| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiajing Ma, Xuhui Li, Xuesi Wan, Jinmei Deng, Yanglei Cheng, Boyuan Liu, Liehua Liu, Lijuan Xu, Haipeng Xiao, Yanbing L. Single-Cell RNA-seq Analysis Reveals a Positive Correlation between Ferroptosis and Beta-Cell Dedifferentiation in Type 2 Diabetes. Biomedicines. vol 12. issue 8. 2024-08-29. PMID:39200152. |
insulin deficiency in patients with type 2 diabetes mellitus (t2d) is associated with beta-cell dysfunction, a condition increasingly recognized to involve processes such as dedifferentiation and apoptosis. |
2024-08-29 |
2024-09-01 |
Not clear |
| Tanin Shafaati, Keshav Gopa. Forkhead box O1 transcription factor; a therapeutic target for diabetic cardiomyopathy. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 27. 2024-08-29. PMID:39206323. |
the known molecular mediators of dbcm are multifactorial, including but not limited to insulin resistance, altered energy metabolism, lipotoxicity, endothelial dysfunction, oxidative stress, apoptosis, and autophagy. |
2024-08-29 |
2024-09-04 |
human |
| Juhi Shah, Tyler Orosz, Avneet Singh, Savan Parameshwar Laxma, Rachel E Gross, Nicholas Smith, Spencer Vroegop, Sydney Sudler, James T Porter, Maria Colon, Lauren Jun, Jeganathan R Babu, Minsub Shim, Thomas L Broderick, Layla Al-Nakkas. Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer's Disease-Related Markers in Male Mice. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201705. |
hfhs feeding also increased protein expression of brain markers of insulin resistance (pgsk-3β, p-ir), apoptosis (caspase 3), early neurofibrillary tangles (cp13), and amyloid-beta precursor (ct20). |
2024-08-29 |
2024-09-04 |
mouse |
| Qian Li, Jialin Fu, Kyoungmin Park, Hetal Shah, Qin Li, I-Hsien Wu, George L Kin. Insulin receptors in vascular smooth muscle cells regulate plaque stability of atherosclerosis. Cardiovascular research. 2024-08-28. PMID:39197028. |
thus, insulin resistance may reduce plaque stability as deleting insulin receptors (ir) in vsmc decreased their proliferation and enhanced apoptosis. |
2024-08-28 |
2024-08-31 |
Not clear |
| Sajad Abolfazli, Alexandra E Butler, Prashant Kesharwani, Amirhossein Sahebka. The beneficial impact of curcumin on cardiac lipotoxicity. The Journal of pharmacy and pharmacology. 2024-08-24. PMID:39180454. |
this stress can be brought on by apoptosis, impaired insulin signaling, endoplasmic reticulum stress, protein kinase c activation, p38 ras-mitogen-activated protein kinase (mapk) activation, or modification of peroxisome proliferator-activated receptors (ppars) family members. |
2024-08-24 |
2024-08-27 |
Not clear |
| Yuxi Zhang, Luke Kuo, Kimberly A Woodhouse, Lindsay E Fitzpatric. Therapeutic Insulin Analogue Concentrations at Infusion Sites Enhanced the Pro-Inflammatory Response and Apoptosis in an In Vitro Macrophage-Material Interaction Model. ACS pharmacology & translational science. vol 7. issue 8. 2024-08-19. PMID:39156741. |
therapeutic insulin analogue concentrations at infusion sites enhanced the pro-inflammatory response and apoptosis in an in vitro macrophage-material interaction model. |
2024-08-19 |
2024-08-21 |
Not clear |
| Yuxi Zhang, Luke Kuo, Kimberly A Woodhouse, Lindsay E Fitzpatric. Therapeutic Insulin Analogue Concentrations at Infusion Sites Enhanced the Pro-Inflammatory Response and Apoptosis in an In Vitro Macrophage-Material Interaction Model. ACS pharmacology & translational science. vol 7. issue 8. 2024-08-19. PMID:39156741. |
additionally, high insulin concentrations arising from therapeutic doses induced macrophage apoptosis with and without adsorbed lysate. |
2024-08-19 |
2024-08-21 |
Not clear |
| Jiangxia Wang, Runlin Gui, Yang Li, Zhuozhuo Li, Zi Li, Shanshan Liu, Miao Zhang, Lu Qian, Xiaobin Fan, Yuyan Xion. SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis. Biochimica et biophysica acta. Molecular cell research. 2024-08-19. PMID:39159685. |
sfrp4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/il-6 signaling axis. |
2024-08-19 |
2024-08-22 |
mouse |
| Lynda Bourebaba, Nabila Bourebaba, Larry Galuppo, Krzysztof Maryc. Artificial mitochondrial transplantation (AMT) reverses aging of mesenchymal stem cells and improves their immunomodulatory properties in LPS-induced synoviocytes inflammation. Biochimica et biophysica acta. Molecular cell research. 2024-08-04. PMID:39098401. |
mitochondria recipient cells were characterized by decreased apoptosis, senescence and endoplasmic reticulum stress while insulin sensitivity was enhanced. |
2024-08-04 |
2024-08-07 |
Not clear |
| M Okulicz, M Billert, T Wojciechowicz, M Skrzypsk. Cytotoxicity of allyl isothiocyanate on insulin-producing INS-1E cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 75. issue 3. 2024-07-23. PMID:39042388. |
therefore, in the present study, we characterized the role of aitc at a wide concentration range (5, 10, 25, 50, 100 μm) in controlling viability, proliferation, apoptosis, mitochondrial condition, mrna expression of encoding pancreatic and duodenal homeobox 1 (pdx1), and ins1, ins2 genes, and insulin content in ins-1e cells. |
2024-07-23 |
2024-07-25 |
rat |
| Xiangjun Sha, Xinlei Zou, Sidi Liu, Canghai Guan, Wujiang Shi, Jianjun Gao, Xiangyu Zhong, Xingming Jian. Forkhead box O1 in metabolic dysfunction-associated fatty liver disease: molecular mechanisms and drug research. Frontiers in nutrition. vol 11. 2024-07-18. PMID:39021599. |
foxo1 mediates the progression of mafld by regulating glucose metabolism, lipid metabolism, insulin resistance, oxidative stress, hepatic fibrosis, hepatocyte autophagy, apoptosis, and immune inflammation. |
2024-07-18 |
2024-07-20 |
human |
| Maitham Alhajamee, Mohammad Khalaj-Kondori, Esmaeil Babaei, Majid Mahdav. A biochemical assessment of apoptosis-inducing impact of Salinomycin in combination with ciprofloxacin on human leukemia KG1-a stem-like cells in the presence and absence of insulin. Molecular biology reports. vol 51. issue 1. 2024-07-13. PMID:39002036. |
besides, insulin is known to activate the pi3k/akt pathway, often disrupted in cancers, leading to enhanced cell survival and resistance to apoptosis. |
2024-07-13 |
2024-07-16 |
human |
| Jiayao Chen, Zhuowen Hao, Hanke Li, Jianping Wang, Tianhong Chen, Ying Wang, Guang Shi, Junwu Wang, Zepu Wang, Zheyuan Zhang, Jingfeng L. Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies. Theranostics. vol 14. issue 10. 2024-07-12. PMID:38994021. |
this review proposes twelve microenvironmental treatment targets for osteoporosis-related pathological changes, including local accumulation of inflammatory factors and reactive oxygen species (ros), imbalance of mitochondrial dynamics, insulin resistance, disruption of bone cell autophagy, imbalance of bone cell apoptosis, changes in neural secretions, aging of bone cells, increased local bone tissue vascular destruction, and decreased regeneration. |
2024-07-12 |
2024-07-14 |
Not clear |
| Hossein Ghazaee, Alireza Raouf Sheibani, Haniyeh Mahdian, Shamim Gholami, Vahid Reza Askari, Vafa Baradaran Rahim. Ellagic acid as potential therapeutic compound for diabetes and its complications: a systematic review from bench to bed. Naunyn-Schmiedeberg's archives of pharmacology. 2024-07-09. PMID:38980410. |
ea counteracted dm and its complications by diminishing inflammation, oxidative stress, hyperglycemia, apoptosis, insulin resistance, obesity, lipid profile, and histopathological alterations. |
2024-07-09 |
2024-07-12 |
Not clear |
| Ayman Hyder, Basma Sheta, Manar Eissa, Jürgen Schrezenmei. Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity. Acta diabetologica. 2024-07-03. PMID:38960943. |
long-term exposure of pancreatic islets to fatty acids (fas), common in obesity, metabolic syndrome, and type 2 diabetes, leads to a compensatory hyperactivity followed by inflammation, apoptosis, dysfunctional beta cells, and results in insulin dependence of the patient. |
2024-07-03 |
2024-07-10 |
Not clear |
| Jane Carissa Sutedja, Bryan Gervais de Liyis, Made Ratna Saraswat. Gamma-aminobutyric acid for delaying type 1 diabetes mellitus: an update. Annals of pediatric endocrinology & metabolism. vol 29. issue 3. 2024-07-03. PMID:38956751. |
various in vitro and in vivo studies have shown that gaba induces proliferation of β cells, increases insulin levels, inhibits β-cell apoptosis, and suppresses t helper 1 cell activity against islet antigens. |
2024-07-03 |
2024-07-06 |
Not clear |
| Minglong Qiu, Leilei Chang, Guoqing Tang, Wenkai Ye, Yiming Xu, Nijiati Tulufu, Zhou Dan, Jin Qi, Lianfu Deng, Changwei L. Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ. Experimental & molecular medicine. 2024-06-30. PMID:38945950. |
in addition to increasing bone mass and reducing blood glucose levels, activating the hif-1α pathway by specifically knocking out von hippel‒lindau (vhl) in osteoblasts partially alleviated the symptoms of streptozotocin (stz)-induced type 1 diabetes mellitus (t1dm), including increased glucose clearance in the diabetic state, protection of pancreatic β cell from stz-induced apoptosis, promotion of pancreatic β cell proliferation, and stimulation of insulin secretion. |
2024-06-30 |
2024-07-03 |
Not clear |
| Maryam Moosavi, Roksana Soukhaklari, Saeid Bagheri-Mohammadi, Bita Firouzan, Pegah Javadpour, Rasoul Ghasem. Nanocurcumin prevents memory impairment, hippocampal apoptosis, Akt and CaMKII-α signaling disruption in the central STZ model of Alzheimer's disease in rat. Behavioural brain research. 2024-06-28. PMID:38942084. |
these findings might suggest that nanocurcumin can restore memory deficit, hippocampal apoptosis as well as akt and camkii-α signaling disruption associated with brain insulin resistance. |
2024-06-28 |
2024-07-01 |
rat |
| Liwei Sun, Hailong Bing, Chenxi Zhang, Lin Lin, Hongkai Lian, Qinjun Chu, Xiaogao Ji. Short-Term Preconditioning with Insulin and Glucose Efficiently Protected the Kidney Against Ischemia-Reperfusion Injury via the P-AKT-Bax-Caspase-3 Signaling Pathway in Mice. Drug design, development and therapy. vol 18. 2024-06-25. PMID:38915866. |
insulin attaches insulin receptor to activate the pi3-kinase/akt signaling to maintain glucose homeostasis and inhibit apoptosis. |
2024-06-25 |
2024-06-27 |
mouse |
| Sumit Patel, Maria S Remed. Loss of β-cell identity and dedifferentiation, not an irreversible process? Frontiers in endocrinology. vol 15. 2024-06-25. PMID:38915897. |
while the decline in insulin production and secretion was previously attributed to apoptosis of insulin-producing β-cells, recent studies indicate that β-cell apoptosis rates are relatively low in diabetes. |
2024-06-25 |
2024-06-27 |
Not clear |