| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriela C Sena, Leandro C Freitas-Lima, Eduardo Merlo, Priscila L Podratz, Julia F P de Araújo, Poliane A A Brandão, Maria T W D Carneiro, Marina C Zicker, Adaliene V M Ferreira, Christina M Takiya, Carolina M de Lemos Barbosa, Marcelo M Morales, Ana Paula Santos-Silva, Leandro Miranda-Alves, Ian V Silva, Jones B Gracel. Environmental obesogen tributyltin chloride leads to abnormal hypothalamic-pituitary-gonadal axis function by disruption in kisspeptin/leptin signaling in female rats. Toxicology and applied pharmacology. vol 319. 2017-05-31. PMID:28161095. |
we analyzed their effects on the tin serum and ovary accumulation (as biomarker of tbt exposure), estrous cyclicity, surge lh levels, gnrh expression, kiss action, fertility, testosterone levels, ovarian apoptosis, uterine inflammation, fibrosis, estrogen negative feedback, body weight gain, insulin, leptin, adiponectin levels, as well as the glucose tolerance (gtt) and insulin sensitivity tests (ist). |
2017-05-31 |
2023-08-13 |
rat |
| Yu Qiao, Yanli Zhao, Yan Liu, Ning Ma, Chuxuan Wang, Jiaqi Zou, Zhiyan Liu, Zhongqiu Zhou, Dong Han, Jun He, Qian Sun, Yicong Liu, Changqing Xu, Zhimin Du, Hui Huan. miR-483-3p regulates hyperglycaemia-induced cardiomyocyte apoptosis in transgenic mice. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-29. PMID:27346130. |
overexpressing mir-483-3p in transgenic mice with diabetes mellitus (dm) exacerbated cardiomyocyte apoptosis by transcriptionally repressing insulin growth factor 1 (igf1). |
2017-05-29 |
2023-08-13 |
mouse |
| Chen Zhang, Juan Wu, Junlin He, Xueqing Liu, Xuemei Chen, Chao Tong, Yubin Ding, Yanqing Geng, Wenqi Chen, Yingxiong Wang, Rufei Ga. The regulation of high insulin levels on ovary apoptosis in early pregnant mice. Biochemical and biophysical research communications. vol 483. issue 1. 2017-05-29. PMID:27940357. |
the regulation of high insulin levels on ovary apoptosis in early pregnant mice. |
2017-05-29 |
2023-08-13 |
mouse |
| Chen Zhang, Juan Wu, Junlin He, Xueqing Liu, Xuemei Chen, Chao Tong, Yubin Ding, Yanqing Geng, Wenqi Chen, Yingxiong Wang, Rufei Ga. The regulation of high insulin levels on ovary apoptosis in early pregnant mice. Biochemical and biophysical research communications. vol 483. issue 1. 2017-05-29. PMID:27940357. |
western blotting showed the expressions of apoptosis related proteins in the ovaries from the insulin group were obviously altered. |
2017-05-29 |
2023-08-13 |
mouse |
| Chen Zhang, Juan Wu, Junlin He, Xueqing Liu, Xuemei Chen, Chao Tong, Yubin Ding, Yanqing Geng, Wenqi Chen, Yingxiong Wang, Rufei Ga. The regulation of high insulin levels on ovary apoptosis in early pregnant mice. Biochemical and biophysical research communications. vol 483. issue 1. 2017-05-29. PMID:27940357. |
all of these results showed that insulin impaired ovarian function during early pregnancy and ovarian apoptosis is imbalanced under the role of insulin. |
2017-05-29 |
2023-08-13 |
mouse |
| Lingling Ding, Fei Gao, Meng Zhang, Wenjiang Yan, Rong Tang, Cheng Zhang, Zi-Jiang Che. Higher PDCD4 expression is associated with obesity, insulin resistance, lipid metabolism disorders, and granulosa cell apoptosis in polycystic ovary syndrome. Fertility and sterility. vol 105. issue 5. 2017-05-23. PMID:26868993. |
higher pdcd4 expression is associated with obesity, insulin resistance, lipid metabolism disorders, and granulosa cell apoptosis in polycystic ovary syndrome. |
2017-05-23 |
2023-08-13 |
Not clear |
| Sang-Ok Lee, Mi-Kyung Lee, Bonsu Ku, Kwang-Hee Bae, Sang Chul Lee, Heon M Lim, Seung Jun Kim, Seung-Wook Ch. High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas. Biochemical and biophysical research communications. vol 478. issue 3. 2017-05-22. PMID:27544031. |
protein tyrosine phosphatase-basophil (ptp-bas) is a membrane-associated protein tyrosine phosphatase with five pdz domains and is involved in apoptosis, tumorigenesis, and insulin signaling. |
2017-05-22 |
2023-08-13 |
human |
| Xiwen Xiong, Xupeng Sun, Qingzhi Wang, Xinlai Qian, Yang Zhang, Xiaoyan Pan, X Charlie Don. SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis. The Journal of endocrinology. vol 231. issue 2. 2017-05-22. PMID:27601447. |
knockdown of sirt6 caused an increase in cell apoptosis and impairment in insulin secretion in response to glucose in min6 cells even in the absence of pa exposure. |
2017-05-22 |
2023-08-13 |
mouse |
| Chun Wu, Gang Xu, Shang-Yi A Tsai, William J Freed, Chun-Ting Le. Transcriptional profiles of type 2 diabetes in human skeletal muscle reveal insulin resistance, metabolic defects, apoptosis, and molecular signatures of immune activation in response to infections. Biochemical and biophysical research communications. vol 482. issue 2. 2017-05-22. PMID:27847319. |
transcriptional profiles of type 2 diabetes in human skeletal muscle reveal insulin resistance, metabolic defects, apoptosis, and molecular signatures of immune activation in response to infections. |
2017-05-22 |
2023-08-13 |
human |
| D N Do, N Bissonnette, P Lacasse, F Miglior, M Sargolzaei, X Zhao, E M Ibeagha-Awem. Genome-wide association analysis and pathways enrichment for lactation persistency in Canadian Holstein cattle. Journal of dairy science. vol 100. issue 3. 2017-05-22. PMID:28088409. |
enrichment analyses of a list of 536 genes in 0.5-mb flanking regions of significant and suggestive snp indicates that synthesis of milk components, regulation of cell apoptosis processes and insulin, and prolactin signaling pathways are important for lp. |
2017-05-22 |
2023-08-13 |
cattle |
| Jia You, Zai Wang, Shiqing Xu, Wenjian Zhang, Qing Fang, Honglin Liu, Liang Peng, Tingting Deng, Jinning Lo. Advanced Glycation End Products Impair Glucose-Stimulated Insulin Secretion of a Pancreatic β-Cell Line INS-1-3 by Disturbance of Microtubule Cytoskeleton via p38/MAPK Activation. Journal of diabetes research. vol 2016. 2017-05-18. PMID:27635403. |
overexposure to ages of pancreatic β-cells leads to decreased insulin secretion and cell apoptosis. |
2017-05-18 |
2023-08-13 |
Not clear |
| Mark P Thomas, Christophe Erneux, Barry V L Potte. SHIP2: Structure, Function and Inhibition. Chembiochem : a European journal of chemical biology. vol 18. issue 3. 2017-05-16. PMID:27907247. |
ship2 has a confirmed role in opsismodysplasia, a disease of bone development, but also interacts with proteins involved in insulin signalling, cytoskeletal function (thus having an impact on endocytosis, adhesion, proliferation and apoptosis) and immune system function. |
2017-05-16 |
2023-08-13 |
Not clear |
| Rabia Johnson, Phiwayinkosi V Dludla, Christo J F Muller, Barbara Huisamen, M Faadiel Essop, Johan Lou. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-05-09. PMID:28146135. |
aspalathin was able to modulate key regulators associated with lipid metabolism (adipoq, apob, cd36, cpt1, pparγ, srebf1/2, scd1 and vldlr), insulin resistance (igf1, akt1, pde3 and map2k1), inflammation (il3, il6, jak2, lepr, socs3, and tnf13) and apoptosis (bcl2 and chuk). |
2017-05-09 |
2023-08-13 |
Not clear |
| Rajagopalan Prasanna, Elbessoumy A Ashraf, Mahmoud A Essa. Chamomile and oregano extracts synergistically exhibit antihyperglycemic, antihyperlipidemic, and renal protective effects in alloxan-induced diabetic rats. Canadian journal of physiology and pharmacology. vol 95. issue 1. 2017-05-02. PMID:27875075. |
insulin, amylase activity, and diabetic renal apoptosis were further evaluated. |
2017-05-02 |
2023-08-13 |
rat |
| LiangHui You, Ning Wang, DanDan Yin, LinTao Wang, FeiYan Jin, YaNan Zhu, QingXin Yuan, Wei D. Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells. Journal of cellular physiology. vol 231. issue 4. 2017-05-01. PMID:26313443. |
after suppression of meg3 expression in vitro, insulin synthesis and secretion were impaired and the rate of beta cells apoptosis was increased. |
2017-05-01 |
2023-08-13 |
mouse |
| LiangHui You, Ning Wang, DanDan Yin, LinTao Wang, FeiYan Jin, YaNan Zhu, QingXin Yuan, Wei D. Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells. Journal of cellular physiology. vol 231. issue 4. 2017-05-01. PMID:26313443. |
these results indicate that meg3 may function as a new regulator of maintaining beta cells identity via affecting insulin production and cell apoptosis. |
2017-05-01 |
2023-08-13 |
mouse |
| Su Jin Lee, Hyung Kyung Kang, Won Sik Eum, Jinseu Park, Soo Young Choi, Hyeok Yil Kwo. Tat-biliverdin reductase A protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity by alleviating oxidative stress and ER stress. Cell biology international. vol 41. issue 5. 2017-05-01. PMID:28198575. |
in this study, tat-mediated transduction of biliverdin reductase a (blvra) was investigated in ins-1 cells to examine whether exogenous supplementation of blvra prevented hiapp-induced apoptosis and dysfunction in insulin secretion in β-cells. |
2017-05-01 |
2023-08-13 |
human |
| Xin-Lei Feng, Yuan-Chao Sun, Min Zhang, Shun-Feng Cheng, Yan-Ni Feng, Jing-Cai Liu, Hong-Hui Wang, Lan Li, Guo-Qing Qin, Wei She. Insulin regulates primordial-follicle assembly in vitro by affecting germ-cell apoptosis and elevating oestrogen. Reproduction, fertility, and development. vol 27. issue 8. 2017-04-28. PMID:24931389. |
insulin regulates primordial-follicle assembly in vitro by affecting germ-cell apoptosis and elevating oestrogen. |
2017-04-28 |
2023-08-13 |
mouse |
| Xin-Lei Feng, Yuan-Chao Sun, Min Zhang, Shun-Feng Cheng, Yan-Ni Feng, Jing-Cai Liu, Hong-Hui Wang, Lan Li, Guo-Qing Qin, Wei She. Insulin regulates primordial-follicle assembly in vitro by affecting germ-cell apoptosis and elevating oestrogen. Reproduction, fertility, and development. vol 27. issue 8. 2017-04-28. PMID:24931389. |
in conclusion, insulin promoted folliculogenesis by facilitating germ-cell apoptosis within the cysts and upregulating oestrogen levels. |
2017-04-28 |
2023-08-13 |
mouse |
| Xiao Wang, Qin Min Ge, Fan Bian, Yan Dong, Chun Mei Huan. Inhibition of TLR4 protects rat islets against lipopolysaccharide-induced dysfunction. Molecular medicine reports. vol 15. issue 2. 2017-04-21. PMID:28101570. |
the present study aimed to investigate the importance of tlr4 during lps‑induced oxidative stress, apoptosis and dysfunction of insulin secretion in isolated islets of rats. |
2017-04-21 |
2023-08-13 |
rat |