| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiyu Wang, Nathaniel W York, Colin G Nichols, Maria S Remed. Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell metabolism. vol 19. issue 5. 2014-12-31. PMID:24746806. |
we demonstrate here that β cell dedifferentiation, rather than apoptosis, is the main mechanism of loss of insulin-positive cells, and redifferentiation accounts for restoration of insulin content and antidiabetic drug responsivity in these animals. |
2014-12-31 |
2023-08-13 |
mouse |
| Yao Wang, Lu Gao, Yuan Li, Hong Chen, Zilin Su. Nifedipine protects INS-1 β-cell from high glucose-induced ER stress and apoptosis. International journal of molecular sciences. vol 12. issue 11. 2014-12-30. PMID:22174617. |
glucose augments ca(2+)-stimulated insulin release in pancreatic β-cells, but chronic high concentration of glucose could induce a sustained level of ca(2+) in β-cells, which leads to cell apoptosis. |
2014-12-30 |
2023-08-12 |
Not clear |
| Valeria Righi, Yiorgos Apidianakis, Nikolaos Psychogios, Laurence G Rahme, Ronald G Tompkins, A Aria Tzik. In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants. International journal of molecular medicine. vol 34. issue 1. 2014-12-30. PMID:24789699. |
since the -ch=ch- signal encompasses protons from ceramide, this latter difference is consistent with the hypothesis that the gst2 mutation is associated with insulin resistance and apoptosis. |
2014-12-30 |
2023-08-13 |
drosophila_melanogaster |
| Juhyun Song, Kyung Ah Park, Won Taek Lee, Jong Eun Le. Apoptosis signal regulating kinase 1 (ASK1): potential as a therapeutic target for Alzheimer's disease. International journal of molecular sciences. vol 15. issue 2. 2014-12-18. PMID:24481061. |
of particular interest, ask1 is associated with many signaling pathways, which include endoplasmic reticulum (er) stress-mediated apoptosis, aβ-induced neurotoxicity, tau protein phosphorylation, and insulin signal transduction. |
2014-12-18 |
2023-08-12 |
Not clear |
| Frank C Brosius, Richard J Cowar. Podocytes, signaling pathways, and vascular factors in diabetic kidney disease. Advances in chronic kidney disease. vol 21. issue 3. 2014-12-16. PMID:24780459. |
reduced insulin action directly leads to albuminuria, increased glomerular matrix accumulation, thickening of the glomerular basement membrane, podocyte apoptosis, and glomerulosclerosis. |
2014-12-16 |
2023-08-13 |
Not clear |
| Shiying Shao, Mingbo Nie, Cai Chen, Xi Chen, Muxun Zhang, Gang Yuan, Xuefeng Yu, Yan Yan. Protective action of liraglutide in beta cells under lipotoxic stress via PI3K/Akt/FoxO1 pathway. Journal of cellular biochemistry. vol 115. issue 6. 2014-12-15. PMID:24415347. |
the apoptosis, proliferation, and insulin secretion capability of min6 cells and islets from c57bl/6j mice were evaluated when exposed to ffas with/without liraglutide. |
2014-12-15 |
2023-08-12 |
mouse |
| Catherine Hajmrle, Mourad Ferdaoussi, Gregory Plummer, Aliya F Spigelman, Krista Lai, Jocelyn E Manning Fox, Patrick E MacDonal. SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets. American journal of physiology. Endocrinology and metabolism. vol 307. issue 8. 2014-12-15. PMID:25139051. |
we examined insulin secretion, intracellular ca²⁺ responses, induction of endoplasmic reticulum stress markers and inducible nitric oxide synthase (inos) expression, and apoptosis by tunel and caspase 3 cleavage. |
2014-12-15 |
2023-08-13 |
mouse |
| M Ramalingam, S-J Ki. Insulin on hydrogen peroxide-induced oxidative stress involves ROS/Ca2+ and Akt/Bcl-2 signaling pathways. Free radical research. vol 48. issue 3. 2014-12-01. PMID:24286466. |
the protective effect of insulin treatment on h2o2-induced oxidative stress in astrocytes by reducing apoptosis may relate to the pi3k/akt pathway. |
2014-12-01 |
2023-08-12 |
rat |
| Edmond Changkyun Park, Seung Il Kim, Yeonhee Hong, Jeong Won Hwang, Gun-Sik Cho, Hye-Na Cha, Jin-Kwan Han, Chul-Ho Yun, So-Young Park, Ik-Soon Jang, Zee-Won Lee, Jong-Soon Choi, Soohyun Kim, Gun-Hwa Ki. Inhibition of CYP4A reduces hepatic endoplasmic reticulum stress and features of diabetes in mice. Gastroenterology. vol 147. issue 4. 2014-11-25. PMID:24983671. |
er stress activates the unfolded protein response pathway, which contributes to apoptosis and insulin resistance. |
2014-11-25 |
2023-08-13 |
mouse |
| Albert Magro, Alice Magro, Sirish Shrestha, Kathy Brundage, Gary Ranki. Metalloproteinase dependent reduction of cell surface cluster determinants upon the induction of apoptosis. International journal of oncology. vol 44. issue 5. 2014-11-13. PMID:24626736. |
overall, the data indicate that the final stages of the pharmacological induction of apoptosis, while proceeding to a full commitment to non-necrotic cell death, involves the degradation of integrin, insulin and epidermal growth factor receptors caused by a programmed dysregulation of the cell's metalloproteinases. |
2014-11-13 |
2023-08-12 |
Not clear |
| Jian Zhang, Christine M Burrington, Samantha K Davenport, Andrew K Johnson, Melissa J Horsman, Saleem Chowdhry, Michael W Green. PKCδ regulates hepatic triglyceride accumulation and insulin signaling in Lepr(db/db) mice. Biochemical and biophysical research communications. vol 450. issue 4. 2014-11-04. PMID:25035929. |
hepatic histology, oxidative stress, apoptosis, gene expression, insulin signaling, and serum parameters were analyzed in lepr(db)(/)(db) and pkcδ(-/-)/lepr(db)(/)(db) mice. |
2014-11-04 |
2023-08-13 |
mouse |
| Maolong Dong, Jun Re. What fans the fire: insights into mechanisms of leptin in metabolic syndrome-associated heart diseases. Current pharmaceutical design. vol 20. issue 4. 2014-11-03. PMID:23688014. |
in addition to its well-established metabolic effects, more recent evidence have depicted a rather pivotal role of leptin in inflammation, oxidative stress, endoplasmic reticulum stress, apoptosis and tissue remodeling en route to the pathogenesis of type 2 diabetes mellitus, hypertension, atherosclerosis, and insulin resistance. |
2014-11-03 |
2023-08-12 |
Not clear |
| Yanxing Chen, Zhihou Liang, Zhu Tian, Julie Blanchard, Chun-Ling Dai, Sonia Chalbot, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23996345. |
the expression of 20 ad-related genes, including those involved in the processing of amyloid precursor protein, cytoskeleton, glucose metabolism, insulin signaling, synaptic function, protein kinases, and apoptosis, was altered, suggesting that stz disturbs multiple metabolic and cell signaling pathways in the brain. |
2014-10-27 |
2023-08-12 |
mouse |
| Niamh Mullooly, Wendy Vernon, David M Smith, Philip Newsholm. Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress response. Experimental physiology. vol 99. issue 3. 2014-10-21. PMID:24334335. |
after 48 h, islets were assessed for glucose-dependent insulin secretion capacity, proliferation or islet cell apoptosis. |
2014-10-21 |
2023-08-12 |
rat |
| Niamh Mullooly, Wendy Vernon, David M Smith, Philip Newsholm. Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress response. Experimental physiology. vol 99. issue 3. 2014-10-21. PMID:24334335. |
we report that elevated levels of branched-chain amino acids have little effect on pancreatic islet cell function or viability; however, increased levels of the amino acid l-arginine were found to be β-cell toxic, causing a dose-dependent decrease in insulin secretion accompanied by a decrease in islet cell proliferation and an increase in islet cell apoptosis. |
2014-10-21 |
2023-08-12 |
rat |
| Maria Giovanna Scioli, Valerio Cervelli, Gaetano Arcuri, Pietro Gentile, Elena Doldo, Alessandra Bielli, Elena Bonanno, Augusto Orland. High insulin-induced down-regulation of Erk-1/IGF-1R/FGFR-1 signaling is required for oxidative stress-mediated apoptosis of adipose-derived stem cells. Journal of cellular physiology. vol 229. issue 12. 2014-10-20. PMID:24818995. |
at physiological concentration, insulin promoted proliferation and survival of ascs in vitro, whereas high insulin level induced their dose-dependent proliferative arrest and apoptosis. |
2014-10-20 |
2023-08-13 |
human |
| Maria Giovanna Scioli, Valerio Cervelli, Gaetano Arcuri, Pietro Gentile, Elena Doldo, Alessandra Bielli, Elena Bonanno, Augusto Orland. High insulin-induced down-regulation of Erk-1/IGF-1R/FGFR-1 signaling is required for oxidative stress-mediated apoptosis of adipose-derived stem cells. Journal of cellular physiology. vol 229. issue 12. 2014-10-20. PMID:24818995. |
specific inhibition of erk-1/2, igf-1r, and fgfr activity promoted asc apoptosis but did not increase insulin effects, whereas egfr and erbb2 inhibition potentiated insulin-induced apoptosis. |
2014-10-20 |
2023-08-13 |
human |
| Chrysovalantou Mihailidou, Athanasios G Papavassiliou, Hippokratis Kiari. A crosstalk between p21 and UPR-induced transcription factor C/EBP homologous protein (CHOP) linked to type 2 diabetes. Biochimie. vol 99. 2014-10-10. PMID:24239558. |
chop has elevated as a critical mediator connecting accumulation and aggregation of unfolded proteins in the er and oxidative stress and also contributes to the induction of apoptosis in β-cell (beta-cell) - cells under conditions of increased insulin demand. |
2014-10-10 |
2023-08-12 |
Not clear |
| Grazia D Femminella, Paul Ediso. Evaluation of neuroprotective effect of glucagon-like peptide 1 analogs using neuroimaging. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 1 Suppl. 2014-10-06. PMID:24529526. |
in transgenic mice, both insulin and glp1 analogs reduced inflammation, increased stem cell proliferation, reduced apoptosis, and increased dendritic growth. |
2014-10-06 |
2023-08-12 |
mouse |
| V Kumar, Uma Bhandari, C D Tripathi, Geetika Khann. Protective Effect of Gymnema sylvestre Ethanol Extract on High Fat Diet-induced Obese Diabetic Wistar Rats. Indian journal of pharmaceutical sciences. vol 76. issue 4. 2014-10-06. PMID:25284929. |
body weight gain, food intake, water intake, hemodynamic parameters (systolic, diastolic, mean arterial blood pressures and heart rate), serum biochemical parameters (leptin, insulin, lipid levels, apolipoprotein b and glucose), cardiomyocyte apoptosis (cardiac caspase-3, na(+)/k(+) atpase activity and dna fragmentation) organs and visceral fat pad weight and oxidative stress parameters were measured. |
2014-10-06 |
2023-08-13 |
rat |