| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to α-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
histopathological examination of the pancreas, the expression levels of insulin, cd44, caspase-3, autophagy markers, p13k/akt, and pancreas/duodenum homeobox protein 1, in pancreatic tissue, and glucose-dependent insulinotropic polypeptide (gip) in the duodenum were detected by hematoxylin and eosin staining, immunofluorescence labeling, and by quantitative real-time polymerase chain reaction. the diabetic rats showed reduced insulin, hyperglycemia, nitrosative stress (no, cat), augmented apoptosis (caspase 3), impaired autophagy (p62/sqstm1, lc3), downregulated pi3k/akt pathway and increased gip expression, and degeneration of pancreatic islets. |
2023-10-05 |
2023-10-07 |
rat |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to α-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
treatment with either bm-mscs or α-toc suppressed the nitrosative stress, reduced apoptosis, recovered autophagy, upregulated pi3k/akt pathway, and subsequently increased insulin levels, decreased blood glucose, and downregulated gip expression with partial restoration of pancreatic islets. based on our findings, the cytoprotective effects of bm-mscs and α-toc in type 1-induced diabetes appeared to be related to repaired autophagy and recovered pi3k/akt signaling. |
2023-10-05 |
2023-10-07 |
rat |
| Joon Kim, Chang-Myung Oh, Hyeongseok Ki. The Interplay of Adipokines and Pancreatic Beta Cells in Metabolic Regulation and Diabetes. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37761031. |
chronic obesity and insulin resistance can lead to the release of excess fatty acids and inflammatory molecules from the adipose tissue, contributing to beta cell dysfunction and apoptosis, which are key factors in developing type 2 diabetes. |
2023-09-28 |
2023-10-07 |
Not clear |
| Eman Fawzy El Azab, Saleha Y M Alakilli, Abdulrahman M Saleh, Hassan H Alhassan, Hamad H Alanazi, Heba Bassiony Ghanem, Sara Osman Yousif, Heba Abu Alrub, Nahla Anber, Elyasa Mustafa Elfaki, Alneil Hamza, Shaymaa Abdulmale. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762060. |
type 2 diabetes (t2d) is a chronic metabolic condition associated with obesity, oxidative stress-mediated inflammation, apoptosis, and impaired insulin signaling. |
2023-09-28 |
2023-10-07 |
Not clear |
| Uma D Kabra, Martin Jastroc. Mitochondrial Dynamics and Insulin Secretion. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762083. |
the disruption of mitochondrial dynamics is linked to defects in energy production and increased apoptosis, ultimately impairing insulin secretion and β cell death. |
2023-09-28 |
2023-10-07 |
Not clear |
| Marakiya T Moetlediwa, Rudzani Ramashia, Carmen Pheiffer, Salam J J Titinchi, Sithandiwe E Mazibuko-Mbeje, Babalwa U Jac. Therapeutic Effects of Curcumin Derivatives against Obesity and Associated Metabolic Complications: A Review of In Vitro and In Vivo Studies. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762669. |
these curcumin derivatives modulated adipogenesis, lipid metabolism, insulin resistance, steatosis, lipotoxicity, inflammation, oxidative stress, endoplasmic reticulum stress, apoptosis, autophagy, fibrosis, and dyslipidemia to a greater extent than curcumin. |
2023-09-28 |
2023-10-07 |
Not clear |
| Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Don. Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. Life sciences. 2023-09-27. PMID:37758017. |
these data suggest that long-term simulated weightlessness induces cognitive impairment as well as neuronal apoptosis and neural degeneration, partially through hippocampal insulin resistance via pten up-regulation. |
2023-09-27 |
2023-10-07 |
rat |
| Liang Yan, Yachun Ya. Therapeutic potential of sulforaphane in liver diseases: a review. Frontiers in pharmacology. vol 14. 2023-09-14. PMID:37705537. |
recently, a growing number of studies have reported that sfn could significantly ameliorate hepatic steatosis and prevent the development of fatty liver, improve insulin sensitivity, attenuate oxidative damage and liver injury, induce apoptosis, and inhibit the proliferation of hepatoma cells through multiple signaling pathways. |
2023-09-14 |
2023-10-07 |
human |
| I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. |
it has been established that in animals with dm, gaba suppresses apoptosis and stimulates the regeneration of β-cells, increases β-cell mass and insulin production.experimental data have been obtained indicating a synergistic effect of gaba when combined with glucagon-like peptide-1 (glp-1) receptor agonists, dpp-4 inhibitors and sodium-glucose cotransporter 2 (sglt-2) inhibitors, when a more pronounced pancreoprotective effect is observed, due to decrease in oxidative and nitrosative stress, inflammation, increase in the level of klotho protein, nrf-2 activity and antioxidant defense enzymes, suppression of nf-kb activity and expression of pro-inflammatory cytokines. |
2023-09-11 |
2023-10-07 |
Not clear |
| I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. |
as a result, all this leads to a decrease in apoptosis and death of β-cells, an increase in β-cell mass, insulin production and, at the same time, a decrease in glucagon levels and insulin resistance.the review substantiates the feasibility of using gaba and drugs with a positive gabaeric effect in combination with new generation antidiabetic agents: glp-1 receptor agonists, dpp-4 inhibitors and sglt-2 inhibitors in order to increase their antidiabetic potential.the search was carried out in the databases pubmed, elibrary, medline. |
2023-09-11 |
2023-10-07 |
Not clear |
| Bin Liu, Qingfei Meng, Xin Gao, Huihui Sun, Zhixiang Xu, Yishu Wang, Honglan Zho. Lipid and glucose metabolism in senescence. Frontiers in nutrition. vol 10. 2023-09-08. PMID:37680899. |
given the important roles of these types of metabolism, we review the evidence for how key metabolic enzymes influence senescence and how senescence-related secretory phenotypes, autophagy, apoptosis, insulin signaling pathways, and environmental factors modulate glucose and lipid homeostasis. |
2023-09-08 |
2023-10-07 |
Not clear |
| Rodrigo Daza-Arnedo, Jorge Rico-Fontalvo, Gustavo Aroca-Martínez, Tomás Rodríguez-Yanez, María Cristina Martínez-Ávila, Amilkar Almanza-Hurtado, María Cardona-Blanco, Carlos Henao-Velásquez, Jorge Fernández-Franco, Mario Unigarro-Palacios, Carolina Osorio-Restrepo, Isabella Uparella-Gulf. Insulin and the kidneys: a contemporary view on the molecular basis. Frontiers in nephrology. vol 3. 2023-09-07. PMID:37675359. |
insulin acts on a range of tissues, from the glomerulus to the renal tubule, by modulating different functions such as glomerular filtration, gluconeogenesis, natriuresis, glucose uptake, regulation of ion transport, and the prevention of apoptosis. |
2023-09-07 |
2023-10-07 |
Not clear |
| James M Gruschus, Daniel L Morris, Nico Tjandr. Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6. Scientific reports. vol 13. issue 1. 2023-08-29. PMID:37644144. |
these peptides have various effects in cell culture and animal models, affecting neuroprotection, insulin sensitivity, and apoptosis, and some are secreted, potentially having extracellular signaling roles. |
2023-08-29 |
2023-09-07 |
Not clear |
| Sarah Ali-Berrada, Jeanne Guitton, Sophie Tan-Chen, Anna Gyulkhandanyan, Eric Hajduch, Hervé Le Stunf. Circulating Sphingolipids and Glucose Homeostasis: An Update. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628901. |
sphingolipids are structural components of membranes, but in response to obesity, they are implicated in the regulation of various cellular processes, including inflammation, apoptosis, cell proliferation, autophagy, and insulin resistance which favors dysregulation of glucose metabolism. |
2023-08-26 |
2023-09-07 |
Not clear |
| Yinli Shi, Pei Sheng, Ming Guo, Kai Chen, Yun Zhao, Xu Wang, Mianhua Wu, Bo L. Banxia Xiexin Decoction Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via JNK/SIRT1/Foxo3a Signaling Pathway. Current computer-aided drug design. 2023-08-23. PMID:37608672. |
the medicinal compound banxia xiexin decoction (bxxxd) from traditional chinese medicine (tcm) has shown potential in improving insulin resistance, regulating endoplasmic reticulum stress (ers), and inhibiting cell apoptosis through various pathways. |
2023-08-23 |
2023-09-07 |
Not clear |
| Xiue Wei, Wenhua Che, Qiufeng Wang, Lili Y. Evaluation of adiponectin and TNF-α expression in diabetic patients and its relationship with cardiovascular diseases. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 5. 2023-08-12. PMID:37571897. |
diabetes is caused by peripheral insulin resistance and lack of insulin secretion due to the apoptosis of pancreatic beta cells. |
2023-08-12 |
2023-08-16 |
human |
| Chan Yang, Hanyu Liu, Ziyan Xie, Qiangfei Yang, Lian Du, Chunguang Xi. The protective role of shenqi compound in type 2 diabetes: A comprehensive investigation of pancreatic β-cell function and mass. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-08-12. PMID:37572639. |
the results demonstrate multiple beneficial effects of sqc, including significant control of blood glucose levels (p < 0.05), inhibition of insulin resistance (measured by western blot), reduction of hyperinsulinemia (p < 0.05), attenuation of oxidative stress (p < 0.05), suppression of inflammation (p < 0.05), protection against islet hypertrophy and beta cell proliferation (evaluated through pathological staining), and inhibition of β-cell apoptosis and senescence (also assessed through pathological staining). |
2023-08-12 |
2023-08-16 |
rat |
| Xin Ding, Lili Zhang, Xinping Zhang, Yang Qin, Ke Yu, Xiaokun Yan. Intranasal insulin alleviates traumatic brain injury by inhibiting autophagy and endoplasmic reticulum stress-mediated apoptosis through the PI3K/Akt/mTOR signaling pathway. Neuroscience. 2023-08-12. PMID:37572876. |
intranasal insulin alleviates traumatic brain injury by inhibiting autophagy and endoplasmic reticulum stress-mediated apoptosis through the pi3k/akt/mtor signaling pathway. |
2023-08-12 |
2023-08-16 |
mouse |
| Xin Ding, Lili Zhang, Xinping Zhang, Yang Qin, Ke Yu, Xiaokun Yan. Intranasal insulin alleviates traumatic brain injury by inhibiting autophagy and endoplasmic reticulum stress-mediated apoptosis through the PI3K/Akt/mTOR signaling pathway. Neuroscience. 2023-08-12. PMID:37572876. |
tunel assay and western blotting also indicated that intranasal insulin inhibited er stress-mediated apoptosis. |
2023-08-12 |
2023-08-16 |
mouse |
| Xin Ding, Lili Zhang, Xinping Zhang, Yang Qin, Ke Yu, Xiaokun Yan. Intranasal insulin alleviates traumatic brain injury by inhibiting autophagy and endoplasmic reticulum stress-mediated apoptosis through the PI3K/Akt/mTOR signaling pathway. Neuroscience. 2023-08-12. PMID:37572876. |
our results suggest that intranasal insulin can ameliorate tbi by regulating autophagy and er stress-mediated apoptosis through the pi3k/akt/mtor signaling pathway, providing a promising therapeutic strategy for tbi. |
2023-08-12 |
2023-08-16 |
mouse |