| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Tan, A Tong, Y X. Pancreatic β-cell function is inhibited by miR-3666 in type 2 diabetes mellitus by targeting adiponectin. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 6. 2019-07-10. PMID:31141089. |
overexpression of adipoq promoted insulin secretion after glucose stimulation, promoted cell proliferation, inhibited cell apoptosis, and partially abolished the effects of mir-3666 overexpression on insulin secretion, cell proliferation, and cell apoptosis of ins-1 cells. |
2019-07-10 |
2023-08-13 |
human |
| J Tan, A Tong, Y X. Pancreatic β-cell function is inhibited by miR-3666 in type 2 diabetes mellitus by targeting adiponectin. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 6. 2019-07-10. PMID:31141089. |
in conclusion, our results revealed that mir-3666 inhibited pancreatic cell proliferation, reduced insulin sensitivity, and promoted apoptosis by targeting adipoq. |
2019-07-10 |
2023-08-13 |
human |
| Ayman M Mahmoud, Rene J Hernández Bautista, Mansur A Sandhu, Omnia E Hussei. Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health. Oxidative medicine and cellular longevity. vol 2019. 2019-07-09. PMID:30962863. |
citrus flavonoids scavenge free radicals, improve glucose tolerance and insulin sensitivity, modulate lipid metabolism and adipocyte differentiation, suppress inflammation and apoptosis, and improve endothelial dysfunction. |
2019-07-09 |
2023-08-13 |
Not clear |
| Tsehay Abebe, Jana Mahadevan, Lindsey Bogachus, Stephanie Hahn, Michele Black, Elizabeth Oseid, Fumihiko Urano, Vincenzo Cirulli, R Paul Robertso. Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet-induced oxidative stress. JCI insight. vol 2. issue 24. 2019-07-08. PMID:29263299. |
these theories include inflammation, apoptosis, replication, neogenesis, autophagy, differentiation, dedifferentiation, and decreased levels of insulin gene regulatory proteins. |
2019-07-08 |
2023-08-13 |
rat |
| Hong-Yan Wang, Qiang-Ming Li, Nian-Jun Yu, Wei-Dong Chen, Xue-Qiang Zha, De-Ling Wu, Li-Hua Pan, Jun Duan, Jian-Ping Lu. Dendrobium huoshanense polysaccharide regulates hepatic glucose homeostasis and pancreatic β-cell function in type 2 diabetic mice. Carbohydrate polymers. vol 211. 2019-07-08. PMID:30824102. |
the histological analysis, the periodic acid-schiff staining and the immunofluorescence staining of insulin, glucagon and apoptosis showed that the hypoglycemic effect of gxg was related to the improvement of pancreatic β-cell quantity and function and the regulation of hepatic glucose metabolism. |
2019-07-08 |
2023-08-13 |
mouse |
| Bárbara Maiztegui, Carolina Lisi Román, Juan José Gagliardino, Luis Emilio Flore. Impaired endocrine-metabolic homeostasis: underlying mechanism of its induction by unbalanced diet. Clinical science (London, England : 1979). vol 132. issue 8. 2019-07-01. PMID:29626110. |
insulin secretion, β-cell apoptosis, intracellular insulin and leptin mediators, and oxidative stress (os) markers were also measured in islets isolated from each experimental group. |
2019-07-01 |
2023-08-13 |
human |
| Laongdao Thongnak, Anchalee Pongchaidecha, Krit Jaikumkao, Varanuj Chatsudthipong, Nipon Chattipakorn, Anusorn Lungkaphi. The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats. Scientific reports. vol 7. issue 1. 2019-06-28. PMID:29051569. |
therefore, atorvastatin plus insulin seems to exert the additive effect in improving renal functionby alleviating hyperglycemiaand the modulation of oxidative stress, inflammation and apoptosis. |
2019-06-28 |
2023-08-13 |
rat |
| Kota Wakiyama, Yoshihiko Kitajima, Tomokazu Tanaka, Masao Kaneki, Kazuyoshi Yanagihara, Shinichi Aishima, Jun Nakamura, Hirokazu Noshir. Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis. Scientific reports. vol 7. issue 1. 2019-06-26. PMID:28978999. |
low-dose yc-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis. |
2019-06-26 |
2023-08-13 |
Not clear |
| Chi Teng Vong, Hisa Hui Ling Tseng, Yiu Wa Kwan, Simon Ming-Yuen Lee, Maggie Pui Man Ho. Novel protective effect of O-1602 and abnormal cannabidiol, GPR55 agonists, on ER stress-induced apoptosis in pancreatic β-cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-21. PMID:30841431. |
insulin resistance and β-cell dysfunction are the main defects in type 2 diabetes mellitus (t2dm), and β-cell dysfunction and apoptosis is the critical determinant in the progression of t2dm. |
2019-06-21 |
2023-08-13 |
mouse |
| Roberto de Sire, Gianenrico Rizzatti, Fabio Ingravalle, Marco Pizzoferrato, Valentina Petito, Loris Lopetuso, Cristina Graziani, Alessandro de Sire, Maria Chiara Mentella, Maria Cristina Mele, Antonio Gasbarrini, Franco Scaldaferr. Skeletal muscle-gut axis: emerging mechanisms of sarcopenia for intestinal and extra intestinal diseases. Minerva gastroenterologica e dietologica. vol 64. issue 4. 2019-06-17. PMID:30016852. |
sarcopenia and cachexia represent two conditions of reduction of muscle mass, sharing several elements involved in their pathogenesis, such as systemic inflammation, impaired muscle protein synthesis, increased muscle apoptosis, mitochondrial dysfunction in skeletal muscle tissue and insulin resistance. |
2019-06-17 |
2023-08-13 |
Not clear |
| Hajar Oghbaei, Mohammad Reza Alipour, Gholamreza Hamidian, Mahdi Ahmadi, Vajihe Ghorbanzadeh, Rana Keyhanmanes. Two months sodium nitrate supplementation alleviates testicular injury in streptozotocin-induced diabetic male rats. Experimental physiology. vol 103. issue 12. 2019-06-07. PMID:30088840. |
these favourable effects may be associated with increased serum insulin and decreased serum glucose, and with modulation of apoptosis in testis. |
2019-06-07 |
2023-08-13 |
rat |
| Yusuf Hussain, Sunil K Jain, Puneet K Samaiy. Short-term westernized (HFFD) diet fed in adolescent rats: Effect on glucose homeostasis, hippocampal insulin signaling, apoptosis and related cognitive and recognition memory function. Behavioural brain research. vol 361. 2019-06-04. PMID:30584898. |
short-term westernized (hffd) diet fed in adolescent rats: effect on glucose homeostasis, hippocampal insulin signaling, apoptosis and related cognitive and recognition memory function. |
2019-06-04 |
2023-08-13 |
rat |
| K C Duru, E G Kovaleva, I G Danilova, P van der Bijl, A V Belousov. The potential beneficial role of isoflavones in type 2 diabetes mellitus. Nutrition research (New York, N.Y.). vol 59. 2019-05-28. PMID:30442228. |
different mechanisms have been highlighted in the progression of this disease such as dysfunction of pancreatic β-cells, insulin resistance, elevated levels of free fatty acids which result in overproduction of reactive oxygen species, as well as pancreatic β-cell failure and apoptosis. |
2019-05-28 |
2023-08-13 |
human |
| Heather B Clair, Christina M Pinkston, Shesh N Rai, Marian Pavuk, Nina D Dutton, Guy N Brock, Russell A Prough, Keith Cameron Falkner, Craig J McClain, Matthew C Cav. Liver Disease in a Residential Cohort With Elevated Polychlorinated Biphenyl Exposures. Toxicological sciences : an official journal of the Society of Toxicology. vol 164. issue 1. 2019-05-24. PMID:29684222. |
Σpcbs was inversely associated with insulin resistance/production, leptin, and hepatocyte apoptosis, while other adipocytokines were increased. |
2019-05-24 |
2023-08-13 |
human |
| Wang Deng, Chang-Yi Li, Jin Tong, Jing He, Yan Zhao, Dao-Xin Wan. Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide‑induced lung injury. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30628684. |
insulin protected the pulmonary epithelial barrier, reduced the apoptosis of alveolar epithelial cells, attenuated pulmonary edema, improved alveolar fluid clearance, and increased the expression levels of α‑, β‑ and γ‑enac in mice. |
2019-05-24 |
2023-08-13 |
mouse |
| Nadav Shinhar, Dana Marcoviciu, Dror Dicke. Reduction in Serum Triglyceride Levels in Diabetic Patients May Result in Decreased Insulin Dependence and Disease Regression. The Israel Medical Association journal : IMAJ. vol 20. issue 6. 2019-05-22. PMID:29911757. |
the toxic effect of high lipid levels on β-cell function consists of impaired insulin gene expression, apoptosis, and reduced glucose-stimulated insulin secretion. |
2019-05-22 |
2023-08-13 |
Not clear |
| Ying Zhao, Hanchen Sun, Xiaosai Li, Yumei Zha, Weikai Ho. Hydroxysafflor yellow A attenuates high glucose-induced pancreatic β-cells oxidative damage via inhibiting JNK/c-jun signaling pathway. Biochemical and biophysical research communications. vol 505. issue 2. 2019-05-21. PMID:30249395. |
after 72 h of cultivation, the related indexes of oxidative stress (reactive oxygen species, catalase, glutathione peroxidase, lipid peroxidation, and superoxide dismutase), apoptosis (caspase3, parp) and the function of glucose stimulated insulin secretion were determined. |
2019-05-21 |
2023-08-13 |
rat |
| Sandra A Rebuffat, Emmanuelle Sidot, Caroline Guzman, Jacqueline Azay-Milhau, Bernard Jover, Anne-Dominique Lajoix, Sylvie Peraldi-Rou. Adipose tissue derived-factors impaired pancreatic β-cell function in diabetes. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 10. 2019-05-20. PMID:30048752. |
p-wat conditioned-medium from pre-diabetes rats stimulates insulin secretion, cellular proliferation and apoptosis of ins-1 cells. |
2019-05-20 |
2023-08-13 |
rat |
| Sandra A Rebuffat, Emmanuelle Sidot, Caroline Guzman, Jacqueline Azay-Milhau, Bernard Jover, Anne-Dominique Lajoix, Sylvie Peraldi-Rou. Adipose tissue derived-factors impaired pancreatic β-cell function in diabetes. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 10. 2019-05-20. PMID:30048752. |
however, inhibition of conditioned-medium chemokines acting via cxcr2 receptor do not change cellular proliferation apoptosis and insulin secretion of ins-1 cells induced by p-wat conditioned-medium. |
2019-05-20 |
2023-08-13 |
rat |
| Zonghong Li, Hongyang Liu, Zhangjing Niu, Wen Zhong, Miaomiao Xue, Jifeng Wang, Fuquan Yang, Yue Zhou, Yifa Zhou, Tao Xu, Junjie Ho. Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity. Molecular & cellular proteomics : MCP. vol 17. issue 11. 2019-05-17. PMID:30082485. |
chronic hyperlipidemia causes the dysfunction of pancreatic β-cells, such as apoptosis and impaired insulin secretion, which are aggravated in the presence of hyperglycemia. |
2019-05-17 |
2023-08-13 |
Not clear |