| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alice Matone, Eleonora Derlindati, Luca Marchetti, Valentina Spigoni, Alessandra Dei Cas, Barbara Montanini, Diego Ardigò, Ivana Zavaroni, Corrado Priami, Riccardo C Bonadonn. Identification of an early transcriptomic signature of insulin resistance and related diseases in lymphomonocytes of healthy subjects. PloS one. vol 12. issue 8. 2017-10-10. PMID:28777829. |
321 genes composed the gene set distinguishing the insulin resistant and sensitive groups, within which the "adrenergic signaling in cardiomyocytes" kegg pathway was significantly represented, suggesting a pattern of increased intracellular camp and ca2+, and apoptosis in the ir group. |
2017-10-10 |
2023-08-13 |
human |
| Barbara Di Camillo, Azzurra Carlon, Federica Eduati, Gianna Maria Toffol. A rule-based model of insulin signalling pathway. BMC systems biology. vol 10. issue 1. 2017-10-04. PMID:27245161. |
the insulin signalling pathway (isp) is an important biochemical pathway, which regulates some fundamental biological functions such as glucose and lipid metabolism, protein synthesis, cell proliferation, cell differentiation and apoptosis. |
2017-10-04 |
2023-08-13 |
Not clear |
| Quan-Yu Zhang, Ling-Ping Zhao, Xiao-Xiang Tian, Cheng-Hui Yan, Yang Li, Yan-Xia Liu, Pi-Xiao Wang, Xiao-Jing Zhang, Ya-Ling Ha. The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance. Hepatology (Baltimore, Md.). vol 66. issue 3. 2017-10-04. PMID:28508477. |
mechanistically, creg interacts directly with apoptosis signal-regulating kinase 1 (ask1) and inhibits its phosphorylation, thereby blocking the downstream mkk4/7-jnk1 signaling pathway and leading to significantly alleviated obesity, insulin resistance, and hepatic steatosis. |
2017-10-04 |
2023-08-13 |
Not clear |
| Andrew T Templin, Tanya Samarasekera, Daniel T Meier, Meghan F Hogan, Mahnaz Mellati, Michael T Crow, Richard N Kitsis, Sakeneh Zraika, Rebecca L Hull, Steven E Kah. Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation. Diabetes. vol 66. issue 10. 2017-10-02. PMID:28729244. |
islet amyloid is present in more than 90% of individuals with type 2 diabetes, where it contributes to β-cell apoptosis and insufficient insulin secretion. |
2017-10-02 |
2023-08-13 |
mouse |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Pattarapong Satjaritanun, Xiaojie Wang, Guang Liang, Xiaokun Li, Chao Jiang, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats. Hormones and behavior. vol 85. 2017-09-26. PMID:27566237. |
fgf21-treated obese-insulin resistant rats had improved peripheral insulin sensitivity, increased hippocampal synaptic plasticity, increased dendritic spine density, restored brain mitochondrial function, attenuated brain cells apoptosis and increased brain fgf21 signaling, leading to a prevention of cognitive decline. |
2017-09-26 |
2023-08-13 |
human |
| Azazul Islam Chowdhury, Peter Bergste. GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2. Molecular and cellular endocrinology. vol 439. 2017-09-25. PMID:27566229. |
when socs2 was knocked down, palmitate-induced down-regulation of irs-1 and pakt(t308) was prevented and gsis, proinsulin to insulin ratio and apoptosis was restored. |
2017-09-25 |
2023-08-13 |
human |
| Francielle Graus-Nunes, Thatiany de Souza Marinho, Sandra Barbosa-da-Silva, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mell. Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice. Molecular and cellular endocrinology. vol 439. 2017-09-25. PMID:27780713. |
high-fat diet yielded overweight, insulin resistance, islet apoptosis and hypertrophy. |
2017-09-25 |
2023-08-13 |
mouse |
| Xinghua Qin, Xiaoliang Li, Chuanming Liu, Ziwei Che. A novel mechanism of pre-transplant insulin resistance contributing to post-transplant complications: Cyclosporin A-induced O-GlcNAcylation. Biochemical and biophysical research communications. vol 492. issue 2. 2017-09-25. PMID:28830815. |
thus, in this study, using a cellular model of palmitate-induced insulin resistance, we evaluate the effect of csa on apoptosis in skeletal muscle c2c12 cells with palmitate-induced insulin resistance. |
2017-09-25 |
2023-08-13 |
Not clear |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats. Toxicology and applied pharmacology. vol 333. 2017-09-20. PMID:28807765. |
sglt2-inhibitor and dpp-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in hfd-induced obese rats. |
2017-09-20 |
2023-08-13 |
rat |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats. Toxicology and applied pharmacology. vol 333. 2017-09-20. PMID:28807765. |
single therapy resulted in equally improved brain mitochondrial function, insulin signaling, apoptosis and prevented cognitive decline. |
2017-09-20 |
2023-08-13 |
rat |
| Atilla Engi. Adipose Tissue Hypoxia in Obesity and Its Impact on Preadipocytes and Macrophages: Hypoxia Hypothesis. Advances in experimental medicine and biology. vol 960. 2017-09-12. PMID:28585205. |
hypoxia affects a number of biological functions, such as angiogenesis, cell proliferation, apoptosis, inflammation and insulin resistance. |
2017-09-12 |
2023-08-13 |
human |
| Shinwon Ha, Seol-Hwa Jeong, Kyungrim Yi, Kyung Min Chung, Caroline Jeeyeon Hong, Seong Who Kim, Eun-Kyoung Kim, Seong-Woon Y. Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells. The Journal of biological chemistry. vol 292. issue 33. 2017-09-05. PMID:28655770. |
because the apoptotic capability of the hcn cells was intact, our findings suggested activation of unique molecular mechanisms linking insulin withdrawal to acd rather than apoptosis. |
2017-09-05 |
2023-08-13 |
human |
| Chunhua Dai, Nora S Kayton, Alena Shostak, Greg Poffenberger, Holly A Cyphert, Radhika Aramandla, Courtney Thompson, Ioannis G Papagiannis, Christopher Emfinger, Masakazu Shiota, John M Stafford, Dale L Greiner, Pedro L Herrera, Leonard D Shultz, Roland Stein, Alvin C Power. Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. The Journal of clinical investigation. vol 126. issue 5. 2017-08-31. PMID:27064285. |
contrary to rodent islet studies, neither insulin resistance nor hyperglycemia led to human β cell proliferation or apoptosis. |
2017-08-31 |
2023-08-13 |
mouse |
| Di Zhu, Xinglin Zhang, Yajie Niu, Zhijun Diao, Bo Ren, Xingyu Li, Zhigang Liu, Xuebo Li. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 107. issue Pt A. 2017-08-29. PMID:28655651. |
compared with control, ca inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. |
2017-08-29 |
2023-08-13 |
mouse |
| Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Takashi Yasukawa, Kazuhiro Ishimaru, Shingo Yasuhara, Yong-Ming Yu, J A Jeevendra Martyn, Ronald G Tompkins, Kentaro Shimokado, Masao Kanek. iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53. PloS one. vol 12. issue 1. 2017-08-16. PMID:28099528. |
inflammation and apoptosis develop in skeletal muscle after major trauma, including burn injury, and play a pivotal role in insulin resistance and muscle wasting. |
2017-08-16 |
2023-08-13 |
mouse |
| Yue-Xian Xing, Liu Yang, Hong-Yu Kuang, Xin-Yuan Gao, Hao-Ling Li. Function of obestatin in the digestive system. Nutrition (Burbank, Los Angeles County, Calif.). vol 34. 2017-08-15. PMID:28063509. |
most studies suggest that obestatin is a pleiotropic peptide, which acts by suppressing the motility of the gastrointestinal tract, regulating the secretion of insulin, reducing inflammation and apoptosis, and promoting proliferation. |
2017-08-15 |
2023-08-13 |
Not clear |
| Schohraya Spahis, Edgard Delvin, Jean-Michel Borys, Emile Lev. Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis. Antioxidants & redox signaling. vol 26. issue 10. 2017-08-10. PMID:27452109. |
although nafld represents the predominant cause of chronic liver disorders, the mechanisms of its development and progression remain incompletely understood, even if various scientific groups ascribed them to the occurrence of insulin resistance, dyslipidemia, inflammation, and apoptosis. |
2017-08-10 |
2023-08-13 |
Not clear |
| Perinur Bozaykut, Ali Sahin, Betul Karademir, Nesrin Kartal Oze. Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis. Mechanisms of ageing and development. vol 157. 2017-08-04. PMID:27393639. |
activated er stress maintains protein homeostasis however, delayed or inadequate er stress responses may induce fat accumulation, insulin resistance, inflammation, apoptosis, and autophagy, all of which increase with age and play crucial roles in the pathogenesis of nash. |
2017-08-04 |
2023-08-13 |
Not clear |
| Donatella Paola Provvisiero, Claudia Pivonello, Giovanna Muscogiuri, Mariarosaria Negri, Cristina de Angelis, Chiara Simeoli, Rosario Pivonello, Annamaria Cola. Influence of Bisphenol A on Type 2 Diabetes Mellitus. International journal of environmental research and public health. vol 13. issue 10. 2017-08-03. PMID:27782064. |
clinical studies on humans and preclinical studies on in vivo, ex vivo, and in vitro models indicate that bpa, mostly at low doses, may have a role in increasing type 2 diabetes mellitus developmental risk, directly acting on pancreatic cells, in which bpa induces the impairment of insulin and glucagon secretion, triggers inhibition of cell growth and apoptosis, and acts on muscle, hepatic, and adipose cell function, triggering an insulin-resistant state. |
2017-08-03 |
2023-08-13 |
human |
| T-J Xu, Y Liu, P Li, X L Xu, J R Zen. Insulin in combination with selenium inhibits HG/Pal-induced cardiomyocyte apoptosis by Cbl-b regulating p38MAPK/CBP/Ku70 pathway. European review for medical and pharmacological sciences. vol 20. issue 15. 2017-07-26. PMID:27467007. |
insulin in combination with selenium inhibits hg/pal-induced cardiomyocyte apoptosis by cbl-b regulating p38mapk/cbp/ku70 pathway. |
2017-07-26 |
2023-08-13 |
Not clear |