Carretero Hernández, Virginia Sánchez Robledo, Leonardo Catalano Iniesta, Sixto Carrero, Jose Carreter. Dopamine modulates insulin release and is involved in the survival of rat pancreatic beta cells. PloS one. vol 10. issue 4. 2016-01-18. PMID:25886074. |
the aim of the present study is to analyze whether dopamine is a regulator of the proliferation and apoptosis of rat pancreatic beta cells after glucose-stimulated insulin secretion. |
2016-01-18 |
2023-08-13 |
rat |
| Maria Jose Garcia Barrado, Maria Carmen Iglesias Osma, Enrique J Blanco, Marta Carretero Hernández, Virginia Sánchez Robledo, Leonardo Catalano Iniesta, Sixto Carrero, Jose Carreter. Dopamine modulates insulin release and is involved in the survival of rat pancreatic beta cells. PloS one. vol 10. issue 4. 2016-01-18. PMID:25886074. |
the cellular proliferation rate of pancreatic islets and beta cells was studied with immunocytochemical double labelling for both insulin and pcna (proliferating cell nuclear antigen), and active caspase-3 was detected to evaluate apoptosis. |
2016-01-18 |
2023-08-13 |
rat |
| Leticia P Roma, Jessica Duprez, Jean-Christophe Jona. Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration. American journal of physiology. Endocrinology and metabolism. vol 309. issue 7. 2016-01-18. PMID:26264555. |
after culture, β-cell apoptosis and islet gene mrna levels were measured, and the acute glucose-induced increase in nad(p)h autofluorescence, intracellular calcium concentration, and insulin secretion were tested in the absence or presence of ro. |
2016-01-18 |
2023-08-13 |
rat |
| Lidao Bao, Xudong Fu, Mingwen Si, Yi Wang, Ruilian Ma, Xianhua Ren, Haijun L. MicroRNA-185 targets SOCS3 to inhibit beta-cell dysfunction in diabetes. PloS one. vol 10. issue 2. 2016-01-15. PMID:25658748. |
overexpression of mir-185 enhanced insulin secretion of pancreatic β-cells, promoted cell proliferation and protected cells from apoptosis. |
2016-01-15 |
2023-08-13 |
mouse |
| M Agostina Santoro, R Eric Blue, Sarah F Andres, Amanda T Mah, Laurianne Van Landeghem, P Kay Lun. Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon. American journal of physiology. Gastrointestinal and liver physiology. vol 309. issue 7. 2016-01-15. PMID:26251471. |
prior human studies link elevated insulin and reduced apoptosis to risk of colorectal adenomas. |
2016-01-15 |
2023-08-13 |
mouse |
| Sher Zaman Safi, Kalaivani Batumalaie, Marzida Mansor, Karuthan Chinna, Syam Mohan, Hamed Karimian, Rajes Qvist, Muhammad Aqeel Ashraf, Garcie Ong Siok Ya. Glutamine treatment attenuates hyperglycemia-induced mitochondrial stress and apoptosis in umbilical vein endothelial cells. Clinics (Sao Paulo, Brazil). vol 70. issue 8. 2016-01-13. PMID:26247670. |
the aim of this study was to determine the in vitro effect of glutamine and insulin on apoptosis, mitochondrial membrane potential, cell permeability, and inflammatory cytokines in hyperglycemic umbilical vein endothelial cells. |
2016-01-13 |
2023-08-13 |
Not clear |
| Joao Rocha, Maria-Eduardo Figueira, Andreia Barateiro, Adelaide Fernandes, Dora Brites, Rui Pinto, Marisa Freitas, Eduarda Fernandes, Helder Mota-Filipe, Bruno Sepode. Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat. Shock (Augusta, Ga.). vol 43. issue 4. 2016-01-11. PMID:25394244. |
today, we know that this kinase is involved in the regulation of many cell functions, including insulin signaling, specification of cell fate during embryonic development, and the control of cell division and apoptosis. |
2016-01-11 |
2023-08-13 |
rat |
| Jiangzheng Liu, Xin Wang, Zhengwu Peng, Tao Zhang, Hao Wu, Weihua Yu, Deqing Kong, Ying Liu, Hua Bai, Rui Liu, Xiaodi Zhang, Chunxu Ha. The effects of insulin pre-administration in mice exposed to ethanol: alleviating hepatic oxidative injury through anti-oxidative, anti-apoptotic activities and deteriorating hepatic steatosis through SRBEP-1c activation. International journal of biological sciences. vol 11. issue 5. 2016-01-11. PMID:25892964. |
for addressing the effects and mechanisms of insulin pre-administration on ethanol-induced liver oxidative injury, we investigated histopathology, inflammatory factors, apoptosis, mitochondrial dysfunction, oxidative stress, antioxidant defense system, ethanol metabolic enzymes and lipid disorder in liver of ethanol-exposed mice pretreatment with insulin or not. |
2016-01-11 |
2023-08-13 |
mouse |
| Jiangzheng Liu, Xin Wang, Zhengwu Peng, Tao Zhang, Hao Wu, Weihua Yu, Deqing Kong, Ying Liu, Hua Bai, Rui Liu, Xiaodi Zhang, Chunxu Ha. The effects of insulin pre-administration in mice exposed to ethanol: alleviating hepatic oxidative injury through anti-oxidative, anti-apoptotic activities and deteriorating hepatic steatosis through SRBEP-1c activation. International journal of biological sciences. vol 11. issue 5. 2016-01-11. PMID:25892964. |
second, insulin pre-administration could significantly reduce apoptosis and ameliorate mitochondrial dysfunction in liver of mice exposed to ethanol, supporting by decreasing caspases-3 activities and the ratio of bax/bcl-2, increasing mitochondrial viability and mitochondrial oxygen consumption, inhibition of the decline of atp levels and mitochondrial ros accumulation. |
2016-01-11 |
2023-08-13 |
mouse |
| Wu Qi Nan, Zhang Ling, Chen Bin. The influence of the telomere-telomerase system on diabetes mellitus and its vascular complications. Expert opinion on therapeutic targets. vol 19. issue 6. 2016-01-08. PMID:25677239. |
dna damage and apoptosis are associated with oxidative stress and are involved in the dysfunction of pancreatic β cells, insulin resistance, and its vascular complications. |
2016-01-08 |
2023-08-13 |
Not clear |