| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hari B Keshava, Ashkan Mowla, Leslie J Heinberg, Philip R Schauer, Stacy A Brethauer, Ali Aminia. Bariatric surgery may reduce the risk of Alzheimer's diseases through GLP-1 mediated neuroprotective effects. Medical hypotheses. vol 104. 2018-04-23. PMID:28673587. |
glp-1 improves insulin secretion, inhibits apoptosis and induce pancreatic islet neogenesis, promotes satiety, and can regulate heart rate and blood pressure. |
2018-04-23 |
2023-08-13 |
Not clear |
| Chin Fen Teo, Enas Gad El-Karim, Lance Well. Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin. Glycobiology. vol 26. issue 11. 2018-04-05. PMID:27072814. |
these results strongly suggest that the defect in insulin action upon pugnac treatment does not derive from its inhibition of oga or hexa/b, and that there is an unknown target of pugnac that is the likely culprit in inhibiting the protective effect of insulin from apoptosis. |
2018-04-05 |
2023-08-13 |
Not clear |
| Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik, Sameer Mohamma. TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook. Current drug targets. vol 18. issue 9. 2018-04-02. PMID:28137209. |
overexpression of txnip in animal models has been shown to induce apoptosis of pancreatic β-cells, reduce insulin sensitivity in peripheral tissues like skeletal muscle and adipose, and decrease energy expenditure. |
2018-04-02 |
2023-08-13 |
Not clear |
| Tomoko Takai, Tomokazu Matsuda, Yuki Matsuura, Kaho Inoue, Emi Suzuki, Ayumi Kanno, Maki Kimura-Koyanagi, Shun-Ichiro Asahara, Naoya Hatano, Wataru Ogawa, Yoshiaki Kid. Casein kinase 2 phosphorylates and stabilizes C/EBPβ in pancreatic β cells. Biochemical and biophysical research communications. vol 497. issue 1. 2018-03-22. PMID:29448105. |
we found that c/ebpβ is phosphorylated by ck2 under ampk suppression and er stress, which are important from the viewpoint of the worsening pathological condition of type 2 diabetes, such as decreased insulin secretion and apoptosis of pancreatic β cells. |
2018-03-22 |
2023-08-13 |
Not clear |
| Bing Zhao, Zebao Zhen. Insulin Growth Factor 1 Protects Neural Stem Cells Against Apoptosis Induced by Hypoxia Through Akt/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase (Akt/MAPK/ERK) Pathway in Hypoxia-Ishchemic Encephalopathy. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-13. PMID:28420864. |
insulin growth factor 1 protects neural stem cells against apoptosis induced by hypoxia through akt/mitogen-activated protein kinase/extracellular signal-regulated kinase (akt/mapk/erk) pathway in hypoxia-ishchemic encephalopathy. |
2018-03-13 |
2023-08-13 |
rat |
| Ting Li, Guang-Yao Lin, Li Zhong, Yan Zhou, Jia Wang, Yue Zhu, Yang Feng, Xiao-Qing Cai, Qing Liu, Olivier Nosjean, Jean A Boutin, Pierre Renard, De-Hua Yang, Ming-Wei Wan. W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta pharmacologica Sinica. vol 38. issue 7. 2018-02-26. PMID:28502980. |
overexpression of txnip not only induces β-cell apoptosis but also reduces insulin production. |
2018-02-26 |
2023-08-13 |
mouse |
| Ting Li, Guang-Yao Lin, Li Zhong, Yan Zhou, Jia Wang, Yue Zhu, Yang Feng, Xiao-Qing Cai, Qing Liu, Olivier Nosjean, Jean A Boutin, Pierre Renard, De-Hua Yang, Ming-Wei Wan. W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta pharmacologica Sinica. vol 38. issue 7. 2018-02-26. PMID:28502980. |
furthermore, w2476 treatment prevented ins-1e cells from apoptosis induced by chronic exposure of high glucose and enhanced insulin production in vitro. |
2018-02-26 |
2023-08-13 |
mouse |
| Mingming Wang, Jing Sun, Bo Xu, Marcin Chrusciel, Jun Gao, Maciej Bazert, Joanna Stelmaszewska, Yunyun Xu, Hongwen Zhang, Leszek Pawelczyk, Fei Sun, Suk Ying Tsang, Nafis Rahman, Slawomir Wolczynski, Xiangdong L. Functional Characterization of MicroRNA-27a-3p Expression in Human Polycystic Ovary Syndrome. Endocrinology. vol 159. issue 1. 2018-02-21. PMID:29029022. |
after kgn cells were stimulated with insulin for 48 hours, there was increased expression of smad5 protein and decreased apoptosis. |
2018-02-21 |
2023-08-13 |
human |
| J Lozano-Bartolomé, G Llauradó, M M Rodriguez, J M Fernandez-Real, J F Garcia-Fontgivell, J Puig, E Maymó-Masip, J Vendrell, M R Chacó. Reduced circulating levels of sTWEAK are associated with NAFLD and may affect hepatocyte triglyceride accumulation. International journal of obesity (2005). vol 40. issue 9. 2018-02-20. PMID:27121253. |
previous data demonstrated that low circulating levels of tumour necrosis factor weak inducer of apoptosis (stweak) were associated with obesity, diabetes and insulin resistance, all traits associated with an increased risk of nalfd. |
2018-02-20 |
2023-08-13 |
Not clear |
| Xin Zhou, Dewu Han, Ruiling Xu, Huiwen Wu, Chongxiao Qu, Feng Wang, Xiangyu Wang, Yuanchang Zha. Glycine protects against high sucrose and high fat-induced non-alcoholic steatohepatitis in rats. Oncotarget. vol 7. issue 49. 2018-02-12. PMID:27784003. |
the level of tnfα and mcp-1 in plasma, the content of tnfα in the liver, the insulin resistance index, inflammatory cell infiltration, hepatocyte apoptosis, reactive oxygen species (ros) generation, and endoplasmic stress-associated protein expression were unaltered at 4 weeks. |
2018-02-12 |
2023-08-13 |
rat |
| Tarek K Motawi, Hebatallah A Darwish, Manal A Hamed, Nagy S El-Rigal, Asmaa F Aboul Nase. A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26867655. |
the evaluation was done through the estimation of the levels of blood glucose, serum insulin, and oxidative stress markers: malondialdehyde (mda), superoxide dismutase (sod), and glutathione (gsh); neurotransmitters: acetylcholinesterase (ache) and dopamine (da); vasoconstrictor indices: intercellular adhesion molecule-1 (icam-1), vascular cell adhesion molecule-1(vcam-1), and angiotensin ii (ang ii); and apoptosis markers: tumor necrosis factor-α (tnf-α) and caspase-3 as well as the histopathological picture of the cerebellum region of the brain. |
2018-02-07 |
2023-08-13 |
rat |
| Chan-Min Liu, Jie-Qiong Ma, Jian-Mei Sun, Zhao-Jun Feng, Chao Cheng, Wei Yang, Hong Jian. Association of changes in ER stress-mediated signaling pathway with lead-induced insulin resistance and apoptosis in rats and their prevention by A-type dimeric epigallocatechin-3-gallate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 110. 2018-02-07. PMID:29107025. |
association of changes in er stress-mediated signaling pathway with lead-induced insulin resistance and apoptosis in rats and their prevention by a-type dimeric epigallocatechin-3-gallate. |
2018-02-07 |
2023-08-13 |
rat |
| Chan-Min Liu, Jie-Qiong Ma, Jian-Mei Sun, Zhao-Jun Feng, Chao Cheng, Wei Yang, Hong Jian. Association of changes in ER stress-mediated signaling pathway with lead-induced insulin resistance and apoptosis in rats and their prevention by A-type dimeric epigallocatechin-3-gallate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 110. 2018-02-07. PMID:29107025. |
the present study aims to examine the protective effects of a-type-egcg-dimer on pb-induced hepatic insulin resistance, endoplasmic reticulum (er) stress and apoptosis in rats. |
2018-02-07 |
2023-08-13 |
rat |
| Chan-Min Liu, Jie-Qiong Ma, Jian-Mei Sun, Zhao-Jun Feng, Chao Cheng, Wei Yang, Hong Jian. Association of changes in ER stress-mediated signaling pathway with lead-induced insulin resistance and apoptosis in rats and their prevention by A-type dimeric epigallocatechin-3-gallate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 110. 2018-02-07. PMID:29107025. |
our results suggest that a-type-egcg-dimer might be a potential natural candidate for the prevention of hepatic insulin resistance and apoptosis induced by pb. |
2018-02-07 |
2023-08-13 |
rat |
| Marta Fichna, Piotr Fichn. Glucocorticoids and beta-cell function. Endokrynologia Polska. vol 68. issue 5. 2018-01-30. PMID:29168546. |
the mechanism remains ambiguous but might involve its direct influence upon expression of molecules essential for glucose sensing and metabolism, enhanced glucose cycling, down-regulated insulin gene transcription, hampered insulin exocytosis, amplified alpha-adrenergic signalling, and/or increased beta-cell apoptosis. |
2018-01-30 |
2023-08-13 |
mouse |
| Kevin It. Insights into the percutaneous penetration of antidiabetic agents. Journal of drug targeting. vol 25. issue 2. 2018-01-29. PMID:27499038. |
it has been suggested that destruction of β cells through apoptosis leads to type 1 diabetes (t1dm) while type 2 diabetes (t2dm) is caused mainly by increased insulin resistance. |
2018-01-29 |
2023-08-13 |
Not clear |
| Kuntol Rakshit, Jingyi Qian, Jason Ernst, Aleksey V Matveyenk. Circadian variation of the pancreatic islet transcriptome. Physiological genomics. vol 48. issue 9. 2018-01-25. PMID:27495157. |
several transcriptional pathways essential for proper islet function (e.g., insulin secretion, oxidative phosphorylation), cell survival (e.g., insulin signaling, apoptosis) and cell proliferation (dna replication, homologous recombination) demonstrated significant time-dependent variations. |
2018-01-25 |
2023-08-13 |
mouse |
| Pradip K Kamat, Anuradha Kalani, Shivika Rai, Santosh Kumar Tota, Ashok Kumar, Abdullah S Ahma. Streptozotocin Intracerebroventricular-Induced Neurotoxicity and Brain Insulin Resistance: a Therapeutic Intervention for Treatment of Sporadic Alzheimer's Disease (sAD)-Like Pathology. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26298663. |
streptozotocin (stz) produces similar characteristic pathology of sad such as altered glucose metabolism, insulin signaling, synaptic dysfunction, protein kinases such as protein kinase b/c, glycogen synthase-3β (gsk-3β) activation, tau hyperphosphorylation, aβ deposition, and neuronal apoptosis. |
2018-01-16 |
2023-08-13 |
Not clear |
| Dornadula Sireesh, Munuswamy-Ramanujam Ganesh, Umapathy Dhamodharan, Murugesan Sakthivadivel, Srinivasan Sivasubramanian, Palani Gunasekaran, Kunka Mohanram Ramkuma. Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade. The Journal of nutritional biochemistry. vol 44. 2018-01-08. PMID:28343084. |
in this study, we investigated pts confer protection against cytokine-induced β-cell apoptosis and its role on insulin secretion in streptozotocin (stz)-induced diabetic mice. |
2018-01-08 |
2023-08-13 |
mouse |
| Qiurong Wang, Jun Re. mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. Pharmacological research. vol 111. 2018-01-05. PMID:27363949. |
these data suggest that trehalose may rescue against insulin resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 mapk and foxo1 without affecting phosphorylation of akt. |
2018-01-05 |
2023-08-13 |
mouse |