| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Xing, Di Yang, Jing Lu, De-Li Don. Insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating Akt. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25490386. |
insulin did not elicit cardiomyocyte apoptosis, but antagonized bmp4-induced cardiomyocyte apoptosis. |
2015-03-13 |
2023-08-13 |
Not clear |
| Yue Xing, Di Yang, Jing Lu, De-Li Don. Insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating Akt. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25490386. |
in conclusion, insulin prevents bmp4-induced cardiomyocyte apoptosis and the underlying mechanisms include activation of akt. |
2015-03-13 |
2023-08-13 |
Not clear |
| Barjesh C Sharma, Ajay Kumar, Vishal Garg, Ravi S Reddy, Puja Sakhuja, Shiv K Sari. A Randomized Controlled Trial Comparing Efficacy of Pentoxifylline and Pioglitazone on Metabolic Factors and Liver Histology in Patients with Non-alcoholic Steatohepatitis. Journal of clinical and experimental hepatology. vol 2. issue 4. 2015-03-10. PMID:25755455. |
non-alcoholic steatohepatitis (nash) involves increased hepatic macrosteatosis due to increased insulin resistance and non-hepatic processes including oxidative stress, apoptosis, and increased pro-inflammatory cytokines. |
2015-03-10 |
2023-08-13 |
Not clear |
| Sayuri Tanaka, Shozo Yano, Abdullah M Sheikh, Atsushi Nagai, Toshitsugu Sugimot. Effects of uremic toxin p-cresol on proliferation, apoptosis, differentiation, and glucose uptake in 3T3-L1 cells. Artificial organs. vol 38. issue 7. 2015-03-09. PMID:24417700. |
high concentrations of p-cresol disturbed the cell cycle, induced apoptosis, inhibited the differentiation of preadipocytes into mature adipocytes, and decreased glucose uptake at baseline and after insulin stimulation. |
2015-03-09 |
2023-08-12 |
mouse |
| Gérald J Prud'homme, Yelena Glinka, Oleksandr Udovyk, Craig Hasilo, Steven Paraskevas, Qinghua Wan. GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25193706. |
gaba increased insulin production and reduced drug-induced apoptosis, and these actions were reversed by sirt1 inhibitors. |
2015-02-25 |
2023-08-13 |
human |
| Won-Mo Yang, Wan Le. CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25195818. |
ctrp5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of ampk and fatty acid oxidation. |
2015-02-25 |
2023-08-13 |
Not clear |
| Won-Mo Yang, Wan Le. CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25195818. |
lipotoxicity resulting from a high concentration of saturated fatty acids is closely linked to development of insulin resistance, as well as apoptosis in skeletal muscle. |
2015-02-25 |
2023-08-13 |
Not clear |
| Won-Mo Yang, Wan Le. CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25195818. |
we found that globular domain of ctrp5 (gctrp5) prevented palmitate-induced apoptosis and insulin resistance in myocytes by inhibiting the activation of caspase-3, reactive oxygen species accumulation, and irs-1 reduction. |
2015-02-25 |
2023-08-13 |
Not clear |
| Jia Xiao, Feiyue Xing, Jie Huo, Man Lung Fung, Emily C Liong, Yick Pang Ching, Aimin Xu, Raymond Chuen Chung Chang, Kwok Fai So, George L Tipo. Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. Scientific reports. vol 4. 2015-02-24. PMID:24998389. |
when compared with nash rats treated for 12 weeks, therapeutic lbp treatment for 4 weeks during 12 weeks of nash induction showed ameliorative effects on: (1) increased body and wet liver weights; (2) insulin resistance and glucose metabolic dysfunction; (3) elevated level of serum aminotransferases; (4) fat accumulation in the liver and increased serum free fatty acid (ffa) level; (5) hepatic fibrosis; (6) hepatic oxidative stress; (7) hepatic inflammatory response; and (8) hepatic apoptosis. |
2015-02-24 |
2023-08-13 |
rat |
| Jacqueline F Rivera, Safia Costes, Tatyana Gurlo, Charles G Glabe, Peter C Butle. Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity. The Journal of clinical investigation. vol 124. issue 8. 2015-02-18. PMID:25036708. |
type 2 diabetes (t2d) is characterized by a deficiency in β cell mass, increased β cell apoptosis, and extracellular accumulation of islet amyloid derived from islet amyloid polypeptide (iapp), which β cells coexpress with insulin. |
2015-02-18 |
2023-08-13 |
mouse |
| Aimon K Alkanani, Naoko Hara, Roberto Gianani, Danny Zipri. Kilham Rat Virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis. Virology. vol 468-470. 2015-02-17. PMID:25129435. |
krv induces genes involved in type i and type ii interferon pathways in islet cell lines in vitro and in islets from day-5-infected animals in vivo via mechanisms that do not involve insulitis, beta cell apoptosis, or impaired insulin expression. |
2015-02-17 |
2023-08-13 |
rat |
| Luisa Costa, Francesco Caso, Mariangela Atteno, Antonio Del Puente, Md Abud Darda, Paolo Caso, Augusta Ortolan, Ugo Fiocco, Roberta Ramonda, Leonardo Punzi, Raffaele Scarp. Impact of 24-month treatment with etanercept, adalimumab, or methotrexate on metabolic syndrome components in a cohort of 210 psoriatic arthritis patients. Clinical rheumatology. vol 33. issue 6. 2015-02-13. PMID:23959447. |
tumor necrosis factor (tnf)-α is a pro-inflammatory adipocytokine mainly produced by monocytes and macrophages with a central role in inflammatory responses, but it also induces adipocytes apoptosis, promotes insulin resistance, and stimulates lipolysis. |
2015-02-13 |
2023-08-12 |
Not clear |
| Gemma Rojo-Martínez, Elsa Maymó-Masip, M Mar Rodríguez, Esther Solano, Albert Goday, Federico Soriguer, Sergio Valdés, Felipe Javier Chaves, Elías Delgado, Natalia Colomo, Pilar Hernández, Joan Vendrell, Matilde R Chacó. Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: results of the Di@bet.es study. PloS one. vol 9. issue 6. 2015-02-12. PMID:24978196. |
serum levels of soluble tnf-like weak inducer of apoptosis (stweak) and its scavenger receptor cd163 (scd163) have been linked to insulin resistance. |
2015-02-12 |
2023-08-13 |
Not clear |
| Shaoping Zhang, Hong Liu, Chia Lin Chuang, Xiaoling Li, Maggie Au, Lin Zhang, Anthony R J Phillips, David W Scott, Garth J S Coope. The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 12. 2015-02-04. PMID:25138158. |
this is the first report to show that ha-evoked diabetes is associated with age, insulin resistance, progressive islet dysfunction, and β-cell apoptosis, which interact variably to cause the different diabetes syndromes. |
2015-02-04 |
2023-08-13 |
mouse |
| Yang Yang, Fengbiao Wen, Lifeng Dang, Yuxia Fan, Donglei Liu, Kai Wu, Song Zha. Insulin enhances apoptosis induced by cisplatin in human esophageal squamous cell carcinoma EC9706 cells related to inhibition of autophagy. Chinese medical journal. vol 127. issue 2. 2015-01-28. PMID:24438628. |
insulin enhances apoptosis induced by cisplatin in human esophageal squamous cell carcinoma ec9706 cells related to inhibition of autophagy. |
2015-01-28 |
2023-08-12 |
human |
| Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Aggunda N Yateesh, Korrapati Neelima, Srikanth Mrudula, Madhusudhan Reddy, Rachapalli Smitha, Sanghamitra Biswas, Bhawna Chandravanshi, Puttrevana M Pallavi, Anup M Oommen, Madanahalli R Jagannath, Baggavalli B Somes. Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function. BMC cell biology. vol 15. 2015-01-22. PMID:24974801. |
chronic inflammation-mediated β-cell apoptosis is known to decrease β-cell mass in diabetes leading to reduced insulin secretion. |
2015-01-22 |
2023-08-13 |
Not clear |
| Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Aggunda N Yateesh, Korrapati Neelima, Srikanth Mrudula, Madhusudhan Reddy, Rachapalli Smitha, Sanghamitra Biswas, Bhawna Chandravanshi, Puttrevana M Pallavi, Anup M Oommen, Madanahalli R Jagannath, Baggavalli B Somes. Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function. BMC cell biology. vol 15. 2015-01-22. PMID:24974801. |
we hypothesized that gpr40 activation can protect β-cells from inflammation-induced apoptosis and restore glucose stimulated insulin secretion. |
2015-01-22 |
2023-08-13 |
Not clear |
| Olatz Villate, Jean-Valery Turatsinze, Loriana G Mascali, Fabio A Grieco, Tatiane C Nogueira, Daniel A Cunha, Tarlliza R Nardelli, Michael Sammeth, Vishal A Salunkhe, Jonathan L S Esguerra, Lena Eliasson, Lorella Marselli, Piero Marchetti, Decio L Eiziri. Nova1 is a master regulator of alternative splicing in pancreatic beta cells. Nucleic acids research. vol 42. issue 18. 2015-01-15. PMID:25249621. |
in line with these findings, nova1 silencing inhibited insulin secretion and induced apoptosis basally and after cytokine treatment in rodent and human beta cells. |
2015-01-15 |
2023-08-13 |
human |
| Hai-Lian Wang, Chun-Yang Li, Bin Zhang, Yuan-De Liu, Bang-Min Lu, Zheng Shi, Na An, Liang-Kai Zhao, Jing-Jing Zhang, Jin-Ku Bao, Yi Wan. Mangiferin facilitates islet regeneration and β-cell proliferation through upregulation of cell cycle and β-cell regeneration regulators. International journal of molecular sciences. vol 15. issue 5. 2015-01-06. PMID:24853132. |
mangiferin-treated mice exhibited an improved glycemia and glucose tolerance, increased serum insulin levels, enhanced β-cell hyperplasia, elevated β-cell proliferation and reduced β-cell apoptosis. |
2015-01-06 |
2023-08-13 |
mouse |
| K-Lynn N Hogh, Michael N Craig, Christopher E Uy, Heli Nygren, Ali Asadi, Madeline Speck, Jordie D Fraser, Alexander P Rudecki, Robert K Baker, Matej Orešič, Sarah L Gra. Overexpression of PPARγ specifically in pancreatic β-cells exacerbates obesity-induced glucose intolerance, reduces β-cell mass, and alters islet lipid metabolism in male mice. Endocrinology. vol 155. issue 10. 2015-01-05. PMID:25051434. |
we show β-cell-specific pparγ1 or pparγ2 overexpression in diet-induced obese mice exacerbated obesity-induced glucose intolerance with decreased β-cell mass, increased islet cell apoptosis, and decreased plasma insulin compared with obese control mice (β-egfp-hfd mice). |
2015-01-05 |
2023-08-13 |
mouse |