| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yazeed Jamalat, Yaser Gamallat, Pires Sanches Jaceline Gislaine, Abdo Meyiah, Abdullah Shopit, Hailong Li, Bashir Ahmed, Peng Chu, Hongyang Wang, Xiaodong Li, Jinyong Peng, Xiaodong Ma, Zeyao Tan. Phosphocreatine attenuates endoplasmic reticulum stress-mediated hepatocellular apoptosis ameliorates insulin resistance in diabetes model. Biochemical and biophysical research communications. vol 506. issue 3. 2019-05-17. PMID:30366667. |
phosphocreatine attenuates endoplasmic reticulum stress-mediated hepatocellular apoptosis ameliorates insulin resistance in diabetes model. |
2019-05-17 |
2023-08-13 |
rat |
| Yazeed Jamalat, Yaser Gamallat, Pires Sanches Jaceline Gislaine, Abdo Meyiah, Abdullah Shopit, Hailong Li, Bashir Ahmed, Peng Chu, Hongyang Wang, Xiaodong Li, Jinyong Peng, Xiaodong Ma, Zeyao Tan. Phosphocreatine attenuates endoplasmic reticulum stress-mediated hepatocellular apoptosis ameliorates insulin resistance in diabetes model. Biochemical and biophysical research communications. vol 506. issue 3. 2019-05-17. PMID:30366667. |
liver tissues proteins further evaluated for apoptosis, endoplasmic reticulum stress (er), and insulin resistance biomarkers using western blotting. |
2019-05-17 |
2023-08-13 |
rat |
| Junfeng Li, Zhihong Wang, Liwei Ren, Linling Fan, Wenjuan Liu, Yaojing Jiang, Harry K Lau, Rui Liu, Qinghua Wan. Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival. Cell communication and signaling : CCS. vol 16. issue 1. 2019-05-15. PMID:30409165. |
insulin signaling pathway in β-cell is essential to promote β-cells proliferation and survival, while nodal-alk7-smad3 signaling involves β-cells apoptosis. |
2019-05-15 |
2023-08-13 |
Not clear |
| Junfeng Li, Zhihong Wang, Liwei Ren, Linling Fan, Wenjuan Liu, Yaojing Jiang, Harry K Lau, Rui Liu, Qinghua Wan. Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival. Cell communication and signaling : CCS. vol 16. issue 1. 2019-05-15. PMID:30409165. |
we attempted to address inter-relationship between nodal and insulin in modulating β-cell proliferation and apoptosis. |
2019-05-15 |
2023-08-13 |
Not clear |
| Jian Wang, Hong-Man Xue, Yan-Ru Chen, Hong-Gui Xu, Shao-Fen Lin, Xi-Kang Tang, Chun Che. Evaluation of Insulin-mediated Regulation of AKT Signaling in Childhood Acute Lymphoblastic Leukemia. Journal of pediatric hematology/oncology. vol 41. issue 2. 2019-05-14. PMID:30688831. |
in response to increased glucose levels, insulin is secreted, and several studies have shown that insulin-induced akt signaling can regulate tumor cell proliferation and apoptosis. |
2019-05-14 |
2023-08-13 |
Not clear |
| Yanan Zhu, Yihui Li, Chengting Dai, Lu Sun, Lianghui You, Wei De, Qingxin Yuan, Ning Wang, Yuanyuan Che. Inhibition of Lincpint expression affects insulin secretion and apoptosis in mouse pancreatic β cells. The international journal of biochemistry & cell biology. vol 104. 2019-05-13. PMID:30201298. |
inhibition of lincpint expression affects insulin secretion and apoptosis in mouse pancreatic β cells. |
2019-05-13 |
2023-08-13 |
mouse |
| Masaji Sakaguchi, Weikang Cai, Chih-Hao Wang, Carly T Cederquist, Marcos Damasio, Erica P Homan, Thiago Batista, Alfred K Ramirez, Manoj K Gupta, Martin Steger, Nicolai J Wewer Albrechtsen, Shailendra Kumar Singh, Eiichi Araki, Matthias Mann, Sven Enerbäck, C Ronald Kah. FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Nature communications. vol 10. issue 1. 2019-05-09. PMID:30952843. |
thus, foxk1/k2 are reciprocally regulated to foxo1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function. |
2019-05-09 |
2023-08-13 |
Not clear |
| Yan Wang, Jingjing Xue, Yan Li, Xin Zhou, Shun Qiao, Dewu Ha. Telmisartan protects against high glucose/high lipid-induced apoptosis and insulin secretion by reducing the oxidative and ER stress. Cell biochemistry and function. vol 37. issue 3. 2019-05-08. PMID:30907023. |
telmisartan protects against high glucose/high lipid-induced apoptosis and insulin secretion by reducing the oxidative and er stress. |
2019-05-08 |
2023-08-13 |
rat |
| Yan Wang, Jingjing Xue, Yan Li, Xin Zhou, Shun Qiao, Dewu Ha. Telmisartan protects against high glucose/high lipid-induced apoptosis and insulin secretion by reducing the oxidative and ER stress. Cell biochemistry and function. vol 37. issue 3. 2019-05-08. PMID:30907023. |
high glucose/high lipid (hg/hl)-induced apoptosis of pancreatic β-cells impairs its function of insulin secretion and is generally believed to be the key factor in the development of diabetes. |
2019-05-08 |
2023-08-13 |
rat |
| Yan Wang, Jingjing Xue, Yan Li, Xin Zhou, Shun Qiao, Dewu Ha. Telmisartan protects against high glucose/high lipid-induced apoptosis and insulin secretion by reducing the oxidative and ER stress. Cell biochemistry and function. vol 37. issue 3. 2019-05-08. PMID:30907023. |
in this study, we investigated whether telmisartan exerted a protective effect against hg/hl-induced apoptosis and insulin secretion in vitro as well as in vivo; 10-μm telmisartan treatment significantly reduced hg (25 mm) or/and hl (0.4 mm palmitic acid) induced-cell apoptosis and greatly improved insulin secretion in ins-1 pancreatic β-cells, which is consistent in an obesity rat model induced by hg/hl diets. |
2019-05-08 |
2023-08-13 |
rat |
| Yan Wang, Jingjing Xue, Yan Li, Xin Zhou, Shun Qiao, Dewu Ha. Telmisartan protects against high glucose/high lipid-induced apoptosis and insulin secretion by reducing the oxidative and ER stress. Cell biochemistry and function. vol 37. issue 3. 2019-05-08. PMID:30907023. |
in the present study, we demonstrated that telmisartan, a common drug used for hypertension treatment, has a protective effect against high glucose/high lipid-induced cell apoptosis and greatly improves the insulin secretion function by inhibiting the oxidative stress and er stress. |
2019-05-08 |
2023-08-13 |
rat |
| Jing Pan, Yu-Qin Di, Yong-Bo Li, Cai-Hua Chen, Jin-Xing Wang, Xiao-Fan Zha. Insulin and 20-hydroxyecdysone oppose each other in the regulation of phosphoinositide-dependent kinase-1 expression during insect pupation. The Journal of biological chemistry. vol 293. issue 48. 2019-04-29. PMID:30305395. |
insulin promotes larval growth of insects by stimulating the synthesis of the steroid hormone 20-hydroxyecdysone (20e), which induces pupation and apoptosis. |
2019-04-29 |
2023-08-13 |
Not clear |
| Zhi-Xing Li, Hai-Hua Zhang, Dan-Chun Lan, Xiao-Zhuan Chen, Jian Su. [Progress of researches on mechanisms of acupuncture therapy for insulin resistance]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 3. 2019-04-25. PMID:30945509. |
in the present paper, we summarized development of researches on the mechanism of acupuncture therapy underlying improvement of ir in recent 10 years from 1) regulating expression of hypothalamic phosphatidylinositol-3-kinase (pi3k)-p85 and pi3k-p110 proteins in obesity rats; 2) regulating the levels of some related proteins of insulin target tissues (liver and skeletal muscle), such as insulin receptor substrate-1 (irs)-1 and -2, glucose transporter mrnas and proteins, sterol regulatory element-binding protein 1 (srebp-1) and fatty acid synthetase proteins; 3) suppressing inflammatory reaction of liver tissue and down-regulating serum adiponectin in t2dm rats; 4) raising the activity of superoxide dismutase (sod) and reducing the levels of reactive oxygen species, and malondialdehyde (mda) contents of quadriceps femoris in spontaneous ir rats; and 5) attenuating structural injury of pancreas islet and apoptosis of pancreatic β cells in diabetes rats. |
2019-04-25 |
2023-08-13 |
rat |
| Marco Bugliani, Farooq Syed, Flavia M M Paula, Bilal A Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L Eizirik, Piero Marchett. DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes. Molecular and cellular endocrinology. vol 473. 2019-04-22. PMID:29409957. |
finally, dpp-4 inhibition augmented glucose-stimulated insulin secretion, reduced apoptosis and improved ultrastructure in t2d beta cells. |
2019-04-22 |
2023-08-13 |
human |
| John Bassler, Alan Ducatman, Meenal Elliott, Sijin Wen, Banrida Wahlang, John Barnett, Matthew C Cav. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environmental pollution (Barking, Essex : 1987). vol 247. 2019-04-22. PMID:30823334. |
measured serum biomarkers included: perfluorohexane sulfonate (pfhxs); perfluorooctanoic acid (pfoa); perfluorooctane sulfonate (pfos); perfluorononanoic acid (pfna); cytokeratin 18 m30 (ck18 m30, hepatocyte apoptosis); adipocytokines; insulin; and cleaved complement 3 (c3a). |
2019-04-22 |
2023-08-13 |
human |
| Rong-Xing Liu, Yan Ma, Xue-Lian Hu, Yun-Peng Liao, Xiang-Nan Hu, Bai-Cheng He, Wen-Juan Su. Pioglitazone/metformin adduct regulates insulin secretion and inhibits high glucose-induced apoptosis via p21-p53-MDM2 signaling in INS-1 cells. Journal of cellular biochemistry. vol 119. issue 7. 2019-04-17. PMID:29369427. |
pioglitazone/metformin adduct regulates insulin secretion and inhibits high glucose-induced apoptosis via p21-p53-mdm2 signaling in ins-1 cells. |
2019-04-17 |
2023-08-13 |
Not clear |
| Rong-Xing Liu, Yan Ma, Xue-Lian Hu, Yun-Peng Liao, Xiang-Nan Hu, Bai-Cheng He, Wen-Juan Su. Pioglitazone/metformin adduct regulates insulin secretion and inhibits high glucose-induced apoptosis via p21-p53-MDM2 signaling in INS-1 cells. Journal of cellular biochemistry. vol 119. issue 7. 2019-04-17. PMID:29369427. |
the aim of this study was to investigate the effects of pioglitazone/metformin adduct on high glucose-induced insulin secretion and apoptosis in ins-1 cells. |
2019-04-17 |
2023-08-13 |
Not clear |
| Rong-Xing Liu, Yan Ma, Xue-Lian Hu, Yun-Peng Liao, Xiang-Nan Hu, Bai-Cheng He, Wen-Juan Su. Pioglitazone/metformin adduct regulates insulin secretion and inhibits high glucose-induced apoptosis via p21-p53-MDM2 signaling in INS-1 cells. Journal of cellular biochemistry. vol 119. issue 7. 2019-04-17. PMID:29369427. |
treatment of ins-1 cells with 1 μm pioglitazone/metformin adduct in the presence of 33.33 mm glucose greatly improveded the levels of insulin and apoptosis rates compared to those of the control group. |
2019-04-17 |
2023-08-13 |
Not clear |
| Rong-Xing Liu, Yan Ma, Xue-Lian Hu, Yun-Peng Liao, Xiang-Nan Hu, Bai-Cheng He, Wen-Juan Su. Pioglitazone/metformin adduct regulates insulin secretion and inhibits high glucose-induced apoptosis via p21-p53-MDM2 signaling in INS-1 cells. Journal of cellular biochemistry. vol 119. issue 7. 2019-04-17. PMID:29369427. |
our results indicate that pioglitazone/metformin adduct is superior to pioglitazone and/or metformin in regulating high glucose-induced insulin secretion and apoptosis in ins-1 cells. |
2019-04-17 |
2023-08-13 |
Not clear |
| Mike M Nguyen, Jessica A Martinez, Chiu-Hsieh Hsu, Mitchell Sokoloff, Robert S Krouse, Blake A Gibson, Raymond B Nagle, Howard L Parnes, Catherine Cordova, H-H Sherry Cho. Bioactivity and prostate tissue distribution of metformin in a preprostatectomy prostate cancer cohort. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 27. issue 6. 2019-04-16. PMID:28692586. |
prostatectomy and serum samples were analyzed for metformin concentrations, serum biomarkers of drug activity (prostate-specific antigen, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein 3, sex hormone-binding globulin, and testosterone) and tissue biomarkers of proliferation, apoptosis, cell cycle regulation, and mtor inhibition. |
2019-04-16 |
2023-08-13 |
human |