| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stella Amarachi Ihim, Yukiko K Kaneko, Moe Yamamoto, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikaw. Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells. Biological & pharmaceutical bulletin. vol 46. issue 4. 2023-04-02. PMID:37005308. |
in the present study, the anti-diabetic effect of apigenin on pancreatic β-cell insulin secretion, apoptosis, and the mechanism underlying its anti-diabetic effects, were investigated in the ins-id β-cell line. |
2023-04-02 |
2023-08-14 |
Not clear |
| Stella Amarachi Ihim, Yukiko K Kaneko, Moe Yamamoto, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikaw. Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells. Biological & pharmaceutical bulletin. vol 46. issue 4. 2023-04-02. PMID:37005308. |
these results suggest that apigenin is an attractive candidate with remarkable and potent anti-diabetic effects on β-cells, which are mediated by facilitating glucose-stimulated insulin secretion and preventing er stress-mediated β-cell apoptosis, the latter of which may be possibly mediated by reduced expression of chop and txnip, thereby promoting β-cell survival and function. |
2023-04-02 |
2023-08-14 |
Not clear |
| Chuanxing Feng, Yuge Jiang, Guoqing Wu, Yonghui Shi, Yueting Ge, Bowen Li, Xiangrong Cheng, Xue Tang, Jianjin Zhu, Guowei L. Dietary Methionine Restriction Improves Gastrocnemius Muscle Glucose Metabolism through Improved Insulin Secretion and H19/IRS-1/Akt Pathway in Middle-Aged Mice. Journal of agricultural and food chemistry. 2023-03-30. PMID:36995760. |
mouse islets β cell line β-tc6 cells and mouse myoblast cell line c2c12 cells were used to establish the apoptosis or insulin resistance model. |
2023-03-30 |
2023-08-14 |
mouse |
| Chuanxing Feng, Yuge Jiang, Guoqing Wu, Yonghui Shi, Yueting Ge, Bowen Li, Xiangrong Cheng, Xue Tang, Jianjin Zhu, Guowei L. Dietary Methionine Restriction Improves Gastrocnemius Muscle Glucose Metabolism through Improved Insulin Secretion and H19/IRS-1/Akt Pathway in Middle-Aged Mice. Journal of agricultural and food chemistry. 2023-03-30. PMID:36995760. |
in conclusion, mr alleviates pancreatic apoptosis and promotes insulin secretion. |
2023-03-30 |
2023-08-14 |
mouse |
| Na Won Park, Eun Soo Lee, Kyung Bong Ha, Su Ho Jo, Hong Min Kim, Mi-Hye Kwon, Choon Hee Chun. Umbelliferone Ameliorates Hepatic Steatosis and Lipid-Induced ER Stress in High-Fat Diet-Induced Obese Mice. Yonsei medical journal. vol 64. issue 4. 2023-03-30. PMID:36996895. |
among the characteristics of non-alcoholic fatty liver disease (nafld), hepatic steatosis is due to excessive fat accumulation and causes liver damage and lipotoxicity, which are associated with insulin resistance, endoplasmic reticulum (er) stress, and apoptosis. |
2023-03-30 |
2023-08-14 |
mouse |
| Peng Lin, Ming Xu, Qiuhua Yang, Minxia Chen, Songlin Gu. Inoculation of Freund's adjuvant in European eel (Anguilla anguilla) revealed key KEGG pathways and DEGs of host anti-Edwardsiella anguillarum infection. Fish & shellfish immunology. 2023-03-30. PMID:36997037. |
we found 3795 up and 3548 down regulated degs in the compare of fcia_inf vs con_inf, of which 5 enriched kegg pathways of "lysosome", "autophagy", "apoptosis", "c-type lectin receptor signaling" and "insulin signaling" were ascertained, and 26 of 30 top go terms in the compare were significantly enriched. |
2023-03-30 |
2023-08-14 |
Not clear |
| Fatemeh Maghool, Mohammad Hassan Emami, Razieh Alipour, Samane Mohammadzadeh, Nasrin Sereshki, Sayed Ali Ehsan Dehkordi, Alireza Fahim, Zahra Tayarani-Najaran, Afsana Sheikh, Prashant Kesharwani, Amirhossein Sahebka. Rescue effect of curcumin against copper toxicity. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 78. 2023-03-29. PMID:36989586. |
diacetylcurcumin (dac) and metal-curcumin complexes) possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Xinrong Li, Yuxu He, Shuang Wu, Peiwen Zhang, Mailin Gan, Lei Chen, Ye Zhao, Lili Niu, Shunhua Zhang, Yanzhi Jiang, Zongyi Guo, Jinyong Wang, Linyuan Shen, Li Zh. Regulation of SIRT1 in Ovarian Function: PCOS Treatment. Current issues in molecular biology. vol 45. issue 3. 2023-03-28. PMID:36975503. |
subsequent studies have found that sirtuins are involved in various physiological processes, including cell proliferation, apoptosis, cell cycle progression, and insulin signaling, and they have been extensively studied as cancer genes. |
2023-03-28 |
2023-08-14 |
Not clear |
| Mirjana T Macvanin, Zoran Gluvic, Jelena Radovanovic, Magbubah Essack, Xin Gao, Esma R Isenovi. Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs. Frontiers in endocrinology. vol 14. 2023-03-23. PMID:36950696. |
evidence suggests that non-coding rnas, such as long non-coding rnas (lncrnas) and micrornas (mirnas), regulate diabetic cardiomyopathy-related processes such as insulin resistance, cardiomyocyte apoptosis and inflammation, emphasizing their heart-protective effects. |
2023-03-23 |
2023-08-14 |
human |
| Jaime Santo-Domingo, Steve Lassueur, Antonio Núñez Galindo, Pilar Alvarez-Illera, Silvia Romero-Sanz, Elena Caldero-Escudero, Sergio de la Fuente, Loïc Dayon, Andreas Wiederkeh. SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin secreting cells. Journal of cell science. 2023-03-21. PMID:36942724. |
importantly, insulin secreting cells lacking slc25a46 had an exacerbated sensitivity to lipotoxic conditions undergoing massive apoptosis when exposed to palmitate. |
2023-03-21 |
2023-08-14 |
Not clear |
| Jintao Liu, Yilong Lin, Cai Peng, Chunyang Jiang, Juan Li, Wenyu Wang, Shuyue Luo, Pengbin Fu, Zhenxin Lin, Yujie Liang, Heqing Shen, Yi Lin, Jie We. Bisphenol F induced hyperglycemia via activation of oxidative stress-responsive miR-200 family in the pancreas. Ecotoxicology and environmental safety. vol 255. 2023-03-16. PMID:36924560. |
and moreover, we demonstrated a novel toxicological mechanism in that bpf disrupted the keap1-nrf2 redox system to upregulate mir-141/200b/c which controlled pancreatic insulin production and apoptosis via mettl14 and xiap, respectively. |
2023-03-16 |
2023-08-14 |
mouse |
| Shoumeng Yan, Nan Yao, Xiaotong Li, Mengzi Sun, Yixue Yang, Weiwei Cui, Bo L. The Association between the Differential Expression of lncRNA and Type 2 Diabetes Mellitus in People with Hypertriglyceridemia. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901708. |
when silencing the enst00000462455.1 for min6 in high glucose and high fat, the relative cell survival rate and insulin secretion decreased, the apoptosis rate increased, and the expression of the transcription factors ins1, pdx-1, glut2, foxo1, and ets1 that maintained the function and activity of pancreatic β cells decreased ( |
2023-03-11 |
2023-08-14 |
human |
| Anila Khalique, Abdul Khader Mohammed, Nujood Mohammed Al-Khadran, Mutaz Al Gharaibeh, Eman Abu-Gharbieh, Waseem El-Huneidi, Nabil Sulaiman, Jalal Taneer. Reduced Retinoic Acid Receptor Beta (Rarβ) Affects Pancreatic β-Cell Physiology. Biology. vol 11. issue 7. 2023-03-08. PMID:36101450. |
silencing of rarβ in ins-1 cells impaired insulin secretion without affecting cell viability or apoptosis. |
2023-03-08 |
2023-08-16 |
human |
| Dongdong Zhao, Xiaozhou Zhang, Yongxin Bian, Lu Meng, Yutong Wu, Yidi Ma, Chen Li, Jingjing Wang, Zizheng Fu, Jingyuan Dai, Deqi Yin, Shumei Lin, Jianmin H. Taurine reduces apoptosis mediated by endoplasmic reticulum stress in islet β-cells induced by high-fat and -glucose diets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-03-02. PMID:36863558. |
poor eating habits, especially high-fat and -glucose diets intake, can lead to endoplasmic reticulum (er) stress in islet β-cells, insulin resistance, and islet β-cell dysfunction and cause islet β-cell apoptosis, which leads to type 2 diabetes mellitus (t2dm). |
2023-03-02 |
2023-08-14 |
human |
| Dongdong Zhao, Xiaozhou Zhang, Yongxin Bian, Lu Meng, Yutong Wu, Yidi Ma, Chen Li, Jingjing Wang, Zizheng Fu, Jingyuan Dai, Deqi Yin, Shumei Lin, Jianmin H. Taurine reduces apoptosis mediated by endoplasmic reticulum stress in islet β-cells induced by high-fat and -glucose diets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-03-02. PMID:36863558. |
in addition, taurine improves blood lipid content and islets pathological changes, regulates the relative protein expression in er stress and apoptosis, increases the insulin sensitivity index (homa-is), and reduces the insulin resistance index (homac-ir) of sd rats fed with a high-fat and -glucose diet. |
2023-03-02 |
2023-08-14 |
human |
| Maryam Mazraesefidi, Mehdi Mahmoodi, Mohammadreza Hajizade. Effects of silibinin on apoptosis and insulin secretion in rat RINm5F pancreatic β-cells. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023-02-10. PMID:36762428. |
effects of silibinin on apoptosis and insulin secretion in rat rinm5f pancreatic β-cells. |
2023-02-10 |
2023-08-14 |
rat |
| Pu Zang, Cuihua Yang, Haiyan Lei, Qingyu Guo, Wei Wang, Jiaqing Sha. Ghrelin regulates the proliferation and apoptosis of high glucose-induced islet cells through the PI3K-Akt signaling pathway. Cell biology international. 2023-01-31. PMID:36718083. |
the effects of ghrelin on the viability, proliferation, apoptosis, and insulin release of high glucose-induced islet cells were detected by cell counting kit-8, 5-ethynyl-2'-deoxyuridine, flow cytometry, and enzyme-linked immunosorbent assays, respectively. |
2023-01-31 |
2023-08-14 |
Not clear |
| Ayman Hyde. Naturally-occurring carboxylic acids from traditional antidiabetic plants as potential pancreatic islet FABP3 inhibitors. A molecular docking-aided study. Chemico-biological interactions. 2023-01-29. PMID:36709838. |
in diabetes, which is a lipid disease, long-term exposure of pancreatic islet beta cells to fatty acids (fas) increases basal insulin release, reduces glucose-stimulated insulin secretion, causes islet beta cell inflammation, failure and apoptosis. |
2023-01-29 |
2023-08-14 |
Not clear |
| Jian-Hong Qi, Pu-Yu Chen, Ding-Yuan Cai, Yi Wang, Yue-Lei Wei, Su-Ping He, Wei Zho. Exploring novel targets of sitagliptin for type 2 diabetes mellitus: Network pharmacology, molecular docking, molecular dynamics simulation, and SPR approaches. Frontiers in endocrinology. vol 13. 2023-01-26. PMID:36699034. |
it is well known that sitagliptin can specifically inhibit the activity of dpp4 to promote insulin secretion, inhibit islet β cell apoptosis and reduce blood glucose levels, while other pharmacological mechanisms are still unclear, such as improving insulin resistance, anti-inflammatory, anti-oxidative stress, and anti-fibrosis. |
2023-01-26 |
2023-08-14 |
Not clear |
| Antonino Belfiore, Rosaria Valentina Rapicavoli, Rosario Le Moli, Rosamaria Lappano, Andrea Morrione, Ernestina Marianna De Francesco, Veronica Vell. IGF2: A Role in Metastasis and Tumor Evasion from Immune Surveillance? Biomedicines. vol 11. issue 1. 2023-01-21. PMID:36672737. |
the involvement of igf2 in carcinogenesis depends on its ability to link high energy intake, increase cell proliferation, and suppress apoptosis to cancer risk, and this is likely the key mechanism bridging insulin resistance to cancer. |
2023-01-21 |
2023-08-14 |
Not clear |