| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jamie M R Tarlton, Steven Patterson, Annette Graha. MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes Mellitus. Biology. vol 10. issue 6. 2021-07-05. PMID:34203703. |
alterations in lipid metabolism within beta cells and islets contributes to dysfunction and apoptosis of beta cells, leading to loss of insulin secretion and the onset of type 2 diabetes. |
2021-07-05 |
2023-08-13 |
Not clear |
| Taewon Han, Eun Ko, Minji Kim, Moonsung Choi, Changho Lee, In-Ho Kim, Sooim Shin, Min Young U. Mori Ramulus Inhibits Pancreatic β-Cell Apoptosis and Prevents Insulin Resistance by Restoring Hepatic Mitochondrial Function. Antioxidants (Basel, Switzerland). vol 10. issue 6. 2021-07-05. PMID:34204891. |
mori ramulus inhibits pancreatic β-cell apoptosis and prevents insulin resistance by restoring hepatic mitochondrial function. |
2021-07-05 |
2023-08-13 |
mouse |
| Taewon Han, Eun Ko, Minji Kim, Moonsung Choi, Changho Lee, In-Ho Kim, Sooim Shin, Min Young U. Mori Ramulus Inhibits Pancreatic β-Cell Apoptosis and Prevents Insulin Resistance by Restoring Hepatic Mitochondrial Function. Antioxidants (Basel, Switzerland). vol 10. issue 6. 2021-07-05. PMID:34204891. |
thus, me provides protection against pancreatic β-cell apoptosis and prevents insulin resistance by improving mitochondrial function. |
2021-07-05 |
2023-08-13 |
mouse |
| Eman Salah El-Shafey, Eslam Samy Elsherbin. The role of apoptosis and autophagy in the insulin-enhancing activity of oxovanadium(IV) bipyridine complex in streptozotocin-induced diabetic mice. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 33. issue 2-3. 2021-06-29. PMID:32318895. |
defective insulin secretion can result from impaired β-cell function which is mediated by many process including apoptosis and autophagy. |
2021-06-29 |
2023-08-13 |
mouse |
| Heting Wang, Cécile Saint-Martin, Jialu Xu, Li Ding, Ruodan Wang, Wenli Feng, Ming Liu, Hua Shu, Zhenqian Fan, Leena Haataja, Peter Arvan, Christine Bellanné-Chantelot, Jingqiu Cui, Yumeng Huan. Biological behaviors of mutant proinsulin contribute to the phenotypic spectrum of diabetes associated with insulin gene mutations. Molecular and cellular endocrinology. vol 518. 2021-06-29. PMID:32916194. |
specifically, compared to mody mutants g(b20)r and p(b28)l that partially affected folding and trafficking of co-expressed wt-proinsulin, the ndm mutant c(a7)y resulted in an almost complete blockade of the er export of wt-proinsulin, decreasing insulin production, inducing more severe er stress and apoptosis. |
2021-06-29 |
2023-08-13 |
Not clear |
| Kathryn A McGurk, Bernard D Keavney, Anna Nicolao. Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studies. Atherosclerosis. vol 327. 2021-06-29. PMID:34004484. |
the signalling activities of ceramides in vascular inflammation and apoptosis, associations between circulating ceramides and coronary artery disease risk, type-2 diabetes and insulin resistance, and the potential importance of ceramides with regard to acvd risk factors, such as blood pressure, lipoproteins and lifestyle factors, are also discussed. |
2021-06-29 |
2023-08-13 |
Not clear |
| Ding Yao, Yang GangYi, Wu QiNa. Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword. Genes & diseases. vol 8. issue 4. 2021-06-29. PMID:34179308. |
recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. |
2021-06-29 |
2023-08-13 |
Not clear |
| H Q Hu, J T Qiao, F Q Liu, J B Wang, S Sha, Q He, C Cui, J Song, N Zang, L S Wang, Z Sun, L Chen, X G Ho. The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes. Molecular and cellular endocrinology. vol 518. 2021-06-25. PMID:32781250. |
gene silencing of sting or irf3 ameliorated pa-induced ins-1 cell inflammation and apoptosis, and reversed impaired insulin synthesis. |
2021-06-25 |
2023-08-13 |
mouse |
| Raffaella Buzzetti, Simona Zampetti, Paolo Pozzill. Impact of obesity on the increasing incidence of type 1 diabetes. Diabetes, obesity & metabolism. vol 22. issue 7. 2021-06-24. PMID:32157790. |
possible mechanisms of the enhancement of β-cell autoimmunity by obesity include: a) insulin resistance-induced β-cell secretory demand triggering autoimmunity through cytokine release, neo-epitope antigen formation and increase in β-cell apoptosis, and b) obesity-induced low-grade inflammation with pro-inflammatory cytokines secreted by locally infiltrating macrophages, which contribute to the presentation by islet cells of autoantigens generally not accessible to t cells. |
2021-06-24 |
2023-08-13 |
human |
| Sathish Babu Vasamsetti, Emilie Coppin, Xinyi Zhang, Jonathan Florentin, Sasha Koul, Matthias Götberg, Andrew S Clugston, Floyd Thoma, John Sembrat, Grant C Bullock, Dennis Kostka, Claudette M St Croix, Ansuman Chattopadhyay, Mauricio Rojas, Suresh R Mulukutla, Partha Dutt. Apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction. Science translational medicine. vol 12. issue 553. 2021-06-23. PMID:32718989. |
apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction. |
2021-06-23 |
2023-08-13 |
mouse |
| Sathish Babu Vasamsetti, Emilie Coppin, Xinyi Zhang, Jonathan Florentin, Sasha Koul, Matthias Götberg, Andrew S Clugston, Floyd Thoma, John Sembrat, Grant C Bullock, Dennis Kostka, Claudette M St Croix, Ansuman Chattopadhyay, Mauricio Rojas, Suresh R Mulukutla, Partha Dutt. Apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction. Science translational medicine. vol 12. issue 553. 2021-06-23. PMID:32718989. |
mechanistically, vat-resident macrophage apoptosis and de novo insulin resistance in mouse models of mi were linked to diminished concentrations of macrophage colony-stimulating factor and adiponectin. |
2021-06-23 |
2023-08-13 |
mouse |
| Yong Zou, Zhengtang Q. Understanding the Role of Exercise in Nonalcoholic Fatty Liver Disease: ERS-Linked Molecular Pathways. Mediators of inflammation. vol 2020. 2021-06-21. PMID:32774148. |
nonalcoholic fatty liver disease (nafld) is globally prevalent and characterized by abnormal lipid accumulation in the liver, frequently accompanied by insulin resistance (ir), enhanced hepatic inflammation, and apoptosis. |
2021-06-21 |
2023-08-13 |
Not clear |
| Shuang Li, Qingyu Zhao, Kai Zhang, Wenjuan Sun, Jing Li, Xiaoqing Guo, Jingdong Yin, Junmin Zhang, Chaohua Tan. Selenium Deficiency-Induced Pancreatic Pathology Is Associated with Oxidative Stress and Energy Metabolism Disequilibrium. Biological trace element research. vol 199. issue 1. 2021-06-18. PMID:32314143. |
the results showed that se deficiency reduced the concentrations of insulin and glucagon in the serum and of se in pancreas, decreased the number of islets and cells in the local islets, and induced pancreatic apoptosis. |
2021-06-18 |
2023-08-13 |
Not clear |
| Peilang Yang, Xiqiao Wang, Di Wang, Yan Shi, Meng Zhang, Tianyi Yu, Dan Liu, Min Gao, Xiong Zhang, Yan Li. Topical insulin application accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization. Journal of cell science. vol 133. issue 19. 2021-06-18. PMID:32878940. |
our study revealed that insulin promoted apoptosis of neutrophils and subsequently triggered polarization of macrophages. |
2021-06-18 |
2023-08-13 |
Not clear |
| Yali Zhang, Xiaomin Yu, Mimi Wang, Yan Ding, Hui Guo, Jiankang Liu, Ying Chen. Hyperoside from Z. bungeanum leaves restores insulin secretion and mitochondrial function by regulating pancreatic cellular redox status in diabetic mice. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33161043. |
excessive production of reactive oxygen species (ros) and activation of caspases in mitochondria inhibit insulin secretion and promote apoptosis of pancreatic β-cells. |
2021-06-18 |
2023-08-13 |
mouse |
| Yali Zhang, Xiaomin Yu, Mimi Wang, Yan Ding, Hui Guo, Jiankang Liu, Ying Chen. Hyperoside from Z. bungeanum leaves restores insulin secretion and mitochondrial function by regulating pancreatic cellular redox status in diabetic mice. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33161043. |
in current study, hzl was administered to high fat diet and alloxan-induced diabetic mice, and appeared to significantly ameliorate the damage of glucose metabolism and insulin secretion as well as restore the structural integrity of pancreas, and inhibit β-cell apoptosis. |
2021-06-18 |
2023-08-13 |
mouse |
| Limei Piao, Yanglong Li, Megumi Narisawa, Xionghu Shen, Xian Wu Chen. Role of Dipeptidyl Peptidase-4 in Atherosclerotic Cardiovascular Disease in Humans and Animals with Chronic Stress. International heart journal. vol 62. issue 3. 2021-06-10. PMID:33994495. |
over the last 10 years, emerging data have demonstrated unexpected roles of dpp-4 in extracellular and intracellular signaling, immune activation, inflammation, oxidative stress production, cell apoptosis, insulin resistance, and lipid metabolism. |
2021-06-10 |
2023-08-13 |
Not clear |
| Maryam Abolghasemi, Soleiman Mahjou. Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle. Molecular biology reports. vol 48. issue 4. 2021-06-09. PMID:33993404. |
therefore, in this paper, we will summarize the function of numerous lncrnas in the apoptosis and proliferation of granulosa cells (gcs), insulin resistance (ir), and steroidogenesis in pcos. |
2021-06-09 |
2023-08-13 |
Not clear |
| Kaijian Hou, Yongru Chen, Dan Zhu, Genben Chen, Fengwu Chen, Ningning Xu, Khan Barakat, Jiehong Zheng, Xi Xie, Rongping Che. Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1a and pERK1/2. Frontiers in bioscience (Landmark edition). vol 25. 2021-06-07. PMID:32472767. |
loss of pancreatic beta-cells by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the diabetes mellitus. |
2021-06-07 |
2023-08-13 |
mouse |
| Minggang Cheng, Yichen Guo, Weichuan Zhong, Xueyan Chen, Guangzhou Gu. Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten. Biochemical genetics. 2021-06-04. PMID:34085179. |
moreover, min6 cells were induced by 5 mg/dl ua and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay, flow cytometry and glucose-stimulated insulin secretion (gsis), respectively. |
2021-06-04 |
2023-08-13 |
Not clear |