| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hengchang Li, Jian Li, Qian Yu, Chunling Dai, Jinhua Gu, Shengwei Peng, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. Sevoflurane-induced neuronal apoptosis in neonatal mice is prevented with intranasal administration of insulin. American journal of translational research. vol 12. issue 12. 2021-01-14. PMID:33437390. |
more importantly, we found that insulin administered through intranasal delivery prior to anesthesia prevented anesthesia-induced over-activation of neuronal apoptosis. |
2021-01-14 |
2023-08-13 |
mouse |
| Shanza Mukhtar, Zeng Xiaoxiong, Samina Qamer, Muhammad Saad, Muhammad Samee Mubarik, Ahmed Hossam Mahmoud, Osama B Mohamme. Hepatoprotective activity of silymarin encapsulation against hepatic damage in albino rats. Saudi journal of biological sciences. vol 28. issue 1. 2021-01-12. PMID:33424359. |
in conclusion, the results suggest that smr acts as a hepatoprotective agent by inhibiting the fibrogenisis and apoptosis in liver, as well as insulin resistance. |
2021-01-12 |
2023-08-13 |
rat |
| Sajid Ali Rajput, Munazza Raza Mirza, M Iqbal Choudhar. Bergenin protects pancreatic beta cells against cytokine-induced apoptosis in INS-1E cells. PloS one. vol 15. issue 12. 2021-01-11. PMID:33347462. |
these included (i) increase in beta cell viability (by measuring cellular atp levels) (ii) suppression of beta cell apoptosis (by measuring caspase activity), (iii) improvement in beta cell function (by measuring glucose-stimulated insulin secretion), and (iv) improvement of beta cells mitochondrial physiological functions. |
2021-01-11 |
2023-08-13 |
rat |
| Sajid Ali Rajput, Munazza Raza Mirza, M Iqbal Choudhar. Bergenin protects pancreatic beta cells against cytokine-induced apoptosis in INS-1E cells. PloS one. vol 15. issue 12. 2021-01-11. PMID:33347462. |
this study shows for the first time that bergenin protected beta cells from cytokine-induced apoptosis and restored insulin secretory function by virtue of its anti-inflammatory, antioxidant and anti-apoptotic properties. |
2021-01-11 |
2023-08-13 |
rat |
| Dominika Nackiewicz, Meixia Dan, Madeleine Speck, Samuel Z Chow, Yi-Chun Chen, J Andrew Pospisilik, C Bruce Verchere, Jan A Ehse. Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1. iScience. vol 23. issue 1. 2021-01-10. PMID:31962237. |
igf-1 neutralization during stz treatment decreased insulin secretion without affecting islet cell apoptosis or proliferation. |
2021-01-10 |
2023-08-13 |
mouse |
| Liping Li, Faxuan Wang, Jianjun Zhang, Kai Wang, Xiaoming De, Ling Li, Yuhong Zhan. Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells. Ecotoxicology and environmental safety. vol 208. 2021-01-08. PMID:33091774. |
hoechst 33342/propidium iodide (pi) staining and annexin v-fitc/pi staining, 2',7'-dichlorofluorescein diacetate assay, and glucose-induced insulin secretion assay were used to detect cell apoptosis rates, intracellular reactive oxygen species (ros), and insulin secretion in ins-1, respectively. |
2021-01-08 |
2023-08-13 |
human |
| Hu Peng, Xing Qin, Sainan Chen, Asli F Ceylan, Maolong Dong, Zhaofen Lin, Jun Re. Parkin deficiency accentuates chronic alcohol intake-induced tissue injury and autophagy defects in brain, liver and skeletal muscle. Acta biochimica et biophysica Sinica. vol 52. issue 6. 2021-01-06. PMID:32427312. |
although parkin ablation itself did not generate any notable effects on liver enzymes, insulin sensitivity, tissue carbonyl damage, apoptosis, tissue morphology, autophagy or mitochondrial respiration, it accentuated alcohol intake-induced tissue damage, apoptosis, morphological change, autophagy/mitophagy failure and mitochondrial injury without affecting insulin sensitivity. |
2021-01-06 |
2023-08-13 |
mouse |
| Muhammad Sajid Hamid Akash, Shakila Sabir, Kanwal Rehma. Bisphenol A-induced metabolic disorders: From exposure to mechanism of action. Environmental toxicology and pharmacology. vol 77. 2021-01-04. PMID:32200274. |
bpa induces apoptosis by caspase activation after mitochondrial damage and it impairs insulin signaling pathways by altering associated ion channel activity especially potassium channels. |
2021-01-04 |
2023-08-13 |
human |
| Albert Vacheron, Anne Wynn, Jeff Zuber, Solomon S Solomo. Metformin: Possible Use of a Diabetes Drug in Treatment of Cancer. Clinical research in diabetes and endocrinology. vol 1. issue 1. 2021-01-03. PMID:33385166. |
tnf-alpha interferes with insulin signaling to produce insulin resistance in the insulin signaling pathway and promotes apoptosis through nf-kb in the apoptosis pathway. |
2021-01-03 |
2023-08-13 |
Not clear |
| Jian Zhao, Jianrong Gao, Huan L. Ferulic acid confers protection on islet β cells and placental tissues of rats with gestational diabetes mellitus. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 1. 2020-12-30. PMID:32359381. |
these results indicate that ferulic acid protects β cells from gdm-induced apoptosis and improves insulin signaling in placenta of female rats with gdm. |
2020-12-30 |
2023-08-13 |
rat |
| Hemin Jiang, Yuwei Liu, Yu Qian, Ziyang Shen, Yunqiang He, Rui Gao, Min Shen, Shu Chen, Qi Fu, Tao Yan. CHL1 promotes insulin secretion and negatively regulates the proliferation of pancreatic β cells. Biochemical and biophysical research communications. vol 525. issue 4. 2020-12-28. PMID:32184019. |
gain- or loss-of function studies were conducted in min6 cells to determine the effects of chl1 on cell proliferation, apoptosis, cell cycle, and insulin secretion. |
2020-12-28 |
2023-08-13 |
mouse |
| Napatsorn Saiyasit, Titikorn Chunchai, Dillon Prus, Kanokphong Suparan, Pansa Pittayapong, Nattayaporn Apaijai, Wasana Pratchayasakul, Jirapas Sripetchwandee, Nipon Chattipakorn M D Ph D, Siriporn C Chattipakor. Gut dysbiosis develops before metabolic disturbance and cognitive decline in high-fat diet-induced obese condition. Nutrition (Burbank, Los Angeles County, Calif.). vol 69. 2020-12-23. PMID:31580986. |
therefore, the aim of this study was to test the hypothesis that gut dysbiosis, peripheral inflammation, and peripheral insulin resistance occur before the brain inflammatory response, hippocampal synaptic dysplasticity, oxidative stress, apoptosis, and cognitive impairment in hfd-fed rats. |
2020-12-23 |
2023-08-13 |
rat |
| Anna Zalewska, Izabela Szarmach, Małgorzata Żendzian-Piotrowska, Mateusz Maciejczy. The Effect of N-Acetylcysteine on Respiratory Enzymes, ADP/ATP Ratio, Glutathione Metabolism, and Nitrosative Stress in the Salivary Gland Mitochondria of Insulin Resistant Rats. Nutrients. vol 12. issue 2. 2020-12-17. PMID:32059375. |
this is the first study to assess the effect of n-acetylcysteine (nac) on the mitochondrial respiratory system, as well as free radical production, glutathione metabolism, nitrosative stress, and apoptosis in the salivary gland mitochondria of rats with high-fat diet (hfd)-induced insulin resistance (ir). |
2020-12-17 |
2023-08-13 |
rat |
| Pawel A Kolodziejski, Maciej Sassek, Jakub Bien, Natalia Leciejewska, Dawid Szczepankiewicz, Beata Szczepaniak, Malgorzata Wojciechowska, Leszek Nogowski, Krzysztof W Nowak, Mathias Z Strowski, Ewa Pruszynska-Oszmale. FGF-1 modulates pancreatic β-cell functions/metabolism: An in vitro study. General and comparative endocrinology. vol 294. 2020-12-16. PMID:32360543. |
by using insulin-producing ins-1e cells and isolated pancreatic islets, we investigated the effect of fgf-1 on cell proliferation, viability, apoptosis, and insulin expression and secretion. |
2020-12-16 |
2023-08-13 |
rat |
| Elena Bellafante, Saraid McIlvride, Vanya Nikolova, Hei Man Fan, Luiza Borges Manna, Jenny Chambers, Mavis Machirori, Anita Banerjee, Kevin Murphy, Marcus Martineau, Kristina Schoonjans, Hanns-Ulrich Marschall, Peter Jones, Catherine Williamso. Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis. Scientific reports. vol 10. issue 1. 2020-12-16. PMID:32661285. |
cholic acid feeding resulted in reduced pancreatic β-cell proliferation and increased apoptosis in pregnancy, without altering insulin sensitivity, suggesting that raised bile acids affect β-cell mass but are insufficient to impair glucose tolerance. |
2020-12-16 |
2023-08-13 |
mouse |
| Wenqian Zhang, Meng Zuo, Juan Lu, Yuxia Wan. Adiponectin Reduces Embryonic Loss Rate and Ameliorates Trophoblast Apoptosis in Early Pregnancy of Mice with Polycystic Ovary Syndrome by Affecting the AMPK/PI3K/Akt/FoxO3a Signaling Pathway. Reproductive sciences (Thousand Oaks, Calif.). vol 27. issue 12. 2020-12-15. PMID:32588392. |
reports in recent years have suggested that adiponectin (apn) improves insulin resistance and inhibits apoptosis by activating the amp-activated protein kinase (ampk) pathway and the pi3k/akt signaling pathway after binding to its receptor. |
2020-12-15 |
2023-08-13 |
mouse |
| Li Xiong, Yingying Gong, Liting Wu, Jin Li, Weiman He, Xiaonan Zhu, Haipeng Xia. LncRNA-Malat1 is Involved in Lipotoxicity-Induced ß-cell Dysfunction and the Therapeutic Effect of Exendin-4 via Ptbp1. Endocrinology. vol 161. issue 7. 2020-12-14. PMID:32324218. |
the results of tunel, western blot and flow cytometric analyses, and gsis assays revealed that malat1 knockdown significantly induced β-cell apoptosis and inhibited insulin secretion. |
2020-12-14 |
2023-08-13 |
mouse |
| Steve Harakeh, Mohammed Almuhayawi, Soad Al Jaouni, Saad Almasaudi, Saber Hassan, Turki Al Amri, Najiah Azhar, Elham Abd-Allah, Soad Ali, Nagla El-Shitany, Shaker A Mous. Antidiabetic effects of novel ellagic acid nanoformulation: Insulin-secreting and anti-apoptosis effects. Saudi journal of biological sciences. vol 27. issue 12. 2020-12-12. PMID:33304158. |
the mechanisms behind these effects are inhibition of beta-cell apoptosis and stimulation of insulin production. |
2020-12-12 |
2023-08-13 |
rat |
| Fred E Bertran. The cross-talk of NOTCH and GSK-3 signaling in colon and other cancers. Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 9. 2020-12-07. PMID:32389646. |
the gsk-3 kinases, gsk-3α and gsk-3β, have a central role in regulating multiple cellular processes such as glycogen synthesis, insulin signaling, cell proliferation and apoptosis. |
2020-12-07 |
2023-08-13 |
human |
| Akira Mima, Toshinori Yasuzawa, Tomomi Nakamura, Shigeru Ueshim. Linagliptin affects IRS1/Akt signaling and prevents high glucose-induced apoptosis in podocytes. Scientific reports. vol 10. issue 1. 2020-12-04. PMID:32238837. |
we proposed that hyperglycaemia can induce podocyte apoptosis by inhibiting the action of podocyte survival factors, thus inactivating the cellular effects of insulin signalling. |
2020-12-04 |
2023-08-13 |
Not clear |