| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefan Riwaldt, Monica Monici, Asbjørn Graver Petersen, Uffe Birk Jensen, Katja Evert, Desiré Pantalone, Kirsten Utpatel, Matthias Evert, Markus Wehland, Marcus Krüger, Sascha Kopp, Sofie Frandsen, Thomas Corydon, Jayashree Sahana, Johann Bauer, Ronald Lützenberg, Manfred Infanger, Daniela Grim. Preparation of A Spaceflight: Apoptosis Search in Sutured Wound Healing Models. International journal of molecular sciences. vol 18. issue 12. 2018-08-27. PMID:29207508. |
to prepare the esa (european space agency) spaceflight project "wound healing and sutures in unloading conditions", we studied mechanisms of apoptosis in wound healing models based on ex vivo skin tissue cultures, kept for 10 days alive in serum-free dmem/f12 medium supplemented with bovine serum albumin, hydrocortisone, insulin, ascorbic acid and antibiotics at 32 °c. |
2018-08-27 |
2023-08-13 |
cattle |
| Jérémie Gautheron, Mihael Vucur, Anne T Schneider, Ilenia Severi, Christoph Roderburg, Sanchari Roy, Matthias Bartneck, Peter Schrammen, Mauricio Berriel Diaz, Josef Ehling, Felix Gremse, Felix Heymann, Christiane Koppe, Twan Lammers, Fabian Kiessling, Niels Van Best, Oliver Pabst, Gilles Courtois, Andreas Linkermann, Stefan Krautwald, Ulf P Neumann, Frank Tacke, Christian Trautwein, Douglas R Green, Thomas Longerich, Norbert Frey, Mark Luedde, Matthias Bluher, Stephan Herzig, Mathias Heikenwalder, Tom Luedd. The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance. Nature communications. vol 7. 2018-08-22. PMID:27323669. |
genetic inactivation of ripk3 promotes increased caspase-8-dependent adipocyte apoptosis and wat inflammation, associated with impaired insulin signalling in wat as the basis for glucose intolerance. |
2018-08-22 |
2023-08-13 |
mouse |
| Jérémie Gautheron, Mihael Vucur, Anne T Schneider, Ilenia Severi, Christoph Roderburg, Sanchari Roy, Matthias Bartneck, Peter Schrammen, Mauricio Berriel Diaz, Josef Ehling, Felix Gremse, Felix Heymann, Christiane Koppe, Twan Lammers, Fabian Kiessling, Niels Van Best, Oliver Pabst, Gilles Courtois, Andreas Linkermann, Stefan Krautwald, Ulf P Neumann, Frank Tacke, Christian Trautwein, Douglas R Green, Thomas Longerich, Norbert Frey, Mark Luedde, Matthias Bluher, Stephan Herzig, Mathias Heikenwalder, Tom Luedd. The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance. Nature communications. vol 7. 2018-08-22. PMID:27323669. |
together, these findings provide evidence that ripk3 in wat maintains tissue homeostasis and suppresses inflammation and adipocyte apoptosis, suggesting that systemic targeting of necroptosis might be associated with the risk of promoting insulin resistance in obese patients. |
2018-08-22 |
2023-08-13 |
mouse |
| Marie H Solheim, Jonathon N Winnay, Thiago M Batista, Anders Molven, Pål R Njølstad, C Ronald Kah. Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes. Diabetes. vol 67. issue 7. 2018-08-16. PMID:29724723. |
phosphatidylinositol 3-kinase (pi3k) plays a central role in insulin signaling, glucose metabolism, cell growth, cell development, and apoptosis. |
2018-08-16 |
2023-08-13 |
mouse |
| Jitjiroj Ittichaicharoen, Nattayaporn Apaijai, Pongpan Tanajak, Piangkwan Sa-Nguanmoo, Nipon Chattipakorn, Siriporn Chattipakor. Dipeptidyl peptidase-4 inhibitor enhances restoration of salivary glands impaired by obese-insulin resistance. Archives of oral biology. vol 85. 2018-08-15. PMID:29073562. |
chronic high-fat diet consumption causes not only obese- insulin resistance, but also leads to pathological changes in salivary glands, including increased mitochondrial dysfunction, apoptosis, oxidative stress, and inflammation. |
2018-08-15 |
2023-08-13 |
Not clear |
| Fusun Oztay, Serap Sancar-Bas, Selda Gezginci-Oktayoglu, Merve Ercin, Sehnaz Bolken. Exendin-4 partly ameliorates - hyperglycemia-mediated tissue damage in lungs of streptozotocin-induced diabetic mice. Peptides. vol 99. 2018-08-01. PMID:29225158. |
structural alterations, oxidative stress, apoptosis, insulin signaling and expressions of prosurfactant-c, alpha-smooth muscle actin, collagen-i and fibronectin were evaluated in lung tissue. |
2018-08-01 |
2023-08-13 |
mouse |
| Fusun Oztay, Serap Sancar-Bas, Selda Gezginci-Oktayoglu, Merve Ercin, Sehnaz Bolken. Exendin-4 partly ameliorates - hyperglycemia-mediated tissue damage in lungs of streptozotocin-induced diabetic mice. Peptides. vol 99. 2018-08-01. PMID:29225158. |
although exendin-4 treatment improved pulmonary edema, apoptosis, oxidative stress, and lung injury, it led to the disrupted insulin signaling and interstitial collagen accumulation in the lungs of diabetic mice. |
2018-08-01 |
2023-08-13 |
mouse |
| Krzysztof Marycz, Katarzyna Kornicka, Jolanta Szlapka-Kosarzewska, Christine Weis. Excessive Endoplasmic Reticulum Stress Correlates with Impaired Mitochondrial Dynamics, Mitophagy and Apoptosis, in Liver and Adipose Tissue, but Not in Muscles in EMS Horses. International journal of molecular sciences. vol 19. issue 1. 2018-07-26. PMID:29316632. |
therefore, in the present study, we analyzed insulin-sensitive tissues, i.e., muscles, liver and adipose tissue in order to evaluate insulin resistance and apoptosis. |
2018-07-26 |
2023-08-13 |
human |
| Yue Zhang, Xiao-Lin Yu, Jie Zhu, Shu-Ying Liu, Xiang-Meng Liu, Quan-Xiu Dong, Jia-Qian Chai, Rui-Tian Li. Intravenous immunoglobulin improves glucose control and β-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers. International immunopharmacology. vol 54. 2018-07-25. PMID:29145032. |
in present study, we showed that ivig treatment significantly improved glucose control and insulin sensitivity, and prevented β-cell apoptosis by lowering toxic iapp oligomer levels, attenuating islet inflammation and activating autophagy in human iapp transgenic mouse model. |
2018-07-25 |
2023-08-13 |
mouse |
| Jianbo Che, Bing Liang, Yuan Zhang, Yi Wang, Jianyu Tang, Gongning Sh. Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K/Akt/mTOR pathway in human endothelial cells. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 31. 2018-07-24. PMID:28985493. |
furthermore, insulin also abated the effect of kaempferol on cell viability and apoptosis in ox-ldl-induced huvecs. |
2018-07-24 |
2023-08-13 |
human |
| Zhigang Zhang, Siyu Li, Huijie Jiang, Biying Liu, Zhanjun Lv, Changming Guo, Haili Zhan. Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes. Molecular nutrition & food research. vol 61. issue 9. 2018-07-23. PMID:28436198. |
increased serum free fatty acid (ffa) occurs in subjects with non-alcoholic fatty liver disease (nafld) and also triggers oxidative stress, apoptosis, and insulin resistance. |
2018-07-23 |
2023-08-13 |
human |
| Wenyan Tian, Fei Teng, Jing Zhao, Jinping Gao, Chao Gao, Dandan Sun, Guoyan Liu, Yanfang Zhang, Shizhu Yu, Wei Zhang, Yingmei Wang, Fengxia Xu. Estrogen and insulin synergistically promote type 1 endometrial cancer progression. Cancer biology & therapy. vol 18. issue 12. 2018-07-20. PMID:29172956. |
cell growth in vitro and in vivo, effects of insulin and estradiol on apoptosis and cell cycle distribution were measured after estradiol and insulin stimulation. |
2018-07-20 |
2023-08-13 |
human |
| Ovidiu Ciobanu, Raluca Elena Sandu, Adrian Tudor Balseanu, Alexandra Zavaleanu, Andrei Gresita, Eugen Bogdan Petcu, Adriana Uzoni, Aurel Popa-Wagne. Caloric restriction stabilizes body weight and accelerates behavioral recovery in aged rats after focal ischemia. Aging cell. vol 16. issue 6. 2018-07-19. PMID:28961383. |
likewise, calorie-restricted aged rats showed significant poststroke increases in serum glucose, insulin, and igf1 levels, as well as cr-specific changes in the expression of gene transcripts involved in glycogen metabolism, igf signaling, apoptosis, arteriogenesis, and hypoxia. |
2018-07-19 |
2023-08-13 |
rat |
| David A Landry, Chloé Fortin, Anne-Marie Bellefleur, Rémi Labrecque, François-Xavier Grand, Christian Vigneault, Patrick Blondin, Marc-André Sirar. Comparative analysis of granulosa cell gene expression in association with oocyte competence in FSH-stimulated Holstein cows. Reproduction, fertility, and development. vol 29. issue 12. 2018-07-17. PMID:28420480. |
these are involved in cell proliferation, apoptosis, lipid metabolism, retinol availability and insulin signalling. |
2018-07-17 |
2023-08-13 |
cattle |
| Yu Wang, Yang Hu, Zhaoping Zeng, Yinghua Li, Huipeng Su, Yiwei Li, Ruiping Wang, Mingqian Zhang, Yongli Yang, Jie Den. Influence of androgen on myocardial apoptosis and expression of myocardial IR and IRS‑1 in chronic heart failure rat models. Molecular medicine reports. vol 17. issue 1. 2018-07-16. PMID:29115626. |
taken together, these results demonstrated that androgen supplementation could improve insulin resistance and affect the expression of ir and irs‑1 in chf, thereby reducing myocardial apoptosis and improving cardiac function. |
2018-07-16 |
2023-08-13 |
rat |
| Kanwal Rehman, Muhammad Sajid Hamid Akash, Aamira Liaqat, Shagufta Kamal, Muhammad Imran Qadir, Akhtar Rasu. Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus. Critical reviews in eukaryotic gene expression. vol 27. issue 3. 2018-07-12. PMID:29199608. |
interleukin-6 (il-6) is a proinflammatory cytokine that decisively induces the development of insulin resistance and pathogenesis of type 2 diabetes mellitus (t2dm) through the generation of inflammation by controlling differentiation, migration, proliferation, and cell apoptosis. |
2018-07-12 |
2023-08-13 |
Not clear |
| L X Guo, J H Liu, X X Zheng, Z Y Yin, J Kosaraju, K Y Ta. Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 110. 2018-07-10. PMID:28363490. |
geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells. |
2018-07-10 |
2023-08-13 |
rat |
| Gulay Nephan, Zeynep Mine Coskun, Sema Bolken. Dipeptidyl peptidase-4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance. Cell biochemistry and function. vol 36. issue 4. 2018-07-10. PMID:29748970. |
the study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (ir). |
2018-07-10 |
2023-08-13 |
rat |
| Zhu Zeng, Rui Yu, Fanglei Zuo, Bo Zhang, Huiqin Ma, Shangwu Che. Recombinant Lactococcus lactis expressing bioactive exendin-4 to promote insulin secretion and beta-cell proliferation in vitro. Applied microbiology and biotechnology. vol 101. issue 19. 2018-07-09. PMID:28828521. |
our data suggest that the rexd4 secreted by l. lactis is a bioactive insulinotropic peptide and functional glp-1 receptor agonist that enhances glucose-dependent insulin secretion and activates the pi3-k/akt signal pathway; furthermore, it may be involved in improving proliferation and inhibiting apoptosis of ins-1 cells in in vitro treatments. |
2018-07-09 |
2023-08-13 |
Not clear |
| Laurits J Holm, Martin Haupt-Jorgensen, Jesper Larsen, Jano D Giacobini, Mesut Bilgin, Karsten Buschar. L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. PloS one. vol 13. issue 3. 2018-07-09. PMID:29543915. |
sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. |
2018-07-09 |
2023-08-13 |
mouse |