| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qianqian Cao, Xiaojie Zhang, Fengfeng Xie, Yangping Li, Feng Li. Long-noncoding RNA HOXA transcript at the distal tip ameliorates the insulin resistance and hepatic gluconeogenesis in mice with gestational diabetes mellitus via the microRNA-423-5p/wingless-type MMTV integration site family member 7A axis. Bioengineered. vol 13. issue 5. 2022-06-01. PMID:35642360. |
the enriched hottip or silenced mir-423-5p alleviated the levels of gdm-relatedbiochemical indices, enhanced the insulin homeostasis, elevated glut2 expression and decreased g-6-pase and pepck expression, mitigated the pathological changes of pancreatic tissues, and hindered the apoptosis of pancreatic cells. |
2022-06-01 |
2023-08-13 |
mouse |
| Hadi Rajabi, Mahdi Ahmadi, Somayeh Aslani, Shirin Saberianpour, Reza Rahbarghaz. Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes. Advanced pharmaceutical bulletin. vol 12. issue 2. 2022-05-27. PMID:35620334. |
exendin-4 is approximately similar to glucagon-like peptide, thus it can bind to the glucagon-like peptide-1 receptor (glp-1r) and activated different signaling pathways that are involved in various bioactivities such as apoptosis, insulin secretion and inactivation of microglial. |
2022-05-27 |
2023-08-13 |
Not clear |
| Ioanna A Anastasiou, Ioanna Eleftheriadou, Anastasios Tentolouris, Panagiotis Sarantis, Andriani Angelopoulou, Athanasia Katsaouni, Iordanis Mourouzis, Michalis V Karamouzis, Vasilios Gorgoulis, Constantinos Pantos, Nikolaos Tentolouri. Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta-TC-6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide. Journal of biochemical and molecular toxicology. 2022-05-20. PMID:35593412. |
then, we measured apoptosis, cell cycle, and insulin levels. |
2022-05-20 |
2023-08-13 |
Not clear |
| Genaro G Ortiz, Miguel Huerta, Héctor A González-Usigli, Erandis D Torres-Sánchez, Daniela Lc Delgado-Lara, Fermín P Pacheco-Moisés, Mario A Mireles-Ramírez, Blanca Mg Torres-Mendoza, Roxana I Moreno-Cih, Irma E Velázquez-Brizuel. Cognitive disorder and dementia in type 2 diabetes mellitus. World journal of diabetes. vol 13. issue 4. 2022-05-18. PMID:35582669. |
recent evidence shows that deleting brain insulin receptors leads to mild obesity and insulin resistance without influencing brain size and apoptosis development. |
2022-05-18 |
2023-08-13 |
mouse |
| Rebekah J Nicholson, Marie K Norris, Annelise M Poss, William L Holland, Scott A Summer. The Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease. Annual review of nutrition. 2022-05-18. PMID:35584813. |
sphingolipids such as ceramides are among the most deleterious and bioactive metabolites that accrue, as they participate in selective insulin resistance, dyslipidemia, oxidative stress and apoptosis. |
2022-05-18 |
2023-08-13 |
Not clear |
| Fadi W Adel, Ye Zheng, Siu-Hin Wan, Christie Greason, Shuchong Pan, Syed Ameenuddin, Horng H Che. Insulin Therapy is Associated With Increased Myocardial Interstitial Fibrosis and Cardiomyocyte Apoptosis in a Rodent Model of Experimental Diabetes. Frontiers in physiology. vol 13. 2022-05-16. PMID:35574440. |
insulin therapy is associated with increased myocardial interstitial fibrosis and cardiomyocyte apoptosis in a rodent model of experimental diabetes. |
2022-05-16 |
2023-08-13 |
Not clear |
| Dongjuan Wang, Kun Liu, Jinyan Zhong, Xin Li, Jie Zhang, Gongxin Wang, Ni Li, Tianwen Li, Harvey Davis, Ibrahim El-Gaby, Guoliang Hao, Honghua Ye, Dan L. Molecular Correlates of Early Onset of Diabetic Cardiomyopathy: Possible Therapeutic Targets. Oxidative medicine and cellular longevity. vol 2022. 2022-04-25. PMID:35464763. |
rna-sequencing analysis of ventricular tissue revealed a differential transcriptome profile and abnormal activation of pathways involved in fatty acid metabolism, oxidative phosphorylation, cardiac structure and function, insulin resistance, calcium signalling, apoptosis, and tnf signalling. |
2022-04-25 |
2023-08-13 |
human |
| Jiawen Cui, Xinyi Kang, Yanxing Shan, Mingjin Zhang, Ying Gao, Wei Wu, Liping Che. miR-1227-3p participates in the development of fetal growth restriction via regulating trophoblast cell proliferation and apoptosis. Scientific reports. vol 12. issue 1. 2022-04-18. PMID:35430618. |
taken together, mir-1227-3p may participate in the development of fgr via regulating trophoblast cell proliferation and apoptosis by targeting genes involved in the insulin pathway. |
2022-04-18 |
2023-08-13 |
Not clear |
| Waseem El-Huneidi, Shabana Anjum, Mohamed A Saleh, Yasser Bustanji, Eman Abu-Gharbieh, Jalal Taneer. Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake. Molecules (Basel, Switzerland). vol 27. issue 7. 2022-04-12. PMID:35408495. |
carnosic acid protects ins-1 β-cells against streptozotocin-induced damage by inhibiting apoptosis and improving insulin secretion and glucose uptake. |
2022-04-12 |
2023-08-13 |
Not clear |
| Ashish Rao Sathyanarayana, Chung-Kuang Lu, Chih-Chuang Liaw, Chia-Chuan Chang, Hsin-Ying Han, Brian D Green, Wei-Jan Huang, Cheng Huang, Wen-Di He, Lin-Chien Lee, Hui-Kang Li. 1,2,3,4,6-Penta-O-galloyl-d-glucose Interrupts the Early Adipocyte Lifecycle and Attenuates Adiposity and Hepatic Steatosis in Mice with Diet-Induced Obesity. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409415. |
pgg mainly induces apoptosis, and this effect is independent of its insulin mimetic action. |
2022-04-12 |
2023-08-13 |
mouse |
| Roma Patel, Nishant Parmar, Nirali Rathwa, Sayantani Pramanik Palit, Yansui Li, Adolfo Garcia-Ocaña, Rasheedunnisa Begu. A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets. Biochimica et biophysica acta. Molecular cell research. 2022-04-01. PMID:35364117. |
further, in both the models, combination therapy reduces fbg levels, increases plasma insulin levels and glucose tolerance and promotes β-cell proliferation, β-cell transdifferentiation, and reduces β-cell apoptosis. |
2022-04-01 |
2023-08-13 |
mouse |
| Yaeni Kim, Ji Hee Lim, Eun Nim Kim, Yu Ah Hong, Hun-Jun Park, Sungjin Chung, Bum Soon Choi, Yong-Soo Kim, Ji Yong Park, Hye Won Kim, Cheol Whee Par. Adiponectin receptor agonist ameliorates cardiac lipotoxicity via enhancing ceramide metabolism in type 2 diabetic mice. Cell death & disease. vol 13. issue 3. 2022-03-30. PMID:35351872. |
adiporon ameliorated insulin resistance, fibrosis, m1-dominant inflammation, and apoptosis in association with reduced accumulations of free fatty acid, triglycerides, and tlr4-related ceramide in the heart. |
2022-03-30 |
2023-08-13 |
mouse |
| Jing Zhang, Quansheng Fen. Pharmacological Effects and Molecular Protective Mechanisms of Astragalus Polysaccharides on Nonalcoholic Fatty Liver Disease. Frontiers in pharmacology. vol 13. 2022-03-21. PMID:35308224. |
lipid metabolism, insulin resistance (ir), oxidative stress (os), endoplasmic reticulum stress (ers), inflammation, fibrosis, autophagy, and apoptosis are some of the pathogenic pathways involved. |
2022-03-21 |
2023-08-13 |
Not clear |
| Junyuan Deng, Yujie Guo, Jiali Du, Jichun Gu, Lei Kong, Boan Tao, Ji Li, Deliang F. The Intricate Crosstalk Between Insulin and Pancreatic Ductal Adenocarcinoma: A Review From Clinical to Molecular. Frontiers in cell and developmental biology. vol 10. 2022-03-07. PMID:35252207. |
on the other hand, insulin promotes pancreatic cancer initiation and sustains pda development by eliciting tumorigenic inflammation, regulating lipid and glucose metabolic reprogram, overcoming apoptosis through the crosstalk with igf-1, stimulating cancer metastasis, and activating tumor microenvironment formation (inflammation, fibrosis, and angiogenesis). |
2022-03-07 |
2023-08-13 |
Not clear |
| Mingyu Zou, Jinhua Chi, Zhiwen Jiang, Wei Zhang, Huiwen Hu, Ruibao Ju, Chenqi Liu, Tianjiao Xu, Shuo Wang, Zhilong Feng, Wanshun Liu, Baoqin Ha. Functional thermosensitive hydrogels based on chitin as RIN-m5F cell carrier for the treatment of diabetes. International journal of biological macromolecules. 2022-03-05. PMID:35247418. |
on the other hand, n-acetylglucosamine (nag) and carboxymethyl chitosan (cmcs) provided favorable capacity for promoting cell proliferation, delaying cell apoptosis, and facilitating the insulin secretion of rat pancreatic beta cells (rin-m5f) in three-dimensional culture. |
2022-03-05 |
2023-08-13 |
mouse |
| Lianbin Xu, Xueyan Lin, Xiuli Li, Zhiyong Hu, Qiuling Hou, Yun Wang, Zhonghua Wan. Integration of transcriptomics and metabolomics provides metabolic and functional insights into reduced insulin secretion in MIN6 β-cells exposed to deficient and excessive arginine. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 3. 2022-02-24. PMID:35199385. |
this descriptive bioinformatics analysis suggested that the disturbed carbohydrate, lipid, and amino acid metabolisms, as well as the increased apoptosis and elevated oxidative stress, contributed to the reduced insulin secretion and lower gsis in β-cells induced by la or ha treatments, while some underlying mechanisms need to be further explored. |
2022-02-24 |
2023-08-13 |
Not clear |
| Mengdi Wang, Zhuoran Zhang, Qingqing Huo, Maolong Wang, Yong Sun, Hongling Liu, Jing Chang, Bin He, Yan Lian. Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy. ACS applied materials & interfaces. 2022-02-24. PMID:35199981. |
as compared to free mgf, mgf/gdpp nanoparticles appeared to be more concentrated in the pancreas, with better blood glucose and glucose tolerance, enhanced insulin levels, increased β-cell proliferation, reduced β-cell apoptosis, and islet repair in vivo. |
2022-02-24 |
2023-08-13 |
Not clear |
| Jeffrey O Adoga, Mahendra L Channa, Anand Nada. Type-2 diabetic rat heart: The effect of kolaviron on mTOR-1, P70S60K, PKC-α, NF-kB, SOD-2, NRF-2, eNOS, AKT-1, ACE, and P38 MAPK gene expression profile. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 148. 2022-02-24. PMID:35202911. |
this study determined the effect of kolaviron on the expression profile of genes associated with the insulin signaling pathway and involved in regulating glucose and lipid metabolism, oxidative stress, inflammation, vascular functions, pro-survival and the apoptosis pathway in the heart of type-2 diabetic rats. |
2022-02-24 |
2023-08-13 |
rat |
| Zhiyi Shen, Yongkai Yu, Yuqian Yang, Xiao Xiao, Tong Sun, Xiaoai Chang, Wei Tang, Yunxia Zhu, Xiao Ha. miR-25 and miR-92b regulate insulin biosynthesis and pancreatic β-cell apoptosis. Endocrine. 2022-02-23. PMID:35194770. |
mir-25 and mir-92b regulate insulin biosynthesis and pancreatic β-cell apoptosis. |
2022-02-23 |
2023-08-13 |
Not clear |
| Yue L. Gypenoside A attenuates dysfunction of pancreatic β cells by activating PDX1 signal transduction via the inhibition of miR-150-3p both in vivo and in vitro. Journal of biochemical and molecular toxicology. 2022-02-22. PMID:35191145. |
hfd administration suppressed glucose tolerance, delayed insulin release, and induced insulin resistance and pancreas apoptosis in mice, which was indicative of the dysfunction of β pancreatic cells. |
2022-02-22 |
2023-08-13 |
mouse |