| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanis H Harith, Belinda A Di Bartolo, Siân P Cartland, Scott Genner, Mary M Kavurm. Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand. Journal of diabetes. vol 8. issue 4. 2017-04-18. PMID:26333348. |
insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand. |
2017-04-18 |
2023-08-13 |
Not clear |
| Jatuporn Sujjitjoon, Suwattanee Kooptiwut, Nalinee Chongjaroen, Namoiy Semprasert, Wanthanee Hanchang, Kanjana Chanprasert, Watip Tangjittipokin, Pa-Thai Yenchitsomanus, Nattachet Plengvidhy. PAX4 R192H and P321H polymorphisms in type 2 diabetes and their functional defects. Journal of human genetics. vol 61. issue 11. 2017-04-06. PMID:27334367. |
pax4 variant proteins were investigated for repressor function on human insulin and glucagon promoters and for cell viability and apoptosis upon high glucose exposure. |
2017-04-06 |
2023-08-13 |
human |
| Yuan Li, Tianyou Luo, Liang Wang, Jing Wu, Shixin Gu. MicroRNA-19a-3p enhances the proliferation and insulin secretion, while it inhibits the apoptosis of pancreatic β cells via the inhibition of SOCS3. International journal of molecular medicine. vol 38. issue 5. 2017-03-21. PMID:27666763. |
microrna-19a-3p enhances the proliferation and insulin secretion, while it inhibits the apoptosis of pancreatic β cells via the inhibition of socs3. |
2017-03-21 |
2023-08-13 |
Not clear |
| Yuan Li, Tianyou Luo, Liang Wang, Jing Wu, Shixin Gu. MicroRNA-19a-3p enhances the proliferation and insulin secretion, while it inhibits the apoptosis of pancreatic β cells via the inhibition of SOCS3. International journal of molecular medicine. vol 38. issue 5. 2017-03-21. PMID:27666763. |
mir‑19a‑3p mimic was further used to transfect pancreatic β cells, and we found that the overexpression of mir-19a-3p promoted cell proliferation and insulin secretion, while it suppressed the apoptosis of pancreatic β cells. |
2017-03-21 |
2023-08-13 |
Not clear |
| Yuan Li, Tianyou Luo, Liang Wang, Jing Wu, Shixin Gu. MicroRNA-19a-3p enhances the proliferation and insulin secretion, while it inhibits the apoptosis of pancreatic β cells via the inhibition of SOCS3. International journal of molecular medicine. vol 38. issue 5. 2017-03-21. PMID:27666763. |
moreover, the sirna-induced downregulation of socs3 also enhanced cell proliferation and insulin secretion, while it inhibited the apoptosis of pancreatic β cells. |
2017-03-21 |
2023-08-13 |
Not clear |
| Yuan Li, Tianyou Luo, Liang Wang, Jing Wu, Shixin Gu. MicroRNA-19a-3p enhances the proliferation and insulin secretion, while it inhibits the apoptosis of pancreatic β cells via the inhibition of SOCS3. International journal of molecular medicine. vol 38. issue 5. 2017-03-21. PMID:27666763. |
in addition, the overexpression of socs3 reversed the effects of mir‑19a‑3p overexpression on cell proliferation, insulin secretion and on the apoptosis of pancreatic β cells, which further indicates that socs3 acts as a downstream effector in the mir-19a-3p-mediated function of pancreatic β cells. |
2017-03-21 |
2023-08-13 |
Not clear |
| Mei Li Ng, Carol Wadham, Olga A Sukochev. The role of sphingolipid signalling in diabetes‑associated pathologies (Review). International journal of molecular medicine. vol 39. issue 2. 2017-03-16. PMID:28075451. |
there is strong evidence supporting the critical roles of sphk and s1p in the progression of diabetes mellitus, including insulin sensitivity and insulin secretion, pancreatic β‑cell apoptosis, and the development of diabetic inflammatory state. |
2017-03-16 |
2023-08-13 |
Not clear |
| Paula K Bautista-Niño, Eliana Portilla-Fernandez, Douglas E Vaughan, A H Jan Danser, Anton J M Rok. DNA Damage: A Main Determinant of Vascular Aging. International journal of molecular sciences. vol 17. issue 5. 2017-03-15. PMID:27213333. |
central to this review is the role of diverse types of dna damage (telomeric, non-telomeric and mitochondrial), of cellular changes (apoptosis, senescence, autophagy), mediators of senescence and cell growth (plasminogen activator inhibitor-1 (pai-1), cyclin-dependent kinase inhibitors, senescence-associated secretory phenotype (sasp)/senescence-messaging secretome (sms), insulin and insulin-like growth factor 1 (igf-1) signaling), the adenosine monophosphate-activated protein kinase (ampk)-mammalian target of rapamycin (mtor)-nuclear factor kappa b (nfκb) axis, reactive oxygen species (ros) vs. endothelial nitric oxide synthase (enos)-cyclic guanosine monophosphate (cgmp) signaling, phosphodiesterase (pde) 1 and 5, transcription factor nf-e2-related factor-2 (nrf2), and diet restriction. |
2017-03-15 |
2023-08-13 |
mouse |
| Linqin Ma, Jingchun Zhang, Yue Li. Roles and Mechanisms of Obstructive Sleep Apnea-Hypopnea Syndrome and Chronic Intermittent Hypoxia in Atherosclerosis: Evidence and Prospective. Oxidative medicine and cellular longevity. vol 2016. 2017-03-13. PMID:27293515. |
here, we review clinical and fundamental studies reported during the last 10 years on the occurrence and development of as mediated by cih, focusing on inflammation, oxidative stress, insulin resistance, cell apoptosis, vascular endothelial injury, platelet activation, and neuroendocrine disorders. |
2017-03-13 |
2023-08-13 |
Not clear |
| Shuyun Liu, Lanlan Zhang, Jingqiu Cheng, Yanrong Lu, Jingping Li. Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response. International journal of nanomedicine. vol 11. 2017-02-28. PMID:27729786. |
in vitro and in vivo results showed that hgf-loaded kld2r/hep gel promoted β-cell survival and insulin secretion, and inhibited cell apoptosis, cytokine release, t-cell infiltration, and activation of nfκb/p38 mapk pathways in β-cells. |
2017-02-28 |
2023-08-13 |
rat |
| Seong Lin Teoh, Srijit Da. Tumour biology of obesity-related cancers: understanding the molecular concept for better diagnosis and treatment. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 11. 2017-02-17. PMID:27623943. |
any disturbance in the production of sex hormones and insulin, leads to distortion in the balance between cell proliferation, differentiation and apoptosis. |
2017-02-17 |
2023-08-13 |
Not clear |
| Tatsuo Tomit. Apoptosis in pancreatic β-islet cells in Type 2 diabetes. Bosnian journal of basic medical sciences. vol 16. issue 3. 2017-02-15. PMID:27209071. |
the etiology of t2dm is multifactorial, including obesity-associated insulin resistance, defective insulin secretion, and loss of β-cell mass through β-cell apoptosis. |
2017-02-15 |
2023-08-13 |
mouse |
| Hajar Shali, Majid Ahmadi, Hossein Samadi Kafil, Abbasali Dorosti, Mehdi Yousef. IGF1R and c-met as therapeutic targets for colorectal cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 82. 2017-02-07. PMID:27470393. |
these receptors bind to their specific ligands, insulin growth factors (igfs) and hepatocyte growth factor (hgf), respectively, and promote signaling cascades which mediates many functions such as proliferation and protection against apoptosis, cell scattering, tumor cell motility, invasion and metastasis. |
2017-02-07 |
2023-08-13 |
Not clear |
| Hao-Hao Zhang, Xiao-Jun Ma, Li-Na Wu, Yan-Yan Zhao, Peng-Yu Zhang, Ying-Hui Zhang, Ming-Wei Shao, Fei Liu, Fei Li, Gui-Jun Qi. Sirtuin-3 (SIRT3) protects pancreatic β-cells from endoplasmic reticulum (ER) stress-induced apoptosis and dysfunction. Molecular and cellular biochemistry. vol 420. issue 1-2. 2017-02-06. PMID:27449933. |
however, sirt3 overexpression in nit1 and ins1 cells reversed these effects, resulting in higher insulin secretion, decreased β-cell apoptosis, and downregulation of the expression of er stress-associated genes. |
2017-02-06 |
2023-08-13 |
rat |
| Sabbir Khan, Gopabandhu Jen. Valproic Acid Improves Glucose Homeostasis by Increasing Beta-Cell Proliferation, Function, and Reducing its Apoptosis through HDAC Inhibition in Juvenile Diabetic Rat. Journal of biochemical and molecular toxicology. vol 30. issue 9. 2017-02-03. PMID:27079868. |
vpa treatment significantly decreased plasma glucose, beta-cell damage, and apoptosis as well as increased the beta-cell function, insulin level/expression. |
2017-02-03 |
2023-08-13 |
rat |
| Shermineh Moeini-Nodeh, Mahban Rahimifard, Maryam Baeeri, Mohammad Abdollah. Functional Improvement in Rats' Pancreatic Islets Using Magnesium Oxide Nanoparticles Through Antiapoptotic and Antioxidant Pathways. Biological trace element research. vol 175. issue 1. 2017-01-19. PMID:27234250. |
also, in that time of exposure, cell apoptosis investigation by flow cytometry and insulin test showed that mgo nps, in a concentration of 100 μg/ml, decreased the rate of apoptotic cells via inhibiting caspase-9 activity and made a significant increase in the level of insulin secretion. |
2017-01-19 |
2023-08-13 |
rat |
| J S Oliveira, A A N Silva, V A Silv. Phytotherapy in reducing glycemic index and testicular oxidative stress resulting from induced diabetes: a review. Brazilian journal of biology = Revista brasleira de biologia. vol 0. 2017-01-12. PMID:27409225. |
plant extracts were evaluated according to their effects on blood glucose and insulin levels, antioxidant enzymes and oxidant levels, lipid peroxidation, total protein, testosterone levels, gonadosomatic index, diameter of seminiferous tubules, seminiferous epithelium height and integrity, number of germ cells at stage vii and apoptosis in the seminiferous epithelium, sperm production, motility, viability and morphology. |
2017-01-12 |
2023-08-13 |
Not clear |
| D I Kuzmenko, T K Klimentyev. Role of Ceramide in Apoptosis and Development of Insulin Resistance. Biochemistry. Biokhimiia. vol 81. issue 9. 2017-01-12. PMID:27682164. |
role of ceramide in apoptosis and development of insulin resistance. |
2017-01-12 |
2023-08-13 |
Not clear |
| D I Kuzmenko, T K Klimentyev. Role of Ceramide in Apoptosis and Development of Insulin Resistance. Biochemistry. Biokhimiia. vol 81. issue 9. 2017-01-12. PMID:27682164. |
molecular mechanisms of the involvement of ceramide in apoptosis in pancreatic β-cells and its role in the formation of insulin resistance in pathogenesis of type 2 diabetes are reviewed. |
2017-01-12 |
2023-08-13 |
Not clear |
| Lara Bellini, Mélanie Campana, Rana Mahfouz, Aurélie Carlier, Julien Véret, Christophe Magnan, Eric Hajduch, Hervé Le Stunf. Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes. Expert opinion on therapeutic targets. vol 19. issue 8. 2017-01-10. PMID:25814122. |
excess circulating fatty acids (fas), which characterize obesity, induce insulin resistance, steatosis, β cells dysfunction and apoptosis. |
2017-01-10 |
2023-08-13 |
Not clear |