| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Nakamura, A J Barber, D A Antonetti, K F LaNoue, K A Robinson, M G Buse, T W Gardne. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. The Journal of biological chemistry. vol 276. issue 47. 2001-12-20. PMID:11560942. |
exposure of r28 cells, a model of retinal neurons, to 20 mm glucose for 24 h attenuated the ability of 10 nm insulin to rescue them from serum deprivation-induced apoptosis and to phosphorylate akt compared with 5 mm glucose. |
2001-12-20 |
2023-08-12 |
Not clear |
| M Nakamura, A J Barber, D A Antonetti, K F LaNoue, K A Robinson, M G Buse, T W Gardne. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. The Journal of biological chemistry. vol 276. issue 47. 2001-12-20. PMID:11560942. |
glucosamine not only impaired the neuroprotective effect of insulin but also induced apoptosis in r28 cells in a dose-dependent fashion. |
2001-12-20 |
2023-08-12 |
Not clear |
| M Nakamura, A J Barber, D A Antonetti, K F LaNoue, K A Robinson, M G Buse, T W Gardne. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. The Journal of biological chemistry. vol 276. issue 47. 2001-12-20. PMID:11560942. |
via perturbation of the neuroprotective effect of insulin mediated by akt and via induction of apoptosis possibly by altered glycosylation of proteins. |
2001-12-20 |
2023-08-12 |
Not clear |
| G Hodgson, J H Hager, S Volik, S Hariono, M Wernick, D Moore, N Nowak, D G Albertson, D Pinkel, C Collins, D Hanahan, J W Gra. Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. Nature genetics. vol 29. issue 4. 2001-12-20. PMID:11694878. |
carcinomas that develop in the pancreatic islets of transgenic mice expressing the sv40 t-antigens (tag) under transcriptional control of the rat insulin ii promoter (rip) progress through well-characterized stages that are similar to aspects of human tumor progression, including hyperplastic growth, increased angiogenesis and reduced apoptosis. |
2001-12-20 |
2023-08-12 |
mouse |
| E Giovannucc. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. The Journal of nutrition. vol 131. issue 11 Suppl. 2001-12-19. PMID:11694656. |
insulin and insulin-like growth factor (igf) axes are major determinants of proliferation and apoptosis and thus may influence carcinogenesis. |
2001-12-19 |
2023-08-12 |
human |
| J Mahiou, U Walter, F Lepault, F Godeau, J F Bach, L Chatenou. In vivo blockade of the Fas-Fas ligand pathway inhibits cyclophosphamide-induced diabetes in NOD mice. Journal of autoimmunity. vol 16. issue 4. 2001-12-07. PMID:11437491. |
there is compelling evidence to show that insulin dependent diabetes ensues from selective apoptosis of pancreatic beta-cells mediated by autoreactive t-lymphocytes. |
2001-12-07 |
2023-08-12 |
mouse |
| T Yamauchi, J Kamon, H Waki, K Murakami, K Motojima, K Komeda, T Ide, N Kubota, Y Terauchi, K Tobe, H Miki, A Tsuchida, Y Akanuma, R Nagai, S Kimura, T Kadowak. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11533050. |
moreover, although heterozygous ppargamma deficiency and tzd have opposite effects on total wat mass, heterozygous ppargamma deficiency decreases lipogenesis in wat, whereas tzd stimulate adipocyte differentiation and apoptosis, thereby both preventing adipocyte hypertrophy, which is associated with alleviation of insulin resistance presumably due to decreases in free fatty acids, and tumor necrosis factor alpha, and up-regulation of adiponectin, at least in part. |
2001-12-07 |
2023-08-12 |
Not clear |
| E Marcinkowska, A Chrobak, A Wiedłoch. Evading apoptosis by calcitriol-differentiated human leukemic HL-60 cells is not mediated by changes in CD95 receptor system but by increased sensitivity of these cells to insulin. Experimental cell research. vol 270. issue 1. 2001-12-04. PMID:11597134. |
evading apoptosis by calcitriol-differentiated human leukemic hl-60 cells is not mediated by changes in cd95 receptor system but by increased sensitivity of these cells to insulin. |
2001-12-04 |
2023-08-12 |
human |
| P Domingo, X Matías-Guiu, R M Pujol, J C Domingo, J A Arroyo, M A Sambeat, G Vázque. Switching to nevirapine decreases insulin levels but does not improve subcutaneous adipocyte apoptosis in patients with highly active antiretroviral therapy-associated lipodystrophy. The Journal of infectious diseases. vol 184. issue 9. 2001-12-04. PMID:11598845. |
switching to nevirapine decreases insulin levels but does not improve subcutaneous adipocyte apoptosis in patients with highly active antiretroviral therapy-associated lipodystrophy. |
2001-12-04 |
2023-08-12 |
Not clear |
| S Goetze, F Blaschke, P Stawowy, D Bruemmer, C Spencer, K Graf, M Gräfe, R E Law, E Flec. TNFalpha inhibits insulin's antiapoptotic signaling in vascular smooth muscle cells. Biochemical and biophysical research communications. vol 287. issue 3. 2001-11-01. PMID:11563846. |
by activating the insulin receptor (ir) --> irs-1 --> phosphatidylinositol-3-kinase (pi3k) --> akt-pathway, insulin protects vascular smooth muscle cells (vsmc) from undergoing apoptosis. |
2001-11-01 |
2023-08-12 |
rat |
| S Goetze, F Blaschke, P Stawowy, D Bruemmer, C Spencer, K Graf, M Gräfe, R E Law, E Flec. TNFalpha inhibits insulin's antiapoptotic signaling in vascular smooth muscle cells. Biochemical and biophysical research communications. vol 287. issue 3. 2001-11-01. PMID:11563846. |
we next examined the effect of tnfalpha on insulin's protective actions on h(2)o(2)-induced apoptosis. |
2001-11-01 |
2023-08-12 |
rat |
| S Goetze, F Blaschke, P Stawowy, D Bruemmer, C Spencer, K Graf, M Gräfe, R E Law, E Flec. TNFalpha inhibits insulin's antiapoptotic signaling in vascular smooth muscle cells. Biochemical and biophysical research communications. vol 287. issue 3. 2001-11-01. PMID:11563846. |
insulin alone prevented 72.8% of h(2)o(2)-induced apoptosis, which was significantly inhibited by tnfalpha. |
2001-11-01 |
2023-08-12 |
rat |
| A J Barber, M Nakamura, E B Wolpert, C E Reiter, G M Seigel, D A Antonetti, T W Gardne. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11443130. |
insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/akt-mediated mechanism that reduces the activation of caspase-3. |
2001-10-18 |
2023-08-12 |
rat |
| A J Barber, M Nakamura, E B Wolpert, C E Reiter, G M Seigel, D A Antonetti, T W Gardne. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11443130. |
the ability of insulin to protect neurons from apoptosis was examined in differentiated r28 cells, a neural cell line derived from the neonatal rat retina. |
2001-10-18 |
2023-08-12 |
rat |
| A J Barber, M Nakamura, E B Wolpert, C E Reiter, G M Seigel, D A Antonetti, T W Gardne. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11443130. |
10 nm insulin maximally reduced the amount of apoptosis with a similar potency as 1.3 nm (10 ng/ml) insulin-like growth factor 1, which acted as a positive control. |
2001-10-18 |
2023-08-12 |
rat |
| A J Barber, M Nakamura, E B Wolpert, C E Reiter, G M Seigel, D A Antonetti, T W Gardne. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11443130. |
inhibition of pi 3-kinase with wortmannin or ly294002 blocked the ability of insulin to rescue the cells from apoptosis. |
2001-10-18 |
2023-08-12 |
rat |
| R Kaaks, A Lukanov. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. The Proceedings of the Nutrition Society. vol 60. issue 1. 2001-08-23. PMID:11310428. |
the anabolic signals by insulin or igf-i can promote tumour development by inhibiting apoptosis, and by stimulating cell proliferation. |
2001-08-23 |
2023-08-12 |
Not clear |
| B Tyrberg, A Andersson, L A Bor. Species differences in susceptibility of transplanted and cultured pancreatic islets to the beta-cell toxin alloxan. General and comparative endocrinology. vol 122. issue 3. 2001-08-02. PMID:11356036. |
furthermore, ultrastructural signs of apoptosis and necrosis, disturbances in the insulin secretory pattern during and after an alloxan perifusion, and islet lysosomal enzyme activities were studied in vitro in islets from some species. |
2001-08-02 |
2023-08-12 |
mouse |
| S M de La Monte, J R Wand. Mitochondrial dna damage and impaired mitochondrial function contribute to apoptosis of insulin-stimulated ethanol-exposed neuronal cells. Alcoholism, clinical and experimental research. vol 25. issue 6. 2001-08-02. PMID:11410727. |
an important consequence of ethanol inhibition of insulin signaling is increased apoptosis due to reduced levels of insulin-stimulated phosphoinositol-3-kinase activity. |
2001-08-02 |
2023-08-12 |
Not clear |
| A L Scarim, M Arnush, L A Blair, J Concepcion, M R Heitmeier, D Scheuner, R J Kaufman, J Ryerse, R M Buller, J A Corbet. Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis. The American journal of pathology. vol 159. issue 1. 2001-08-02. PMID:11438474. |
in contrast, the combination of poly ic and interferon (ifn)-gamma stimulates dna damage, apoptosis, and necrosis of islet cells, and this damage is associated with the inhibition of glucose-stimulated insulin secretion. |
2001-08-02 |
2023-08-12 |
mouse |