| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ercument Dirice, Sevim Kahraman, Wenyu Jiang, Abdelfattah El Ouaamari, Dario F De Jesus, Adrian K K Teo, Jiang Hu, Dan Kawamori, Jason L Gaglia, Diane Mathis, Rohit N Kulkarn. Soluble factors secreted by T cells promote β-cell proliferation. Diabetes. vol 63. issue 1. 2014-02-24. PMID:24089508. |
adoptive transfer of diabetogenic cd4(+) and cd8(+) t cells, but not b cells, selectively promoted β-cell proliferation in vivo independent from the effects of blood glucose or circulating insulin or by modulating apoptosis. |
2014-02-24 |
2023-08-12 |
Not clear |
| Alessandra Baragli, Lessandra Baragli, Cristina Grande, Iacopo Gesmundo, Fabio Settanni, Marina Taliano, Davide Gallo, Eleonora Gargantini, Ezio Ghigo, Riccarda Granat. Obestatin enhances in vitro generation of pancreatic islets through regulation of developmental pathways. PloS one. vol 8. issue 5. 2014-02-18. PMID:23741322. |
obestatin prevents β-cell apoptosis, preserves β-cell mass and stimulates insulin secretion in vitro and in vivo, in both normal and diabetic conditions. |
2014-02-18 |
2023-08-12 |
mouse |
| Alessandra Baragli, Lessandra Baragli, Cristina Grande, Iacopo Gesmundo, Fabio Settanni, Marina Taliano, Davide Gallo, Eleonora Gargantini, Ezio Ghigo, Riccarda Granat. Obestatin enhances in vitro generation of pancreatic islets through regulation of developmental pathways. PloS one. vol 8. issue 5. 2014-02-18. PMID:23741322. |
treatment of cultured islets of langerhans with obestatin (i) enriched cells expressing the mesenchymal/neuronal marker nestin, which is associated with pancreatic precursors; (ii) increased cell survival and reduced apoptosis during precursor selection; (iii) promoted the generation of islet-like cell clusters (iccs) with increased insulin gene expression and c-peptide secretion. |
2014-02-18 |
2023-08-12 |
mouse |
| Luciana Mendonça Arantes, Natalia Oliveira Bertolini, Rodrigo Ferreira de Moura, Maria Alice Rostom de Mello, Eliete Lucian. Insulin concentrations in cerebellum and body balance in diabetic male rats: aerobic training effects. Physiology & behavior. vol 118. 2014-02-12. PMID:23684905. |
brain insulin has had widespread metabolic, neurotrophic, and neuromodulatory functions and has been involved in the central regulation of food intake and body weight, learning and memory, neuronal development, and neuronal apoptosis. |
2014-02-12 |
2023-08-12 |
rat |
| M Cazzaniga, A DeCensi, G Pruneri, M Puntoni, L Bottiglieri, C Varricchio, A Guerrieri-Gonzaga, O D Gentilini, G Pagani, P Dell'Orto, M Lazzeroni, D Serrano, G Viale, B Bonann. The effect of metformin on apoptosis in a breast cancer presurgical trial. British journal of cancer. vol 109. issue 11. 2014-02-11. PMID:24157825. |
we determined whether metformin induced a modulation of apoptosis by terminal deoxynucleotidyl transferase dutp nick end labelling (tunel) overall and by insulin resistance status in a presurgical trial. |
2014-02-11 |
2023-08-12 |
Not clear |
| Wayne H-H Sheu, Jane Z Kuo, I-Te Lee, Yi-Jen Hung, Wen-Jane Lee, Hin-Yeung Tsai, J-S Wang, Mark O Goodarzi, Ronald Klein, Barbara E K Klein, Eli Ipp, Shin-Yi Lin, Xiuqing Guo, Chang-Hsun Hsieh, Kent D Taylor, Chia-Po Fu, Jerome I Rotter, Yii-Der I Che. Genome-wide association study in a Chinese population with diabetic retinopathy. Human molecular genetics. vol 22. issue 15. 2014-01-31. PMID:23562823. |
these genes are still of particular interest because they are involved in insulin regulation, inflammation, lipid signaling and apoptosis pathways, all of which are possibly involved with dr. our finding nominates possible novel loci as potential dr susceptibility genes in the chinese that are independent of the level of hba1c and duration of diabetes and may provide insight into the pathophysiology of dr. |
2014-01-31 |
2023-08-12 |
human |
| Ivana Hollan, Pier Luigi Meroni, Joseph M Ahearn, J W Cohen Tervaert, Sam Curran, Carl S Goodyear, Knut A Hestad, Bashar Kahaleh, Marcello Riggio, Kelly Shields, Mary C Wask. Cardiovascular disease in autoimmune rheumatic diseases. Autoimmunity reviews. vol 12. issue 10. 2014-01-21. PMID:23541482. |
besides other factors, inflammation and immunologic abnormalities, the quantity and quality of lipoproteins, hypertension, insulin resistance/hyperglycemia, obesity and underweight, presence of platelets bearing complement protein c4d, reduced number and function of endothelial progenitor cells, apoptosis of endothelial cells, epigenetic mechanisms, renal disease, periodontal disease, depression, hyperuricemia, hypothyroidism, sleep apnea and vitamin d deficiency may contribute to the premature cvd. |
2014-01-21 |
2023-08-12 |
Not clear |
| Ewa Barg, Jan Szopa, Karolina A Pesz, Kazimierz Gąsiorowsk. Indices of insulin resistance and dyslipidemia are correlated with lymphocyte proneness to apoptosis in obese or overweight low birth weight children. Hormone research in paediatrics. vol 79. issue 5. 2014-01-17. PMID:23689125. |
indices of insulin resistance and dyslipidemia are correlated with lymphocyte proneness to apoptosis in obese or overweight low birth weight children. |
2014-01-17 |
2023-08-12 |
Not clear |
| Ewa Barg, Jan Szopa, Karolina A Pesz, Kazimierz Gąsiorowsk. Indices of insulin resistance and dyslipidemia are correlated with lymphocyte proneness to apoptosis in obese or overweight low birth weight children. Hormone research in paediatrics. vol 79. issue 5. 2014-01-17. PMID:23689125. |
our aim was to study the relationship between markers of cell proneness to apoptosis and indices of insulin resistance and dyslipidemia in children born with low birth weight (lbw). |
2014-01-17 |
2023-08-12 |
Not clear |
| Gabriel E Hoffman, Benjamin A Logsdon, Jason G Meze. PUMA: a unified framework for penalized multiple regression analysis of GWAS data. PLoS computational biology. vol 9. issue 6. 2014-01-17. PMID:23825936. |
our analysis replicates known associations for these diseases and we discover novel etiologically relevant susceptibility loci that are invisible to standard single marker tests, including six novel associations implicating genes involved in pancreatic function, insulin pathways and immune-cell function in type 1 diabetes; three novel associations implicating genes in pro- and anti-inflammatory pathways in crohn's disease; and one novel association implicating a gene involved in apoptosis pathways in rheumatoid arthritis. |
2014-01-17 |
2023-08-12 |
Not clear |
| Hjalti Kristinsson, David M Smith, Peter Bergsten, Ernest Sargsya. FFAR1 is involved in both the acute and chronic effects of palmitate on insulin secretion. Endocrinology. vol 154. issue 11. 2014-01-08. PMID:24035997. |
although acute exposure to ffas stimulates glucose-stimulated insulin secretion (gsis), prolonged exposure impairs gsis and causes apoptosis. |
2014-01-08 |
2023-08-12 |
human |
| Stephanie Duncanson, Athanassios Sambani. Dual factor delivery of CXCL12 and Exendin-4 for improved survival and function of encapsulated beta cells under hypoxic conditions. Biotechnology and bioengineering. vol 110. issue 8. 2014-01-06. PMID:23436382. |
delivery of ex-4 increased insulin secretion rate under both normoxic and hypoxic conditions, and additionally reduced apoptosis under hypoxic conditions. |
2014-01-06 |
2023-08-12 |
Not clear |
| Li Chen, Yuyan Zhao, Delu Zheng, Shujing Ju, Yang Shen, Lei Gu. Orexin A Affects INS-1 Rat Insulinoma Cell Proliferation via Orexin Receptor 1 and the AKT Signaling Pathway. International journal of endocrinology. vol 2013. 2014-01-02. PMID:24382962. |
ins-1 amount of cell proliferation, viability and apoptosis, insulin secretion, ox1r protein expression, caspase-3 activity, and akt protein levels were determined. |
2014-01-02 |
2023-08-12 |
rat |
| Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, Alaa Galadari, Faisal Thayyullathi. Role of ceramide in diabetes mellitus: evidence and mechanisms. Lipids in health and disease. vol 12. 2013-12-31. PMID:23835113. |
studies using cultured cells, animal models, and human subjects demonstrate that ceramide is a key player in the induction of β-cell apoptosis, insulin resistance, and reduction of insulin gene expression. |
2013-12-31 |
2023-08-12 |
human |
| Razvan T Radulesc. Oncoprotein metastasis: an expanded topography. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 54. issue 2. 2013-12-27. PMID:23771064. |
insulin, osteopontin, interleukin-6, anterior gradient-2 protein, cellular apoptosis susceptibility protein and hepatoma-derived growth factor, as well as distinct peptide fragments thereof might henceforth serve as pivotal biomarkers for opm in clinical chemistry, molecular morphology, pathology and oncology and, as a result, guide as potential targets future structure-based interventions in cancer treatment. |
2013-12-27 |
2023-08-12 |
Not clear |
| Yu Wu, Tingting Wu, Jun Wu, Lei Zhao, Qing Li, Zac Varghese, John F Moorhead, Stephen H Powis, Yaxi Chen, Xiong Z Rua. Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet. The Journal of endocrinology. vol 219. issue 3. 2013-12-27. PMID:24029730. |
however, in contrast with hfd-fed alone, chronic inflammation in hfd-fed mice decreased both islet mass and insulin content, reduced the genetic expression of insulin synthesis and secretion, and increased β cell apoptosis. |
2013-12-27 |
2023-08-12 |
mouse |
| Jana Mahadevan, Susan Parazzoli, Elizabeth Oseid, Ann V Hertzel, David A Bernlohr, Sara N Vallerie, Chang-qin Liu, Melissa Lopez, Jamie S Harmon, R Paul Robertso. Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats. Diabetes. vol 62. issue 10. 2013-12-10. PMID:23801580. |
ebselen doubled β-cell mass, prevented apoptosis, prevented expression of oxidative stress markers, and enhanced intranuclear localization of pancreatic and duodenal homeobox (pdx)-1 and v-maf musculoaponeurotic fibrosarcoma oncogene family, protein a (mafa), two critical insulin transcription factors. |
2013-12-10 |
2023-08-12 |
mouse |
| Sachin Supale, Fabrizio Thorel, Carsten Merkwirth, Asllan Gjinovci, Pedro L Herrera, Luca Scorrano, Paolo Meda, Thomas Langer, Pierre Maechle. Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development. Diabetes. vol 62. issue 10. 2013-12-10. PMID:23863811. |
defective insulin supply in β-phb2(-/-) mice was contributed by both β-cell dysfunction and apoptosis, temporarily compensated by increased β-cell proliferation. |
2013-12-10 |
2023-08-12 |
mouse |
| Pietro Vajro, Giulia Paolella, Marco Poeta, Cristina Pizza, Maria Sangermano, Grazia Mass. Pediatric non alcoholic fatty liver disease: more on novel treatment targets. BMC pediatrics. vol 13. 2013-12-03. PMID:23870449. |
among a number of proposed innovative approaches targeting novel pathomechanisms, probiotics appear an interesting and reasonable option acting on gut-liver axis malfunction through the modulation of diet-driven, obesogenic, and inflammatory intestinal microbiota.a combined multiple pharmacological therapy directed simultaneously towards novel and old pathomechanisms (including, e.g., insulin resistance, oxidative stress, gut-liver axis, apoptosis) along with lifestyle interventions however might be necessary both in adult and pediatric nafld therapy. |
2013-12-03 |
2023-08-12 |
Not clear |
| Xuan Wang, Lin Jiang, Ola Wallerman, Ulla Engström, Adam Ameur, Rajesh Kumar Gupta, Yu Qi, Leif Andersson, Nils Wels. Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 40. 2013-12-03. PMID:24043816. |
we propose that zbed6 supports proliferation and survival of beta cells, possibly at the expense of specialized beta cell function-i.e., insulin production-because (i) the nuclear zbed6 were the predominant forms in rapidly proliferating βtc-6 cells, but not in human islet cells; (ii) down-regulation of zbed6 in βtc-6 cells resulted in altered morphology, decreased proliferation, a partial s/g2 cell-cycle arrest, increased expression of beta cell-specific genes, and higher rates of apoptosis; (iii) silencing of zbed6 in the human panc-1 duct cell line reduced proliferation rates; and (iv) zbed6 binding was preferentially to genes that control transcription, macromolecule biosynthesis, and apoptosis. |
2013-12-03 |
2023-08-12 |
mouse |