| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaomei Zhang, Huifeng Zhang, Weidong Qiang, Yongxin Guo, Di Wu, Xin Su. Oral administration of human FGF21 expressed by mycelium of Cordyceps militaris improves blood glucose and lipid in type II diabetes mellitus. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 10. 2023-04-28. PMID:37114272. |
in animal experiments, oral rhfgf21 obviously reduced the levels of glucose, insulin, tg, t-cho, nefa, and ldl-c in the blood, the contents of alt, ast, tnf-α, mcp-1, f4/80, cd68 and cd11b in the fatty liver, and the apoptosis of pancreatic cells. |
2023-04-28 |
2023-08-14 |
human |
| Lin-Hua Wang, Yang-Yang Wang, Lian Liu, Quan Gon. From Diabetes to Diabetic Complications: Role of Autophagy. Current medical science. 2023-04-28. PMID:37115396. |
autophagy decreases β-cell apoptosis, promotes β-cell proliferation, and alleviates insulin resistance. |
2023-04-28 |
2023-08-14 |
Not clear |
| Kushagra Goswami, Badruddeen, Muhammad Arif, Juber Akhtar, Mohammad Irfan Khan, Mohammad Ahma. Flavonoids, isoflavonoids and others bioactives for insulin sensitizations. Current diabetes reviews. 2023-04-27. PMID:37102490. |
quercetin has been proven to boost insulin production by insulinoma 1 (ins-1) cells and also protect cell apoptosis. |
2023-04-27 |
2023-08-14 |
mouse |
| Uddipak Rai, Dhirodatta Senapati, Mandeep Kumar Aror. Insights on the role of anti-inflammatory and immunosuppressive agents in the amelioration of diabetes. Diabetology international. vol 14. issue 2. 2023-04-24. PMID:37090130. |
thus, this stress condition exacerbates the apoptosis of β-cells leading to insufficient production of insulin, resulting in hyperglycemia which signifies late stage t2d. |
2023-04-24 |
2023-08-14 |
Not clear |
| Zhi Zhou, Xiaopo Zhang, Guohui Yi, Yong Zhang, Juan Zhang, Can Tan, Bangbei Wan, Yejuan Li, Hui Lu, Weiying L. LINC00092 derived from follicular fluid alleviated the symptoms of PCOS through inactivation of phosphatase and tensin homolog by recruiting KDM5A. Reproductive biology. vol 23. issue 2. 2023-04-21. PMID:37084543. |
ff-evs treatment ameliorated letrozole-induced enhancement of weight, insulin resistance, dyslipidemia, and lh/fsh ratio, reduction of luteal cells, granulosa cells, and healthy follicles, prolonged oestrus, oestrous cycle arrest, ovarian tissue fibrosis, and ovarian cell apoptosis in rats, which were counteracted by treatment with shrna targeting linc00092. |
2023-04-21 |
2023-08-14 |
rat |
| Chong Song, Xian Long, Jianbin He, Yongpan Huan. Recent evaluation about inflammatory mechanisms in nonalcoholic fatty liver disease. Frontiers in pharmacology. vol 14. 2023-04-03. PMID:37007030. |
thus, inhibition of inflammation improves nafld by reducing intrahepatic fat content, increasing β-oxidation of fatty acids, inducing hepato-protective autophagy, overexpressing peroxisome proliferator-activated receptor- γ (ppar-γ), as well as attenuating hepatocyte apoptosis and increasing insulin sensitivity. |
2023-04-03 |
2023-08-14 |
Not clear |
| Shunyao Liu, Yuejia Tao, Danna Ma, Jing E, Jiang Song, Bo Li, Li Bao, Guoqing Zhang, Hongyan Luo, Shilu Cao, Yali Zhen. TFP5 attenuates cyclin-dependent kinase 5-mediated islet β-cell damage in diabetes. Chemical biology & drug design. 2023-04-02. PMID:37005089. |
cdk5 was upregulated under high glucose conditions in vivo and in vitro, which resulted in inflammation, oxidative stress, and apoptosis of islet β-cells, thereby decreasing insulin secretion. |
2023-04-02 |
2023-08-14 |
Not clear |
| Shunyao Liu, Yuejia Tao, Danna Ma, Jing E, Jiang Song, Bo Li, Li Bao, Guoqing Zhang, Hongyan Luo, Shilu Cao, Yali Zhen. TFP5 attenuates cyclin-dependent kinase 5-mediated islet β-cell damage in diabetes. Chemical biology & drug design. 2023-04-02. PMID:37005089. |
however, tfp5 treatment inhibited the overexpression of cdk5; reduced the inflammatory response, oxidative stress, and apoptosis of islet β cells; and restored insulin secretion. |
2023-04-02 |
2023-08-14 |
Not clear |
| Stella Amarachi Ihim, Yukiko K Kaneko, Moe Yamamoto, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikaw. Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells. Biological & pharmaceutical bulletin. vol 46. issue 4. 2023-04-02. PMID:37005308. |
in the present study, the anti-diabetic effect of apigenin on pancreatic β-cell insulin secretion, apoptosis, and the mechanism underlying its anti-diabetic effects, were investigated in the ins-id β-cell line. |
2023-04-02 |
2023-08-14 |
Not clear |
| Stella Amarachi Ihim, Yukiko K Kaneko, Moe Yamamoto, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikaw. Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells. Biological & pharmaceutical bulletin. vol 46. issue 4. 2023-04-02. PMID:37005308. |
these results suggest that apigenin is an attractive candidate with remarkable and potent anti-diabetic effects on β-cells, which are mediated by facilitating glucose-stimulated insulin secretion and preventing er stress-mediated β-cell apoptosis, the latter of which may be possibly mediated by reduced expression of chop and txnip, thereby promoting β-cell survival and function. |
2023-04-02 |
2023-08-14 |
Not clear |
| Chuanxing Feng, Yuge Jiang, Guoqing Wu, Yonghui Shi, Yueting Ge, Bowen Li, Xiangrong Cheng, Xue Tang, Jianjin Zhu, Guowei L. Dietary Methionine Restriction Improves Gastrocnemius Muscle Glucose Metabolism through Improved Insulin Secretion and H19/IRS-1/Akt Pathway in Middle-Aged Mice. Journal of agricultural and food chemistry. 2023-03-30. PMID:36995760. |
mouse islets β cell line β-tc6 cells and mouse myoblast cell line c2c12 cells were used to establish the apoptosis or insulin resistance model. |
2023-03-30 |
2023-08-14 |
mouse |
| Chuanxing Feng, Yuge Jiang, Guoqing Wu, Yonghui Shi, Yueting Ge, Bowen Li, Xiangrong Cheng, Xue Tang, Jianjin Zhu, Guowei L. Dietary Methionine Restriction Improves Gastrocnemius Muscle Glucose Metabolism through Improved Insulin Secretion and H19/IRS-1/Akt Pathway in Middle-Aged Mice. Journal of agricultural and food chemistry. 2023-03-30. PMID:36995760. |
in conclusion, mr alleviates pancreatic apoptosis and promotes insulin secretion. |
2023-03-30 |
2023-08-14 |
mouse |
| Na Won Park, Eun Soo Lee, Kyung Bong Ha, Su Ho Jo, Hong Min Kim, Mi-Hye Kwon, Choon Hee Chun. Umbelliferone Ameliorates Hepatic Steatosis and Lipid-Induced ER Stress in High-Fat Diet-Induced Obese Mice. Yonsei medical journal. vol 64. issue 4. 2023-03-30. PMID:36996895. |
among the characteristics of non-alcoholic fatty liver disease (nafld), hepatic steatosis is due to excessive fat accumulation and causes liver damage and lipotoxicity, which are associated with insulin resistance, endoplasmic reticulum (er) stress, and apoptosis. |
2023-03-30 |
2023-08-14 |
mouse |
| Peng Lin, Ming Xu, Qiuhua Yang, Minxia Chen, Songlin Gu. Inoculation of Freund's adjuvant in European eel (Anguilla anguilla) revealed key KEGG pathways and DEGs of host anti-Edwardsiella anguillarum infection. Fish & shellfish immunology. 2023-03-30. PMID:36997037. |
we found 3795 up and 3548 down regulated degs in the compare of fcia_inf vs con_inf, of which 5 enriched kegg pathways of "lysosome", "autophagy", "apoptosis", "c-type lectin receptor signaling" and "insulin signaling" were ascertained, and 26 of 30 top go terms in the compare were significantly enriched. |
2023-03-30 |
2023-08-14 |
Not clear |
| Fatemeh Maghool, Mohammad Hassan Emami, Razieh Alipour, Samane Mohammadzadeh, Nasrin Sereshki, Sayed Ali Ehsan Dehkordi, Alireza Fahim, Zahra Tayarani-Najaran, Afsana Sheikh, Prashant Kesharwani, Amirhossein Sahebka. Rescue effect of curcumin against copper toxicity. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 78. 2023-03-29. PMID:36989586. |
diacetylcurcumin (dac) and metal-curcumin complexes) possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Xinrong Li, Yuxu He, Shuang Wu, Peiwen Zhang, Mailin Gan, Lei Chen, Ye Zhao, Lili Niu, Shunhua Zhang, Yanzhi Jiang, Zongyi Guo, Jinyong Wang, Linyuan Shen, Li Zh. Regulation of SIRT1 in Ovarian Function: PCOS Treatment. Current issues in molecular biology. vol 45. issue 3. 2023-03-28. PMID:36975503. |
subsequent studies have found that sirtuins are involved in various physiological processes, including cell proliferation, apoptosis, cell cycle progression, and insulin signaling, and they have been extensively studied as cancer genes. |
2023-03-28 |
2023-08-14 |
Not clear |
| Mirjana T Macvanin, Zoran Gluvic, Jelena Radovanovic, Magbubah Essack, Xin Gao, Esma R Isenovi. Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs. Frontiers in endocrinology. vol 14. 2023-03-23. PMID:36950696. |
evidence suggests that non-coding rnas, such as long non-coding rnas (lncrnas) and micrornas (mirnas), regulate diabetic cardiomyopathy-related processes such as insulin resistance, cardiomyocyte apoptosis and inflammation, emphasizing their heart-protective effects. |
2023-03-23 |
2023-08-14 |
human |
| Jaime Santo-Domingo, Steve Lassueur, Antonio Núñez Galindo, Pilar Alvarez-Illera, Silvia Romero-Sanz, Elena Caldero-Escudero, Sergio de la Fuente, Loïc Dayon, Andreas Wiederkeh. SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin secreting cells. Journal of cell science. 2023-03-21. PMID:36942724. |
importantly, insulin secreting cells lacking slc25a46 had an exacerbated sensitivity to lipotoxic conditions undergoing massive apoptosis when exposed to palmitate. |
2023-03-21 |
2023-08-14 |
Not clear |
| Jintao Liu, Yilong Lin, Cai Peng, Chunyang Jiang, Juan Li, Wenyu Wang, Shuyue Luo, Pengbin Fu, Zhenxin Lin, Yujie Liang, Heqing Shen, Yi Lin, Jie We. Bisphenol F induced hyperglycemia via activation of oxidative stress-responsive miR-200 family in the pancreas. Ecotoxicology and environmental safety. vol 255. 2023-03-16. PMID:36924560. |
and moreover, we demonstrated a novel toxicological mechanism in that bpf disrupted the keap1-nrf2 redox system to upregulate mir-141/200b/c which controlled pancreatic insulin production and apoptosis via mettl14 and xiap, respectively. |
2023-03-16 |
2023-08-14 |
mouse |
| Shoumeng Yan, Nan Yao, Xiaotong Li, Mengzi Sun, Yixue Yang, Weiwei Cui, Bo L. The Association between the Differential Expression of lncRNA and Type 2 Diabetes Mellitus in People with Hypertriglyceridemia. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901708. |
when silencing the enst00000462455.1 for min6 in high glucose and high fat, the relative cell survival rate and insulin secretion decreased, the apoptosis rate increased, and the expression of the transcription factors ins1, pdx-1, glut2, foxo1, and ets1 that maintained the function and activity of pancreatic β cells decreased ( |
2023-03-11 |
2023-08-14 |
human |