| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Xia, Meiyi Son. Role of Non-coding RNA in Diabetic Cardiomyopathy. Advances in experimental medicine and biology. vol 1229. 2020-07-01. PMID:32285412. |
the evidences have shown that mirnas are regulators in diabetic cardiomyopathy, such as insulin resistance, cardiomyocytes apoptosis, and inflammatory, especially their protective effect on heart function. |
2020-07-01 |
2023-08-13 |
human |
| Carlos Godoy-Parejo, Chunhao Deng, Weiwei Liu, Guokai Che. Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells. Stem cells (Dayton, Ohio). vol 37. issue 8. 2020-06-25. PMID:31021484. |
in this article, we show that insulin suppresses caspase cleavage and apoptosis after dissociation. |
2020-06-25 |
2023-08-13 |
human |
| Hongqiang Zhao, Shujuan Ta. MiRNA-221 protects islet β cell function in gestational diabetes mellitus by targeting PAK1. Biochemical and biophysical research communications. vol 520. issue 1. 2020-06-23. PMID:31587871. |
regulatory effects of mirna-221 on proliferation, apoptosis and insulin secretion in ins-1 cells were assessed. |
2020-06-23 |
2023-08-13 |
rat |
| Hongqiang Zhao, Shujuan Ta. MiRNA-221 protects islet β cell function in gestational diabetes mellitus by targeting PAK1. Biochemical and biophysical research communications. vol 520. issue 1. 2020-06-23. PMID:31587871. |
overexpression of mirna-221 stimulated insulin secretion, cell proliferation and suppressed apoptosis in ins-1 cells. |
2020-06-23 |
2023-08-13 |
rat |
| Hongqiang Zhao, Shujuan Ta. MiRNA-221 protects islet β cell function in gestational diabetes mellitus by targeting PAK1. Biochemical and biophysical research communications. vol 520. issue 1. 2020-06-23. PMID:31587871. |
mirna-221 regulates proliferation, apoptosis and insulin secretion in islet β cells through targeting pak1, thus protecting gdm-induced islet dysfunction. |
2020-06-23 |
2023-08-13 |
rat |
| Giti Kalantarian, Nasrin Ziamajidi, Roghayeh Abbasalipourkabir, Reza Mahjub, Mohammad Taghi Goodarzi, Massoud Saidijam, Sara Soleimani Asl, Mohammad Jamshid. Effect of insulin-loaded trimethyl chitosan nanoparticles on genes expression in the hippocampus of diabetic rats. Journal of basic and clinical physiology and pharmacology. vol 31. issue 2. 2020-06-19. PMID:31747376. |
insulin and insulin-like growth factors (igfs) inhibit apoptosis of oligodendrocytes. |
2020-06-19 |
2023-08-13 |
rat |
| Sureshbabu Mangali, Audesh Bhat, Mary Priyanka Udumula, Indu Dhar, Dharmarajan Sriram, Arti Dha. Inhibition of protein kinase R protects against palmitic acid-induced inflammation, oxidative stress, and apoptosis through the JNK/NF-kB/NLRP3 pathway in cultured H9C2 cardiomyocytes. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-17. PMID:30259999. |
double-stranded rna-dependent protein kinase (pkr) is a critical regulator of apoptosis, oxidative stress, and inflammation under hyperlipidemic and insulin resistance conditions. |
2020-06-17 |
2023-08-13 |
rat |
| Yingying Pan, Baile Wang, Jujia Zheng, Rongrong Xiong, Zhichao Fan, Yanna Ye, Saisai Zhang, Qinyao Li, Fanghua Gong, Chaoming Wu, Zhuofeng Lin, Xiaokun Li, Xuebo Pa. Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner. Journal of cellular and molecular medicine. vol 23. issue 2. 2020-06-17. PMID:30461198. |
pancreatic fgf21 overexpression significantly increased insulin expression, enhanced gsis, improved islet morphology and reduced β-cell apoptosis in db/db mice. |
2020-06-17 |
2023-08-13 |
mouse |
| Yixiong Tan, Wei Nie, Cheng Chen, Xuesong He, Yuzhi Xu, Xiaoqian Ma, Juan Zhang, Mengqun Tan, Pengfei Rong, Wei Wan. Mesenchymal stem cells alleviate hypoxia-induced oxidative stress and enhance the pro-survival pathways in porcine islets. Experimental biology and medicine (Maywood, N.J.). vol 244. issue 9. 2020-06-16. PMID:31042075. |
however, previous studies mainly focused on other aspects of msc protection such as inducing revascularization, enhancing insulin secretion, and reducing islet apoptosis. |
2020-06-16 |
2023-08-13 |
human |
| Hongyao Hu, Wei Li, Mingxin Liu, Jiarui Xiong, Yanjun Li, Yanzhao Wei, Congxin Huang, Yanhong Tan. C1q/Tumor Necrosis Factor-Related Protein-9 Attenuates Diabetic Nephropathy and Kidney Fibrosis in db/db Mice. DNA and cell biology. vol 39. issue 6. 2020-06-15. PMID:32283037. |
additionally, ctrp9 inhibits apoptosis of endothelial cells, decreases blood glucose level, and increases insulin sensitivity. |
2020-06-15 |
2023-08-13 |
mouse |
| Chayodom Maneechote, Siripong Palee, Nattayaporn Apaijai, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C Chattipakorn, Nipon Chattipakor. Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats. Clinical science (London, England : 1979). vol 133. issue 24. 2020-06-01. PMID:31808509. |
hfd rats developed obese insulin resistance which led to impaired dynamics balance and function of mitochondria, increased cardiac cell apoptosis and dysfunction. |
2020-06-01 |
2023-08-13 |
rat |
| Lei Liu, Chen Liang, Pucheng Mei, Hong Zhu, Meiling Hou, Chunlei Yu, Zhenbo Song, Yongli Bao, Yanxin Huang, Jingwen Yi, Shuyue Wang, Yin Wu, Lihua Zheng, Ying Sun, Guannan Wang, Mingxin Huo, Shaonian Yang, Luguo Sun, Yuxin L. Dracorhodin perchlorate protects pancreatic β-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro and in vivo. The FEBS journal. vol 286. issue 18. 2020-05-29. PMID:31349381. |
we further demonstrated that dp could significantly inhibit β-cell apoptosis induced by 33 mm glucose or 200 μm palmitate by interfering with endoplasmic reticulum stress and mitochondrial pathways and enhance insulin secretion as well. |
2020-05-29 |
2023-08-13 |
mouse |
| Lei Liu, Chen Liang, Pucheng Mei, Hong Zhu, Meiling Hou, Chunlei Yu, Zhenbo Song, Yongli Bao, Yanxin Huang, Jingwen Yi, Shuyue Wang, Yin Wu, Lihua Zheng, Ying Sun, Guannan Wang, Mingxin Huo, Shaonian Yang, Luguo Sun, Yuxin L. Dracorhodin perchlorate protects pancreatic β-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro and in vivo. The FEBS journal. vol 286. issue 18. 2020-05-29. PMID:31349381. |
our findings suggest that pdx1 is a potential target molecule of dp in the treatment of t2dm via the inhibition of glucotoxicity- or lipotoxicity- induced β-cell apoptosis and the attenuation of insulin secretion dysfunction. |
2020-05-29 |
2023-08-13 |
mouse |
| Ziyang Shen, Hemin Jiang, Hsiang-Ting Hsu, Li Qian, Qi Fu, Min Shen, Shu Chen, Tao Yan. MicroRNA-127 inhibits cell proliferation via targeting Kif3b in pancreatic β cells. Aging. vol 11. issue 5. 2020-05-28. PMID:30822278. |
the elevated level of mir-127 attenuated β cell proliferation by repressing kif3b expression without affecting apoptosis and cell cycle, and it dampened insulin secretion. |
2020-05-28 |
2023-08-13 |
mouse |
| Annie L Cao, Laura M Beaver, Carmen P Wong, Laurie G Hudson, Emily H. Zinc deficiency alters the susceptibility of pancreatic beta cells (INS-1) to arsenic exposure. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 32. issue 6. 2020-05-27. PMID:31542844. |
arsenic exposure decreased insulin expression, but co-exposure did not decrease insulin levels beyond the arsenic alone condition, but did result in a further 33% decline in cell proliferation at the 500 ppb arsenic dose, and a significant increase in beta cell apoptosis. |
2020-05-27 |
2023-08-13 |
rat |
| Jee-Yeon Lee, Yeon-Ju Lee, Hye-Yoon Jeon, Eun-Taek Han, Won Sun Park, Seok-Ho Hong, Young-Myeong Kim, Kwon-Soo H. The vicious cycle between transglutaminase 2 and reactive oxygen species in hyperglycemic memory-induced endothelial dysfunction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 11. 2020-05-26. PMID:31462079. |
we found that hyperglycemia induced persistent oxidative stress, expression of inflammatory adhesion molecules, and apoptosis in the aortic endothelium of hgm mice whose blood glucose levels had been normalized by insulin supplementation. |
2020-05-26 |
2023-08-13 |
mouse |
| Ting Xie, Wing Yan So, Xing Yu Li, Po Sing Leun. Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism. Clinical science (London, England : 1979). vol 133. issue 19. 2020-05-25. PMID:31654570. |
fgf21 ameliorated pa-induced lipid accumulation, reversed cell apoptosis, and enhanced glucose-stimulated insulin secretion (gsis) as impaired by lipotoxicity in islet β-cells. |
2020-05-25 |
2023-08-13 |
mouse |
| Ya-Nan Sun, Zhi-Xuan Yang, Fa-Zheng Ren, Bing Fan. FGF19 alleviates palmitate-induced atrophy in C2C12 cells by inhibiting mitochondrial overload and insulin resistance. International journal of biological macromolecules. vol 158. 2020-05-23. PMID:32344084. |
fgf19 addition during the differentiation of c2c12 cells, returned the palmitate-induced mitochondrial respiration and apoptosis to the control levels and improved the insulin sensitivity. |
2020-05-23 |
2023-08-13 |
mouse |
| Ya-Nan Sun, Zhi-Xuan Yang, Fa-Zheng Ren, Bing Fan. FGF19 alleviates palmitate-induced atrophy in C2C12 cells by inhibiting mitochondrial overload and insulin resistance. International journal of biological macromolecules. vol 158. 2020-05-23. PMID:32344084. |
in summary, fgf19 prevented excessive palmitate-induced dysfunction of c2c12 cells by protecting mitochondrial overload and apoptosis and maintaining normal insulin signaling. |
2020-05-23 |
2023-08-13 |
mouse |
| Xiaoyi Yu, Yingzi Luo, Gangyi Chen, Hong Liu, Ni Tian, Xiaoting Zen, Qiuhong Li. Long noncoding RNA IGF2AS regulates high-glucose induced apoptosis in human retinal pigment epithelial cells. IUBMB life. vol 71. issue 10. 2020-05-15. PMID:31317640. |
in an in vitro diabetic apoptosis cell model, we evaluated the function of long noncoding rna, insulin growth factor 2 antisense (igf2-as) in high-glucose-injured human retinal pigment epithelial cells. |
2020-05-15 |
2023-08-13 |
human |