| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suijun Wang, Zhen Yang, Ying Gao, Quanzhong Li, Yong Su, Yanfang Wang, Yun Zhang, Hua Man, Hongxia Li. Pyruvate kinase, muscle isoform 2 promotes proliferation and insulin secretion of pancreatic β-cells via activating Wnt/CTNNB1 signaling. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-28. PMID:26823761. |
these results indicated the inductive roles of pkm2 in pancreatic β-cell nit-1, including promoting cell proliferation and insulin secretion, and inhibiting cell apoptosis, which might be achieved via activating the wnt/ctnnb1 signaling and downstream factors. |
2016-10-28 |
2023-08-13 |
mouse |
| Florence F Wagner, Morten Lundh, Taner Kaya, Patrick McCarren, Yan-Ling Zhang, Shrikanta Chattopadhyay, Jennifer P Gale, Thomas Galbo, Stewart L Fisher, Bennett C Meier, Amedeo Vetere, Sarah Richardson, Noel G Morgan, Dan Ploug Christensen, Tamara J Gilbert, Jacob M Hooker, Mélanie Leroy, Deepika Walpita, Thomas Mandrup-Poulsen, Bridget K Wagner, Edward B Holso. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS chemical biology. vol 11. issue 2. 2016-10-26. PMID:26640968. |
the highly selective hdac3 inhibitor brd3308 suppressed pancreatic β-cell apoptosis induced by inflammatory cytokines, as expected, or now glucolipotoxic stress, and increased functional insulin release. |
2016-10-26 |
2023-08-13 |
human |
| Mahesh Ramalingam, Sung-Jin Ki. Insulin involved Akt/ERK and Bcl-2/Bax pathways against oxidative damages in C6 glial cells. Journal of receptor and signal transduction research. vol 36. issue 1. 2016-10-25. PMID:25299754. |
furthermore, insulin interfered h(2)o(2)-induced intracellular generation of reactive oxygen species and calcium-ion transport, apoptosis, including lipid and protein oxidation products. |
2016-10-25 |
2023-08-13 |
Not clear |
| Himadri Singh, Vikram Parthasarathy, Mohammed Farouk, Vijayalakshmi Venkatesa. Progenitor cells may aid successful islet compensation in metabolically healthy obese individuals. Medical hypotheses. vol 86. 2016-10-17. PMID:26549352. |
based on many indirect evidences in human studies such as unchanged β-cell replication, apoptosis and size during compensation in insulin resistance in humans, we suggest successful β-cells mass compensation in metabolically healthy obesity is contributed by neoformation of β-cells, through expansion of progenitor cells/stem cells in synergy with β-cell replication. |
2016-10-17 |
2023-08-13 |
human |
| Bo Kyoung Yeo, Caroline Jeeyeon Hong, Kyung Min Chung, Hanwoong Woo, Kyungchan Kim, Seonghee Jung, Eun-Kyoung Kim, Seong-Woon Y. Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal. Molecular brain. vol 9. 2016-10-14. PMID:27000202. |
valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal. |
2016-10-14 |
2023-08-13 |
Not clear |
| Sumaira Z Hasnain, Johannes B Prins, Michael A McGucki. Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes. Journal of molecular endocrinology. vol 56. issue 2. 2016-10-11. PMID:26576641. |
in this review we focus on the deleterious effects of oxidative stress and endoplasmic reticulum (er) stress on β-cell insulin biosynthesis and secretion and on inflammatory signalling and apoptosis with a particular emphasis on type 2 diabetes (t2d). |
2016-10-11 |
2023-08-13 |
Not clear |
| Feng-Fei Li, Bi-Jun Chen, Wei Li, Ling Li, Min Zha, S Zhou, M G Bachem, Zi-Lin Su. Islet Stellate Cells Isolated from Fibrotic Islet of Goto-Kakizaki Rats Affect Biological Behavior of Beta-Cell. Journal of diabetes research. vol 2016. 2016-10-05. PMID:26697502. |
ins-1 cell proliferation, apoptosis, and insulin production were measured after being treated with iscs supernatant (sn). |
2016-10-05 |
2023-08-13 |
rat |
| Siyuan Kong, Jinxue Ruan, Leilei Xin, Junhua Fan, Jihan Xia, Zhiguo Liu, Yulian Mu, Shulin Yang, Kui L. Multi‑transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis. Molecular medicine reports. vol 13. issue 1. 2016-09-26. PMID:26648014. |
multi‑transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis. |
2016-09-26 |
2023-08-13 |
human |
| Yuxiang Dai, Wen Zhang, Xiaoming Zhou, Jixin Sh. Activation of the Protein Kinase B (Akt) Reduces Nur77-induced Apoptosis During Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rat. Annals of clinical and laboratory science. vol 45. issue 6. 2016-09-26. PMID:26663789. |
to determine whether activation of akt is directly associated with nur77 dependent apoptosis pathway, we hypothesized that insulin, an activator of akt, may effectively ameliorate ebi by inhibiting nur77 transcriptional activity. |
2016-09-26 |
2023-08-13 |
rat |
| Chan Gyu Lee, Ja Hyun Koo, Sang Geon Ki. Phytochemical regulation of Fyn and AMPK signaling circuitry. Archives of pharmacal research. vol 38. issue 12. 2016-09-23. PMID:25951818. |
another important kinase that regulates energy metabolism is fyn kinase, a member of the src family kinases that plays a role in various cellular responses such as insulin signaling, cell growth, oxidative stress and apoptosis. |
2016-09-23 |
2023-08-13 |
Not clear |
| X Y Chen, G M Li, Q Dong, H Pen. MiR-577 inhibits pancreatic β-cell function and survival by targeting fibroblast growth factor 21 (FGF-21) in pediatric diabetes. Genetics and molecular research : GMR. vol 14. issue 4. 2016-09-19. PMID:26634512. |
we demonstrated that, although fgf-21 does not acutely stimulate insulin secretion in isolated islets from normal rats, it increases insulin secretion and insulin content in diabetic islets and protects β-cells from apoptosis via the activation of extracellular signal-regulated kinase 1/2 and akt signaling pathways. |
2016-09-19 |
2023-08-13 |
rat |
| Sita Sharan Patel, Vineet Mehta, Harish Changotra, Malairaman Udayaban. Depression mediates impaired glucose tolerance and cognitive dysfunction: A neuromodulatory role of rosiglitazone. Hormones and behavior. vol 78. 2016-09-15. PMID:26631485. |
the effect of rosi on insulin signaling, autophagy and apoptosis were evaluated in the hippocampus. |
2016-09-15 |
2023-08-13 |
mouse |
| Sita Sharan Patel, Vineet Mehta, Harish Changotra, Malairaman Udayaban. Depression mediates impaired glucose tolerance and cognitive dysfunction: A neuromodulatory role of rosiglitazone. Hormones and behavior. vol 78. 2016-09-15. PMID:26631485. |
cus significantly impaired hippocampal insulin signaling, membrane translocation of glucose transporter type 4 (glut4) as well as decreased the expression of autophagy5, autophagy7, b-cell lymphoma 2 and apoptosis inhibitory protein 2. |
2016-09-15 |
2023-08-13 |
mouse |
| Wei-huang Zhuang, Mao-juan Huang, Jing-xin Pa. [Inhibitory Effect of High Concentration Insulin on the Proliferation of Human Leukemia Cell Strain K562]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 47. issue 3. 2016-09-15. PMID:27468475. |
to study the impact of high concentration insulin on the proliferation and apoptosis of k562 cell strain. |
2016-09-15 |
2023-08-13 |
human |
| Tao Bai, Fan Wang, Nicholas Mellen, Yang Zheng, Lu Ca. Diabetic cardiomyopathy: role of the E3 ubiquitin ligase. American journal of physiology. Endocrinology and metabolism. vol 310. issue 7. 2016-08-23. PMID:26732687. |
as the number of cases of diabetes continues to rise, it is urgent to develop new strategies to protect against dcm, which is characterized by cardiac hypertrophy, increased apoptosis, fibrosis, and altered insulin metabolism. |
2016-08-23 |
2023-08-13 |
Not clear |
| N U Ashraf, T A Sheik. Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease. Free radical research. vol 49. issue 12. 2016-08-19. PMID:26223319. |
the signalling pathway activated by disruption of endoplasmic reticulum (er) homoeostasis, called as unfolded protein response, is linked with membrane biosynthesis, insulin action, inflammation and apoptosis. |
2016-08-19 |
2023-08-13 |
Not clear |
| Ping Yang, Yunfei Zhao, Lei Zhao, Jun Yuan, Yao Chen, Zac Varghese, John F Moorhead, Yaxi Chen, Xiong Z Rua. Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo. Scientific reports. vol 5. 2016-08-17. PMID:26449763. |
in vivo, rapamycin treatment also ameliorated the impaired insulin signaling induced by inflammatory stress, but it induced pancreatic β-cell apoptosis, reduced pancreatic β-cell function and enhanced hepatic gluconeogenesis, thereby resulting in hyperglycemia and glucose intolerance in casein-injected mice. |
2016-08-17 |
2023-08-13 |
mouse |
| Fang Chen, Jia Liu, Yanyang Wang, Tijun Wu, Wei Shan, Yunxia Zhu, Xiao Ha. Aldosterone induces clonal β-cell failure through glucocorticoid receptor. Scientific reports. vol 5. 2016-08-09. PMID:26287126. |
as expected, aldosterone induced apoptosis and β-cell dysfunction, including impairment of insulin synthesis and secretion, which were reversed by glucocorticoid receptor (gr) antagonists or gr-specific sirna. |
2016-08-09 |
2023-08-13 |
Not clear |
| Fang Chen, Jia Liu, Yanyang Wang, Tijun Wu, Wei Shan, Yunxia Zhu, Xiao Ha. Aldosterone induces clonal β-cell failure through glucocorticoid receptor. Scientific reports. vol 5. 2016-08-09. PMID:26287126. |
consequently, overexpression of mafa increased synthesis and secretion of insulin, and decreased apoptosis in clonal β-cells exposed to aldosterone. |
2016-08-09 |
2023-08-13 |
Not clear |
| Sireesh Dornadula, Bhakkiyalakshmi Elango, Ponjayanthi Balashanmugam, Rajaguru Palanisamy, Ramkumar Kunka Mohanra. Pathophysiological insights of methylglyoxal induced type-2 diabetes. Chemical research in toxicology. vol 28. issue 9. 2016-08-08. PMID:26250540. |
mg is a major precursor of the advanced glycation end product (age) and promotes impaired functions of insulin signaling, glut transporters, anion channels, kinases, and endothelial cells and is finally involved in apoptosis. |
2016-08-08 |
2023-08-13 |
Not clear |