| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Lin, Yin Jin, Xiang Hu, Erjiong Huang, Qihan Zh. AMPK/PGC-1α/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice. Biochemistry. Biokhimiia. vol 86. issue 11. 2021-12-15. PMID:34906049. |
effects of icariin on blood indices, glucose tolerance, insulin sensitivity, histopathological morphology, cell apoptosis, lipid accumulation, and ampk signaling were analyzed. |
2021-12-15 |
2023-08-13 |
mouse |
| Wei Lin, Yin Jin, Xiang Hu, Erjiong Huang, Qihan Zh. AMPK/PGC-1α/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice. Biochemistry. Biokhimiia. vol 86. issue 11. 2021-12-15. PMID:34906049. |
furthermore, icariin treatment (100-200 mg/kg) counteracted the nafld-reduced glucose tolerance and insulin sensitivity and modulated histopathological changes, cell apoptosis, and lipid accumulation in liver tissues. |
2021-12-15 |
2023-08-13 |
mouse |
| Bing Zhao, Zebao Zhen. Retracted: Insulin Growth Factor 1 Protects Neural Stem Cells Against Apoptosis Induced by Hypoxia Through Akt/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase (Akt/MAPK/ERK) Pathway in Hypoxia-Ishchemic Encephalopathy. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-12-14. PMID:34903709. |
retracted: insulin growth factor 1 protects neural stem cells against apoptosis induced by hypoxia through akt/mitogen-activated protein kinase/extracellular signal-regulated kinase (akt/mapk/erk) pathway in hypoxia-ishchemic encephalopathy. |
2021-12-14 |
2023-08-13 |
Not clear |
| Bing Zhao, Zebao Zhen. Retracted: Insulin Growth Factor 1 Protects Neural Stem Cells Against Apoptosis Induced by Hypoxia Through Akt/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase (Akt/MAPK/ERK) Pathway in Hypoxia-Ishchemic Encephalopathy. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-12-14. PMID:34903709. |
insulin growth factor 1 protects neural stem cells against apoptosis induced by hypoxia through akt/mitogen-activated protein kinase/extracellular signal-regulated kinase (akt/mapk/erk) pathway in hypoxia-ishchemic encephalopathy. |
2021-12-14 |
2023-08-13 |
Not clear |
| Nils Wierup, Mia Abels, Liliya Shcherbina, Andreas Lindqvis. The role of CART in islet biology. Peptides. 2021-12-13. PMID:34896575. |
cart increases insulin secretion, reduces glucagon secretion, and protects against beta cell death by reducing apoptosis and increasing proliferation. |
2021-12-13 |
2023-08-13 |
human |
| Youzi Dong, Quanlin Zhao, Yuguo Wan. Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy. Scientific reports. vol 11. issue 1. 2021-12-08. PMID:34593896. |
kegg pathway enrichment analysis shows that these targets are related to apoptosis, oxidative stress, inflammation, insulin resistance, etc. |
2021-12-08 |
2023-08-13 |
rat |
| Shifang Deng, Lei Yang, Ke Ma, Wei Bia. Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic β cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression. Bioengineered. vol 12. issue 2. 2021-12-08. PMID:34699323. |
the proliferation, apoptosis, and insulin secretion were measured using cck8, flow cytometry, and elisa, respectively. |
2021-12-08 |
2023-08-13 |
mouse |
| Shifang Deng, Lei Yang, Ke Ma, Wei Bia. Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic β cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression. Bioengineered. vol 12. issue 2. 2021-12-08. PMID:34699323. |
we found that hg+pa treatment reduced min6 cell viability, insulin secretion, and pdx1 expression and promoted min6 cell apoptosis. |
2021-12-08 |
2023-08-13 |
mouse |
| Syed Ali Raza Shah, M Israr Khan, Hira Jawaid, Urooj Qureshi, Zaheer Ul-Haq, M Rahman Hafizu. Nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through ERK1/2 signaling pathway in an animal model of apoptosis. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 29. issue 2. 2021-12-03. PMID:34495496. |
nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through erk1/2 signaling pathway in an animal model of apoptosis. |
2021-12-03 |
2023-08-13 |
Not clear |
| Syed Ali Raza Shah, M Israr Khan, Hira Jawaid, Urooj Qureshi, Zaheer Ul-Haq, M Rahman Hafizu. Nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through ERK1/2 signaling pathway in an animal model of apoptosis. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 29. issue 2. 2021-12-03. PMID:34495496. |
in this context, we investigated cinnamic acid in combination with nicotinamide on the regulation of insulin secretion and apoptosis in pancreatic β-cells using streptozotocin (stz)-induced apoptotic model in vivo. |
2021-12-03 |
2023-08-13 |
Not clear |
| Olga V Saik, Vadim V Klimonto. Hypoglycemia, Vascular Disease and Cognitive Dysfunction in Diabetes: Insights from Text Mining-Based Reconstruction and Bioinformatics Analysis of the Gene Networks. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830301. |
enrichment analysis of gene ontology (go) biological processes showed that the regulation of insulin secretion, glucose homeostasis, apoptosis, nitric oxide biosynthesis, and cell signaling are significantly enriched for hypoglycemia. |
2021-11-30 |
2023-08-13 |
Not clear |
| Chenyu Zhu, Rui Xu, Yuxin Li, Michael Andrade, Deng Ping Yi. Gastric bypass prevents diabetes in genetically modified mice and chemically induced diabetic mice. PloS one. vol 16. issue 10. 2021-11-29. PMID:34673835. |
remarkably, rygb improved liver steatosis, preserved the pancreatic β-cells and reduced β-cell apoptosis with increases in circulating insulin and adiponectin in young prediabetic bks-db/db mice. |
2021-11-29 |
2023-08-13 |
mouse |
| Joonyub Lee, Kun-Ho Yoo. Diabetes duration and obesity matter in autologous mesenchymal stem/stromal cell transplantation in type 2 diabetes patients. Journal of diabetes investigation. 2021-11-27. PMID:34837356. |
sustained increased insulin demand compels β cells into apoptosis and dedifferentiation resulting in decreased β cell mass. |
2021-11-27 |
2023-08-13 |
Not clear |
| Shanshan Song, Yang Yang, Jing He, Junfeng Tan. [miR-494 promotes islet β cell proliferation, inhibits apoptosis and increases insulin secretion by activating Wnt/β-catenin signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 11. 2021-11-24. PMID:34809740. |
[mir-494 promotes islet β cell proliferation, inhibits apoptosis and increases insulin secretion by activating wnt/β-catenin signaling pathway]. |
2021-11-24 |
2023-08-13 |
human |
| Shanshan Song, Yang Yang, Jing He, Junfeng Tan. [miR-494 promotes islet β cell proliferation, inhibits apoptosis and increases insulin secretion by activating Wnt/β-catenin signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 11. 2021-11-24. PMID:34809740. |
conclusion mir-494 promotes islet β cell proliferation, inhibits apoptosis and increases insulin secretion by activating wnt/β-catenin signaling pathway. |
2021-11-24 |
2023-08-13 |
human |
| Ya-Nan Xu, Zheng Wang, Shao-Kun Zhang, Jia-Rong Xu, Zhi-Xiong Pan, Xiao Wei, Hong-Hua Wen, Yan-Shi Luo, Mao-Jun Guo, Qun Zh. Low-grade elevation of palmitate and lipopolysaccharide synergistically induced β-cell damage via inhibition of neutral ceramidase. Molecular and cellular endocrinology. vol 539. 2021-11-23. PMID:34610358. |
this study aimed to investigate the synergistic effects of low-grade elevation of palmitate and lps on viability, apoptosis and insulin secretion in the rat pancreatic β-cell line ins-1 or islets and the role of sphingolipids in this process. |
2021-11-23 |
2023-08-13 |
rat |
| Ya-Nan Xu, Zheng Wang, Shao-Kun Zhang, Jia-Rong Xu, Zhi-Xiong Pan, Xiao Wei, Hong-Hua Wen, Yan-Shi Luo, Mao-Jun Guo, Qun Zh. Low-grade elevation of palmitate and lipopolysaccharide synergistically induced β-cell damage via inhibition of neutral ceramidase. Molecular and cellular endocrinology. vol 539. 2021-11-23. PMID:34610358. |
we showed that low-grade elevation of palmitate or lps alone did not affect the viability, apoptosis, glucose-stimulated insulin secretion (gsis) or intracellular insulin content of ins-1 cells or islets, while the combination of the two synergistically inhibited cell viability, induced apoptosis and decreased basal insulin secretion in ins-1 cells or islets. |
2021-11-23 |
2023-08-13 |
rat |
| Xianxuan Wang, Hongshu Sui, Yanping Su, Shang Zha. Protective effects of sodium selenite on insulin secretion and diabetic retinopathy in rats with type 1 diabetes mellitus. Pakistan journal of pharmaceutical sciences. vol 34. issue 5. 2021-11-22. PMID:34803009. |
of note, the insulin secretion in pancreatic β cells as well as serum insulin levels were strikingly heightened while apoptosis level of pancreatic tissues was lowered in the high-sel group (vs. stz and low-sel groups). |
2021-11-22 |
2023-08-13 |
rat |
| Li Li, Yun Sun, Yinong Zhang, Weixi Wang, Cuifang Y. Mutant Huntingtin Impairs Pancreatic β-cells by Recruiting IRS-2 and Disturbing the PI3K/AKT/FoxO1 Signaling Pathway in Huntington's Disease. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:34331233. |
in addition, 160q cells were more prone to apoptosis and exhibited deficient glucose-stimulated insulin expression and secretion. |
2021-11-19 |
2023-08-13 |
mouse |
| Sule Cilekar, Selvihan Beysel, Savas Karatas, Aydin Balci, Kursad Akaslan, Ali Unc. Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome. Scientific reports. vol 11. issue 1. 2021-11-18. PMID:34764367. |
circulating soluble tumor necrosis factor (tnf)-like weak inducer of apoptosis (stweak) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. |
2021-11-18 |
2023-08-13 |
Not clear |