| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mengting Ke, Guangzhen He, Huawei Wang, Siyuan Cheng, Yancheng X. Sigma receptor knockdown augments dysfunction and apoptosis of beta cells induced by palmitate. Experimental biology and medicine (Maywood, N.J.). vol 246. issue 13. 2021-11-17. PMID:33715527. |
we showed sig-1r inactivation in min6 cells could not only decrease cell proliferation but also inhibit cell cycle, and this inhibitory effect on cell cycle might be achieved by regulating the foxm1/plk1/cenpa pathway. moreover, sig-1r deficiency increased min6 cells sensitivity to lipotoxicity, exaggerated palmitate (pa)-induced apoptosis, and impaired insulin secretion. |
2021-11-17 |
2023-08-13 |
Not clear |
| Mingtai Chen, Ying Xie, Shenglan Gong, Yunqiao Wang, Hao Yu, Tianran Zhou, Furong Huang, Xin Guo, Huanhuan Zhang, Ruolan Huang, Zhiyi Han, Yufeng Xing, Qiang Liu, Guangdong Tong, Hua Zho. Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis. Pharmacological research. vol 172. 2021-11-16. PMID:34450307. |
the mechanism of the nash progression is complex, including lipid metabolism dysfunction, insulin resistance, oxidative stress, inflammation, apoptosis, fibrosis and gut microbiota dysbiosis. |
2021-11-16 |
2023-08-13 |
Not clear |
| Krit Jaikumkao, Sasivimon Promsan, Laongdao Thongnak, Myat T Swe, Monruedee Tapanya, Khin T Htun, Suchart Kothan, Nuttawadee Intachai, Anusorn Lungkaphi. Dapagliflozin ameliorates pancreatic injury and activates kidney autophagy by modulating the AMPK/mTOR signaling pathway in obese rats. Journal of cellular physiology. vol 236. issue 9. 2021-11-10. PMID:33559163. |
the effects of dapagliflozin on insulin resistance, kidney autophagy, pancreatic oxidative stress, endoplasmic reticulum (er) stress, inflammation, and apoptosis in high-fat diet-induced obese rats were elucidated. |
2021-11-10 |
2023-08-13 |
rat |
| G F Bomfim, G K F Merighe, S A de Oliveira, J A Negra. Acute and chronic effects of cortisol on milk yield, the expression of key receptors, and apoptosis of mammary epithelial cells in Saanen goats. Journal of dairy science. 2021-11-10. PMID:34756435. |
the objective of this study was to investigate the relationship between cort, insulin, prolactin, growth hormone, and insulin-like growth factor-1 in milk as well as the effect of cort on the expression of receptors of insulin (insr), prolactin (prlr), growth hormone (ghr); we also studied the insulin-like growth factor-1 (igf1r), glucocorticoid (nr3c1), mineralocorticoid (nr3c2), b-cell lymphoma 2 (bcl2), bcl-2-like protein x (bax) genes, and the apoptosis rate of mammary epithelial cells of lactating saanen goats in vivo and in vitro. |
2021-11-10 |
2023-08-13 |
Not clear |
| Yu Bao, Zhengyan Zhao, Huihui Ga. Effect of hTIMP-1 overexpression in human umbilical cord mesenchymal stem cells on the repair of pancreatic islets in type-1 diabetic mice. Cell biology international. vol 45. issue 5. 2021-11-08. PMID:33404139. |
an in vitro coculture system of huc-mscs and streptozotocin-induced islets was established to examine the morphology, apoptosis, and insulin secretion of the cocultured islets. |
2021-11-08 |
2023-08-13 |
mouse |
| Mary Priyanka Udumula, Sureshbabu Mangali, Jaspreet Kalra, Deepika Dasari, Srashti Goyal, Vandana Krishna, Srivarsha Reddy Bollareddy, Dharamrajan Sriram, Arti Dhar, Audesh Bha. High fructose and streptozotocin induced diabetic impairments are mitigated by Indirubin-3-hydrazone via downregulation of PKR pathway in Wistar rats. Scientific reports. vol 11. issue 1. 2021-11-02. PMID:34155273. |
fibrosis was detected in insulin sensitive tissues and organs using sirius red and masson's trichrome staining and apoptosis by tunel assay. |
2021-11-02 |
2023-08-13 |
rat |
| Ana Elena Rodriguez-Rodriguez, Esteban Porrini, Armando Torre. Beta-Cell Dysfunction Induced by Tacrolimus: A Way to Explain Type 2 Diabetes? International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34638652. |
our group has shown that insulin resistance and glucolipotoxicity, without favouring the appearance of apoptosis, modify key nuclear factors for the maintenance of identity and functionality of β-cells. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yijiao Xu, Xiao Wei, Xingjia Li, Yu Chen, Xiaodong Mao, Guofang Chen, Chao Li. Cadmium inhibits signal transducer and activator of transcription 6 leading to pancreatic β cell apoptosis. Endocrine journal. 2021-11-01. PMID:34719525. |
in addition, cadmium suppressed cell viability and promoted apoptosis of min6 cells, downregulated insulin secretion and genesis of min6 cells under high glucose conditions, while inhibiting stat6. |
2021-11-01 |
2023-08-13 |
Not clear |
| Rita Marleta Dewi, Megawati Megawati, Lucia Dwi Antik. Antidiabetic properties of dietary chrysin: a cellular mechanism review. Mini reviews in medicinal chemistry. 2021-11-01. PMID:34720081. |
this review discussed the antidiabetic action of chrysin and its mechanisms, including targeting different mechanisms such as stimulation of insulin signaling, blockage of endoplasmic reticulum stress and oxidative damage, promotion of skeletal glucose uptake, as well as modulation of apoptosis and autophagy signaling. |
2021-11-01 |
2023-08-13 |
Not clear |
| Mahsa Taherizadeh, Masoud Khoshnia, Sedigheh Shams, Zahra Hesari, Hamidreza Joshaghan. Plasma Changes of Branched-Chain Amino Acid in Patients with Esophageal Cancer. Middle East journal of digestive diseases. vol 13. issue 1. 2021-10-30. PMID:34712438. |
background studies have indicated that branched amino acids play a crucial role in gene expression, protein metabolism, apoptosis, and restoration of hepatocytes and insulin resistance. |
2021-10-30 |
2023-08-13 |
Not clear |
| N B Chagay, G Ya Khayt, T M Vdovina, A A Shaforos. [Cystic fibrosis being a polyendocrine disease (Review)]. Problemy endokrinologii. vol 67. issue 2. 2021-10-28. PMID:34004101. |
subnormal cftr activity leads to stagnation of mucociliary clearance, inhibition of intestinal transport.in addition to exocrine disorders, cftr mutations are associated with a decrease in volume, mass, increased apoptosis of β-cells of the pancreas, a significant suppression of insulin exocytosis in response to stimulation with glucose and glucagon-like peptide-1, hyperglucagonemia against the background of a defect in the suppression of α-cell function by insulin, but a decrease in maximum capacity α-cells.deficiency and progressive decline in bone mineral density is an expected secondary manifestation of cf due to pancreatic exocrine insufficiency with malabsorption of nutrients and fat-soluble vitamins. |
2021-10-28 |
2023-08-13 |
Not clear |
| David Aguilar-Recarte, Xavier Palomer, Manuel Vázquez-Carrer. Uncovering the role of apolipoprotein C-III in insulin resistance. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis. vol 33. issue 2. 2021-10-27. PMID:33303217. |
the present review focuses on the key mechanisms by which apoc-iii could promote type 2 diabetes mellitus, including exacerbation of insulin resistance in skeletal muscle, activation of β-cell apoptosis, promotion of weight gain through its effects on white adipose tissue and hypothalamus, and attenuation of the beneficial effects of high-density lipoproteins on glucose metabolism. |
2021-10-27 |
2023-08-13 |
Not clear |
| Waseem El-Huneidi, Shabana Anjum, Abdul Khader Mohammed, Hema Unnikannan, Rania Saeed, Khuloud Bajbouj, Eman Abu-Gharbieh, Jalal Taneer. Copine 3 "CPNE3" is a novel regulator for insulin secretion and glucose uptake in pancreatic β-cells. Scientific reports. vol 11. issue 1. 2021-10-23. PMID:34667273. |
silencing of cpne3 in ins-1 cells impaired glucose-stimulated insulin secretion (gsis), insulin content and glucose uptake efficiency without affecting cell viability or inducing apoptosis. |
2021-10-23 |
2023-08-13 |
human |
| Oana Herlea-Pana, Venkateswararao Eeda, Ram Babu Undi, Hui-Ying Lim, Weidong Wan. Pharmacological Inhibition of Inositol-Requiring Enzyme 1α RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes. Frontiers in endocrinology. vol 12. 2021-10-23. PMID:34675883. |
these benefits were accompanied by a concomitant protection of functional β-cell mass, as shown by the suppression of β-cell apoptosis, increase in mature insulin production and reduction of proinsulin level. |
2021-10-23 |
2023-08-13 |
mouse |
| Ya-Fan Dai, Yu-Bang Shen, Shen-Tong Wang, Jia-Hua Zhang, Yu-Hong Su, Sheng-Chen Bao, Xiao-Yan Xu, Jia-Le L. RNA-Seq Transcriptome Analysis of the Liver and Brain of the Black Carp (Mylopharyngodon piceus) During Fasting. Marine biotechnology (New York, N.Y.). vol 23. issue 3. 2021-10-21. PMID:33864541. |
the kegg pathway analysis showed significant differences in expression of genes involved in metabolic and immune pathways, such as the insulin signaling pathway, pi3k-akt signaling pathway, camp signaling pathway, foxo signaling pathway, ampk signaling pathway, endocytosis, and apoptosis. |
2021-10-21 |
2023-08-13 |
Not clear |
| Y J Park, S Lee, T J Kieffer, G L Warnock, N Safikhan, M Speck, Z Hao, M Woo, L Marzba. Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide. Diabetologia. 2021-10-21. PMID:22301943. |
cultured hiapp-expressing mouse islets with fas deletion had similar amyloid levels, but lower caspase-3 activation and beta cell apoptosis, and a higher islet beta:alpha cell ratio and insulin response to glucose, compared with islets expressing fas and hiapp. |
2021-10-21 |
2023-08-12 |
mouse |
| Hai-Jun Li, Xiang-Ming Che, Wei Zhao, Shi-Cai He, Zheng-Liang Zhang, Rui Che. Diet-induced obesity potentiates the growth of gastric cancer in mice. Experimental and therapeutic medicine. vol 4. issue 4. 2021-10-21. PMID:23170114. |
both serum insulin and visfatin concentrations correlated positively with tumor proliferation and negatively with tumor apoptosis. |
2021-10-21 |
2023-08-12 |
mouse |
| Naoaki Sakata, Andre Obenaus, Nathaniel Chan, John Mace, Richard Chinnock, Eba Hathou. Factors affecting islet graft embolization in the liver of diabetic mice. Islets. vol 1. issue 1. 2021-10-20. PMID:20428330. |
liver specimens were stained for hematoxylin and eosin (necrosis), insulin and tunel (apoptosis). |
2021-10-20 |
2023-08-12 |
mouse |
| Danny Hung-Chieh Chou, Jeremy R Duvall, Baudouin Gerard, Haibo Liu, Bhaumik A Pandya, Byung-Chul Suh, Erin M Forbeck, Patrick Faloon, Bridget K Wagner, Lisa A Marcaurell. Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis. ACS medicinal chemistry letters. vol 2. issue 9. 2021-10-20. PMID:21927648. |
screening of this compound collection in a cell-based assay for the suppression of cytokine-induced beta-cell apoptosis resulted in the identification of a small-molecule suppressor capable of restoring glucose-stimulated insulin secretion in a rat beta-cell line. |
2021-10-20 |
2023-08-12 |
rat |
| Wiktoria Ratajczak, Sarah D Atkinson, Catriona Kell. A20 controls expression of beta-cell regulatory genes and transcription factors. Journal of molecular endocrinology. vol 67. issue 4. 2021-10-19. PMID:34463643. |
a20 deficiency increased apoptosis, impaired glucose-induced insulin secretion, and reduced expression of beta-cell regulatory genes and transcription factors. |
2021-10-19 |
2023-08-13 |
human |