| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. |
it has been established that in animals with dm, gaba suppresses apoptosis and stimulates the regeneration of β-cells, increases β-cell mass and insulin production.experimental data have been obtained indicating a synergistic effect of gaba when combined with glucagon-like peptide-1 (glp-1) receptor agonists, dpp-4 inhibitors and sodium-glucose cotransporter 2 (sglt-2) inhibitors, when a more pronounced pancreoprotective effect is observed, due to decrease in oxidative and nitrosative stress, inflammation, increase in the level of klotho protein, nrf-2 activity and antioxidant defense enzymes, suppression of nf-kb activity and expression of pro-inflammatory cytokines. |
2023-09-11 |
2023-10-07 |
Not clear |
| I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. |
as a result, all this leads to a decrease in apoptosis and death of β-cells, an increase in β-cell mass, insulin production and, at the same time, a decrease in glucagon levels and insulin resistance.the review substantiates the feasibility of using gaba and drugs with a positive gabaeric effect in combination with new generation antidiabetic agents: glp-1 receptor agonists, dpp-4 inhibitors and sglt-2 inhibitors in order to increase their antidiabetic potential.the search was carried out in the databases pubmed, elibrary, medline. |
2023-09-11 |
2023-10-07 |
Not clear |
| Bin Liu, Qingfei Meng, Xin Gao, Huihui Sun, Zhixiang Xu, Yishu Wang, Honglan Zho. Lipid and glucose metabolism in senescence. Frontiers in nutrition. vol 10. 2023-09-08. PMID:37680899. |
given the important roles of these types of metabolism, we review the evidence for how key metabolic enzymes influence senescence and how senescence-related secretory phenotypes, autophagy, apoptosis, insulin signaling pathways, and environmental factors modulate glucose and lipid homeostasis. |
2023-09-08 |
2023-10-07 |
Not clear |
| Rodrigo Daza-Arnedo, Jorge Rico-Fontalvo, Gustavo Aroca-Martínez, Tomás Rodríguez-Yanez, María Cristina Martínez-Ávila, Amilkar Almanza-Hurtado, María Cardona-Blanco, Carlos Henao-Velásquez, Jorge Fernández-Franco, Mario Unigarro-Palacios, Carolina Osorio-Restrepo, Isabella Uparella-Gulf. Insulin and the kidneys: a contemporary view on the molecular basis. Frontiers in nephrology. vol 3. 2023-09-07. PMID:37675359. |
insulin acts on a range of tissues, from the glomerulus to the renal tubule, by modulating different functions such as glomerular filtration, gluconeogenesis, natriuresis, glucose uptake, regulation of ion transport, and the prevention of apoptosis. |
2023-09-07 |
2023-10-07 |
Not clear |
| James M Gruschus, Daniel L Morris, Nico Tjandr. Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6. Scientific reports. vol 13. issue 1. 2023-08-29. PMID:37644144. |
these peptides have various effects in cell culture and animal models, affecting neuroprotection, insulin sensitivity, and apoptosis, and some are secreted, potentially having extracellular signaling roles. |
2023-08-29 |
2023-09-07 |
Not clear |
| Sarah Ali-Berrada, Jeanne Guitton, Sophie Tan-Chen, Anna Gyulkhandanyan, Eric Hajduch, Hervé Le Stunf. Circulating Sphingolipids and Glucose Homeostasis: An Update. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628901. |
sphingolipids are structural components of membranes, but in response to obesity, they are implicated in the regulation of various cellular processes, including inflammation, apoptosis, cell proliferation, autophagy, and insulin resistance which favors dysregulation of glucose metabolism. |
2023-08-26 |
2023-09-07 |
Not clear |
| Yinli Shi, Pei Sheng, Ming Guo, Kai Chen, Yun Zhao, Xu Wang, Mianhua Wu, Bo L. Banxia Xiexin Decoction Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via JNK/SIRT1/Foxo3a Signaling Pathway. Current computer-aided drug design. 2023-08-23. PMID:37608672. |
the medicinal compound banxia xiexin decoction (bxxxd) from traditional chinese medicine (tcm) has shown potential in improving insulin resistance, regulating endoplasmic reticulum stress (ers), and inhibiting cell apoptosis through various pathways. |
2023-08-23 |
2023-09-07 |
Not clear |
| Xiue Wei, Wenhua Che, Qiufeng Wang, Lili Y. Evaluation of adiponectin and TNF-α expression in diabetic patients and its relationship with cardiovascular diseases. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 5. 2023-08-12. PMID:37571897. |
diabetes is caused by peripheral insulin resistance and lack of insulin secretion due to the apoptosis of pancreatic beta cells. |
2023-08-12 |
2023-08-16 |
human |
| Chan Yang, Hanyu Liu, Ziyan Xie, Qiangfei Yang, Lian Du, Chunguang Xi. The protective role of shenqi compound in type 2 diabetes: A comprehensive investigation of pancreatic β-cell function and mass. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-08-12. PMID:37572639. |
the results demonstrate multiple beneficial effects of sqc, including significant control of blood glucose levels (p < 0.05), inhibition of insulin resistance (measured by western blot), reduction of hyperinsulinemia (p < 0.05), attenuation of oxidative stress (p < 0.05), suppression of inflammation (p < 0.05), protection against islet hypertrophy and beta cell proliferation (evaluated through pathological staining), and inhibition of β-cell apoptosis and senescence (also assessed through pathological staining). |
2023-08-12 |
2023-08-16 |
rat |
| Xin Ding, Lili Zhang, Xinping Zhang, Yang Qin, Ke Yu, Xiaokun Yan. Intranasal insulin alleviates traumatic brain injury by inhibiting autophagy and endoplasmic reticulum stress-mediated apoptosis through the PI3K/Akt/mTOR signaling pathway. Neuroscience. 2023-08-12. PMID:37572876. |
intranasal insulin alleviates traumatic brain injury by inhibiting autophagy and endoplasmic reticulum stress-mediated apoptosis through the pi3k/akt/mtor signaling pathway. |
2023-08-12 |
2023-08-16 |
mouse |
| Xin Ding, Lili Zhang, Xinping Zhang, Yang Qin, Ke Yu, Xiaokun Yan. Intranasal insulin alleviates traumatic brain injury by inhibiting autophagy and endoplasmic reticulum stress-mediated apoptosis through the PI3K/Akt/mTOR signaling pathway. Neuroscience. 2023-08-12. PMID:37572876. |
tunel assay and western blotting also indicated that intranasal insulin inhibited er stress-mediated apoptosis. |
2023-08-12 |
2023-08-16 |
mouse |
| Xin Ding, Lili Zhang, Xinping Zhang, Yang Qin, Ke Yu, Xiaokun Yan. Intranasal insulin alleviates traumatic brain injury by inhibiting autophagy and endoplasmic reticulum stress-mediated apoptosis through the PI3K/Akt/mTOR signaling pathway. Neuroscience. 2023-08-12. PMID:37572876. |
our results suggest that intranasal insulin can ameliorate tbi by regulating autophagy and er stress-mediated apoptosis through the pi3k/akt/mtor signaling pathway, providing a promising therapeutic strategy for tbi. |
2023-08-12 |
2023-08-16 |
mouse |
| Dezhao Li, Yaoshan Dun, Dake Qi, Jeffrey W Ripley-Gonzalez, Jie Dong, Nanjiang Zhou, Ling Qiu, Jie Zhang, Tanghao Zeng, Baiyang You, Suixin Li. Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease. Scientific reports. vol 13. issue 1. 2023-08-11. PMID:37567977. |
finally, the liver was then harvested to assess lipid deposition, lipid metabolism, apoptosis, and autophagy, while blood was collected to determine blood glucose and insulin. |
2023-08-11 |
2023-08-16 |
mouse |
| Kaixi Ding, Wei Jiang, Juejue Zhangwang, Yu Wang, Jing Zhang, Ming Le. The potential of traditional herbal active ingredients in the treatment of sarcopenia animal models: focus on therapeutic effects and mechanisms. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-01. PMID:37526688. |
the review results showed that the pathological mechanisms in sarcopenia-related animal models include imbalanced protein metabolism, oxidative stress, inflammation, apoptosis, insulin resistance, endoplasmic reticulum stress, impaired mitochondrial biogenesis, and autophagy-lysosome system aggravation. |
2023-08-01 |
2023-08-14 |
Not clear |
| Kehan Wu, Yaqiao Wang, Runmin Liu, Hao Wang, Tao Ru. The role of mammalian Sirtuin 6 in cardiovascular diseases and diabetes mellitus. Frontiers in physiology. vol 14. 2023-07-27. PMID:37497437. |
sirt6 enjoys a unique structure, important biological functions, and is involved in multiple cellular processes such as stress response, mitochondrial biogenesis, transcription, insulin resistance, inflammatory response, chromatin silencing, and apoptosis. |
2023-07-27 |
2023-08-14 |
human |
| Xue-Hua Wang, Zhong-Fu Zuo, Lu Meng, Qi Yang, Pan Lv, Li-Pan Zhao, Xiao-Bai Wang, Yu-Fei Wang, Ying Huang, Cong Fu, Wen-Qiang Liu, Xue-Zheng Liu, De-Yu Zhen. Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3β signaling pathway. Psychopharmacology. 2023-07-25. PMID:37490132. |
salidroside, a nature compound isolated from rhodiola rosea l, has the effects of anti-inflammatory and antioxidant, hypoglycemic and lipid-lowering, improving insulin resistance, inhibiting cell apoptosis, and protecting neurons. |
2023-07-25 |
2023-08-14 |
mouse |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results have shown differentially expressed p53 target genes involved in apoptosis (bax, fas, pmaip1, and casp8), cell cycle (cyclins, cyclin dependent kinases), glucose metabolism and insulin resistance (thbs1), and p53 regulation (mdm2). |
2023-07-19 |
2023-08-14 |
human |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
p53 plays a critical role in the regulation of apoptosis and cell cycle arrest, metabolism and insulin resistance. |
2023-07-19 |
2023-08-14 |
human |
| Stanley T Lewis, Frank Greenway, Tori R Tucker, Michael Alexander, Levonika K Jackson, Scott A Hepford, Brian Loveridge, Jonathan R T Lake. A Receptor Story: Insulin Resistance Pathophysiology and Physiologic Insulin Resensitization's Role as a Treatment Modality. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446104. |
in the case of type-2 diabetes, β-cell mass is reduced due to apoptosis and β cells secrete insulin asynchronously. |
2023-07-14 |
2023-08-14 |
Not clear |
| Jianjia Huang, Xiaoyue Pang, Xinting Zhang, Wenyue Qiu, Xuluan Zhang, Rongmei Wang, Wenting Xie, Yuman Bai, Shuilian Zhou, Jianzhao Liao, Zhaojun Xiong, Zhaoxin Tang, Rongsheng S. N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF-α-mediated apoptotic pathways and affecting linear ubiquitination. Translational research : the journal of laboratory and clinical medicine. 2023-07-08. PMID:37422055. |
this study confirmed that nac combined with insulin can promote the linear ubiquitination of ripk1, nemo and c-flip and regulate the apoptosis pathway mediated by tnf-α to attenuate the myocardial injury caused by type 1 dm. |
2023-07-08 |
2023-08-14 |
Not clear |