| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vanessa Legry, Derrick M Van Rooyen, Barbara Lambert, Christine Sempoux, Laurence Poekes, Regina Español-Suñer, Olivier Molendi-Coste, Yves Horsmans, Geoffrey C Farrell, Isabelle A Leclerc. Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice. Clinical science (London, England : 1979). vol 127. issue 7. 2014-09-30. PMID:24766485. |
these results show that signals driving hepatic inflammation, apoptosis and insulin resistance are independent of er stress in obese diabetic mice with steatohepatitis. |
2014-09-30 |
2023-08-13 |
mouse |
| Hai-Tao Liu, Hai-Feng Zhang, Rui Si, Quan-Jiang Zhang, Kun-Ru Zhang, Wen-Yi Guo, Hai-Chang Wang, Feng Ga. Insulin protects isolated hearts from ischemia/reperfusion injury: cross-talk between PI3-K/Akt and JNKs. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 5. 2014-09-29. PMID:17940706. |
compared with the control group, insulin treatment in mi/r rats exerted protective effects as evidenced by reduced myocardial is [(28.9 +/- 2.0)% vs (45.0 +/- 4.0) %, n=6, p<0.01], inhibited cardiomyocyte apoptosis [decreased ai: (16.0 +/- 0.7) % vs (27.6 +/- 1.3) %, n=6, p<0.01] and improved recovery of cardiac systolic/diastolic function (including lvdp and +/-lvdp/dt(max)) at the end of reperfusion. |
2014-09-29 |
2023-08-12 |
rat |
| Omotayo O Erejuwa, Siti A Sulaiman, Mohd S Ab Waha. Effects of honey and its mechanisms of action on the development and progression of cancer. Molecules (Basel, Switzerland). vol 19. issue 2. 2014-09-26. PMID:24566317. |
these include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. |
2014-09-26 |
2023-08-12 |
Not clear |
| Mi-Young Song, Ui-Jin Bae, Kyu Yun Jang, Byung-Hyun Par. Transplantation of betacellulin-transduced islets improves glucose intolerance in diabetic mice. Experimental & molecular medicine. vol 46. 2014-09-25. PMID:24875130. |
finally, cultured islets transduced with betacellulin displayed increased proliferation, reduced apoptosis and enhanced glucose-stimulated insulin secretion in the presence of cytokines. |
2014-09-25 |
2023-08-13 |
mouse |
| Ailsa A Welc. Nutritional influences on age-related skeletal muscle loss. The Proceedings of the Nutrition Society. vol 73. issue 1. 2014-09-24. PMID:24229650. |
in terms of catabolism the ubiquitin proteasome system, apoptosis, autophagy, inflammation, oxidation and insulin resistance are among the major mechanisms proposed. |
2014-09-24 |
2023-08-12 |
Not clear |
| Liselotte Fransson, Victoria Rosengren, Titu Kumar Saha, Nina Grankvist, Tohidul Islam, Richard E Honkanen, Åke Sjöholm, Henrik Ortsäte. Mitogen-activated protein kinases and protein phosphatase 5 mediate glucocorticoid-induced cytotoxicity in pancreatic islets and β-cells. Molecular and cellular endocrinology. vol 383. issue 1-2. 2014-09-19. PMID:24361515. |
in addition to inducing insulin resistance, glucocorticoids impair β-cell function and cause β-cell apoptosis. |
2014-09-19 |
2023-08-12 |
Not clear |
| Wei Zhang, Chao Ni, Jie Sheng, Yanyin Hua, Jiangbo Ma, Lijun Wang, Yu Zhao, Yubo Xin. TLQP-21 protects human umbilical vein endothelial cells against high-glucose-induced apoptosis by increasing G6PD expression. PloS one. vol 8. issue 11. 2014-09-18. PMID:24278172. |
past studies have reported that tlqp-21 could stimulate insulin secretion in pancreatic cells and protect these cells from apoptosis, which suggests that tlqp-21 has a potential function in diabetes therapy. |
2014-09-18 |
2023-08-12 |
human |
| Kai-Chun Cheng, Akihiro Asakawa, Ying-Xiao Li, Hsien-Hui Chung, Haruka Amitani, Takatoshi Ueki, Juei-Tang Cheng, Akio Inu. Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in Wistar rats. PloS one. vol 9. issue 1. 2014-09-16. PMID:24404172. |
phosphatase and tensin homolog (pten) is a phosphoinositide phosphatase that regulates crucial cellular functions, including insulin signaling, lipid and glucose metabolism, as well as survival and apoptosis. |
2014-09-16 |
2023-08-12 |
rat |
| Nan Hu, Maolong Dong, Jun Re. Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis. American journal of physiology. Regulatory, integrative and comparative physiology. vol 306. issue 10. 2014-09-16. PMID:24622975. |
hydrogen sulfide alleviates cardiac contractile dysfunction in an akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis. |
2014-09-16 |
2023-08-12 |
mouse |
| Xiaojin Li, Bing Xue, Xuan Wang, Lianqing Sun, Tingting Zhang, Ling Qu, Xiaoman Zou, Yiming M. Reduced expression of the LRP16 gene in mouse insulinoma (MIN6) cells exerts multiple effects on insulin content, proliferation and apoptosis. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 32. issue 2. 2014-09-11. PMID:22528219. |
reduced expression of the lrp16 gene in mouse insulinoma (min6) cells exerts multiple effects on insulin content, proliferation and apoptosis. |
2014-09-11 |
2023-08-12 |
mouse |
| Chia-Lei Lin, Lyda Williams, Yoshinori Seki, Harpreet Kaur, Kirsten Hartil, Ariana Fiallo, A Scott Glenn, Ellen B Katz, Maureen J Charron, Patricia M Vugui. Effects of genetics and in utero diet on murine pancreatic development. The Journal of endocrinology. vol 222. issue 2. 2014-09-05. PMID:24895417. |
at embryonic day 18.5, fetuses were killed and pancreata isolated for analysis of morphology and expression of genes involved in insulin (ins) cell development, proliferation, apoptosis, glucose transport and function. |
2014-09-05 |
2023-08-13 |
mouse |
| Gholamreza Taheripak, Salar Bakhtiyari, Masoumeh Rajabibazl, Parvin Pasalar, Reza Meshkan. Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells. Free radical biology & medicine. vol 65. 2014-09-02. PMID:24120971. |
in summary, our results indicate that ptp1b modulation results in (1) alterations in mitochondrial function by changes in the activity of sirt1/nf-κb/pgc-1α pathways and (2) changes in apoptosis that result from either a direct effect of ptp1b on the insulin signaling pathway or an indirect influence on ceramide content, ros generation, jnk activation, and foxo-1 nuclear translocation. |
2014-09-02 |
2023-08-12 |
Not clear |
| Daniel Khananshvil. Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions. Pflugers Archiv : European journal of physiology. vol 466. issue 1. 2014-08-11. PMID:24281864. |
mammalian ncx variants (ncx1-3) and their splice variants are expressed in a tissue-specific manner to modulate the heartbeat rate and contractile force, the brain's long-term potentiation and learning, blood pressure, renal ca(2+) reabsorption, the immune response, neurotransmitter and insulin secretion, apoptosis and proliferation, mitochondrial bioenergetics, etc. |
2014-08-11 |
2023-08-12 |
Not clear |
| Thomas H Sanderson, Gargi Mahapatra, Petr Pecina, Qinqin Ji, Kebing Yu, Christopher Sinkler, Ashwathy Varughese, Rita Kumar, Melissa J Bukowski, Renee N Tousignant, Arthur R Salomon, Icksoo Lee, Maik Hütteman. Cytochrome C is tyrosine 97 phosphorylated by neuroprotective insulin treatment. PloS one. vol 8. issue 11. 2014-08-08. PMID:24223835. |
these data suggest a mechanism whereby cytc is targeted for phosphorylation by insulin signaling, which may prevent its release from the mitochondria and the induction of apoptosis. |
2014-08-08 |
2023-08-12 |
rat |
| Min Zha, Wei Xu, Qing Zhai, Fengfei Li, Bijun Chen, Zilin Su. High glucose aggravates the detrimental effects of pancreatic stellate cells on Beta-cell function. International journal of endocrinology. vol 2014. 2014-08-06. PMID:25097548. |
in vitro the effects of pscs conditioned medium (pscs-cm) and/or high concentration of glucose on ins-1 cell function was assessed by measuring insulin secretion, ins-1 cell survival, apoptosis, and endoplasmic reticulum stress (er stress) associated chop expression. |
2014-08-06 |
2023-08-13 |
rat |
| Min Zha, Wei Xu, Qing Zhai, Fengfei Li, Bijun Chen, Zilin Su. High glucose aggravates the detrimental effects of pancreatic stellate cells on Beta-cell function. International journal of endocrinology. vol 2014. 2014-08-06. PMID:25097548. |
in vitro, pscs-cm caused impaired ins-1 cell viability and insulin secretion and increased apoptosis, which were more pronounced in the presence of high glucose. |
2014-08-06 |
2023-08-13 |
rat |
| Yoon Sin Oh, Hee-Sook Ju. Role of bioactive food components in diabetes prevention: effects on Beta-cell function and preservation. Nutrition and metabolic insights. vol 7. 2014-08-05. PMID:25092987. |
published data suggest that there might be direct effects of bioactive compounds on enhancing insulin secretion and preventing beta-cell apoptosis, and some compounds might modulate beta-cell proliferation. |
2014-08-05 |
2023-08-13 |
Not clear |
| Eva Márquez, Marta Riera, Julio Pascual, María José Sole. Albumin inhibits the insulin-mediated ACE2 increase in cultured podocytes. American journal of physiology. Renal physiology. vol 306. issue 11. 2014-07-31. PMID:24671333. |
our results suggest that modulation of renin-angiotensin system balance, fibrosis, and apoptosis by insulin in the podocyte may be an important factor in preventing the development and progression of diabetic kidney disease, but the presence of albuminuria seems to block these beneficial effects. |
2014-07-31 |
2023-08-12 |
mouse |
| William Samuel, R Krishnan Kutty, Todd Duncan, Camasamudram Vijayasarathy, Bryan C Kuo, Krysten M Chapa, T Michael Redmon. Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells. Journal of cellular physiology. vol 229. issue 8. 2014-07-21. PMID:24357007. |
increase in scd expression is strongly implicated in the proliferation and survival of cancer cells, whereas its decrease is known to impair proliferation, induce apoptosis, and restore insulin sensitivity. |
2014-07-21 |
2023-08-12 |
human |
| William Samuel, R Krishnan Kutty, Todd Duncan, Camasamudram Vijayasarathy, Bryan C Kuo, Krysten M Chapa, T Michael Redmon. Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells. Journal of cellular physiology. vol 229. issue 8. 2014-07-21. PMID:24357007. |
we examined whether fenretinide, (n-(4-hydroxyphenyl)retinamide, 4hpr), which induces apoptosis in cancer cells and recently shown to improve insulin sensitivity, can modulate the expression of scd. |
2014-07-21 |
2023-08-12 |
human |