| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Dawson, R Goswami, J Kilkus, D Wiesner, S Dawso. The formation of ceramide from sphingomyelin is associated with cellular apoptosis. Acta biochimica Polonica. vol 45. issue 2. 1999-01-20. PMID:9821861. |
apoptosis is also important in normal brain development and neuronal survival is dependent upon phosphatidylinositol 3-kinase (pi3-kinase) activation by growth factors (insulin, nerve growth factor etc.). |
1999-01-20 |
2023-08-12 |
Not clear |
| I D Román, N Rodríguez-Henche, J A Fueyo, J A Zueco, C Menor, J C Prieto, L G Guijarr. Cyclosporin A induces apoptosis in rat hepatocytes in culture. Archives of toxicology. vol 72. issue 9. 1999-01-07. PMID:9806427. |
cyclosporin a (csa) at concentrations up to 1 microm induced apoptosis in a dose-dependent manner in cultured rat hepatocytes for 48 h in the presence of insulin and epidermal growth factor (egf). |
1999-01-07 |
2023-08-12 |
rat |
| A Herrler, C A Krusche, H M Beie. Insulin and insulin-like growth factor-I promote rabbit blastocyst development and prevent apoptosis. Biology of reproduction. vol 59. issue 6. 1998-12-28. PMID:9828171. |
insulin and insulin-like growth factor-i promote rabbit blastocyst development and prevent apoptosis. |
1998-12-28 |
2023-08-12 |
rabbit |
| A Herrler, C A Krusche, H M Beie. Insulin and insulin-like growth factor-I promote rabbit blastocyst development and prevent apoptosis. Biology of reproduction. vol 59. issue 6. 1998-12-28. PMID:9828171. |
in contrast, coat-free embryos cultured without igf-i or insulin supplementation show apoptosis. |
1998-12-28 |
2023-08-12 |
rabbit |
| A Herrler, C A Krusche, H M Beie. Insulin and insulin-like growth factor-I promote rabbit blastocyst development and prevent apoptosis. Biology of reproduction. vol 59. issue 6. 1998-12-28. PMID:9828171. |
because igf-i stimulates cell proliferation and prevents apoptosis, we investigated whether insulin or igf-i may act as "survival factors" in preimplantation development. |
1998-12-28 |
2023-08-12 |
rabbit |
| A Herrler, C A Krusche, H M Beie. Insulin and insulin-like growth factor-I promote rabbit blastocyst development and prevent apoptosis. Biology of reproduction. vol 59. issue 6. 1998-12-28. PMID:9828171. |
by immunohistochemistry we could show that addition of insulin (0.68-68 nm) decreased apoptosis and increased cell proliferation in a dose-dependent manner, supporting blastocyst development significantly. |
1998-12-28 |
2023-08-12 |
rabbit |
| W Lee-Kwon, D Park, P V Baskar, S Kole, M Bernie. Antiapoptotic signaling by the insulin receptor in Chinese hamster ovary cells. Biochemistry. vol 37. issue 45. 1998-12-21. PMID:9843380. |
we have sought to determine whether insulin can promote cell survival and protect chinese hamster ovary (cho) cells from apoptosis induced by serum starvation. |
1998-12-21 |
2023-08-12 |
Not clear |
| W Lieberthal, V Triaca, J S Koh, P J Pagano, J S Levin. Role of superoxide in apoptosis induced by growth factor withdrawal. The American journal of physiology. vol 275. issue 5. 1998-12-10. PMID:9815127. |
both epidermal growth factor (egf) and high-dose insulin directly inhibit apoptosis of mpt cells deprived of growth factors. |
1998-12-10 |
2023-08-12 |
mouse |
| W Lieberthal, V Triaca, J S Koh, P J Pagano, J S Levin. Role of superoxide in apoptosis induced by growth factor withdrawal. The American journal of physiology. vol 275. issue 5. 1998-12-10. PMID:9815127. |
growth factor deprivation also results in activation of caspase activity, which is inhibited by egf and high-dose insulin as well as by the ros scavengers and antioxidants that inhibit apoptosis. |
1998-12-10 |
2023-08-12 |
mouse |
| S Janciauskiene, B Ahré. Different sensitivity to the cytotoxic action of IAPP fibrils in two insulin-producing cell lines, HIT-T15 and RINm5F cells. Biochemical and biophysical research communications. vol 251. issue 3. 1998-12-03. PMID:9791005. |
iapp fibrils (apoptosis (tunel assay), and glucose-stimulated insulin secretion and the cytosolic concentration of ca2+ were unaffected. |
1998-12-03 |
2023-08-12 |
Not clear |
| L Yenush, C Zanella, T Uchida, D Bernal, M F Whit. The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin. Molecular and cellular biology. vol 18. issue 11. 1998-11-23. PMID:9774692. |
the pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin. |
1998-11-23 |
2023-08-12 |
Not clear |
| L Yenush, C Zanella, T Uchida, D Bernal, M F Whit. The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin. Molecular and cellular biology. vol 18. issue 11. 1998-11-23. PMID:9774692. |
32d cells have few insulin receptors and no irs proteins; therefore, insulin failed to inhibit apoptosis during il-3 withdrawal. |
1998-11-23 |
2023-08-12 |
Not clear |
| L Yenush, C Zanella, T Uchida, D Bernal, M F Whit. The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin. Molecular and cellular biology. vol 18. issue 11. 1998-11-23. PMID:9774692. |
insulin stimulated mitogen-activated protein kinase in 32d cells expressing insulin receptors (32dir) but failed to activate the phosphatidylinositol 3 (pi 3)-kinase cascade or to inhibit apoptosis. |
1998-11-23 |
2023-08-12 |
Not clear |
| L Yenush, C Zanella, T Uchida, D Bernal, M F Whit. The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin. Molecular and cellular biology. vol 18. issue 11. 1998-11-23. PMID:9774692. |
by contrast, insulin stimulated the pi 3-kinase cascade, inhibited apoptosis, and promoted replication of 32dir cells expressing irs-1. |
1998-11-23 |
2023-08-12 |
Not clear |
| L Yenush, C Zanella, T Uchida, D Bernal, M F Whit. The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin. Molecular and cellular biology. vol 18. issue 11. 1998-11-23. PMID:9774692. |
however, this truncated irs-1 protein, which retained the nh2-terminal pleckstrin homology (ph) and phosphotyrosine binding (ptb) domains, mediated phosphorylation of pkb/akt, inhibition of apoptosis, and replication of 32dir cells during insulin stimulation. |
1998-11-23 |
2023-08-12 |
Not clear |
| R H Chen, Y H Su, R L Chuang, T Y Chan. Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene. vol 17. issue 15. 1998-11-06. PMID:9788439. |
insulin and insulin receptor substrate 1 (irs-1) are capable of protecting liver cells from apoptosis induced by transforming growth factor-beta1 (tgf-beta). |
1998-11-06 |
2023-08-12 |
Not clear |
| R H Chen, Y H Su, R L Chuang, T Y Chan. Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene. vol 17. issue 15. 1998-11-06. PMID:9788439. |
the ras/mitogen-activated protein kinase (map kinase) and the phosphatidylinositol 3-kinase (pi 3-kinase)/akt pathways are both activated upon insulin stimulation and can protect against apoptosis under certain circumstances. |
1998-11-06 |
2023-08-12 |
Not clear |
| R H Chen, Y H Su, R L Chuang, T Y Chan. Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene. vol 17. issue 15. 1998-11-06. PMID:9788439. |
we investigated which of these pathways is responsible for the protective effect of insulin on tgf-beta-induced apoptosis. |
1998-11-06 |
2023-08-12 |
Not clear |
| R H Chen, Y H Su, R L Chuang, T Y Chan. Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene. vol 17. issue 15. 1998-11-06. PMID:9788439. |
however, rapamycin, the p70s6 kinase inhibitor, had no effect on the protectivity of insulin against tgf-beta-induced apoptosis, suggesting that the antiapoptotic target of pi 3-kinase/akt pathway is independent or lies upstream of the p70s6 kinase. |
1998-11-06 |
2023-08-12 |
Not clear |
| S Morishita, E F Sato, K Takahashi, M Manabe, M Inou. Insulin-induced hypoglycemia elicits thymocyte apoptosis in the rat. Diabetes research and clinical practice. vol 40. issue 1. 1998-11-05. PMID:9699084. |
administration of either glucose or ru486, a glucocorticoid receptor antagonist, inhibited the apoptosis of thymocytes elicited by insulin. |
1998-11-05 |
2023-08-12 |
rat |