| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Congcong Lu, Guoxia Fan, Dianyun Wan. Akebia Saponin D ameliorated kidney injury and exerted anti-inflammatory and anti-apoptotic effects in diabetic nephropathy by activation of NRF2/HO-1 and inhibition of NF-KB pathway. International immunopharmacology. vol 84. 2021-02-25. PMID:32344355. |
blood glucose, insulin, serum creatinine (scr), blood urea nitrogen (bun), renal injury, inflammation, oxidative stress and apoptosis of renal tubular cells were respectively measured and evaluated. |
2021-02-25 |
2023-08-13 |
mouse |
| Tao Yu, Yuan Xiong, Simon Luu, Xiaomeng You, Bing Li, Jiang Xia, Hui Zhu, Youguang Zhao, Haichao Zhou, Guangrong Yu, Yunfeng Yan. The shared KEGG pathways between icariin-targeted genes and osteoporosis. Aging. vol 12. issue 9. 2021-02-25. PMID:32380477. |
the identified icariin-targeted genes are involved in inflammation, insulin resistance, apoptosis, and immune responses, and regulate the pi3k-akt, nf-κb, mapk, and jnk signaling pathways. |
2021-02-25 |
2023-08-13 |
Not clear |
| Ayse Karatug Kaca. Indomethacin decreases insulin secretion by reducing KCa3.1 as a biomarker of pancreatic tumor and causes apoptotic cell death. Journal of biochemical and molecular toxicology. vol 34. issue 7. 2021-02-23. PMID:32128977. |
the relationship between cell death and insulin metabolism was determined with the administration of indomethacin. the cell viability by wst-1; the apoptosis and necrosis levels by elisa kits; malondialdehyde levels by spectrophotometer; and beclin, intracellular insulin, insulin secretion, kca3.1, insulin receptor (ir), glucose transporter type 2 (glut2), activating transcription factor 2 (atf2), elk1, c-jun, akt and phosphorylated atf2, elk1, c-jun, akt, intracellular betacellulin and betacellulin secretion levels by western blot analysis investigated. the ins1, ins2, ir, glut2, atf2, elk1, c-jun, akt, and betacellulin gene expression levels were determined by the real-time quantitative reverse transcription-polymerase chain reaction method. |
2021-02-23 |
2023-08-13 |
rat |
| Jae Hun Jeong, Eun Bee Choi, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Gyeongah Park, Eun Ae Jeong, Hyun Joo Shin, Jaewoong Lee, Kyung Eun Kim, Gu Seob Ro. The Role of SHIP1 on Apoptosis and Autophagy in the Adipose Tissue of Obese Mice. International journal of molecular sciences. vol 21. issue 19. 2021-02-23. PMID:33007882. |
obesity-induced adipocyte apoptosis promotes inflammation and insulin resistance. |
2021-02-23 |
2023-08-13 |
mouse |
| Ayse Basak Engin, Atilla Engi. Protein Kinases Signaling in Pancreatic Beta-cells Death and Type 2 Diabetes. Advances in experimental medicine and biology. vol 1275. 2021-02-15. PMID:33539017. |
in this chapter following subjects, which have critical checkpoints regarding β-cell fate and protein kinases pathways are discussed; hyperglycemia-induced β-cell failure, chronic accumulation of unfolded protein in β-cells, the effect of intracellular reactive oxygen species (ros) signaling to insulin secretion, excessive saturated free fatty acid-induced β-cell apoptosis, mitophagy dysfunction, proinflammatory responses and insulin resistance, and the reprogramming of β-cell for differentiation or dedifferentiation in t2d. |
2021-02-15 |
2023-08-13 |
human |
| H-P Zh. Silence of HOTAIR inhibits insulin secretion and proliferation in pancreatic β cells. European review for medical and pharmacological sciences. vol 24. issue 2. 2021-02-12. PMID:32016983. |
moreover, regulatory effects of hotair on insulin secretion, proliferation, cell cycle, and apoptosis in β cells are determined. |
2021-02-12 |
2023-08-13 |
Not clear |
| Wan Xu, Jie Cui, Feiye Zhou, Mengyao Bai, Ruyuan Deng, Wenqian Wan. Leonurine protects against dexamethasone-induced cytotoxicity in pancreatic β-cells via PI3K/Akt signaling pathway. Biochemical and biophysical research communications. vol 529. issue 3. 2021-02-12. PMID:32736688. |
glucocorticoid excess induces pancreatic β-cell apoptosis and insulin secretion impairment, which may lead to hyperglycemia and steroid diabetes. |
2021-02-12 |
2023-08-13 |
mouse |
| Durgesh Kumar Dwivedi, G B Jen. NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 4. 2021-02-03. PMID:31834465. |
hepatoprotective effects of glb was mediated by decreasing the levels of glucose, triglycerides, cholesterol, dna damage, apoptosis and inflammatory markers, and by improving the anti-oxidant status and insulin signalling pathway in hfd fed rat. |
2021-02-03 |
2023-08-13 |
human |
| Min Liu, Chunyan Liu, Shenli Shen, Jianhui Liu, Fei Yi. Geniposide inhibits glucolipotoxicity and cooperates with Txnip knockdown to potentiate cell adaption to endoplasmic reticulum stress in pancreatic beta cells. Cell biology international. vol 44. issue 7. 2021-02-03. PMID:32215982. |
our previous data demonstrated that geniposide improved glucose-stimulated insulin secretion by accelerating txnip degradation and prevented the early-stage apoptosis of pancreatic β cells induced by palmitate, but the underlying mechanisms are still unclear. |
2021-02-03 |
2023-08-13 |
rat |
| V P Mahendra, K Yogendra Prasad, P Ganesan, Ravi Kuma. Mechanism of rutin mediated inhibition of insulin amyloid formation and protection of Neuro-2a cells from fibril-induced apoptosis. Molecular biology reports. vol 47. issue 4. 2021-02-01. PMID:32240467. |
mechanism of rutin mediated inhibition of insulin amyloid formation and protection of neuro-2a cells from fibril-induced apoptosis. |
2021-02-01 |
2023-08-13 |
Not clear |
| Yunxia Guo, Zhaofang Liu, Ming Wan. NFKB1-mediated downregulation of microRNA-106a promotes oxidative stress injury and insulin resistance in mice with gestational hypertension. Cytotechnology. vol 73. issue 1. 2021-01-30. PMID:33505119. |
oxidative stress injury and insulin resistance in gh mice and apoptosis and inflammation of hepatocytes from gh mice were decreased after silencing nfkb1 or flot2 or overexpressing mir-106a. |
2021-01-30 |
2023-08-13 |
mouse |
| Gaoxiang Wang, Meiqing Xu, Mingran Xi. [Research Advance in Anti-lung Cancer Mechanism of Metformin]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. vol 23. issue 4. 2021-01-25. PMID:32316716. |
its mechanisms mainly include activating adenosine monophosphate-activated protein kinase pathway, improving hyperinsulinemia and insulin resistance, promoting lung cancer cell apoptosis and inhibiting related inflammatory response. |
2021-01-25 |
2023-08-13 |
human |
| Suchismita Daw, Sujata La. Quercetin induces autophagy in myelodysplastic bone marrow including hematopoietic stem/progenitor compartment. Environmental toxicology. vol 36. issue 2. 2021-01-25. PMID:32902906. |
the present study involves flowcytometric protein expression analysis of insulin growth factor receptor (igfr), pi3k-akt-mtor pathway, the autophagy related proteins (atg's), the status of antioxidative molecules sod2 and sdf1 and apoptosis profiling in ethyl-nitroso-urea induced myelodysplasia. |
2021-01-25 |
2023-08-13 |
Not clear |
| Kun Dong, Qiuchen Zhao, Yaqiang Xue, Yaxun Wei, Yi Zhang, Yan Yan. TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance. Gene. vol 768. 2021-01-25. PMID:33122078. |
knock-down of tctp led to 287 differentially expressed genes (degs) that were highly associated with cellular apoptosis and signal response, tnf and nf-κb signaling pathways, glycolysis/gluconeogenesis, insulin resistance, foxo and insulin signaling pathways, adipocytokine and ampk signaling pathways. |
2021-01-25 |
2023-08-13 |
mouse |
| Panwen Liu, Lingyu Cui, Bo Liu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Takashi Ikejim. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiology & behavior. vol 213. 2021-01-22. PMID:31669775. |
silibinin ameliorates stz-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. |
2021-01-22 |
2023-08-13 |
rat |
| Panwen Liu, Lingyu Cui, Bo Liu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Takashi Ikejim. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiology & behavior. vol 213. 2021-01-22. PMID:31669775. |
moreover, silibinin significantly decreased stz-induced tau hyperphosphorylation (ser404) in hippocampus and cerebral cortex, markedly inhibited apoptosis of neurons induced by stz, and up-regulated insulin signal transduction pathway. |
2021-01-22 |
2023-08-13 |
rat |
| Montserrat Pinent, Anna Castell, Isabel Baiges, Gemma Montagut, Lluís Arola, Anna Ardévo. Bioactivity of Flavonoids on Insulin-Secreting Cells. Comprehensive reviews in food science and food safety. vol 7. issue 4. 2021-01-20. PMID:33467792. |
published data suggest that there might be direct effects of flavonoids on insulin secretion, as well as on prevention of beta-cell apoptosis, and they could even act via modulation of proliferation. |
2021-01-20 |
2023-08-13 |
Not clear |
| Amany Abdel-Rahman Mohamed, Safaa I Khater, Ahmed Hamed Arisha, Mohamed M M Metwally, Gomaa Mostafa-Hedeab, Eman S El-Shetr. Chitosan-stabilized selenium nanoparticles alleviate cardio-hepatic damage in type 2 diabetes mellitus model via regulation of caspase, Bax/Bcl-2, and Fas/FasL-pathway. Gene. vol 768. 2021-01-19. PMID:33181259. |
the present study was carried out to explore a novel strategy with the hypothesis that the combined treatment with standard antidiabetic drug metformin (met) and chitosan stabilized nanoparticles (cts-se-nps) may have a potential role on insulin level, hepatic damage and apoptosis, and cardiac injury markers of type 2 diabetes mellitus (t2dm) in rat model. |
2021-01-19 |
2023-08-13 |
rat |
| Swapnil Raj, Liston Augustine Dsouza, Shailendra Pratap Singh, Abhinav Kanwa. Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease. Frontiers in pharmacology. vol 11. 2021-01-16. PMID:33442387. |
sirtuins, nad + dependent proteins belonging to class iii histone deacetylases, are involved in regulating numerous cellular processes including cellular stress, insulin resistance, inflammation, mitochondrial biogenesis, chromatin silencing, cell cycle regulation, transcription, and apoptosis. |
2021-01-16 |
2023-08-13 |
human |
| Hengchang Li, Jian Li, Qian Yu, Chunling Dai, Jinhua Gu, Shengwei Peng, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. Sevoflurane-induced neuronal apoptosis in neonatal mice is prevented with intranasal administration of insulin. American journal of translational research. vol 12. issue 12. 2021-01-14. PMID:33437390. |
sevoflurane-induced neuronal apoptosis in neonatal mice is prevented with intranasal administration of insulin. |
2021-01-14 |
2023-08-13 |
mouse |