| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramachandran Balasubramanian, Hiroshi Maruoka, P Suresh Jayasekara, Zhan-Guo Gao, Kenneth A Jacobso. AMP-activated protein kinase as regulator of P2Y(6) receptor-induced insulin secretion in mouse pancreatic β-cells. Biochemical pharmacology. vol 85. issue 7. 2013-05-07. PMID:23333427. |
extracellular uridine 5'-diphosphate (udp) activates p2y6 receptors (p2y6rs) in pancreatic β-cells to release insulin and reduce apoptosis, which would benefit diabetes. |
2013-05-07 |
2023-08-12 |
mouse |
| S Gezginci-Oktayoglu, A Karatug, S Bolken. The relation among NGF, EGF and insulin is important for triggering pancreatic β cell apoptosis. Diabetes/metabolism research and reviews. vol 28. issue 8. 2013-04-30. PMID:22926925. |
the relation among ngf, egf and insulin is important for triggering pancreatic β cell apoptosis. |
2013-04-30 |
2023-08-12 |
rat |
| S Gezginci-Oktayoglu, A Karatug, S Bolken. The relation among NGF, EGF and insulin is important for triggering pancreatic β cell apoptosis. Diabetes/metabolism research and reviews. vol 28. issue 8. 2013-04-30. PMID:22926925. |
the aim of this study was to investigate the effects of ngf withdrawal on the synthesis and secretion of egf, insulin with respect to β cell apoptosis in hyperglycemic rats. |
2013-04-30 |
2023-08-12 |
rat |
| Sandra Hakim, Micka C Bertucci, Sarah E Conduit, David L Vuong, Christina A Mitchel. Inositol polyphosphate phosphatases in human disease. Current topics in microbiology and immunology. vol 362. 2013-04-17. PMID:23086422. |
the phosphoinositide phosphatases regulate pi3k/akt signalling, insulin signalling, endocytosis, vesicle trafficking, cell migration, proliferation and apoptosis. |
2013-04-17 |
2023-08-12 |
mouse |
| Huilan Sha, Yanhui Li, Xuan Du, Hongbo Wan. Insulin in endometrial carcinoma chemotherapy: a beneficial addition and not a problem. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 5. 2013-04-12. PMID:21063847. |
the effects of insulin or insulin in combination with chemotherapeutic drugs on the proliferation and apoptosis of endometrial carcinoma cells were examined with an aim to determine the efficacy and safety of insulin in endometrial cancer therapy. |
2013-04-12 |
2023-08-12 |
Not clear |
| Huilan Sha, Yanhui Li, Xuan Du, Hongbo Wan. Insulin in endometrial carcinoma chemotherapy: a beneficial addition and not a problem. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 5. 2013-04-12. PMID:21063847. |
insulin plus paclitaxel (combination group) could significantly inhibit cell proliferation (69.38%±2.32% vs 40.31%±4.52% with ishikawa; 64.11%±6.33% vs 45.89%±3.27% with hec-1a) and increase cell apoptosis compared with treatment with paclitaxel alone (paclitaxel group). |
2013-04-12 |
2023-08-12 |
Not clear |
| Inês Falcão-Pires, Adelino F Leite-Moreir. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart failure reviews. vol 17. issue 3. 2013-04-05. PMID:21626163. |
left ventricular hypertrophy, metabolic abnormalities, extracellular matrix changes, small vessel disease, cardiac autonomic neuropathy, insulin resistance, oxidative stress, and apoptosis are the most important contributors to diabetic cardiomyopathy onset and progression. |
2013-04-05 |
2023-08-12 |
human |
| Shiying Shao, Yan Yang, Gang Yuan, Muxun Zhang, Xuefeng Y. Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction. DNA and cell biology. vol 32. issue 2. 2013-03-21. PMID:23347443. |
it is known that ffas are putative mediators of beta-cell dysfunction, which is characterized with impaired glucose-stimulated insulin secretion and increased apoptosis, being defined as lipotoxicity. |
2013-03-21 |
2023-08-12 |
Not clear |
| An-ping Wang, Xia Li, Chen Chao, Gan Huang, Bi-lian Liu, Jian Peng, Zhi-guang Zho. [1α, 25(OH)(2) D(3) protects pancreatic β-cell line from cytokine-induced apoptosis and impaired insulin secretion]. Zhonghua yi xue za zhi. vol 92. issue 10. 2013-03-20. PMID:22781299. |
[1α, 25(oh)(2) d(3) protects pancreatic β-cell line from cytokine-induced apoptosis and impaired insulin secretion]. |
2013-03-20 |
2023-08-12 |
Not clear |
| Ahter D Sanlioglu, Bahri Karacay, Mustafa Kemal Balci, Thomas S Griffith, Salih Sanliogl. Therapeutic potential of VIP vs PACAP in diabetes. Journal of molecular endocrinology. vol 49. issue 3. 2013-03-14. PMID:22991228. |
therefore, an ideal beta-cell-preserving agent is expected to protect beta cells from apoptosis and stimulate postprandial insulin secretion along with increasing beta-cell replication and/or islet neogenesis. |
2013-03-14 |
2023-08-12 |
Not clear |
| Ebru Boslem, Peter J Meikle, Trevor J Bide. Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction. Islets. vol 4. issue 3. 2013-03-08. PMID:22847494. |
sphingolipid metabolites such as ceramide, glycosphingolipids, sphingosine 1-phosphate and gangliosides modulate many β-cell signaling pathways and processes implicated in β-cell diabetic disease such as apoptosis, β-cell cytokine secretion, er-to-golgi vesicular trafficking, islet autoimmunity and insulin gene expression. |
2013-03-08 |
2023-08-12 |
Not clear |
| Ronne Wee Yeh Yeo, Kaiyuan Yang, GuoDong Li, Sai Kiang Li. High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeleton. PloS one. vol 7. issue 9. 2013-02-15. PMID:23024780. |
high glucose predisposes gene expression and erk phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeleton. |
2013-02-15 |
2023-08-12 |
mouse |
| Lídia Cedó, Anna Castell-Auví, Victor Pallarès, Ceereena Ubaida Mohien, Isabel Baiges, Mayte Blay, Anna Ardévol, Montserrat Pinen. Pancreatic islet proteome profile in Zucker fatty rats chronically treated with a grape seed procyanidin extract. Food chemistry. vol 135. issue 3. 2013-02-06. PMID:22953944. |
gene expression analysis supported the role of the first three biological processes, concluding that gspe limits insulin synthesis and secretion and modulates factors involved in apoptosis, but these molecular changes are not sufficient to counteract the genetic background of the zucker model at a physiological level. |
2013-02-06 |
2023-08-12 |
rat |
| Jianhui Liu, Fei Yin, He Xiao, Lixia Guo, Xue Ga. Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced β-cell apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 7. 2013-01-24. PMID:22819839. |
geniposide could prevent oxidative stress-induced neuron apoptosis, and improved glucose stimulated insulin secretion by activating glucagon-like peptide 1 receptor (glp-1r) in ins-1 cells. |
2013-01-24 |
2023-08-12 |
Not clear |
| G Drews, M Düfe. Role of K(ATP) channels in β-cell resistance to oxidative stress. Diabetes, obesity & metabolism. vol 14 Suppl 3. 2013-01-24. PMID:22928572. |
instead β-cells start to secrete less insulin and β-cell mass is diminished by apoptosis. |
2013-01-24 |
2023-08-12 |
Not clear |
| Fernanda S Manoel-Caetano, Danilo J Xavier, Adriane F Evangelista, Paula Takahashi, Cristhianna V Collares, Denis Puthier, Maria C Foss-Freitas, Milton C Foss, Eduardo A Donadi, Geraldo A Passos, Elza T Sakamoto-Hoj. Gene expression profiles displayed by peripheral blood mononuclear cells from patients with type 2 diabetes mellitus focusing on biological processes implicated on the pathogenesis of the disease. Gene. vol 511. issue 2. 2013-01-15. PMID:23036710. |
moreover, we identified two significant signaling pathways: adipocytokine, related to insulin resistance; and ceramide, related to oxidative stress and induction of apoptosis. |
2013-01-15 |
2023-08-12 |
human |
| Elizabeth R Gilbert, Dongmin Li. Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes. Epigenetics. vol 7. issue 8. 2013-01-14. PMID:22810088. |
while peripheral insulin resistance is common during obesity and aging in both animals and people, progression to t2d is largely due to insulin secretory dysfunction and significant apoptosis of functional β-cells, leading to an inability to compensate for insulin resistance. |
2013-01-14 |
2023-08-12 |
Not clear |
| Tamara Saksida, Stanislava Stosic-Grujicic, Gordana Timotijevic, Stellan Sandler, Ivana Stojanovi. Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis. Immunology and cell biology. vol 90. issue 7. 2013-01-04. PMID:22064706. |
therefore, the aim of this study was to explore mif expression in vivo during development of obesity and insulin resistance in high-fat diet (hfd)-fed c57bl/6 mice and whether mif inhibition could affect β-cell apoptosis and dysfunction induced by palmitic acid (pa) in vitro. |
2013-01-04 |
2023-08-12 |
mouse |
| Seok-Woo Hong, Jinmi Lee, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Le. Repression of sterol regulatory element-binding protein 1-c is involved in the protective effects of exendin-4 in pancreatic β-cell line. Molecular and cellular endocrinology. vol 362. issue 1-2. 2013-01-04. PMID:22820130. |
to observe the effect of ex-4, we evaluated glucose-stimulated insulin secretion (gsis) and apoptosis in the min6 pancreatic β-cell line, which were cultured in dmem medium containing 500 μm palmitate, with or without 10 nm ex-4. |
2013-01-04 |
2023-08-12 |
Not clear |
| Seok-Woo Hong, Jinmi Lee, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Le. Repression of sterol regulatory element-binding protein 1-c is involved in the protective effects of exendin-4 in pancreatic β-cell line. Molecular and cellular endocrinology. vol 362. issue 1-2. 2013-01-04. PMID:22820130. |
lipotoxic effects of palmitate in the insulin secretion and apoptosis were significantly prevented by srebp-1 knockdown. |
2013-01-04 |
2023-08-12 |
Not clear |