| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maha Baligh Zickri, Nagwa Abdel Wahab Ahmad, Zeinab Mohamad El Maadawi, Yasmin Kamal Mohamady, Hala Gabr Metwall. Effect of stem cell therapy on induced diabetic keratopathy in albino rat. International journal of stem cells. vol 5. issue 1. 2013-12-03. PMID:24298355. |
topical insulin application did not affect apoptosis and necrosis levels in corneal epithelium. |
2013-12-03 |
2023-08-12 |
rat |
| K Jennbacken, S Ståhlman, L Grahnemo, O Wiklund, L Fogelstran. Glucose impairs B-1 cell function in diabetes. Clinical and experimental immunology. vol 174. issue 1. 2013-12-02. PMID:23731267. |
in-vitro experiments with isolated b-1 cells showed that high concentrations of glucose, but not insulin or leptin, caused a reduced secretion of total igm and copper-oxidized (cuox)-ldl- and malondialdehyde (mda)-ldl-specific igm from b-1 cells in addition to a decreased differentiation into antibody-producing cells, proliferation arrest and increased apoptosis. |
2013-12-02 |
2023-08-12 |
mouse |
| Konstantinos Drosatos, P Christian Schulz. Cardiac lipotoxicity: molecular pathways and therapeutic implications. Current heart failure reports. vol 10. issue 2. 2013-11-19. PMID:23508767. |
recent data have implicated fatty acids and fatty acyl coenzyme a, diacylglycerol, and ceramide in cellular lipotoxicity, which may be caused by apoptosis, defective insulin signaling, endoplasmic reticulum stress, activation of protein kinase c, mapk activation, or modulation of ppars. |
2013-11-19 |
2023-08-12 |
Not clear |
| Takao Iwawaki, Daisuke Oikaw. The role of the unfolded protein response in diabetes mellitus. Seminars in immunopathology. vol 35. issue 3. 2013-11-15. PMID:23529219. |
this review highlights the particular importance of er stress-responsive molecules in insulin biosynthesis, glyconeogenesis, insulin resistance, glucose intolerance, and pancreatic β-cell apoptosis. |
2013-11-15 |
2023-08-12 |
Not clear |
| b' Andr\\xc3\\xa9s D\\xc3\\xadaz-L\\xc3\\xb3pez, Matilde R Chac\\xc3\\xb3n, M\\xc3\\xb2nica Bull\\xc3\\xb3, Elsa Maym\\xc3\\xb3-Masip, Miguel A Mart\\xc3\\xadnez-Gonz\\xc3\\xa1lez, Ram\\xc3\\xb3n Estruch, Joan Vendrell, Josep Basora, Javier D\\xc3\\xadez-Espino, Mar\\xc3\\xada-Isabel Covas, Jordi Salas-Salvad\\xc3\\xb. Serum sTWEAK concentrations and risk of developing type 2 diabetes in a high cardiovascular risk population: a nested case-control study. The Journal of clinical endocrinology and metabolism. vol 98. issue 8. 2013-11-04. PMID:23760626.' |
because serum concentrations of soluble forms of tnf-like weak inducer of apoptosis (stweak) and scavenger receptor cd163 (scd163) have been associated with insulin resistance and type 2 diabetes mellitus (t2d), we tested the associations of stweak and scd163 with the future development of t2d in elderly subjects at high cardiovascular risk. |
2013-11-04 |
2023-08-12 |
human |
| Minoru Ito, Michiaki Nagasawa, Naoki Omae, Masaki Tsunoda, Junichi Ishiyama, Tomohiro Ide, Yunike Akasaka, Koji Murakam. A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes. Journal of lipid research. vol 54. issue 6. 2013-11-01. PMID:23515281. |
insulin plays important roles in apoptosis and lipid droplet (ld) formation, and it is one of the determinants involved in increasing fat mass. |
2013-11-01 |
2023-08-12 |
human |
| Shuyan Gui, Gang Yuan, Lu Wang, Lili Zhou, Ying Xue, Yikai Yu, Jianhua Zhang, Muxun Zhang, Yan Yang, Dao Wen Wan. Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2/PI3K signaling. Journal of cellular biochemistry. vol 114. issue 7. 2013-10-29. PMID:23296977. |
wnt3a also promoted nit-1 cell proliferation, inhibited cytokine-induced beta-cell apoptosis, and increased insulin secretion. |
2013-10-29 |
2023-08-12 |
Not clear |
| Susumu Hirabayashi, Thomas J Baranski, Ross L Caga. Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling. Cell. vol 154. issue 3. 2013-10-28. PMID:23911328. |
whereas most tissues displayed insulin resistance, ras/src tumors retained insulin pathway sensitivity, increased the ability to import glucose, and resisted apoptosis. |
2013-10-28 |
2023-08-12 |
drosophila_melanogaster |
| An-ping Wang, Xia Li, Ying Zheng, Bi-lian Liu, Gan Huang, Xiang Yan, Zhenqi Liu, Zhiguang Zho. Thiazolidinediones protect mouse pancreatic β-cells directly from cytokine-induced cytotoxicity through PPARγ-dependent mechanisms. Acta diabetologica. vol 50. issue 2. 2013-10-25. PMID:21153483. |
the apoptosis rate and caspase-3 activity were remarkably increased, and insulin secretion response to glucose was impaired severely by exposure to il-1β/ifn-γ for 48 h compared to control cells, whereas apoptosis rate and caspase-3 activity were significantly decreased in cells with treatment of rosiglitazone (rgz) or pioglitazone (pig), and the capacity for insulin secretion response to glucose was recovered. |
2013-10-25 |
2023-08-12 |
mouse |
| Atsushi Masamune, Tooru Shimosegaw. Pancreatic stellate cells--multi-functional cells in the pancreas. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. vol 13. issue 2. 2013-10-25. PMID:23561965. |
pscs induce apoptosis and decrease insulin expression in β-cells, suggesting a novel mechanism of diabetes in diseased pancreas. |
2013-10-25 |
2023-08-12 |
Not clear |
| Chi-Hao Wu, Hsin-Tzu Hsieh, Jer-An Lin, Gow-Chin Ye. Alternanthera paronychioides protects pancreatic β-cells from glucotoxicity by its antioxidant, antiapoptotic and insulin secretagogue actions. Food chemistry. vol 139. issue 1-4. 2013-10-18. PMID:23561118. |
results showed that eeap and quercetin but not ferulic acid protected β-cells from glucotoxicity through several mechanisms, including: (1) maintaining β-cell viability; (2) suppressing reactive oxygen species production; (3) reducing characteristic features of apoptosis; (4) inhibiting the activation of caspase-9 and caspase-3 and the cleavage of poly (adp-ribose) polymerase; (5) upregulating pancreatic and duodenal homeobox 1 gene expression and the insulin secretagogue action of pancreatic β-cells. |
2013-10-18 |
2023-08-12 |
Not clear |
| P Huang, Z R Zhou, M Q Zheng, F X Sh. Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway in the duodenal mucosa of rats subjected to water immersion and restraint stress. Genetics and molecular research : GMR. vol 11. issue 4. 2013-10-17. PMID:23079979. |
the insulin growth factor 1/phosphatase and tensin homologue deleted on chromosome 10/akt/forkhead box (igf-1/pten/akt/foxo) signaling pathway reportedly exhibits gastroprotective effects by reducing water immersion and restraint stress (wrs)-induced gastric mucosal cell apoptosis. |
2013-10-17 |
2023-08-12 |
rat |
| Adam D Barlow, Michael L Nicholson, Terry P Herber. Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms. Diabetes. vol 62. issue 8. 2013-10-01. PMID:23881200. |
these mechanisms include reductions in β-cell size, mass, proliferation and insulin secretion alongside increases in apoptosis, autophagy, and peripheral insulin resistance. |
2013-10-01 |
2023-08-12 |
Not clear |
| Masahisa Handa, Sandra Vanegas, Betty A Maddux, Nerissa Mendoza, Shirley Zhu, Ira D Goldfine, Amer M Mirz. XOMA 052, an anti-IL-1β monoclonal antibody, prevents IL-1β-mediated insulin resistance in 3T3-L1 adipocytes. Obesity (Silver Spring, Md.). vol 21. issue 2. 2013-09-30. PMID:23401297. |
this inflammation impairs insulin secretion by inducing beta-cell apoptosis. |
2013-09-30 |
2023-08-12 |
Not clear |
| Cosimo Giannini, Ariel E Feldstein, Nicola Santoro, Grace Kim, Romy Kursawe, Bridget Pierpont, Sonia Capri. Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage. The Journal of clinical endocrinology and metabolism. vol 98. issue 7. 2013-09-30. PMID:23626003. |
herein, we measured plasma fgf-21 levels in lean and obese adolescents with low and high hepatic fat content (hff% <5.5% and hff% ≥ 5.5%, respectively) and explored their relationship with hepatic fat content, measures of hepatic apoptosis, and insulin sensitivity. |
2013-09-30 |
2023-08-12 |
Not clear |
| Neetu Singh, Vishal Ranjan, Deeba Zaidi, Hari Shyam, Aparna Singh, Divya Lodha, Ramesh Sharma, Umesh Verma, Jaya Dixit, Anil K Balapur. Insulin catalyzes the curcumin-induced wound healing: an in vitro model for gingival repair. Indian journal of pharmacology. vol 44. issue 4. 2013-09-19. PMID:23087505. |
although curcumin (cur) and insulin regulate apoptosis, their impact as a combination on hgf in wound repair remains unknown. |
2013-09-19 |
2023-08-12 |
human |
| Jin-Ying Tian, Ling Chen, Xiao-Lin Zhang, Juan Li, Jing Han, Xiao-Meng Yang, Pei-Cheng Zhang, Pei-Ge Du, Li-Ping An, Fei Y. [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum on metabolic syndrome treatment III--controlling blood glucose]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 38. issue 10. 2013-09-19. PMID:23947140. |
in the palmitate-induced rinm5f cell model, ff16 could effectively reduce the apoptosis and enhance the glucose-stimulated insulin secretion, respectively. |
2013-09-19 |
2023-08-12 |
mouse |
| A Hosseini, M Baeeri, M Rahimifard, M Navaei-Nigjeh, A Mohammadirad, N Pourkhalili, S Hassani, M Kamali, M Abdollah. Antiapoptotic effects of cerium oxide and yttrium oxide nanoparticles in isolated rat pancreatic islets. Human & experimental toxicology. vol 32. issue 5. 2013-09-09. PMID:23696423. |
exposure of islets to h2o2 (50 µm, 2 h) increased intracellular oxidant formation such as reactive oxygen species and subsequently apoptosis and decreased viability, glucose-induced adenosine triphosphate (atp) production and glucose-stimulated insulin secretion. |
2013-09-09 |
2023-08-12 |
rat |
| A Hosseini, M Baeeri, M Rahimifard, M Navaei-Nigjeh, A Mohammadirad, N Pourkhalili, S Hassani, M Kamali, M Abdollah. Antiapoptotic effects of cerium oxide and yttrium oxide nanoparticles in isolated rat pancreatic islets. Human & experimental toxicology. vol 32. issue 5. 2013-09-09. PMID:23696423. |
pretreatment with ceo2 and/or y2o3 nanoparticles reduced the oxidant formation and apoptosis and increased viability, glucose-induced atp production and glucose-stimulated insulin secretion. |
2013-09-09 |
2023-08-12 |
rat |
| Dong Han, Yasuhiko Yamamoto, Seiichi Munesue, So Motoyoshi, Hidehito Saito, Myat Thu Thu Win, Takuo Watanabe, Koichi Tsuneyama, Hiroshi Yamamot. Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes. Genes to cells : devoted to molecular & cellular mechanisms. vol 18. issue 4. 2013-09-05. PMID:23410183. |
compared with rage(+/+) db/db mice, rage(-/-) db/db mice showed higher β-cell number and mass with less apoptosis as well as glucose tolerance with higher insulin secretion without any differences in serum levels of ffa and adiponectin. |
2013-09-05 |
2023-08-12 |
mouse |