| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rada Cherngwelling, Nattavadee Pengrattanachot, Myat Theingi Swe, Laongdao Thongnak, Sasivimon Promsan, Nichakorn Phengpol, Prempree Sutthasupha, Anusorn Lungkaphi. Agomelatine protects against obesity-induced renal injury by inhibiting endoplasmic reticulum stress/apoptosis pathway in rats. Toxicology and applied pharmacology. vol 425. 2021-08-06. PMID:34081941. |
our results indicated that hf rats demonstrated insulin resistance which was accompanied by an impairment of renal function and renal organic anion transporter 3 (oat3) function as well as renal oxidative stress, er stress, and apoptosis. |
2021-08-06 |
2023-08-13 |
rat |
| Li Zheng, Yalan Wang, Yanhong Li, Li Li, Xiaohong Wang, Yan L. miR-765 targeting PDX1 impairs pancreatic β-cell function to induce type 2 diabetes. Archives of physiology and biochemistry. 2021-08-06. PMID:34357821. |
together with gsis assay, cck-8, tunel assay, glycolysis assay, and mitochondrial respiration assay, mir-765 overexpression impaired insulin secretion cell viability, glycolysis, and mitochondrial respiration, while enhanced cell apoptosis in pancreatic β-cell. |
2021-08-06 |
2023-08-13 |
Not clear |
| Yanyan Zhu, Haixia Yang, Jianjun Deng, Daidi Fa. Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice. Journal of agricultural and food chemistry. vol 69. issue 30. 2021-08-05. PMID:34309383. |
in this study, we found that rg5 intervention significantly inhibited blood glucose increases in db/db mice, improved liver function damage and hepatocyte apoptosis, and activated the irs-1/phosphatidylinositol 3-kinase/akt insulin metabolism signaling pathway. |
2021-08-05 |
2023-08-13 |
mouse |
| Kai Zhang, Yijian Zhang, Cheng Chen, Yuexing Yuan, Xiaotian Jiang, Xiangjiang Yuan, Yao Wan. miR-139-5p mediates the palmitate-induced inhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1 cells. Acta biochimica et biophysica Sinica. vol 53. issue 8. 2021-08-04. PMID:34142698. |
high fatty acid reduces insulin secretion in pancreatic β-cells and mir-139-5p is increased in diabetic pancreatic tissues and induces islet β-cell apoptosis. |
2021-08-04 |
2023-08-13 |
mouse |
| Suping Xin, Xinhua Y. Oxalomalate regulates the apoptosis and insulin secretory capacity in streptozotocin-induced pancreatic β-cells. Drug development research. vol 81. issue 4. 2021-08-02. PMID:31904108. |
oxalomalate regulates the apoptosis and insulin secretory capacity in streptozotocin-induced pancreatic β-cells. |
2021-08-02 |
2023-08-13 |
rat |
| Aram Minas, Hatef Talebi, Morteza Taravat Ray, Mohammad Yari Eisalou, Marco G Alves, Mazdak Raz. Insulin treatment to type 1 male diabetic rats protects fertility by avoiding testicular apoptosis and cell cycle arrest. Gene. vol 799. 2021-07-30. PMID:34274473. |
insulin treatment to type 1 male diabetic rats protects fertility by avoiding testicular apoptosis and cell cycle arrest. |
2021-07-30 |
2023-08-13 |
rat |
| Aram Minas, Hatef Talebi, Morteza Taravat Ray, Mohammad Yari Eisalou, Marco G Alves, Mazdak Raz. Insulin treatment to type 1 male diabetic rats protects fertility by avoiding testicular apoptosis and cell cycle arrest. Gene. vol 799. 2021-07-30. PMID:34274473. |
herein, we hypothesized that insulin treatment to t1d rats protects testicular physiology by mediating mechanisms associated with apoptosis and cell cycle. |
2021-07-30 |
2023-08-13 |
rat |
| Ping Xu, Juan Xiao, Shuixia Ch. Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetic rats. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33724628. |
thus, we concluded that pl excellently rescued pancreatic β cells through mitigating hyperglycemia via dynamic insulin secretion, activating antioxidants, and inhibiting inflammation and apoptosis in the pancreatic and hepatic tissue of diabetic rats. |
2021-07-27 |
2023-08-13 |
rat |
| Nesrine S El Sayed, Esraa A Kandil, Mamdooh H Ghoneu. Probiotics Fermentation Technology, a Novel Kefir Product, Ameliorates Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer's Disease in Mice. Oxidative medicine and cellular longevity. vol 2021. 2021-07-27. PMID:34306309. |
gut microbiota dysfunction (dysbiosis) is implicated in the pathology of ad and is associated with several detrimental consequences, including neurotransmitter depletion, oxidative stress, inflammation, apoptosis, and insulin resistance, which all contribute to the onset of ad. |
2021-07-27 |
2023-08-13 |
mouse |
| Maha Ali, Marwa H Bakr, Lobna A Abdelzaher, Sally A Sayed, Vishal Mali, Ankit A Desai, Eman Radwa. Lisofylline mitigates cardiac inflammation in a mouse model of obesity through improving insulin secretion and activating cardiac AMPK signaling pathway. Cytokine. vol 138. 2021-07-26. PMID:33341003. |
we observed that lsf alleviated obesity-induced cardiac injury indirectly by improving both pancreatic β-cell function and insulin sensitivity, as well as, directly via upregulation of cardiac ampk expression and downregulation of cardiac inflammation and apoptosis. |
2021-07-26 |
2023-08-13 |
mouse |
| Gaofeng Qin, Yahan Wang, Zhenhong Liu, Lulu Mana, Shuaiyang Huang, Pengwen Wan. Shenzhiling oral solution promotes myelin repair through PI3K/Akt-mTOR pathway in STZ-induced SAD mice. 3 Biotech. vol 11. issue 7. 2021-07-24. PMID:34295606. |
a model of sporadic alzheimer's disease induced with bilateral intraventricular injection of streptozotocin leads to insulin resistance in the brain accompanied by memory decline, synaptic dysfunction, amyloid plaque deposition, oxidative stress, and neuronal apoptosis, all of which mimic the pathologies associated with sporadic alzheimer's disease. |
2021-07-24 |
2023-08-13 |
mouse |
| Marta Tesi, Marco Bugliani, Gianmarco Ferri, Mara Suleiman, Carmela De Luca, Emanuele Bosi, Matilde Masini, Vincenzo De Tata, Conny Gysemans, Francesco Cardarelli, Miriam Cnop, Decio L Eizirik, Piero Marchetti, Lorella Marsell. Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis. Biomolecules. vol 11. issue 2. 2021-07-23. PMID:33669901. |
pro-inflammatory cytokines induce insulin and glucagon double positive human islet cells that are resistant to apoptosis. |
2021-07-23 |
2023-08-13 |
human |
| Ling Tong, Weiliang Li, Ying Zhang, Fan Zhou, Yan Zhao, Linlin Zhao, Jing Liu, Zhirui Song, Mengchen Yu, Chengrui Zhou, Airong Y. Tacrolimus inhibits insulin release and promotes apoptosis of Min6 cells through the inhibition of the PI3K/Akt/mTOR pathway. Molecular medicine reports. vol 24. issue 3. 2021-07-19. PMID:34278483. |
tacrolimus inhibits insulin release and promotes apoptosis of min6 cells through the inhibition of the pi3k/akt/mtor pathway. |
2021-07-19 |
2023-08-13 |
mouse |
| Ling Tong, Weiliang Li, Ying Zhang, Fan Zhou, Yan Zhao, Linlin Zhao, Jing Liu, Zhirui Song, Mengchen Yu, Chengrui Zhou, Airong Y. Tacrolimus inhibits insulin release and promotes apoptosis of Min6 cells through the inhibition of the PI3K/Akt/mTOR pathway. Molecular medicine reports. vol 24. issue 3. 2021-07-19. PMID:34278483. |
in conclusion, tacrolimus decreased the activity and insulin secretion of pancreatic β cells and induced the apoptosis of islet β cells by inhibiting the mrna expression levels of pi3k, akt and mtor and reducing the phosphorylation of akt and mtor proteins in the pi3k/akt/mtor signaling pathway, which may ultimately lead to the occurrence of diabetes mellitus, and may be considered as one of the specific mechanisms of ptdm caused by tacrolimus. |
2021-07-19 |
2023-08-13 |
mouse |
| Tijun Wu, Jiahui Wang, Yaru Zhang, Yixue Shao, Xirui Li, Yuqing Guo, Wenyu Dong, Lin Wang, Fang Chen, Xiao Ha. Lentinan protects against pancreatic β-cell failure in chronic ethanol consumption-induced diabetic mice via enhancing β-cell antioxidant capacity. Journal of cellular and molecular medicine. 2021-07-13. PMID:33837638. |
in addition, lnt ameliorates chronic ethanol consumption-induced β-cell dysfunction, which is characterized by reduced insulin synthesis, defected insulin secretion and increased cell apoptosis. |
2021-07-13 |
2023-08-13 |
mouse |
| Li Zhou, Xiao Han, Wei Li, Ning Wang, Lan Yao, Yunhe Zhao, Liqun Zhan. N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2. Reproductive sciences (Thousand Oaks, Calif.). 2021-07-13. PMID:34254281. |
fto overexpression facilitated cell proliferation, hindered cell apoptosis, and induced insulin resistance in gcs. |
2021-07-13 |
2023-08-13 |
Not clear |
| Yu Bai, Qiang Du, Le Zhang, Ling Li, Lei Tang, Wei Zhang, Runyu Du, Ping Li, Ling L. Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells. The Journal of pharmacy and pharmacology. vol 73. issue 8. 2021-07-09. PMID:33779714. |
fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of rhoa/rho kinase/insulin/nuclear factor-κb signalling pathway in htr-8/svneo cells. |
2021-07-09 |
2023-08-13 |
Not clear |
| Rui Sun, Wanli Xue, Juzhen Zha. Hsa_circ_0054633 mediates apoptosis and insulin secretion in human pancreatic β cells through miR-409-3p/caspase-8 axis. Diabetes research and clinical practice. vol 176. 2021-07-06. PMID:33901624. |
hsa_circ_0054633 mediates apoptosis and insulin secretion in human pancreatic β cells through mir-409-3p/caspase-8 axis. |
2021-07-06 |
2023-08-13 |
human |
| Yuanyuan Zhang, Shuang Gao, Kaini Liang, Zhaozhao Wu, Xiaojun Yan, Wei Liu, Junyang Li, Bingjie Wu, Yanan D. Exendin-4 gene modification and microscaffold encapsulation promote self-persistence and antidiabetic activity of MSCs. Science advances. vol 7. issue 27. 2021-07-06. PMID:34215590. |
meanwhile, msc-ex-4-secreted exendin-4 suppressed senescence and apoptosis of pancreatic β cells through endocrine effects, while msc-ex-4-secreted bioactive factors (e.g., igfbp2 and apom) paracrinely augmented insulin sensitivity and decreased lipid accumulation in hepatocytes through pi3k-akt activation. |
2021-07-06 |
2023-08-13 |
mouse |
| Retracted: Salidroside from Rhodiola wallichiana var. cholaensis reverses insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Journal of food biochemistry. 2021-07-05. PMID:34165188. |
cholaensis reverses insulin resistance and stimulates the glp-1 secretion by alleviating ros-mediated activation of mapks signaling pathway and mitigating apoptosis. |
2021-07-05 |
2023-08-13 |
Not clear |