| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuheng Ma, Noah Moruzzi, Sergiu-Bogdan Catrina, Valdemar Grill, Anneli Björklun. Hyperoxia inhibits glucose-induced insulin secretion and mitochondrial metabolism in rat pancreatic islets. Biochemical and biophysical research communications. vol 443. issue 1. 2014-05-06. PMID:24299957. |
negative effects on insulin secretion and complexes iii and iv waned after a 22 h period of normoxia following hyperoxia whereas complexes i and ii were still diminished, ros production was increased and rates of apoptosis tended to be increased (p=0.07). |
2014-05-06 |
2023-08-12 |
rat |
| Julien Puyal, Jannick Pétremand, Gilles Dubuis, Coralie Rummel, Christian Widman. HDLs protect the MIN6 insulinoma cell line against tunicamycin-induced apoptosis without inhibiting ER stress and without restoring ER functionality. Molecular and cellular endocrinology. vol 381. issue 1-2. 2014-05-01. PMID:23994023. |
hdls protect pancreatic beta cells against apoptosis induced by several endoplasmic reticulum (er) stressors, including thapsigargin, cyclopiazonic acid, palmitate and insulin over-expression. |
2014-05-01 |
2023-08-12 |
Not clear |
| Kazuto Tajiri, Yukihiro Shimiz. Branched-chain amino acids in liver diseases. World journal of gastroenterology. vol 19. issue 43. 2014-05-01. PMID:24282351. |
branched chain amino acids (bcaas) have been shown to affect gene expression, protein metabolism, apoptosis and regeneration of hepatocytes, and insulin resistance. |
2014-05-01 |
2023-08-12 |
Not clear |
| Stergios A Polyzos, Jannis Kountouras, Athanasios Papatheodorou, Evangelia Katsiki, Kalliopi Patsiaoura, Efthimia Zafeiriadou, Evridiki Papadopoulou, Christos Zavos, Evangelos Terpo. Adipocytokines and cytokeratin-18 in patients with nonalcoholic fatty liver disease: Introduction of CHA index. Annals of hepatology. vol 12. issue 5. 2014-04-22. PMID:24067262. |
insulin resistance (ir), adipocytokines, oxidative stress and hepatic apoptosis play a pathogenetic role in nonalcoholic fatty liver disease (nafld). |
2014-04-22 |
2023-08-12 |
Not clear |
| Dieter Rondas, Marco Bugliani, Wannes D'Hertog, Kasper Lage, Mathilde Masini, Etienne Waelkens, Piero Marchetti, Chantal Mathieu, Lut Overberg. Glucagon-like peptide-1 protects human islets against cytokine-mediated β-cell dysfunction and death: a proteomic study of the pathways involved. Journal of proteome research. vol 12. issue 9. 2014-04-08. PMID:23937086. |
co-incubation of cytokine-treated human islets with glp-1 resulted in a marked protection of β-cells against cytokine-induced apoptosis and significantly attenuated cytokine-mediated inhibition of glucose-stimulated insulin secretion. |
2014-04-08 |
2023-08-12 |
human |
| Tomader Ali, George Kokotos, Victoria Magrioti, Robert N Bone, James A Mobley, William Hancock, Sasanka Ramanadha. Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977134. |
here we characterized its inhibitory profile in beta-cells and find that fkgk18: (a) inhibits ipla2β with a greater potency (100-fold) than ipla2γ, (b) inhibition of ipla2β is reversible, (c) is an ineffective inhibitor of α-chymotrypsin, and (d) inhibits previously described outcomes of ipla2β activation including (i) glucose-stimulated insulin secretion, (ii) arachidonic acid hydrolysis; as reflected by pge2 release from human islets, (iii) er stress-induced neutral sphingomyelinase 2 expression, and (iv) er stress-induced beta-cell apoptosis. |
2014-04-08 |
2023-08-12 |
human |
| Riwa Ozasa, Tetsuya Okada, Satomi Nadanaka, Takahiko Nagamine, Alisha Zyryanova, Heather Harding, David Ron, Kazutoshi Mor. The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation. Cell structure and function. vol 38. issue 2. 2014-04-07. PMID:23812432. |
inhibition of protein synthesis and knockdown of insulin mrna, which result in less unfolded protein burden, both attenuated subsequent olanzapine-induced apoptosis. |
2014-04-07 |
2023-08-12 |
Not clear |
| Wen-Yan Li, Yang-Liu Song, Cheng-Juan Xiong, Pei-Qi Lu, Li-Xiang Xue, Chun-Xia Yao, Wei-Ping Wang, Shu-Feng Zhang, Shan-Feng Zhang, Qing-Xia Wei, Yan-Yan Zhang, Ji-Min Zhao, Ming-Xi Zan. Insulin induces proliferation and cardiac differentiation of P19CL6 cells in a dose-dependent manner. Development, growth & differentiation. vol 55. issue 7. 2014-04-03. PMID:24020834. |
in this study, we observed for the first time that 10 nmol/l insulin treatment induces cell proliferation and cardiac differentiation of p19cl6 cells, whereas 50 and 100 nmol/l insulin treatment induces p19cl6 cell apoptosis and blocks cardiac differentiation of p19cl6 cells. |
2014-04-03 |
2023-08-12 |
Not clear |
| Muhammad Sajid Akash, Kanwal Rehman, Shuqing Che. Goto-Kakizaki rats: its suitability as non-obese diabetic animal model for spontaneous type 2 diabetes mellitus. Current diabetes reviews. vol 9. issue 5. 2014-03-31. PMID:23855509. |
β-cell dysfunction and apoptosis are recognized as a major cause of insufficient insulin secretion in response to high blood glucose and metabolic demand. |
2014-03-31 |
2023-08-12 |
human |
| Zheng Chen, David L Morris, Lin Jiang, Yong Liu, Liangyou Ru. SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion. Diabetes. vol 63. issue 2. 2014-03-28. PMID:24150605. |
hfd-fed pko mice also had increased β-cell apoptosis, decreased β-cell proliferation, decreased β-cell mass, decreased pancreatic insulin content, impaired insulin secretion, and exacerbated glucose intolerance. |
2014-03-28 |
2023-08-12 |
mouse |
| Fang-Hong Shi, You Wu, De-Zai Dai, Xiao-Dong Cong, Yu-Mao Zhang, Yin Da. Hepatosteatosis and hepatic insulin resistance are blunted by argirein, an anti-inflammatory agent, through normalizing endoplasmic reticulum stress and apoptosis in diabetic liver. The Journal of pharmacy and pharmacology. vol 65. issue 6. 2014-03-27. PMID:23647685. |
hepatosteatosis and hepatic insulin resistance are blunted by argirein, an anti-inflammatory agent, through normalizing endoplasmic reticulum stress and apoptosis in diabetic liver. |
2014-03-27 |
2023-08-12 |
Not clear |
| Detlef Schuppan, Jörn M Schattenber. Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches. Journal of gastroenterology and hepatology. vol 28 Suppl 1. 2014-03-25. PMID:23855299. |
these lead to liver injury via insulin resistance and an excess of free fatty acids in hepatocytes, resulting in oxidant stress and lipotoxicity that promote the activation of intracellular stress kinases and apoptosis or necroapoptosis (nash). |
2014-03-25 |
2023-08-12 |
human |
| Ui-Jin Bae, Mi-Young Song, Hyun-Young Jang, Hyo Jin Gim, Jae-Ha Ryu, Sang-Myeong Lee, Raok Jeon, Byung-Hyun Par. The efficacy of SPA0355 in protecting β cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes. Experimental & molecular medicine. vol 45. 2014-03-20. PMID:24176948. |
the protective effects of spa0355 against cytokine toxicity were further demonstrated by normal insulin secretion and absence of apoptosis of cytokine-treated islets. |
2014-03-20 |
2023-08-12 |
mouse |
| Joanne Sloan-Lancaster, Eyas Abu-Raddad, John Polzer, Jeffrey W Miller, Joel C Scherer, Andrea De Gaetano, Jolene K Berg, William H Landschul. Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1β antibody, in patients with type 2 diabetes. Diabetes care. vol 36. issue 8. 2014-03-17. PMID:23514733. |
inflammation is associated with pancreatic β-cell apoptosis and reduced insulin sensitivity. |
2014-03-17 |
2023-08-12 |
Not clear |
| Tie-Jian Jiang, Zhi-Guang Zho. [Oral administration of insulin inhibits islet beta cell apoptosis and prevents diabetes in NOD mice]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 32. issue 4. 2014-03-10. PMID:17767052. |
[oral administration of insulin inhibits islet beta cell apoptosis and prevents diabetes in nod mice]. |
2014-03-10 |
2023-08-12 |
mouse |
| Tie-Jian Jiang, Zhi-Guang Zho. [Oral administration of insulin inhibits islet beta cell apoptosis and prevents diabetes in NOD mice]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 32. issue 4. 2014-03-10. PMID:17767052. |
to investigate the effect of oral administration of insulin on insulitis beta cell apoptosis and diabetes in non-obese diabetic (nod) mice, and to explore the mechanism of immune tolerance induced by insulin. |
2014-03-10 |
2023-08-12 |
mouse |
| Brian Rady, Yanmei Chen, Pilar Vaca, Qian Wang, Yong Wang, Patrick Salmon, José Oberholze. Overexpression of E2F3 promotes proliferation of functional human β cells without induction of apoptosis. Cell cycle (Georgetown, Tex.). vol 12. issue 16. 2014-03-10. PMID:23907129. |
these cells did not undergo apoptosis and retained their glucose-responsive insulin secretion, showing the ability to reverse diabetes in mice. |
2014-03-10 |
2023-08-12 |
mouse |
| Jiaying Wang, Zhenzhou Jiang, Jinzi Ji, Xinzhi Wang, Tao Wang, Yun Zhang, Ting Tai, Mi Chen, Lixin Sun, Xia Li, Luyong Zhan. Gene expression profiling and pathway analysis of hepatotoxicity induced by triptolide in Wistar rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 58. 2014-03-05. PMID:23639586. |
analyses of these genes identified over-represented functions associated with insulin signaling pathway, glucose metabolism, cell cycle, oxidative stress and apoptosis, which were consistent with the results of significant increase of caspase-3 activity and reduction of serum glucose, gsh/gssg ratio, glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities, liver glycogen. |
2014-03-05 |
2023-08-12 |
rat |
| Jiaying Wang, Zhenzhou Jiang, Jinzi Ji, Xinzhi Wang, Tao Wang, Yun Zhang, Ting Tai, Mi Chen, Lixin Sun, Xia Li, Luyong Zhan. Gene expression profiling and pathway analysis of hepatotoxicity induced by triptolide in Wistar rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 58. 2014-03-05. PMID:23639586. |
these data suggest that tp treatment could alter the hepatic redox status, reduce serum glucose and induce hepatocyte apoptosis, consistent with the differential expression of genes involved in insulin signaling pathway, glucose metabolism pathway and cell stress pathway, all of which might contribute to the overall tp-induced hepatotoxicity. |
2014-03-05 |
2023-08-12 |
rat |
| Sabine Rütti, Caroline Arous, Alexandra C Nica, Makoto Kanzaki, Philippe A Halban, Karim Bouzakr. Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells. FEBS letters. vol 588. issue 1. 2014-02-27. PMID:24239544. |
knockdown of tbc1d1 in beta-cells resulted in increased basal and glucose-stimulated insulin release, decreased proliferation but no change in apoptosis. |
2014-02-27 |
2023-08-12 |
human |