| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Han, Yasuhiko Yamamoto, Seiichi Munesue, So Motoyoshi, Hidehito Saito, Myat Thu Thu Win, Takuo Watanabe, Koichi Tsuneyama, Hiroshi Yamamot. Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes. Genes to cells : devoted to molecular & cellular mechanisms. vol 18. issue 4. 2013-09-05. PMID:23410183. |
palmitate or oleate pretreatment combined with a leptin antagonist induced rage expression, age-elicited apoptosis, and impaired glucose-stimulated insulin secretion by advanced glycation end products (age) in min6 cells. |
2013-09-05 |
2023-08-12 |
mouse |
| Francisco José Tinahones, Leticia Coín Aragüez, Mora Murri, Wilfredo Oliva Olivera, María Dolores Mayas Torres, Nuria Barbarroja, Ricardo Gomez Huelgas, Maria M Malagón, Rajaa El Beka. Caspase induction and BCL2 inhibition in human adipose tissue: a potential relationship with insulin signaling alteration. Diabetes care. vol 36. issue 3. 2013-09-04. PMID:23193206. |
here, we analyze the relationship among obesity, adipose tissue apoptosis, and insulin signaling. |
2013-09-04 |
2023-08-12 |
human |
| Undurti N Da. Arachidonic acid and lipoxin A4 as possible endogenous anti-diabetic molecules. Prostaglandins, leukotrienes, and essential fatty acids. vol 88. issue 3. 2013-08-26. PMID:23295193. |
in both type 1 and type 2 diabetes mellitus, increased production of pro-inflammatory cytokines and reactive oxygen species (ros) occurs that induce apoptosis of β cells and cause peripheral insulin resistance respectively though the degree of their increased production is higher in type 1 and less in type 2 diabetes mellitus. |
2013-08-26 |
2023-08-12 |
Not clear |
| Zhongchan Sun, Guang Tong, Nan Ma, Jianying Li, Xiujuan Li, Shuang Li, Jingyu Zhou, Lize Xiong, Feng Cao, Libo Yao, Haichang Wang, Lan She. NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury. Basic research in cardiology. vol 108. issue 3. 2013-08-16. PMID:23463182. |
reperfusion with insulin inhibited myocardial apoptosis and reduced infarct size, as well as significantly up-regulated myocardial akt and ndrg2 phosphorylation levels compared with the i/r group. |
2013-08-16 |
2023-08-12 |
rat |
| Gianluca Bardini, Carlo M Rotella, Stefano Giannin. Dyslipidemia and diabetes: reciprocal impact of impaired lipid metabolism and Beta-cell dysfunction on micro- and macrovascular complications. The review of diabetic studies : RDS. vol 9. issue 2-3. 2013-08-12. PMID:23403704. |
the accumulation of cholesterol in beta-cells, caused by defective high-density lipoprotein (hdl) cholesterol with reduced cholesterol efflux, induces hyperglycemia, impaired insulin secretion, and beta-cell apoptosis. |
2013-08-12 |
2023-08-12 |
Not clear |
| Stephen B Shears, Jeremy D Weaver, Huanchen Wan. Structural insight into inositol pyrophosphate turnover. Advances in biological regulation. vol 53. issue 1. 2013-08-06. PMID:23107997. |
the diphosphoinositol polyphosphates ("inositol pyrophosphates"; pp-insps) regulate many cellular processes in eukaryotes, including stress responses, apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, telomere maintenance, insulin signaling and neutrophil activation. |
2013-08-06 |
2023-08-12 |
human |
| Larysa V Yuzefovych, Sergiy I Musiyenko, Glenn L Wilson, Lyudmila I Rache. Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice. PloS one. vol 8. issue 1. 2013-08-02. PMID:23342074. |
mitochondrial dna damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice. |
2013-08-02 |
2023-08-12 |
mouse |
| Shan Wu, Fu-er Lu, Hui Don. [Effects of berberine on the pancreatic beta cell apoptosis in rats with insulin resistance]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 31. issue 10. 2013-08-01. PMID:22097210. |
[effects of berberine on the pancreatic beta cell apoptosis in rats with insulin resistance]. |
2013-08-01 |
2023-08-12 |
rat |
| Shan Wu, Fu-er Lu, Hui Don. [Effects of berberine on the pancreatic beta cell apoptosis in rats with insulin resistance]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 31. issue 10. 2013-08-01. PMID:22097210. |
to explore the effects of berberine on the pancreatic 13 cell apoptosis in rats with insulin resistance (ir). |
2013-08-01 |
2023-08-12 |
rat |
| Robin K Minor, Joseph A Baur, Ana P Gomes, Theresa M Ward, Anna Csiszar, Evi M Mercken, Kotb Abdelmohsen, Yu-Kyong Shin, Carles Canto, Morten Scheibye-Knudsen, Melissa Krawczyk, Pablo M Irusta, Alejandro Martín-Montalvo, Basil P Hubbard, Yongqing Zhang, Elin Lehrmann, Alexa A White, Nathan L Price, William R Swindell, Kevin J Pearson, Kevin G Becker, Vilhelm A Bohr, Myriam Gorospe, Josephine M Egan, Mark I Talan, Johan Auwerx, Christoph H Westphal, James L Ellis, Zoltan Ungvari, George P Vlasuk, Peter J Elliott, David A Sinclair, Rafael de Cab. SRT1720 improves survival and healthspan of obese mice. Scientific reports. vol 1. 2013-08-01. PMID:22355589. |
this lifespan extension is accompanied by health benefits including reduced liver steatosis, increased insulin sensitivity, enhanced locomotor activity and normalization of gene expression profiles and markers of inflammation and apoptosis, all in the absence of any observable toxicity. |
2013-08-01 |
2023-08-12 |
mouse |
| Gen-Fa Lü, Hong-Wei Shi, Guang-yuan Wang, Lei Fan, Da-hai Hu, Bi Che. [The protective effects of insulin on cardiocyte apoptosis challenged by burn serum]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. vol 24. issue 4. 2013-07-29. PMID:22464569. |
[the protective effects of insulin on cardiocyte apoptosis challenged by burn serum]. |
2013-07-29 |
2023-08-12 |
Not clear |
| Gen-Fa Lü, Hong-Wei Shi, Guang-yuan Wang, Lei Fan, Da-hai Hu, Bi Che. [The protective effects of insulin on cardiocyte apoptosis challenged by burn serum]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. vol 24. issue 4. 2013-07-29. PMID:22464569. |
to investigate the protective effects of insulin on burn serum-challenged cardiocyte apoptosis and its mechanism. |
2013-07-29 |
2023-08-12 |
Not clear |
| P George, R J McCrimmo. Potential role of non-insulin adjunct therapy in Type 1 diabetes. Diabetic medicine : a journal of the British Diabetic Association. vol 30. issue 2. 2013-07-29. PMID:22804102. |
non-insulin-based adjunct treatments offer a potential means of complementing intensive insulin therapy in type 1 diabetes through addressing some of the physiological disturbances that result from endogenous β-cell destruction, particularly through preservation of β-cell mass and prevention of apoptosis, and suppression of α-cell glucagon release in the postprandial state. |
2013-07-29 |
2023-08-12 |
Not clear |
| Chanyuan Tan, Ulrikke Voss, Siv Svensson, David Erlinge, Björn Old. High glucose and free fatty acids induce beta cell apoptosis via autocrine effects of ADP acting on the P2Y(13) receptor. Purinergic signalling. vol 9. issue 1. 2013-07-26. PMID:22941026. |
in a previous study, we found that adp regulates beta cell insulin secretion and beta cell apoptosis. |
2013-07-26 |
2023-08-12 |
mouse |
| Janine A Higgins, Ian L Brow. Resistant starch: a promising dietary agent for the prevention/treatment of inflammatory bowel disease and bowel cancer. Current opinion in gastroenterology. vol 29. issue 2. 2013-07-22. PMID:23385525. |
resistant starch has been investigated in the past for its effects on bowel health (ph, epithelial thickness, and apoptosis of colorectal cancer cells); reduction in postprandial glycemia; increased insulin sensitivity; and effects on the gut microbiome. |
2013-07-22 |
2023-08-12 |
Not clear |
| Elizabeth R Gilbert, Dongmin Li. Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function. Food & function. vol 4. issue 2. 2013-07-17. PMID:23160185. |
over the past 10 years, numerous studies have demonstrated that genistein has anti-diabetic effects, in particular, direct effects on β-cell proliferation, glucose-stimulated insulin secretion and protection against apoptosis, independent of its functions as an estrogen receptor agonist, antioxidant, or tyrosine kinase inhibitor. |
2013-07-17 |
2023-08-12 |
Not clear |
| Sefirin Djiogue, Armel Hervé Nwabo Kamdje, Lorella Vecchio, Maulilio John Kipanyula, Mohammed Farahna, Yousef Aldebasi, Paul Faustin Seke Ete. Insulin resistance and cancer: the role of insulin and IGFs. Endocrine-related cancer. vol 20. issue 1. 2013-07-02. PMID:23207292. |
a growing body of evidence suggests that insulin and igf1 receptors mediate their effects on regulating cell proliferation, differentiation, apoptosis, glucose transport, and energy metabolism by signaling downstream through insulin receptor substrate molecules and thus play a pivotal role in cell fate determination. |
2013-07-02 |
2023-08-12 |
Not clear |
| Sefirin Djiogue, Armel Hervé Nwabo Kamdje, Lorella Vecchio, Maulilio John Kipanyula, Mohammed Farahna, Yousef Aldebasi, Paul Faustin Seke Ete. Insulin resistance and cancer: the role of insulin and IGFs. Endocrine-related cancer. vol 20. issue 1. 2013-07-02. PMID:23207292. |
the involvement of igfs in carcinogenesis is attributed to their role in linking high energy intake, increased cell proliferation, and suppression of apoptosis to cancer risks, which has been proposed as the key mechanism bridging insulin resistance and cancer. |
2013-07-02 |
2023-08-12 |
Not clear |
| Kerong Shi, Vaishali I Parekh, Swarnava Roy, Shruti S Desai, Sunita K Agarwa. The embryonic transcription factor Hlxb9 is a menin interacting partner that controls pancreatic β-cell proliferation and the expression of insulin regulators. Endocrine-related cancer. vol 20. issue 1. 2013-07-02. PMID:23419452. |
hlxb9 reduces cell proliferation and causes apoptosis in the presence of menin, and it regulates genes that modulate insulin level. |
2013-07-02 |
2023-08-12 |
mouse |
| Anderson C Marçal, Mauro Leonelli, Jarlei Fiamoncini, Francisco C Deschamps, Maria A M Rodrigues, Rui Curi, Angelo R Carpinelli, Luiz R G Britto, Carla R O Carvalh. Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration. Cell biochemistry and function. vol 31. issue 1. 2013-06-27. PMID:22915345. |
thus, we analysed the morphology and apoptosis index in retinas of obese rats in whom insulin resistance had been induced by a high-fat diet (hfd). |
2013-06-27 |
2023-08-12 |
rat |