| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurits J Holm, Lars Krogvold, Jane P Hasselby, Simranjeet Kaur, Laura A Claessens, Mark A Russell, Clayton E Mathews, Kristian F Hanssen, Noel G Morgan, Bobby P C Koeleman, Bart O Roep, Ivan C Gerling, Flemming Pociot, Knut Dahl-Jørgensen, Karsten Buschar. Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia. vol 61. issue 7. 2018-11-26. PMID:29671030. |
sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures. |
2018-11-26 |
2023-08-13 |
mouse |
| Rana Keyhanmanesh, Gholamreza Hamidian, Mohammad Reza Alipour, Minoo Ranjbar, Hajar Oghbae. Protective effects of sodium nitrate against testicular apoptosis and spermatogenesis impairments in streptozotocin-induced diabetic male rats. Life sciences. vol 211. 2018-11-15. PMID:30205097. |
as nitric oxide (no) production is essential for insulin signaling, glucose uptake, endothelial function, and regulation of apoptosis, the loss of bioavailable no may be a mechanism underlying the development of diabetes complication. |
2018-11-15 |
2023-08-13 |
rat |
| Cynthia T Luk, Sally Yu Shi, Erica P Cai, Tharini Sivasubramaniyam, Mansa Krishnamurthy, Jara J Brunt, Stephanie A Schroer, Daniel A Winer, Minna Wo. FAK signalling controls insulin sensitivity through regulation of adipocyte survival. Nature communications. vol 8. 2018-11-09. PMID:28165007. |
in contrast, inhibition of apoptosis, either genetically or pharmacologically, attenuates adipocyte death, restores normal adiposity and improves insulin sensitivity. |
2018-11-09 |
2023-08-13 |
mouse |
| Fei-Juan Kong, Jia-Hua Wu, Shui-Ya Sun, Jia-Qiang Zho. The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury. Scientific reports. vol 7. 2018-11-09. PMID:28294183. |
pretreatment with autophagy inhibitors e-64d/pepstatin a increased er stress-induced cell injuries as indicated by increased cell apoptosis and decreased insulin secretion. |
2018-11-09 |
2023-08-13 |
Not clear |
| Benjamin Lew, In-Yong Kim, Hyungsoo Choi, Kyekyoon Kevin Ki. Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets. Drug delivery and translational research. vol 8. issue 3. 2018-10-15. PMID:29372538. |
the ability of glucagon-like peptide-1 analogs to enhance glucose-dependent insulin secretion and to inhibit β cell apoptosis could be of potential benefit for islet transplantation. |
2018-10-15 |
2023-08-13 |
Not clear |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Xiaojie Wang, Guang Liang, Xiaokun Li, Chao Jiang, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-10-05. PMID:29793329. |
fgf21 and vildagliptin effectively attenuated peripheral insulin resistance, brain mitochondrial dysfunction, brain apoptosis and cognitive decline. |
2018-10-05 |
2023-08-13 |
human |
| Weiwei Liang, Qunhui Yang, Gaofeng Wu, Shumei Lin, Jiancheng Yang, Ying Feng, Jianmin H. Effects of Taurine and L-Arginine on the Apoptosis of Vascular Smooth Muscle Cells in Insulin Resistance Hypertensive Rats. Advances in experimental medicine and biology. vol 975 Pt 2. 2018-10-02. PMID:28849501. |
effects of taurine and l-arginine on the apoptosis of vascular smooth muscle cells in insulin resistance hypertensive rats. |
2018-10-02 |
2023-08-13 |
rat |
| Weiwei Liang, Qunhui Yang, Gaofeng Wu, Shumei Lin, Jiancheng Yang, Ying Feng, Jianmin H. Effects of Taurine and L-Arginine on the Apoptosis of Vascular Smooth Muscle Cells in Insulin Resistance Hypertensive Rats. Advances in experimental medicine and biology. vol 975 Pt 2. 2018-10-02. PMID:28849501. |
in order to find the effects and mechanism of taurine and l-arginine on the apoptosis of vsmcs in insulin resistance hypertensive rats. |
2018-10-02 |
2023-08-13 |
rat |
| Kamel M A Hassanin, Mohamed O Mahmoud, Hossam M Hassan, Abdel-Razik H Abdel-Razik, Lourin N Aziz, Mostafa E Rate. Balanites aegyptiaca ameliorates insulin secretion and decreases pancreatic apoptosis in diabetic rats: Role of SAPK/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 102. 2018-10-02. PMID:29710525. |
balanites aegyptiaca ameliorates insulin secretion and decreases pancreatic apoptosis in diabetic rats: role of sapk/jnk pathway. |
2018-10-02 |
2023-08-13 |
rat |
| Ying Xin, Haiyan Zhang, Zhaotong Jia, Xiaoqian Ding, Yong Sun, Qiang Wang, Tao X. Resveratrol improves uric acid-induced pancreatic β-cells injury and dysfunction through regulation of miR-126. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 102. 2018-10-02. PMID:29710530. |
then, cell viability, apoptosis, apoptosis-associated factors, inos expression and insulin secretion were examined by cck-8, flow cytometry, western blot, qrt-pcr and glucose-stimulated insulin secretion (gsis), respectively. |
2018-10-02 |
2023-08-13 |
mouse |
| Ying Xin, Haiyan Zhang, Zhaotong Jia, Xiaoqian Ding, Yong Sun, Qiang Wang, Tao X. Resveratrol improves uric acid-induced pancreatic β-cells injury and dysfunction through regulation of miR-126. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 102. 2018-10-02. PMID:29710530. |
ua treatment suppressed cell viability, promoted apoptosis, enhanced inos expression and decreased insulin secretion in min6 cells. |
2018-10-02 |
2023-08-13 |
mouse |
| Qi Wang, Yafeng Zheng, Weijing Zhuang, Xu Lu, Xianliang Luo, Baodong Zhen. Genome-wide transcriptional changes in type 2 diabetic mice supplemented with lotus seed resistant starch. Food chemistry. vol 264. 2018-10-02. PMID:29853397. |
the analysis results of gene ontology (go) functions and kyoto encyclopedia of genes and genomes (kegg) pathways indicated that the protective effect of lsrs supplementation was most likely driven by modulating expression levels of various key factors involved in insulin secretion, insulin signal transmission, cell apoptosis, antioxidant activity and p53 signaling pathways. |
2018-10-02 |
2023-08-13 |
mouse |
| Ilgin Yildirim Simsir, Utku Erdem Soyaltin, Sevki Cetinkal. Glucagon like peptide-1 (GLP-1) likes Alzheimer's disease. Diabetes & metabolic syndrome. vol 12. issue 3. 2018-09-26. PMID:29598932. |
glp-1 stimulates insulin secretion, inhibits glucagon secretion, decreases food intake, reduces appetite, delays gastric emptying, provides weight reduction, and protects β cells from apoptosis. |
2018-09-26 |
2023-08-13 |
Not clear |
| J Waldron, W Raymond, G Ostli-Eilertsen, J Nossen. Insulin-like growth factor-1 (IGF1) in systemic lupus erythematosus: relation to disease activity, organ damage and immunological findings. Lupus. vol 27. issue 6. 2018-09-25. PMID:29385899. |
background insulin growth factor-1 (igf1) activates cell proliferation pathways and inhibits apoptosis. |
2018-09-25 |
2023-08-13 |
Not clear |
| Ting Li, Bing Bai, Chenguang Tian, Huihui Wang, Deyue Jiang, Fangfei Ma, Mengting Sha. High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29488615. |
high sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model. |
2018-09-13 |
2023-08-13 |
rat |
| Ting Li, Bing Bai, Chenguang Tian, Huihui Wang, Deyue Jiang, Fangfei Ma, Mengting Sha. High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29488615. |
the present study aimed to investigate the association between insulin resistance (ir), nitric oxide (no) production and myocardial apoptosis in a background of coexisting hypertension in a rodent animal model. |
2018-09-13 |
2023-08-13 |
rat |
| Li Jun Xue, Qi Huang, Jiao E Zeng, Hui Zhu, Cheng Yan X. Up-regulation of receptor interaction protein 140 promotes glucolipotoxicity-induced damage in MIN6 cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 4. 2018-09-11. PMID:29631683. |
cells were separately treated with 500 μm palmitic acid and 25 mm glucose when rip140 expression was upregulated or downregulated, and cell viability, apoptosis rate, the level of oxidative stress and insulin secretion was assessed, as was the expression of related genes. |
2018-09-11 |
2023-08-13 |
Not clear |
| Li Jun Xue, Qi Huang, Jiao E Zeng, Hui Zhu, Cheng Yan X. Up-regulation of receptor interaction protein 140 promotes glucolipotoxicity-induced damage in MIN6 cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 4. 2018-09-11. PMID:29631683. |
overexpression of rip140 promoted apoptosis but inhibited cell viability in min6 cells, and basal insulin secretion and glucose-stimulated insulin secretion levels were altered following treatment with glucose and palmitic acid. |
2018-09-11 |
2023-08-13 |
Not clear |
| Xiaoling Zhu, Yuzhen Li, Qinggang Men. Islet-1 promotes the proliferation and invasion, and inhibits the apoptosis of A375 human melanoma cells. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29568936. |
the aim of this study was to examine the effects of the insulin gene enhancer-binding protein, islet-1 (isl1), on the proliferation, invasion and apoptosis of the human melanoma cell line, a375. |
2018-09-10 |
2023-08-13 |
human |
| Shanxin Li, Hui Li, Di Yang, Xiuyan Yu, David M Irwin, Gang Niu, Huanran Ta. Excessive Autophagy Activation and Increased Apoptosis Are Associated with Palmitic Acid-Induced Cardiomyocyte Insulin Resistance. Journal of diabetes research. vol 2017. 2018-08-31. PMID:29318158. |
excessive autophagy activation and increased apoptosis are associated with palmitic acid-induced cardiomyocyte insulin resistance. |
2018-08-31 |
2023-08-13 |
rat |