| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinwang Li, Siyu Xie, Wendi Ten. Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis. Nutrients. vol 14. issue 1. 2022-01-11. PMID:35010950. |
moreover, sfa treatment reduced hfd-induced body weight gain, alleviated insulin resistance, decreased serum tg, total cholesterol (tc), and alanine aminotransferase (alt) levels, and prevented lipid deposition and apoptosis in the liver. |
2022-01-11 |
2023-08-13 |
mouse |
| Francesca Romana Prandi, Isabella Evangelista, Domenico Sergi, Alberto Palazzuoli, Francesco Rome. Mechanisms of cardiac dysfunction in diabetic cardiomyopathy: molecular abnormalities and phenotypical variants. Heart failure reviews. 2022-01-10. PMID:35001338. |
metabolic alterations such as hyperglycemia, insulin resistance, hyperinsulinemia, and increased metabolism of free fatty acids result in oxidative stress, inflammation, advanced glycation end products formation, abnormalities in calcium homeostasis, and apoptosis that are responsible for structural remodeling. |
2022-01-10 |
2023-08-13 |
Not clear |
| Mohammad Fareed Khan, Alpana Mathur, Vivek Kumar Pandey, Poonam Kakka. Endoplasmic reticulum stress-dependent activation of TRB3-FoxO1 signaling pathway exacerbates hyperglycemic nephrotoxicity: Protection accorded by naringenin. European journal of pharmacology. 2022-01-09. PMID:34998792. |
naringenin also reduced insulin resistance, apoptosis and glycogen accumulation along with enhancement of glucose tolerance in diabetic rats. |
2022-01-09 |
2023-08-13 |
rat |
| Yaodong Wang, Haitao Yu, Jinchun H. Involvement of the Hippo Pathway in the Development of Diabetes. Discovery medicine. vol 31. issue 162. 2021-12-29. PMID:34965370. |
however, various disorders and dysfunctions caused by disruptions in hippo signaling harm parental pancreatic islet cells, promote apoptosis of parental cells, and impair insulin secretion -- leading to the occurrence of diabetes. |
2021-12-29 |
2023-08-13 |
Not clear |
| Selvaraj Jayaraman, Anitha Roy, Srinivasan Vengadassalapathy, Ramya Sekar, Vishnu Priya Veeraraghavan, Ponnulakshmi Rajagopal, Gayathri Rengasamy, Raktim Mukherjee, Durairaj Sekar, Reji Manjunatha. An Overview on the Therapeutic Function of Foods Enriched with Plant Sterols in Diabetes Management. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34943006. |
at the molecular level, these changes induce apoptosis in pancreatic cells and hence lead to insulin insufficiency. |
2021-12-24 |
2023-08-13 |
Not clear |
| Wenjing Zai, Wei Chen, Hongrui Liu, Dianwen J. Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications. Biomedicines. vol 9. issue 12. 2021-12-24. PMID:34944732. |
emerging evidence suggests that il-22 plays important protective functions against nafld by improving insulin sensitivity, modulating lipid metabolism, relieving oxidative and endoplasmic reticulum (er) stress, and inhibiting apoptosis. |
2021-12-24 |
2023-08-13 |
Not clear |
| Ruojia Ma, Yike Zhan, Yamei Zhang, Liangan Wu, Xing Wang, Ming Gu. Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice. Drug development research. 2021-12-20. PMID:34927282. |
sch b ameliorated insulin resistance and lipid accumulation under high glucose conditions, which was partly associated with its inhibition of apoptosis and anti-inflammatory actions. |
2021-12-20 |
2023-08-13 |
mouse |
| Kalie L Tommerdahl, Kristen J Nadeau, Petter Bjornsta. Mechanisms of Cardiorenal Protection of Glucagon-Like Peptide-1 Receptor Agonists. Advances in chronic kidney disease. vol 28. issue 4. 2021-12-19. PMID:34922690. |
glucagon-like peptide-1 (glp-1) receptor agonists (ras), incretin hormones that stimulate postprandial insulin secretion, serve as a promising avenue for treatment of t2d as they result in a variety of antihyperglycemic effects including increased endogenous insulin secretion, decreased gluconeogenesis, inhibition of pancreatic α-cell glucagon production, decreased pancreatic β-cell apoptosis, and increased β-cell proliferation. |
2021-12-19 |
2023-08-13 |
Not clear |
| Wei Lin, Yin Jin, Xiang Hu, Erjiong Huang, Qihan Zh. AMPK/PGC-1α/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice. Biochemistry. Biokhimiia. vol 86. issue 11. 2021-12-15. PMID:34906049. |
effects of icariin on blood indices, glucose tolerance, insulin sensitivity, histopathological morphology, cell apoptosis, lipid accumulation, and ampk signaling were analyzed. |
2021-12-15 |
2023-08-13 |
mouse |
| Wei Lin, Yin Jin, Xiang Hu, Erjiong Huang, Qihan Zh. AMPK/PGC-1α/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice. Biochemistry. Biokhimiia. vol 86. issue 11. 2021-12-15. PMID:34906049. |
furthermore, icariin treatment (100-200 mg/kg) counteracted the nafld-reduced glucose tolerance and insulin sensitivity and modulated histopathological changes, cell apoptosis, and lipid accumulation in liver tissues. |
2021-12-15 |
2023-08-13 |
mouse |
| Bing Zhao, Zebao Zhen. Retracted: Insulin Growth Factor 1 Protects Neural Stem Cells Against Apoptosis Induced by Hypoxia Through Akt/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase (Akt/MAPK/ERK) Pathway in Hypoxia-Ishchemic Encephalopathy. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-12-14. PMID:34903709. |
retracted: insulin growth factor 1 protects neural stem cells against apoptosis induced by hypoxia through akt/mitogen-activated protein kinase/extracellular signal-regulated kinase (akt/mapk/erk) pathway in hypoxia-ishchemic encephalopathy. |
2021-12-14 |
2023-08-13 |
Not clear |
| Bing Zhao, Zebao Zhen. Retracted: Insulin Growth Factor 1 Protects Neural Stem Cells Against Apoptosis Induced by Hypoxia Through Akt/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase (Akt/MAPK/ERK) Pathway in Hypoxia-Ishchemic Encephalopathy. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-12-14. PMID:34903709. |
insulin growth factor 1 protects neural stem cells against apoptosis induced by hypoxia through akt/mitogen-activated protein kinase/extracellular signal-regulated kinase (akt/mapk/erk) pathway in hypoxia-ishchemic encephalopathy. |
2021-12-14 |
2023-08-13 |
Not clear |
| Nils Wierup, Mia Abels, Liliya Shcherbina, Andreas Lindqvis. The role of CART in islet biology. Peptides. 2021-12-13. PMID:34896575. |
cart increases insulin secretion, reduces glucagon secretion, and protects against beta cell death by reducing apoptosis and increasing proliferation. |
2021-12-13 |
2023-08-13 |
human |
| Youzi Dong, Quanlin Zhao, Yuguo Wan. Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy. Scientific reports. vol 11. issue 1. 2021-12-08. PMID:34593896. |
kegg pathway enrichment analysis shows that these targets are related to apoptosis, oxidative stress, inflammation, insulin resistance, etc. |
2021-12-08 |
2023-08-13 |
rat |
| Shifang Deng, Lei Yang, Ke Ma, Wei Bia. Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic β cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression. Bioengineered. vol 12. issue 2. 2021-12-08. PMID:34699323. |
the proliferation, apoptosis, and insulin secretion were measured using cck8, flow cytometry, and elisa, respectively. |
2021-12-08 |
2023-08-13 |
mouse |
| Shifang Deng, Lei Yang, Ke Ma, Wei Bia. Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic β cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression. Bioengineered. vol 12. issue 2. 2021-12-08. PMID:34699323. |
we found that hg+pa treatment reduced min6 cell viability, insulin secretion, and pdx1 expression and promoted min6 cell apoptosis. |
2021-12-08 |
2023-08-13 |
mouse |
| Syed Ali Raza Shah, M Israr Khan, Hira Jawaid, Urooj Qureshi, Zaheer Ul-Haq, M Rahman Hafizu. Nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through ERK1/2 signaling pathway in an animal model of apoptosis. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 29. issue 2. 2021-12-03. PMID:34495496. |
nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through erk1/2 signaling pathway in an animal model of apoptosis. |
2021-12-03 |
2023-08-13 |
Not clear |
| Syed Ali Raza Shah, M Israr Khan, Hira Jawaid, Urooj Qureshi, Zaheer Ul-Haq, M Rahman Hafizu. Nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through ERK1/2 signaling pathway in an animal model of apoptosis. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 29. issue 2. 2021-12-03. PMID:34495496. |
in this context, we investigated cinnamic acid in combination with nicotinamide on the regulation of insulin secretion and apoptosis in pancreatic β-cells using streptozotocin (stz)-induced apoptotic model in vivo. |
2021-12-03 |
2023-08-13 |
Not clear |
| Olga V Saik, Vadim V Klimonto. Hypoglycemia, Vascular Disease and Cognitive Dysfunction in Diabetes: Insights from Text Mining-Based Reconstruction and Bioinformatics Analysis of the Gene Networks. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830301. |
enrichment analysis of gene ontology (go) biological processes showed that the regulation of insulin secretion, glucose homeostasis, apoptosis, nitric oxide biosynthesis, and cell signaling are significantly enriched for hypoglycemia. |
2021-11-30 |
2023-08-13 |
Not clear |
| Chenyu Zhu, Rui Xu, Yuxin Li, Michael Andrade, Deng Ping Yi. Gastric bypass prevents diabetes in genetically modified mice and chemically induced diabetic mice. PloS one. vol 16. issue 10. 2021-11-29. PMID:34673835. |
remarkably, rygb improved liver steatosis, preserved the pancreatic β-cells and reduced β-cell apoptosis with increases in circulating insulin and adiponectin in young prediabetic bks-db/db mice. |
2021-11-29 |
2023-08-13 |
mouse |