| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annika Sommerfeld, Roland Reinehr, Dieter Häussinge. Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25548285. |
coadministration of insulin and ffas, however, abolished hepatocyte proliferation and triggered cd95-dependent apoptosis due to a jnk-dependent association of the activated egfr with cd95, subsequent cd95 tyrosine phosphorylation and formation of the death-inducing signaling complex (disc). |
2015-05-08 |
2023-08-13 |
mouse |
| Annika Sommerfeld, Roland Reinehr, Dieter Häussinge. Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25548285. |
likewise, in presence of ffas insulin increased apoptosis in hepatocytes from wild type but not from alb-cre-fas(fl/fl) mice, which lack functional cd95. |
2015-05-08 |
2023-08-13 |
mouse |
| Levon Manukyan, Sarojini J K A Ubhayasekera, Jonas Bergquist, Ernest Sargsyan, Peter Bergste. Palmitate-induced impairments of β-cell function are linked with generation of specific ceramide species via acylation of sphingosine. Endocrinology. vol 156. issue 3. 2015-04-29. PMID:25535826. |
in the present study, exposure to palmitate induced the level of palmitoyl transferase and cer synthases, enzymes of the cer de novo and salvage pathways, and doubled total cer levels, which was associated with decreased insulin secretion and augmented apoptosis in min6 cells and human islets. |
2015-04-29 |
2023-08-13 |
human |
| S Park, S Kang, D S Kim, B K Shin, N R Moon, J W Dail. Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils. Free radical research. vol 48. issue 8. 2015-04-19. PMID:24807533. |
ischemic gerbils also exhibited impaired glucose tolerance and insulin sensitivity which induced post-stroke hyperglycemia associated with decreased β-cell mass due to increased β-cell apoptosis. |
2015-04-19 |
2023-08-13 |
Not clear |
| Lifang Yang, Dajun Zhao, Jun Ren, Jian Yan. Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy. Biochimica et biophysica acta. vol 1852. issue 2. 2015-04-17. PMID:24846717. |
in this mini-review, we attempted to discuss the activation machinery for er stress in response to these triggers en route to disrupted er function and cellular autophagy or apoptosis, ultimately insulin resistance and development of diabetic cardiomyopathy. |
2015-04-17 |
2023-08-13 |
Not clear |
| Changhwan Ahn, Hyun Yang, Eui-Ju Hong, Eui-Bae Jeun. Regulation and localization of transient receptor potential melastatin 2 in rat uterus. Reproductive sciences (Thousand Oaks, Calif.). vol 21. issue 10. 2015-04-13. PMID:24577155. |
the extracellular or intracellular ions play key roles in physiological functions including muscle contraction, cytokine production, insulin release, and apoptosis. |
2015-04-13 |
2023-08-12 |
rat |
| Heun-Sik Lee, Sanghoon Moon, Jun Ho Yun, MeeHee Lee, Mi Yeong Hwang, Young-Jin Kim, Bok-Ghee Han, Jeong-Min Kim, Bong-Jo Ki. Genome-wide copy number variation study reveals KCNIP1 as a modulator of insulin secretion. Genomics. vol 104. issue 2. 2015-04-13. PMID:24886904. |
the inhibition of kcnip1 led to increased insulin secretion in a glucose-dependent manner, but had no effect on insulin gene transcription as well as cell apoptosis. |
2015-04-13 |
2023-08-13 |
human |
| Xue-Qun Zhang, Cheng-Fu Xu, Chao-Hui Yu, Wei-Xing Chen, You-Ming L. Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease. World journal of gastroenterology. vol 20. issue 7. 2015-04-08. PMID:24587654. |
however, delayed or insufficient responses to er stress may turn physiological mechanisms into pathological consequences, including fat accumulation, insulin resistance, inflammation, and apoptosis, all of which play important roles in the pathogenesis of nafld. |
2015-04-08 |
2023-08-12 |
Not clear |
| Zhimin Gu, Xiaohui Wang, Ruo Qi, Lijuan Wei, Yinping Huo, Yu Ma, Lei Shi, Yongjie Chang, Gongquan Li, Lixiao Zho. Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase. Biochemical and biophysical research communications. vol 457. issue 2. 2015-04-06. PMID:25545058. |
additionally, we observed that oridonin suppressed fatty acid synthase (fas) expression in uveal melanoma cells, and enforced fas expression by insulin partially rescued the cells from oridonin-induced apoptosis, showing that inhibition of fas also contributed to oridonin-mediated apoptosis. |
2015-04-06 |
2023-08-13 |
human |
| Jia Wang, Lu Han, Zhi-hao Wang, Wen-yuan Ding, Yuan-yuan Shang, Meng-xiong Tang, Wen-bo Li, Yun Zhang, Wei Zhang, Ming Zhon. Overexpression of STAMP2 suppresses atherosclerosis and stabilizes plaques in diabetic mice. Journal of cellular and molecular medicine. vol 18. issue 4. 2015-04-02. PMID:24467451. |
our research aims to evaluate the function of the stamp2 gene, an important trigger in insulin resistance (ir), and explore its role in macrophage apoptosis in diabetic atherosclerotic vulnerable plaques. |
2015-04-02 |
2023-08-12 |
mouse |
| Rongying Li, Jeongkyung Lee, Mi-sun Kim, Victoria Liu, Mousumi Moulik, Haiyan Li, Qing Yi, Aini Xie, Wenhao Chen, Lina Yang, Yimin Li, Tsung Huang Tsai, Kazuhiro Oka, Lawrence Chan, Vijay Yechoo. PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice. Diabetes. vol 64. issue 2. 2015-03-31. PMID:25332429. |
however, an enduring restoration of glucose-stimulated insulin secretion and euglycemia occurs only when tolerance is also induced by the targeted overexpression of pd-l1 in the neo-islets, which results in inhibition of proliferation and increased apoptosis of infiltrating cd4(+) t cells. |
2015-03-31 |
2023-08-13 |
mouse |
| John M T Chu, Dicky K M Lee, Daniella P K Wong, Ricky N S Wong, Ken K L Yung, Christopher H K Cheng, Kevin K M Yu. Ginsenosides attenuate methylglyoxal-induced impairment of insulin signaling and subsequent apoptosis in primary astrocytes. Neuropharmacology. vol 85. 2015-03-30. PMID:24878245. |
ginsenosides attenuate methylglyoxal-induced impairment of insulin signaling and subsequent apoptosis in primary astrocytes. |
2015-03-30 |
2023-08-13 |
rat |
| John M T Chu, Dicky K M Lee, Daniella P K Wong, Ricky N S Wong, Ken K L Yung, Christopher H K Cheng, Kevin K M Yu. Ginsenosides attenuate methylglyoxal-induced impairment of insulin signaling and subsequent apoptosis in primary astrocytes. Neuropharmacology. vol 85. 2015-03-30. PMID:24878245. |
in the present study we investigated the effects of mg in disturbing insulin signaling and leading to further cellular apoptosis in rat primary astrocytes. |
2015-03-30 |
2023-08-13 |
rat |
| John M T Chu, Dicky K M Lee, Daniella P K Wong, Ricky N S Wong, Ken K L Yung, Christopher H K Cheng, Kevin K M Yu. Ginsenosides attenuate methylglyoxal-induced impairment of insulin signaling and subsequent apoptosis in primary astrocytes. Neuropharmacology. vol 85. 2015-03-30. PMID:24878245. |
in addition, rd and r-rh2 could improve insulin signaling and inhibit apoptosis, indicating that rd, r-rh2 and related compounds may have therapeutic potential in treating diabetes-induced neurodegeneration. |
2015-03-30 |
2023-08-13 |
rat |
| Rasoul Ghasemi, Asadollah Zarifkar, Karim Rastegar, Nader maghsoudi, Maryam Moosav. Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption. Neuropharmacology. vol 85. 2015-03-30. PMID:24881967. |
insulin protects against aβ-induced spatial memory impairment, hippocampal apoptosis and mapks signaling disruption. |
2015-03-30 |
2023-08-13 |
rat |
| Rasoul Ghasemi, Asadollah Zarifkar, Karim Rastegar, Nader maghsoudi, Maryam Moosav. Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption. Neuropharmacology. vol 85. 2015-03-30. PMID:24881967. |
therefore this study was designed to investigate if intrahippocampal insulin hinders aβ-related memory deterioration, hippocampal apoptosis and mapks signaling alteration induced by aβ. |
2015-03-30 |
2023-08-13 |
rat |
| Stefan Z Lutz, Olga Franck, Anja Böhm, Jürgen Machann, Fritz Schick, Fausto Machicao, Andreas Fritsche, Hans-Ulrich Häring, Harald Staige. Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity. PloS one. vol 9. issue 7. 2015-03-30. PMID:25025664. |
recently, cardiotrophin-1, a member of the interleukin-6 family of cytokines was described to protect beta-cells from apoptosis, to improve glucose-stimulated insulin secretion and insulin resistance, and to prevent streptozotocin-induced diabetes in mice. |
2015-03-30 |
2023-08-13 |
mouse |
| Youde Jiang, Qiuhua Zhang, Eun-Ah Ye, Jena J Steinl. Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice. Journal of neuroinflammation. vol 11. 2015-03-30. PMID:25138272. |
previously, we have shown that tnfα can inhibit normal insulin signal transduction, leading to increased apoptosis in both retinal endothelial cells (rec) and müller cells. |
2015-03-30 |
2023-08-13 |
mouse |
| Yue Xing, Di Yang, Jing Lu, De-Li Don. Insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating Akt. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25490386. |
insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating akt. |
2015-03-13 |
2023-08-13 |
Not clear |
| Yue Xing, Di Yang, Jing Lu, De-Li Don. Insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating Akt. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25490386. |
the aim of the present study is to evaluate the effects of insulin on bmp4-induced cardiomyocyte apoptosis. |
2015-03-13 |
2023-08-13 |
Not clear |