| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayse Basak Engin, Evren Doruk Engin, Atilla Engi. Macrophage Activation Syndrome in Coinciding Pandemics of Obesity and COVID-19: Worse than Bad. Advances in experimental medicine and biology. vol 1460. 2024-09-17. PMID:39287877. |
following viral invasion, sars-cov-2 infection reduces insulin secretion via either inducing β-cell apoptosis or reducing intensity of angiotensin-converting enzyme 2 (ace2) receptors and leads to new-onset diabetes. |
2024-09-17 |
2024-09-20 |
human |
| Ting Yang, Lingling Qiu, Shihao Chen, Zhixiu Wang, Yong Jiang, Hao Bai, Yulin Bi, Guobin Chan. RNA-Seq Analysis of Glycolysis Regulation of Avian Leukosis Virus Subgroup J Replication. Animals : an open access journal from MDPI. vol 14. issue 17. 2024-09-14. PMID:39272286. |
functional enrichment analysis indicated that some circrnas might be involved in regulating the replication of the alv-j virus by influencing some pathways like glycolysis/gluconeogenesis, the nod-like receptor signaling pathway, mapk signaling pathway, p53 signaling pathway, toll-like receptor signaling pathway, insulin signaling pathway, and apoptosis. |
2024-09-14 |
2024-09-16 |
Not clear |
| Xiuxiu Yuan, Yu Zhang, Siyi Wang, Zhiyu D. Protective effects of insulin on dry eye syndrome via TLR4/NF-κB pathway: based on network pharmacology and Frontiers in pharmacology. vol 15. 2024-09-12. PMID:39263577. |
in cell experiments, insulin promoted hcecs proliferation, improved their ability to migrate, and inhibited apoptosis. |
2024-09-12 |
2024-09-14 |
human |
| Hussam A Bukhari, Muhammad Afzal, Fahad A Al-Abbasi, Ryan A Sheikh, May M Alqurashi, Azizah Salim Bawadood, Sami I Alzarea, Abdulaziz Alamri, Nadeem Sayyed, Imran Kazm. In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions. Scientific reports. vol 14. issue 1. 2024-09-04. PMID:39232184. |
various diabetic parameters (blood glucose, insulin, hba1c), lipid profile, inflammatory (tnf-α, il-1β, il-6 and nf-κb), antioxidant enzymes (cat, sod and gsh), oxidative stress indicators (mda), apoptosis marker (caspase-3), hepatic markers (alt and ast), and histopathological changes were assessed. |
2024-09-04 |
2024-09-08 |
human |
| Hongyang Zhu, You Yu, Yuting Li, Shiyao Chang, Yuhui Li. Puerarin ameliorates high glucose-induced MIN6 cell injury by activating PINK1/Parkin-mediated mitochondrial autophagy. Heliyon. vol 10. issue 16. 2024-09-03. PMID:39224278. |
subsequently, cellular insulin secretion was measured using enzyme-linked immunosorbent assay (elisa), apoptosis rate by flow cytometry, mitochondrial membrane potential alteration by jc-1, cellular ros production by the dcfh-da fluorescent probe, and fusion of cellular autophagosomes and lysosomes through adenoviral infection analysis. |
2024-09-03 |
2024-09-05 |
Not clear |
| Hongyang Zhu, You Yu, Yuting Li, Shiyao Chang, Yuhui Li. Puerarin ameliorates high glucose-induced MIN6 cell injury by activating PINK1/Parkin-mediated mitochondrial autophagy. Heliyon. vol 10. issue 16. 2024-09-03. PMID:39224278. |
puerarin intervention markedly attenuated ros production, restored mitochondrial membrane potential, induced pink/parkin-mediated mitochondrial autophagy, suppressed activation of the mitochondrial apoptotic pathway, mitigated apoptosis, and enhanced insulin secretion in a high glucose (hg) environment. |
2024-09-03 |
2024-09-05 |
Not clear |
| Luis Antonio Flores-López, Sergio Enríquez-Flores, Ignacio De La Mora-De La Mora, Itzhel García-Torres, Gabriel López-Velázquez, Rubí Viedma-Rodríguez, Alejandro Ávalos-Rodríguez, Alejandra Contreras-Ramos, Clara Ortega-Camarill. Pancreatic β‑cell apoptosis in type 2 diabetes is related to post‑translational modifications of p53 (Review). Molecular medicine reports. vol 30. issue 5. 2024-09-02. PMID:39219257. |
diabetes mellitus is a disease characterized by insulin resistance and chronic hyperglycemia, mainly due to the loss of pancreatic β‑cells caused by an increase in the rate of apoptosis. |
2024-09-02 |
2024-09-04 |
Not clear |
| Junxia Yu, Ningyan Tian, Yanfen Hu, Ting Ji. RANKL/RANK contributes to the pathological process of type 2 diabetes mellitus through TRAF3 activation of NIK. International immunopharmacology. vol 142. issue Pt A. 2024-09-01. PMID:39217877. |
in vivo experiments demonstrated that srankl-in-3 down-regulated insulin secretion levels by significantly ameliorating pancreatic tissue damage and mitigating apoptosis of high glucose induced β-cells. |
2024-09-01 |
2024-09-04 |
rat |
| Jiajing Ma, Xuhui Li, Xuesi Wan, Jinmei Deng, Yanglei Cheng, Boyuan Liu, Liehua Liu, Lijuan Xu, Haipeng Xiao, Yanbing L. Single-Cell RNA-seq Analysis Reveals a Positive Correlation between Ferroptosis and Beta-Cell Dedifferentiation in Type 2 Diabetes. Biomedicines. vol 12. issue 8. 2024-08-29. PMID:39200152. |
insulin deficiency in patients with type 2 diabetes mellitus (t2d) is associated with beta-cell dysfunction, a condition increasingly recognized to involve processes such as dedifferentiation and apoptosis. |
2024-08-29 |
2024-09-01 |
Not clear |
| Tanin Shafaati, Keshav Gopa. Forkhead box O1 transcription factor; a therapeutic target for diabetic cardiomyopathy. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 27. 2024-08-29. PMID:39206323. |
the known molecular mediators of dbcm are multifactorial, including but not limited to insulin resistance, altered energy metabolism, lipotoxicity, endothelial dysfunction, oxidative stress, apoptosis, and autophagy. |
2024-08-29 |
2024-09-04 |
human |
| Juhi Shah, Tyler Orosz, Avneet Singh, Savan Parameshwar Laxma, Rachel E Gross, Nicholas Smith, Spencer Vroegop, Sydney Sudler, James T Porter, Maria Colon, Lauren Jun, Jeganathan R Babu, Minsub Shim, Thomas L Broderick, Layla Al-Nakkas. Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer's Disease-Related Markers in Male Mice. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201705. |
hfhs feeding also increased protein expression of brain markers of insulin resistance (pgsk-3β, p-ir), apoptosis (caspase 3), early neurofibrillary tangles (cp13), and amyloid-beta precursor (ct20). |
2024-08-29 |
2024-09-04 |
mouse |
| Qian Li, Jialin Fu, Kyoungmin Park, Hetal Shah, Qin Li, I-Hsien Wu, George L Kin. Insulin receptors in vascular smooth muscle cells regulate plaque stability of atherosclerosis. Cardiovascular research. 2024-08-28. PMID:39197028. |
thus, insulin resistance may reduce plaque stability as deleting insulin receptors (ir) in vsmc decreased their proliferation and enhanced apoptosis. |
2024-08-28 |
2024-08-31 |
Not clear |
| Sajad Abolfazli, Alexandra E Butler, Prashant Kesharwani, Amirhossein Sahebka. The beneficial impact of curcumin on cardiac lipotoxicity. The Journal of pharmacy and pharmacology. 2024-08-24. PMID:39180454. |
this stress can be brought on by apoptosis, impaired insulin signaling, endoplasmic reticulum stress, protein kinase c activation, p38 ras-mitogen-activated protein kinase (mapk) activation, or modification of peroxisome proliferator-activated receptors (ppars) family members. |
2024-08-24 |
2024-08-27 |
Not clear |
| Yuxi Zhang, Luke Kuo, Kimberly A Woodhouse, Lindsay E Fitzpatric. Therapeutic Insulin Analogue Concentrations at Infusion Sites Enhanced the Pro-Inflammatory Response and Apoptosis in an In Vitro Macrophage-Material Interaction Model. ACS pharmacology & translational science. vol 7. issue 8. 2024-08-19. PMID:39156741. |
therapeutic insulin analogue concentrations at infusion sites enhanced the pro-inflammatory response and apoptosis in an in vitro macrophage-material interaction model. |
2024-08-19 |
2024-08-21 |
Not clear |
| Yuxi Zhang, Luke Kuo, Kimberly A Woodhouse, Lindsay E Fitzpatric. Therapeutic Insulin Analogue Concentrations at Infusion Sites Enhanced the Pro-Inflammatory Response and Apoptosis in an In Vitro Macrophage-Material Interaction Model. ACS pharmacology & translational science. vol 7. issue 8. 2024-08-19. PMID:39156741. |
additionally, high insulin concentrations arising from therapeutic doses induced macrophage apoptosis with and without adsorbed lysate. |
2024-08-19 |
2024-08-21 |
Not clear |
| Jiangxia Wang, Runlin Gui, Yang Li, Zhuozhuo Li, Zi Li, Shanshan Liu, Miao Zhang, Lu Qian, Xiaobin Fan, Yuyan Xion. SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis. Biochimica et biophysica acta. Molecular cell research. 2024-08-19. PMID:39159685. |
sfrp4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/il-6 signaling axis. |
2024-08-19 |
2024-08-22 |
mouse |
| Lynda Bourebaba, Nabila Bourebaba, Larry Galuppo, Krzysztof Maryc. Artificial mitochondrial transplantation (AMT) reverses aging of mesenchymal stem cells and improves their immunomodulatory properties in LPS-induced synoviocytes inflammation. Biochimica et biophysica acta. Molecular cell research. 2024-08-04. PMID:39098401. |
mitochondria recipient cells were characterized by decreased apoptosis, senescence and endoplasmic reticulum stress while insulin sensitivity was enhanced. |
2024-08-04 |
2024-08-07 |
Not clear |
| M Okulicz, M Billert, T Wojciechowicz, M Skrzypsk. Cytotoxicity of allyl isothiocyanate on insulin-producing INS-1E cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 75. issue 3. 2024-07-23. PMID:39042388. |
therefore, in the present study, we characterized the role of aitc at a wide concentration range (5, 10, 25, 50, 100 μm) in controlling viability, proliferation, apoptosis, mitochondrial condition, mrna expression of encoding pancreatic and duodenal homeobox 1 (pdx1), and ins1, ins2 genes, and insulin content in ins-1e cells. |
2024-07-23 |
2024-07-25 |
rat |
| Xiangjun Sha, Xinlei Zou, Sidi Liu, Canghai Guan, Wujiang Shi, Jianjun Gao, Xiangyu Zhong, Xingming Jian. Forkhead box O1 in metabolic dysfunction-associated fatty liver disease: molecular mechanisms and drug research. Frontiers in nutrition. vol 11. 2024-07-18. PMID:39021599. |
foxo1 mediates the progression of mafld by regulating glucose metabolism, lipid metabolism, insulin resistance, oxidative stress, hepatic fibrosis, hepatocyte autophagy, apoptosis, and immune inflammation. |
2024-07-18 |
2024-07-20 |
human |
| Maitham Alhajamee, Mohammad Khalaj-Kondori, Esmaeil Babaei, Majid Mahdav. A biochemical assessment of apoptosis-inducing impact of Salinomycin in combination with ciprofloxacin on human leukemia KG1-a stem-like cells in the presence and absence of insulin. Molecular biology reports. vol 51. issue 1. 2024-07-13. PMID:39002036. |
besides, insulin is known to activate the pi3k/akt pathway, often disrupted in cancers, leading to enhanced cell survival and resistance to apoptosis. |
2024-07-13 |
2024-07-16 |
human |