| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Aikawa, M Nawano, Y Gu, H Katagiri, T Asano, W Zhu, R Nagai, I Komur. Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt. Circulation. vol 102. issue 23. 2001-02-01. PMID:11104747. |
insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of pi3 kinase/akt. |
2001-02-01 |
2023-08-12 |
Not clear |
| K Maedler, G A Spinas, D Dyntar, W Moritz, N Kaiser, M Y Donat. Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes. vol 50. issue 1. 2001-01-25. PMID:11147797. |
taken together, these results suggest that the lipotoxic effect of the saturated palmitic acid involves an increased apoptosis rate coupled with reduced proliferation capacity of beta-cells and impaired insulin secretion. |
2001-01-25 |
2023-08-12 |
rat |
| P Dupraz, S Cottet, F Hamburger, W Dolci, E Felley-Bosco, B Thoren. Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells. The Journal of biological chemistry. vol 275. issue 48. 2001-01-11. PMID:10967106. |
in particular, cytokine-induced production of nitric oxide has been shown to correlate with beta cell apoptosis and/or inhibition of insulin secretion. |
2001-01-11 |
2023-08-12 |
mouse |
| P Dupraz, S Cottet, F Hamburger, W Dolci, E Felley-Bosco, B Thoren. Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells. The Journal of biological chemistry. vol 275. issue 48. 2001-01-11. PMID:10967106. |
these results demonstrate that il-1beta is involved in inducible nitric oxide synthase gene expression and induction of apoptosis in mouse beta cells but does not contribute to impaired glucose-stimulated insulin secretion. |
2001-01-11 |
2023-08-12 |
mouse |
| A Primot, B Baratte, M Gompel, A Borgne, S Liabeuf, J L Romette, E H Jho, F Costantini, L Meije. Purification of GSK-3 by affinity chromatography on immobilized axin. Protein expression and purification. vol 20. issue 3. 2001-01-11. PMID:11087679. |
it is directly involved in diseases such as cancer (by controlling apoptosis and the levels of beta-catenin and cyclin d1), alzheimer's disease (tau hyperphosphorylation), and diabetes (as a downstream element of insulin action, gsk-3 regulates glycogen and lipid synthesis). |
2001-01-11 |
2023-08-12 |
rat |
| J S Noh, H J Kang, E Y Kim, S Sohn, Y K Chung, S U Kim, B J Gwa. Haloperidol-induced neuronal apoptosis: role of p38 and c-Jun-NH(2)-terminal protein kinase. Journal of neurochemistry. vol 75. issue 6. 2000-12-28. PMID:11080184. |
the present study demonstrates that cortical neurons exposed to haloperidol undergo apoptosis depending on activation of p38 mitogen-activated protein kinase and c-jun-nh(2)-terminal protein kinase sensitive to cycloheximide and insulin. |
2000-12-28 |
2023-08-12 |
Not clear |
| D Brandhorst, H P Hammes, H Brandhorst, A Zwolinski, F Nahidi, A Alt, R G Bretze. Pretransplant induction of HSP-70 in isolated adult pig islets decreases early islet xenograft survival. Cell transplantation. vol 9. issue 3. 2000-12-22. PMID:10972341. |
the observation, that the heat-induced hsp-70 expression decreases early islet xenograft survival as reflected by recovery of grafted insulin, implies an enhancement of islet immunogenicity and the induction of apoptosis. |
2000-12-22 |
2023-08-12 |
rat |
| M M Chi, A L Schlein, K H Mole. High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor. Endocrinology. vol 141. issue 12. 2000-12-22. PMID:11108294. |
high insulin-like growth factor 1 (igf-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the igf-1 receptor. |
2000-12-22 |
2023-08-12 |
mouse |
| M M Chi, A L Schlein, K H Mole. High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor. Endocrinology. vol 141. issue 12. 2000-12-22. PMID:11108294. |
in this study, preimplantation embryos exposed to high concentrations of igf-1 or insulin undergo extensive apoptosis of the icm nuclei. |
2000-12-22 |
2023-08-12 |
mouse |
| P Navarro, A M Valverde, J L Rohn, M Benito, M Lorenz. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 10. issue 5. 2000-12-14. PMID:11042022. |
akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. |
2000-12-14 |
2023-08-12 |
Not clear |
| P Navarro, A M Valverde, J L Rohn, M Benito, M Lorenz. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 10. issue 5. 2000-12-14. PMID:11042022. |
we have recently shown that insulin can rescue serum deprived adipocytes from apoptosis in a pi 3 kinase and map kinase dependent manner. |
2000-12-14 |
2023-08-12 |
Not clear |
| P Navarro, A M Valverde, J L Rohn, M Benito, M Lorenz. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 10. issue 5. 2000-12-14. PMID:11042022. |
insulin rescued serum-deprived immortalized brown adipocytes from apoptosis through phosphatidylinositol (pi) 3-kinase and akt pathways, but independently of p70s6-kinase, as demonstrated by the use of inhibitors such as ly294002 or rapamycin, and transfection experiments with dominant-negative constructs of akt or p85 subunit of pi 3-kinase. |
2000-12-14 |
2023-08-12 |
Not clear |
| P Navarro, A M Valverde, J L Rohn, M Benito, M Lorenz. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 10. issue 5. 2000-12-14. PMID:11042022. |
however, insulin and egf failed to rescue brown adipocytes from ceramide-induced apoptosis, as determined by dna laddering, hypodiploid cells and apoptotic nuclei. |
2000-12-14 |
2023-08-12 |
Not clear |
| A Sjöholm, P O Berggren, R V Coone. gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide. Biochemical and biophysical research communications. vol 277. issue 2. 2000-11-30. PMID:11032727. |
preceding the onset of type 1 diabetes mellitus, pancreatic islets are infiltrated by macrophages secreting interleukin-1beta (il-1beta) which induces beta-cell apoptosis and exerts inhibitory actions on islet beta-cell insulin secretion. |
2000-11-30 |
2023-08-12 |
Not clear |
| S Srinivasan, M Stevens, J W Wile. Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction. Diabetes. vol 49. issue 11. 2000-11-30. PMID:11078462. |
restoration of euglycemia for 2 weeks with insulin implants normalized ncv, deltapsi, and apoptosis. |
2000-11-30 |
2023-08-12 |
rat |
| X Feng, Y Jiang, P Meltzer, P M Ye. Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray. Molecular endocrinology (Baltimore, Md.). vol 14. issue 7. 2000-11-24. PMID:10894146. |
thyroid hormone affected gene expression for a diverse range of cellular pathways and functions, including gluconeogenesis, lipogenesis, insulin signaling, adenylate cyclase signaling, cell proliferation, and apoptosis. |
2000-11-24 |
2023-08-12 |
mouse |
| B B Aggarwa. Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB. Annals of the rheumatic diseases. vol 59 Suppl 1. 2000-11-21. PMID:11053079. |
tumour necrosis factor (tnf) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. |
2000-11-21 |
2023-08-12 |
Not clear |
| J Tesarik, C Mendoza, E Grec. The effect of FSH on male germ cell survival and differentiation in vitro is mimicked by pentoxifylline but not insulin. Molecular human reproduction. vol 6. issue 10. 2000-11-07. PMID:11006315. |
on the other hand, a high concentration of insulin, supposed to act at the insulin-like growth factor i receptor, did not exert any effect either on differentiation or apoptosis of germ cells in vitro. |
2000-11-07 |
2023-08-12 |
human |
| A Pirskanen, J C Kiefer, S D Hauschk. IGFs, insulin, Shh, bFGF, and TGF-beta1 interact synergistically to promote somite myogenesis in vitro. Developmental biology. vol 224. issue 2. 2000-09-18. PMID:10926759. |
further studies indicate that insulin, igfs, bfgf, and shh also stimulate somite cell proliferation and influence apoptosis. |
2000-09-18 |
2023-08-12 |
chicken |
| D Bonnefont-Rousselot, J P Bastard, M C Jaudon, J Delattr. Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes & metabolism. vol 26. issue 3. 2000-09-05. PMID:10880889. |
reciprocally, oxidative stress is involved in the origin of type 1 diabetes, especially via the apoptosis of pancreatic beta-cells, as well as insulin resistance in type 2 diabetes. |
2000-09-05 |
2023-08-12 |
Not clear |