| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Hermann, B Assmus, C Urbich, A M Zeiher, S Dimmele. Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669636. |
incubation with insulin dose-dependently prevented apoptosis induced by tnf-alpha (50 ng/ml). |
2000-03-03 |
2023-08-12 |
human |
| C Hermann, B Assmus, C Urbich, A M Zeiher, S Dimmele. Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669636. |
the extent of apoptosis suppression by insulin was similar to the effect of vascular endothelial growth factor. |
2000-03-03 |
2023-08-12 |
human |
| C Hermann, B Assmus, C Urbich, A M Zeiher, S Dimmele. Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669636. |
in contrast, insulin inhibited caspase-9 activity and prevented caspase-9-induced apoptosis. |
2000-03-03 |
2023-08-12 |
human |
| P Dupraz, C Rinsch, W F Pralong, E Rolland, R Zufferey, D Trono, B Thoren. Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion. Gene therapy. vol 6. issue 6. 2000-02-24. PMID:10455420. |
lentivirus-mediated bcl-2 expression in betatc-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion. |
2000-02-24 |
2023-08-12 |
mouse |
| A Mora, R A González-Polo, J M Fuentes, G Soler, F Centen. Different mechanisms of protection against apoptosis by valproate and Li+. European journal of biochemistry. vol 266. issue 3. 2000-01-31. PMID:10583382. |
insulin also protects against low-k+-induced apoptosis of cerebellar granule cells. |
2000-01-31 |
2023-08-12 |
Not clear |
| N A Danilovich, A Bartke, T A Winter. Ovarian follicle apoptosis in bovine growth hormone transgenic mice. Biology of reproduction. vol 62. issue 1. 2000-01-19. PMID:10611073. |
growth hormone directly or via insulin like-growth factor-i has been shown to inhibit preovulatory follicle apoptosis, which is the underlying mechanism of follicular atresia. |
2000-01-19 |
2023-08-12 |
mouse |
| C L Delaney, H L Cheng, E L Feldma. Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells. Journal of neurobiology. vol 41. issue 4. 2000-01-11. PMID:10590177. |
addition of insulin or igf-i prevented apoptosis. |
2000-01-11 |
2023-08-12 |
rat |
| T Uchida, M G Myers, M F Whit. IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis. Molecular and cellular biology. vol 20. issue 1. 2000-01-10. PMID:10594015. |
insulin strongly inhibited apoptosis of interleukin-3 (il-3)-deprived 32d(ir) cells expressing irs-1 or irs-2 but failed to inhibit apoptosis of cells expressing irs-4. |
2000-01-10 |
2023-08-12 |
human |
| R N Wang, L Rosenber. Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. The Journal of endocrinology. vol 163. issue 2. 1999-12-23. PMID:10556766. |
this change was coincident with both a decrease in beta-cell function (proinsulin gene expression, islet insulin content and stimulated insulin release) and a rise in beta-cell death from apoptosis, as determined by in situ cell death detection (tunel) assay. |
1999-12-23 |
2023-08-12 |
Not clear |
| F Bertrand, C Desbois-Mouthon, A Cadoret, C Prunier, H Robin, J Capeau, A Atfi, G Cherqu. Insulin antiapoptotic signaling involves insulin activation of the nuclear factor kappaB-dependent survival genes encoding tumor necrosis factor receptor-associated factor 2 and manganese-superoxide dismutase. The Journal of biological chemistry. vol 274. issue 43. 1999-11-23. PMID:10521443. |
traf2 contributed to insulin protection against serum withdrawal-induced apoptosis since traf2 overexpression mimicked insulin protection, whereas overexpression of dominant-negative traf2-(87-501) reduced this process. |
1999-11-23 |
2023-08-12 |
Not clear |
| C E Herrman, R A Sanders, J E Klaunig, L R Schwarz, J B Watkin. Decreased apoptosis as a mechanism for hepatomegaly in streptozotocin-induced diabetic rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 50. issue 1. 1999-10-19. PMID:10445763. |
the morphological evidence of apoptosis was decreased by 23% to 76% in the diabetic liver, and was reversed but not normalized by insulin treatment. |
1999-10-19 |
2023-08-12 |
rat |
| S T Christensen, J Chemnitz, E M Straarup, K Kristiansen, D N Wheatley, L Rasmusse. Staurosporine-induced cell death in Tetrahymena thermophila has mixed characteristics of both apoptotic and autophagic degeneration. Cell biology international. vol 22. issue 7-8. 1999-10-12. PMID:10452827. |
our results show that cell death in the presence of staurosporine is associated with morphological and ultrastructural changes similar to both apoptosis and autophagic degeneration, but these in turn can be postponed or prevented by 8-bromo-cyclic gmp, protoporphyrin ix, hemin or actinomycin d, although phorbol ester and insulin were ineffective. |
1999-10-12 |
2023-08-12 |
Not clear |
| J Petrik, B Reusens, E Arany, C Remacle, C Coelho, J J Hoet, D J Hil. A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor-II. Endocrinology. vol 140. issue 10. 1999-10-12. PMID:10499546. |
these findings show that lp diet changes the balance of beta cell replication and apoptosis in fetal and neonatal neonatal life, which may involve an altered length of beta cell cycle, and contribute to the smaller islet size and impaired insulin release seen in later life. |
1999-10-12 |
2023-08-12 |
rat |
| N Giannoukakis, W A Rudert, S C Ghivizzani, A Gambotto, C Ricordi, M Trucco, P D Robbin. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro. Diabetes. vol 48. issue 9. 1999-09-30. PMID:10480601. |
in particular, il-1beta can impair glucose-stimulated insulin production in beta-cells in vitro and can sensitize them to fas (cd95)/fasl-triggered apoptosis. |
1999-09-30 |
2023-08-12 |
human |
| N Giannoukakis, W A Rudert, S C Ghivizzani, A Gambotto, C Ricordi, M Trucco, P D Robbin. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro. Diabetes. vol 48. issue 9. 1999-09-30. PMID:10480601. |
we demonstrate that adenoviral gene delivery of the cdna encoding the interleukin-1 receptor antagonist protein (il-1ra) to cultured islets results in protection of human islets in vitro against il-1beta-induced nitric oxide formation, impairment in glucose-stimulated insulin production, and fas-triggered apoptosis activation. |
1999-09-30 |
2023-08-12 |
human |
| N S Chandel, P T Schumacke. Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms. FEBS letters. vol 454. issue 3. 1999-08-26. PMID:10431801. |
the present article focuses on how rho0 cells have contributed to an understanding of the role that mitochondria play in distinct physiological pathways involved with apoptosis, glucose-induced insulin secretion, and oxygen sensing. |
1999-08-26 |
2023-08-12 |
human |
| B R Ryu, H W Ko, I Jou, J S Noh, B J Gwa. Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I. Journal of neurobiology. vol 39. issue 4. 1999-07-28. PMID:10380075. |
phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and igf-i. |
1999-07-28 |
2023-08-12 |
Not clear |
| B R Ryu, H W Ko, I Jou, J S Noh, B J Gwa. Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I. Journal of neurobiology. vol 39. issue 4. 1999-07-28. PMID:10380075. |
we examined effects of two insulin-like growth factors, insulin and insulin-like growth factor-i (igf-i), against apoptosis, excitotoxicity, and free radical neurotoxicity in cortical cell cultures. |
1999-07-28 |
2023-08-12 |
Not clear |
| B R Ryu, H W Ko, I Jou, J S Noh, B J Gwa. Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I. Journal of neurobiology. vol 39. issue 4. 1999-07-28. PMID:10380075. |
like igf-i, insulin attenuated serum deprivation-induced neuronal apoptosis in a dose-dependent manner at 10-100 ng/ml. |
1999-07-28 |
2023-08-12 |
Not clear |
| B R Ryu, H W Ko, I Jou, J S Noh, B J Gwa. Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I. Journal of neurobiology. vol 39. issue 4. 1999-07-28. PMID:10380075. |
inclusion of wortmannin or ly294002, selective inhibitors of pi 3-k, reversed the insulin effect against apoptosis. |
1999-07-28 |
2023-08-12 |
Not clear |