| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Gómez Flores-Ramos, A Escoto-De Dios, A M Puebla-Pérez, L E Figuera-Villanueva, A Ramos-Silva, R Ramírez-Patiño, J I Delgado-Saucedo, E Salas-González, G M Zúñiga-González, A Alonzo-Rojo, I Gutiérrez-Hurtado, M P Gallegos-Arreol. Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women. Genetics and molecular research : GMR. vol 12. issue 4. 2014-07-16. PMID:24301937. |
the tumor necrosis factor-alpha (tnf-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. |
2014-07-16 |
2023-08-12 |
Not clear |
| Amirah Abdul Rahman, Norwahidah Abdul Karim, Noor Aini Abdul Hamid, Roslan Harun, Wan Zurinah Wan Nga. Senescence-related changes in gene expression of peripheral blood mononuclear cells from octo/nonagenarians compared to their offspring. Oxidative medicine and cellular longevity. vol 2013. 2014-07-15. PMID:24381713. |
interestingly, changes in gene expression were associated with increased capacity for apoptosis (bak1), cell cycle regulation (cdkn1b), metabolic process (lrpap1), insulin action (igf2r), and increased immune and inflammatory response (il27ra), whereas response to stress (hspa8), damage stimulus (xrcc6), and chromatin remodelling (tinf2) pathways were downregulated in octo/nonagenarians. |
2014-07-15 |
2023-08-12 |
Not clear |
| C A Carrera Boada, J M Martínez-Moren. Pathophysiology of diabetes mellitus type 2: beyond the duo "insulin resistance-secretion deficit". Nutricion hospitalaria. vol 28 Suppl 2. 2014-06-30. PMID:23834050. |
the iapp hypersecretion and amylin fibers deposition attached to the endoplasmic reticulum stress caused by excessive workload due to biosynthesis overproduction of insulin and iapp result in ?-cell apoptosis. |
2014-06-30 |
2023-08-12 |
Not clear |
| J M Martínez-Moreno, M Garciacaballer. Influences of the diabetes surgery on pancreatic β-cells mass. Nutricion hospitalaria. vol 28 Suppl 2. 2014-06-30. PMID:23834051. |
in diabetes mellitus type 2 (dmt2), malfunction and apoptosis of β-cell provoke a deficient insulin secretion. |
2014-06-30 |
2023-08-12 |
Not clear |
| Amy Hughes, Darling Rojas-Canales, Chris Drogemuller, Nicolas H Voelcker, Shane T Grey, P T H Coate. IGF2: an endocrine hormone to improve islet transplant survival. The Journal of endocrinology. vol 221. issue 2. 2014-06-30. PMID:24883437. |
this review examines the mechanisms mediating islet cell apoptosis in the peri- and post-transplant period and aims to identify the utility of igf2 to promote islet survival and enhance long-term insulin independence rates within the setting of clinical islet transplantation. |
2014-06-30 |
2023-08-13 |
Not clear |
| Veronika Zámbó, Laura Simon-Szabó, Péter Szelényi, Eva Kereszturi, Gábor Bánhegyi, Miklós Csal. Lipotoxicity in the liver. World journal of hepatology. vol 5. issue 10. 2014-06-24. PMID:24179614. |
the triggered signaling pathways in turn largely contribute to the development of insulin resistance and apoptosis. |
2014-06-24 |
2023-08-12 |
Not clear |
| Feyza Engin, Alena Yermalovich, Truc Nguyen, Truc Ngyuen, Sarah Hummasti, Wenxian Fu, Decio L Eizirik, Diane Mathis, Gökhan S Hotamisligi. Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Science translational medicine. vol 5. issue 211. 2014-06-23. PMID:24225943. |
this reduction was accompanied by (i) a significant decrease in aggressive lymphocytic infiltration in the pancreas, (ii) improved survival and morphology of β cells, (iii) reduced β cell apoptosis, (iv) preserved insulin secretion, and (v) restored expression of upr mediators. |
2014-06-23 |
2023-08-12 |
mouse |
| Kanna Nagaishi, Koji Ataka, Eijiro Echizen, Yoshiaki Arimura, Mineko Fujimiy. Mesenchymal stem cell therapy ameliorates diabetic hepatocyte damage in mice by inhibiting infiltration of bone marrow-derived cells. Hepatology (Baltimore, Md.). vol 59. issue 5. 2014-06-17. PMID:24375439. |
in addition to inducing hepatocyte regeneration in stz-diabetic mice, both therapies also prevented excessive lipid accumulation and apoptosis of hepatocytes and reversed insulin resistance (ir) in hfd-diabetic mice. |
2014-06-17 |
2023-08-12 |
mouse |
| Woon Teck Yap, David M Salvay, Michael A Silliman, Xiaomin Zhang, Zachary G Bannon, Dixon B Kaufman, William L Lowe, Lonnie D She. Collagen IV-modified scaffolds improve islet survival and function and reduce time to euglycemia. Tissue engineering. Part A. vol 19. issue 21-22. 2014-06-12. PMID:23713524. |
collagen iv-modified scaffolds promoted islet cell viability and decreased early-stage apoptosis in islet cells in vitro-phenomena that coincided with enhanced islet metabolic function and glucose-stimulated insulin secretion. |
2014-06-12 |
2023-08-12 |
mouse |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
plasma glucose and insulin levels, hba1c, glucose tolerance, apoptosis, and expression of proliferating cell nuclear antigen (pcna), p38, p53, caspase-3, extracellular signal-regulated kinase-1/2 (erk-1/2), forkhead box protein o1 (foxo1) and insulin receptor substrate-1 (irs-1) as well as histone acetylation were evaluated. |
2014-05-27 |
2023-08-12 |
rat |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
nab treatment decreased plasma glucose, hba1c, beta-cell apoptosis and improved plasma insulin level and glucose homeostasis through hdac inhibition and histone acetylation in diabetic animal as compared to control. |
2014-05-27 |
2023-08-12 |
rat |
| G J Suo, Z X Zha. Xenogeneic islet transplantation of Ad5F35-SOCS1 infected islets for therapy of diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 121. issue 9. 2014-05-15. PMID:24002896. |
furthermore, histological analysis indicated that the infected grafts with overexpression of socs1 showed strong insulin secretion function and decreased apoptosis in the early post-transplant period. |
2014-05-15 |
2023-08-12 |
mouse |
| Pon Velayutham Anandh Babu, Dongmin Liu, Elizabeth R Gilber. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. The Journal of nutritional biochemistry. vol 24. issue 11. 2014-05-12. PMID:24029069. |
flavonoids may exert beneficial effects in diabetes by (i) enhancing insulin secretion and reducing apoptosis and promoting proliferation of pancreatic β-cells; (ii) improving hyperglycemia through regulation of glucose metabolism in hepatocytes; (iii) reducing insulin resistance, inflammation and oxidative stress in muscle and fat and (iv) increasing glucose uptake in skeletal muscle and white adipose tissue. |
2014-05-12 |
2023-08-12 |
Not clear |
| Xiangxiang Shan, Yufeng Miao, Rengen Fan, Changzhi Song, Guangzhou Wu, Zhengqiang Wan, Jian Zhu, Guan Sun, Wenzhang Zha, Xiangming Mu, Guangjun Zhou, Yan Che. Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration. In vitro cellular & developmental biology. Animal. vol 49. issue 8. 2014-05-06. PMID:23771793. |
suppression of grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration. |
2014-05-06 |
2023-08-12 |
Not clear |
| Xiangxiang Shan, Yufeng Miao, Rengen Fan, Changzhi Song, Guangzhou Wu, Zhengqiang Wan, Jian Zhu, Guan Sun, Wenzhang Zha, Xiangming Mu, Guangjun Zhou, Yan Che. Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration. In vitro cellular & developmental biology. Animal. vol 49. issue 8. 2014-05-06. PMID:23771793. |
quantitative polymerase chain reaction and western blot were used to measure expressional changes of key markers of insulin signaling, lipid/glucose metabolism, oxidative stress, and apoptosis. |
2014-05-06 |
2023-08-12 |
Not clear |
| Xiangxiang Shan, Yufeng Miao, Rengen Fan, Changzhi Song, Guangzhou Wu, Zhengqiang Wan, Jian Zhu, Guan Sun, Wenzhang Zha, Xiangming Mu, Guangjun Zhou, Yan Che. Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration. In vitro cellular & developmental biology. Animal. vol 49. issue 8. 2014-05-06. PMID:23771793. |
after 24-h palmitic acid induction, increased fat accumulation, reduced glucose uptake, impaired insulin signaling, enhanced oxidative stress, and increased apoptosis were observed in hepg2 cells. |
2014-05-06 |
2023-08-12 |
Not clear |
| Xiangxiang Shan, Yufeng Miao, Rengen Fan, Changzhi Song, Guangzhou Wu, Zhengqiang Wan, Jian Zhu, Guan Sun, Wenzhang Zha, Xiangming Mu, Guangjun Zhou, Yan Che. Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration. In vitro cellular & developmental biology. Animal. vol 49. issue 8. 2014-05-06. PMID:23771793. |
in conclusion, suppression of grb2 expression in hepg2 cells improved hepatic steatosis, glucose metabolism, oxidative stress, and apoptosis induced by palmitic acid incubation partly though modulating the insulin signaling pathway. |
2014-05-06 |
2023-08-12 |
Not clear |
| Cheng-Juan Xiong, Ping-Fa Li, Yang-Liu Song, Li-Xiang Xue, Zhu-Qing Jia, Chun-Xia Yao, Qing-Xia Wei, Shu-Feng Zhang, Shan-Feng Zhang, Yan-Yan Zhang, Ji-Min Zhao, Tian-Qi Wang, Mao-Feng Guo, Ming-Xi Zan. Insulin induces C2C12 cell proliferation and apoptosis through regulation of cyclin D1 and BAD expression. Journal of cellular biochemistry. vol 114. issue 12. 2014-05-06. PMID:23794242. |
insulin induces c2c12 cell proliferation and apoptosis through regulation of cyclin d1 and bad expression. |
2014-05-06 |
2023-08-12 |
human |
| Cheng-Juan Xiong, Ping-Fa Li, Yang-Liu Song, Li-Xiang Xue, Zhu-Qing Jia, Chun-Xia Yao, Qing-Xia Wei, Shu-Feng Zhang, Shan-Feng Zhang, Yan-Yan Zhang, Ji-Min Zhao, Tian-Qi Wang, Mao-Feng Guo, Ming-Xi Zan. Insulin induces C2C12 cell proliferation and apoptosis through regulation of cyclin D1 and BAD expression. Journal of cellular biochemistry. vol 114. issue 12. 2014-05-06. PMID:23794242. |
additionally, 50 and 100 nm insulin treatment induces c2c12 cell apoptosis. |
2014-05-06 |
2023-08-12 |
human |
| Cheng-Juan Xiong, Ping-Fa Li, Yang-Liu Song, Li-Xiang Xue, Zhu-Qing Jia, Chun-Xia Yao, Qing-Xia Wei, Shu-Feng Zhang, Shan-Feng Zhang, Yan-Yan Zhang, Ji-Min Zhao, Tian-Qi Wang, Mao-Feng Guo, Ming-Xi Zan. Insulin induces C2C12 cell proliferation and apoptosis through regulation of cyclin D1 and BAD expression. Journal of cellular biochemistry. vol 114. issue 12. 2014-05-06. PMID:23794242. |
our results identify for the first time the downstream targets of insulin, cyclin d1, and bad, elucidate a new molecular mechanism of insulin in promoting cell proliferation and apoptosis. |
2014-05-06 |
2023-08-12 |
human |