| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shengyang Fu, Shu Zhao, Huili Chen, Weitao Yang, Xiaohuan Xia, Xiaonan Xu, Zhanping Liang, Xuanran Feng, Zhuo Wang, Pu Ai, Lu Ding, Qingyuan Cai, Yi Wang, Yanyan Zhang, Jie Zhu, Bingbo Zhang, Jialin C Zhen. Insulin-incubated palladium clusters promote recovery after brain injury. Journal of nanobiotechnology. vol 20. issue 1. 2022-06-25. PMID:35752849. |
we found that the positive therapeutic effects of the pd@insulin clusters were mainly attributed to their ros-scavenging ability, as they inhibited excessive neuroinflammation, reduced cell apoptosis, and prevented neuronal loss. |
2022-06-25 |
2023-08-14 |
mouse |
| Hu Zhang, Ji-Ling Liang, Qiu-Yue Wu, Jin-Xiu Li, Ya Liu, Liang-Wen Wu, Jie-Lun Huang, Xiao-Wen Wu, Ming-Hui Wang, Ning Che. Swimming Suppresses Cognitive Decline of HFD-Induced Obese Mice through Reversing Hippocampal Inflammation, Insulin Resistance, and BDNF Level. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745162. |
in the present study, the obesity-induced cognition-declined model was established using 4-week-old mice continuously fed with a high-fat diet (hfd) for 12 weeks, and then the model mice were subjected to an 8-week swimming intervention and corresponding evaluation of relevant indicators, including cognitive capacity, inflammation, insulin signal pathway, brain-derived neurotrophic factor (bndf), and apoptosis, for exploring potential regulatory mechanisms. |
2022-06-24 |
2023-08-14 |
mouse |
| Wendy M McKimpson, Richard N Kitsi. Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets. STAR protocols. vol 3. issue 2. 2022-06-20. PMID:35719268. |
type 2 diabetes is mediated by insulin resistance and pancreatic β-cell failure, the latter reflecting a combination of β-cell dysfunction, dedifferentiation, and apoptosis. |
2022-06-20 |
2023-08-14 |
mouse |
| Constanza Salinas, Gabriel Espinosa, Natalia Morales, Claudio Henríquez, Gabriel Morán, Gonzalo Gajardo, Rafael A Burgos, Benjamin Ubert. Evaluation of peripheral blood polymorphonuclear cell functions after an oral carbohydrate overload in obese and insulin dysregulated horses. Veterinary immunology and immunopathology. vol 250. 2022-06-18. PMID:35716440. |
this study evaluated the effect of acute induced transient hyperglycemia on apoptosis, phagocytosis and oxidative burst activity of peripheral blood polymorphonuclear cells (pmn) of lean and obese adult horses with or without insulin dysregulation. |
2022-06-18 |
2023-08-14 |
Not clear |
| Xian Zhang, Songyuan Luo, Minjie Wang, Qin Huang, Wenqian Fang, Jie Li, Tianxiao Liu, Yuanyuan Zhang, Zhiyong Deng, Cong-Lin Liu, Shuling Guan, Julio E Ayala, Richard A Flavell, Rohit N Kulkarni, Peter Libby, Junli Guo, Zhangsuo Liu, Guo-Ping Sh. IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. Developmental cell. 2022-06-08. PMID:35675813. |
the deficiency of these receptors reduces islet size, β cell proliferation, and insulin secretion but increases β cell apoptosis and exocrine macrophage accumulation after diet-induced glucose intolerance or streptozotocin-induced hyperglycemia. |
2022-06-08 |
2023-08-14 |
mouse |
| Xian Zhang, Songyuan Luo, Minjie Wang, Qin Huang, Wenqian Fang, Jie Li, Tianxiao Liu, Yuanyuan Zhang, Zhiyong Deng, Cong-Lin Liu, Shuling Guan, Julio E Ayala, Richard A Flavell, Rohit N Kulkarni, Peter Libby, Junli Guo, Zhangsuo Liu, Guo-Ping Sh. IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. Developmental cell. 2022-06-08. PMID:35675813. |
the β cell-selective depletion of the ncc or acinar-cell-selective il18r depletion reduces glucose tolerance and insulin sensitivity with impaired β cell proliferation, enhanced β cell apoptosis and macrophage expansion, and inflammation in mouse hyperglycemic pancreas. |
2022-06-08 |
2023-08-14 |
mouse |
| Xing-Xing Lai, Cui-Ping Zhang, Yu-Xin Wu, Yang Yang, Ming-Qing Zhang, Wei-Jian Qin, Rui-Xuan Wang, Hu Sh. Comparative transcriptome analysis reveals physiological responses in liver tissues of Epinephelus coioides under acute hypoxia stress. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 43. 2022-06-02. PMID:35653833. |
enrichment analysis using the gene ontology database showed that the degs were mainly enriched for functions related to cell apoptosis signaling pathways, insulin resistance, antioxidant enzymes, and glycolysis/gluconeogenesis signaling pathways. |
2022-06-02 |
2023-08-14 |
Not clear |
| Chae-Gwan Kong, Jong-Beom Park, Seung Hyo Ki. Inhibitory Effect of Insulin Treatment on Apoptosis of Intervertebral Disc Cells in a Streptozotocin-Induced Diabetic Rat Model. Asian spine journal. 2022-06-02. PMID:35654105. |
inhibitory effect of insulin treatment on apoptosis of intervertebral disc cells in a streptozotocin-induced diabetic rat model. |
2022-06-02 |
2023-08-14 |
rat |
| Qianqian Cao, Xiaojie Zhang, Fengfeng Xie, Yangping Li, Feng Li. Long-noncoding RNA HOXA transcript at the distal tip ameliorates the insulin resistance and hepatic gluconeogenesis in mice with gestational diabetes mellitus via the microRNA-423-5p/wingless-type MMTV integration site family member 7A axis. Bioengineered. vol 13. issue 5. 2022-06-01. PMID:35642360. |
the enriched hottip or silenced mir-423-5p alleviated the levels of gdm-relatedbiochemical indices, enhanced the insulin homeostasis, elevated glut2 expression and decreased g-6-pase and pepck expression, mitigated the pathological changes of pancreatic tissues, and hindered the apoptosis of pancreatic cells. |
2022-06-01 |
2023-08-13 |
mouse |
| Hadi Rajabi, Mahdi Ahmadi, Somayeh Aslani, Shirin Saberianpour, Reza Rahbarghaz. Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes. Advanced pharmaceutical bulletin. vol 12. issue 2. 2022-05-27. PMID:35620334. |
exendin-4 is approximately similar to glucagon-like peptide, thus it can bind to the glucagon-like peptide-1 receptor (glp-1r) and activated different signaling pathways that are involved in various bioactivities such as apoptosis, insulin secretion and inactivation of microglial. |
2022-05-27 |
2023-08-13 |
Not clear |
| Ioanna A Anastasiou, Ioanna Eleftheriadou, Anastasios Tentolouris, Panagiotis Sarantis, Andriani Angelopoulou, Athanasia Katsaouni, Iordanis Mourouzis, Michalis V Karamouzis, Vasilios Gorgoulis, Constantinos Pantos, Nikolaos Tentolouri. Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta-TC-6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide. Journal of biochemical and molecular toxicology. 2022-05-20. PMID:35593412. |
then, we measured apoptosis, cell cycle, and insulin levels. |
2022-05-20 |
2023-08-13 |
Not clear |
| Genaro G Ortiz, Miguel Huerta, Héctor A González-Usigli, Erandis D Torres-Sánchez, Daniela Lc Delgado-Lara, Fermín P Pacheco-Moisés, Mario A Mireles-Ramírez, Blanca Mg Torres-Mendoza, Roxana I Moreno-Cih, Irma E Velázquez-Brizuel. Cognitive disorder and dementia in type 2 diabetes mellitus. World journal of diabetes. vol 13. issue 4. 2022-05-18. PMID:35582669. |
recent evidence shows that deleting brain insulin receptors leads to mild obesity and insulin resistance without influencing brain size and apoptosis development. |
2022-05-18 |
2023-08-13 |
mouse |
| Rebekah J Nicholson, Marie K Norris, Annelise M Poss, William L Holland, Scott A Summer. The Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease. Annual review of nutrition. 2022-05-18. PMID:35584813. |
sphingolipids such as ceramides are among the most deleterious and bioactive metabolites that accrue, as they participate in selective insulin resistance, dyslipidemia, oxidative stress and apoptosis. |
2022-05-18 |
2023-08-13 |
Not clear |
| Fadi W Adel, Ye Zheng, Siu-Hin Wan, Christie Greason, Shuchong Pan, Syed Ameenuddin, Horng H Che. Insulin Therapy is Associated With Increased Myocardial Interstitial Fibrosis and Cardiomyocyte Apoptosis in a Rodent Model of Experimental Diabetes. Frontiers in physiology. vol 13. 2022-05-16. PMID:35574440. |
insulin therapy is associated with increased myocardial interstitial fibrosis and cardiomyocyte apoptosis in a rodent model of experimental diabetes. |
2022-05-16 |
2023-08-13 |
Not clear |
| Dongjuan Wang, Kun Liu, Jinyan Zhong, Xin Li, Jie Zhang, Gongxin Wang, Ni Li, Tianwen Li, Harvey Davis, Ibrahim El-Gaby, Guoliang Hao, Honghua Ye, Dan L. Molecular Correlates of Early Onset of Diabetic Cardiomyopathy: Possible Therapeutic Targets. Oxidative medicine and cellular longevity. vol 2022. 2022-04-25. PMID:35464763. |
rna-sequencing analysis of ventricular tissue revealed a differential transcriptome profile and abnormal activation of pathways involved in fatty acid metabolism, oxidative phosphorylation, cardiac structure and function, insulin resistance, calcium signalling, apoptosis, and tnf signalling. |
2022-04-25 |
2023-08-13 |
human |
| Jiawen Cui, Xinyi Kang, Yanxing Shan, Mingjin Zhang, Ying Gao, Wei Wu, Liping Che. miR-1227-3p participates in the development of fetal growth restriction via regulating trophoblast cell proliferation and apoptosis. Scientific reports. vol 12. issue 1. 2022-04-18. PMID:35430618. |
taken together, mir-1227-3p may participate in the development of fgr via regulating trophoblast cell proliferation and apoptosis by targeting genes involved in the insulin pathway. |
2022-04-18 |
2023-08-13 |
Not clear |
| Waseem El-Huneidi, Shabana Anjum, Mohamed A Saleh, Yasser Bustanji, Eman Abu-Gharbieh, Jalal Taneer. Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake. Molecules (Basel, Switzerland). vol 27. issue 7. 2022-04-12. PMID:35408495. |
carnosic acid protects ins-1 β-cells against streptozotocin-induced damage by inhibiting apoptosis and improving insulin secretion and glucose uptake. |
2022-04-12 |
2023-08-13 |
Not clear |
| Ashish Rao Sathyanarayana, Chung-Kuang Lu, Chih-Chuang Liaw, Chia-Chuan Chang, Hsin-Ying Han, Brian D Green, Wei-Jan Huang, Cheng Huang, Wen-Di He, Lin-Chien Lee, Hui-Kang Li. 1,2,3,4,6-Penta-O-galloyl-d-glucose Interrupts the Early Adipocyte Lifecycle and Attenuates Adiposity and Hepatic Steatosis in Mice with Diet-Induced Obesity. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409415. |
pgg mainly induces apoptosis, and this effect is independent of its insulin mimetic action. |
2022-04-12 |
2023-08-13 |
mouse |
| Roma Patel, Nishant Parmar, Nirali Rathwa, Sayantani Pramanik Palit, Yansui Li, Adolfo Garcia-Ocaña, Rasheedunnisa Begu. A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets. Biochimica et biophysica acta. Molecular cell research. 2022-04-01. PMID:35364117. |
further, in both the models, combination therapy reduces fbg levels, increases plasma insulin levels and glucose tolerance and promotes β-cell proliferation, β-cell transdifferentiation, and reduces β-cell apoptosis. |
2022-04-01 |
2023-08-13 |
mouse |
| Yaeni Kim, Ji Hee Lim, Eun Nim Kim, Yu Ah Hong, Hun-Jun Park, Sungjin Chung, Bum Soon Choi, Yong-Soo Kim, Ji Yong Park, Hye Won Kim, Cheol Whee Par. Adiponectin receptor agonist ameliorates cardiac lipotoxicity via enhancing ceramide metabolism in type 2 diabetic mice. Cell death & disease. vol 13. issue 3. 2022-03-30. PMID:35351872. |
adiporon ameliorated insulin resistance, fibrosis, m1-dominant inflammation, and apoptosis in association with reduced accumulations of free fatty acid, triglycerides, and tlr4-related ceramide in the heart. |
2022-03-30 |
2023-08-13 |
mouse |