| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seiichi Oyadomari, Akio Koizumi, Kiyoshi Takeda, Tomomi Gotoh, Shizuo Akira, Eiichi Araki, Masataka Mor. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. The Journal of clinical investigation. vol 109. issue 4. 2002-03-21. PMID:11854325. |
overexpression of the mutant insulin in mouse min6 beta cells induced chop expression and led to apoptosis. |
2002-03-21 |
2023-08-12 |
mouse |
| Dagmar Scheel-Toellner, Keqing Wang, Nico V Henriquez, Paul R Webb, Rachel Craddock, Darrell Pilling, Arne N Akbar, Mike Salmon, Janet M Lor. Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation. European journal of immunology. vol 32. issue 2. 2002-03-20. PMID:11828365. |
insulin did not inhibit apoptosis in neutrophils or t cells and fmlp did not delay neutrophil apoptosis. |
2002-03-20 |
2023-08-12 |
human |
| D Ross Laybutt, Hideaki Kaneto, Wendy Hasenkamp, Shane Grey, Jean-Christophe Jonas, Dennis C Sgroi, Adam Groff, Christiane Ferran, Susan Bonner-Weir, Arun Sharma, Gordon C Wei. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes. vol 51. issue 2. 2002-03-15. PMID:11812749. |
furthermore, beta-cells of px rats were not vulnerable to apoptosis when further challenged in vivo with dexamethasone, which increases insulin resistance. |
2002-03-15 |
2023-08-12 |
rat |
| Catalina Hernández-Sánchez, Eva Rubio, José Serna, Enrique J de la Rosa, Flora de Pabl. Unprocessed proinsulin promotes cell survival during neurulation in the chick embryo. Diabetes. vol 51. issue 3. 2002-03-15. PMID:11872678. |
we show that in vivo interference with embryonic insulin signaling using antisense oligonucleotides against the insulin receptor increases apoptosis during neurulation. |
2002-03-15 |
2023-08-12 |
chicken |
| Kaoruko Tada Iida, Hiroaki Suzuki, Hirohito Sone, Hitoshi Shimano, Hideo Toyoshima, Shigeru Yatoh, Tomoichiro Asano, Yukichi Okuda, Nobuhiro Yamad. Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway. Arteriosclerosis, thrombosis, and vascular biology. vol 22. issue 3. 2002-03-14. PMID:11884278. |
insulin inhibits apoptosis of macrophage cell line, thp-1 cells, via phosphatidylinositol-3-kinase-dependent pathway. |
2002-03-14 |
2023-08-12 |
human |
| Kaoruko Tada Iida, Hiroaki Suzuki, Hirohito Sone, Hitoshi Shimano, Hideo Toyoshima, Shigeru Yatoh, Tomoichiro Asano, Yukichi Okuda, Nobuhiro Yamad. Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway. Arteriosclerosis, thrombosis, and vascular biology. vol 22. issue 3. 2002-03-14. PMID:11884278. |
insulin administration retarded macrophage apoptosis by means of dna laddering, dimethylthiazol diphenyltetrazolium bromide assay, and annexin v binding assay. |
2002-03-14 |
2023-08-12 |
human |
| Kaoruko Tada Iida, Hiroaki Suzuki, Hirohito Sone, Hitoshi Shimano, Hideo Toyoshima, Shigeru Yatoh, Tomoichiro Asano, Yukichi Okuda, Nobuhiro Yamad. Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway. Arteriosclerosis, thrombosis, and vascular biology. vol 22. issue 3. 2002-03-14. PMID:11884278. |
these data indicate that the survival effect of insulin on the apoptosis of macrophages is associated with the upregulation of bcl-xl expression, and it may be mediated through the phosphatidylinositol-3-kinase signaling pathway. |
2002-03-14 |
2023-08-12 |
human |
| R Gauthier, P Laprise, E Cardin, C Harnois, A Plourde, J C Reed, A Vézina, P H Vacho. Differential sensitivity to apoptosis between the human small and large intestinal mucosae: linkage with segment-specific regulation of BCL-2 homologs and involvement of signaling pathways. Journal of cellular biochemistry. vol 82. issue 2. 2002-02-15. PMID:11527158. |
herein, we report that (1) the inhibition of signal transduction molecules/pathways revealed striking differences in their impact on cell survival in the jejunum and colon (e.g., the inhibition of p125fak induced apoptosis with a significantly greater extent in the jejunum [approximately 43%] than in the colon [approximately 24%]); (2) sharp distinctions between the two segments were noted in the modulatory effects of the various treatments on bcl-2 homolog steady-state levels (e.g., inhibition of tyrosine kinase activities in the jejunum down-regulated all anti-apoptotics analyzed while increasing bax, whereas the same treatment in the colon down-regulated bcl-x(l) only and increased all pro-apoptotics); and (3) in addition to their differential impact on cell survival and bcl-2 homolog expression, the mek/erk and p13-k/akt pathways were found to be distinctively regulated in the jejunum and colon mucosae (e.g., insulin in the jejunum increased p42erk-2 activation without affecting that of p57akt, whereas the same treatment in the colon decreased p42erk-2 activation while increasing that of p57akt). |
2002-02-15 |
2023-08-12 |
human |
| J Zamorano, A L Mora, M Boothby, A D Keega. NF-kappa B activation plays an important role in the IL-4-induced protection from apoptosis. International immunology. vol 13. issue 12. 2002-02-14. PMID:11717189. |
to determine the contribution of co-stimulatory signals to the regulation of apoptosis by il-4, we first analyzed whether tumor necrosis factor (tnf)-alpha, which has been shown to inhibit the activation of irs-1 by insulin, could modify il-4 signaling and protection from apoptosis. |
2002-02-14 |
2023-08-12 |
mouse |
| W Chai, J Chen, H Wang, J Shen, L Ma, X M. The effects of glucose, insulin and oxidized low density lipoprotein on apoptosis in vascular endothelial cells. Chinese medical journal. vol 113. issue 10. 2002-02-14. PMID:11775837. |
the effects of glucose, insulin and oxidized low density lipoprotein on apoptosis in vascular endothelial cells. |
2002-02-14 |
2023-08-12 |
cattle |
| W Chai, J Chen, H Wang, J Shen, L Ma, X M. The effects of glucose, insulin and oxidized low density lipoprotein on apoptosis in vascular endothelial cells. Chinese medical journal. vol 113. issue 10. 2002-02-14. PMID:11775837. |
to study the effects of high concentrations of glucose, insulin and oxidized low density lipoprotein (ox-ldl) on apoptosis in cultured bovine aortic endothelial cells (ecs). |
2002-02-14 |
2023-08-12 |
cattle |
| Jennifer Y Kong, Simon W Rabki. Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin. American journal of physiology. Heart and circulatory physiology. vol 282. issue 2. 2002-02-14. PMID:11788422. |
palmitate-induced cardiac apoptosis is mediated through cpt-1 but not influenced by glucose and insulin. |
2002-02-14 |
2023-08-12 |
chicken |
| Yasuo Ido, David Carling, Neil Ruderma. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. vol 51. issue 1. 2002-02-13. PMID:11756336. |
the results indicate that alterations in fatty-acid metabolism, impaired akt activation by insulin, and increased caspase-3 activity precede visible evidence of apoptosis in huvec incubated in a hyperglycemic medium. |
2002-02-13 |
2023-08-12 |
human |
| J J Wu, X Chen, X C Cao, M S Baker, D B Kaufma. Cytokine-induced metabolic dysfunction of MIN6 beta cells is nitric oxide independent. The Journal of surgical research. vol 101. issue 2. 2002-02-07. PMID:11735275. |
we tested the in vitro effects of interleukin (il)-1 beta, tumor necrosis factor (tnf)alpha, and interferon (ifn)gamma on glucose-stimulated insulin release in the min6 beta-cell line and correlated metabolic dysfunction with no production and rates of apoptosis. |
2002-02-07 |
2023-08-12 |
Not clear |
| M A Lawlor, D R Aless. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? Journal of cell science. vol 114. issue Pt 16. 2002-02-06. PMID:11686294. |
recent evidence indicates that pkb plays a key role in cancer progression by stimulating cell proliferation and inhibiting apoptosis and is also probably a key mediator of insulin signalling. |
2002-02-06 |
2023-08-12 |
Not clear |
| D Mathis, L Vence, C Benois. beta-Cell death during progression to diabetes. Nature. vol 414. issue 6865. 2002-01-28. PMID:11742411. |
apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. |
2002-01-28 |
2023-08-12 |
Not clear |
| T Yamauchi, T Kadowak. [The molecular mechanisms by which PPAR gamma/RXR inhibitors improve insulin resistance]. Nihon rinsho. Japanese journal of clinical medicine. vol 59. issue 11. 2002-01-25. PMID:11712415. |
moreover, ppar gamma/rxr inhibitors decrease lipogenesis in wat, while tzd stimulate adipocyte differentiation and apoptosis, thereby both preventing adipocyte hypertrophy, which is associated with alleviation of insulin resistance presumably due to decreases in ffa, and tnf alpha, and upregulation of adiponectin. |
2002-01-25 |
2023-08-12 |
Not clear |
| T J Wilki. The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes. Diabetologia. vol 44. issue 7. 2002-01-02. PMID:11508279. |
the 'accelerator hypothesis' identifies three processes which variably accelerate the loss of beta cells through apoptosis: constitution, insulin resistance and autoimmunity. |
2002-01-02 |
2023-08-12 |
Not clear |
| M Nakamura, A J Barber, D A Antonetti, K F LaNoue, K A Robinson, M G Buse, T W Gardne. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. The Journal of biological chemistry. vol 276. issue 47. 2001-12-20. PMID:11560942. |
excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. |
2001-12-20 |
2023-08-12 |
Not clear |
| M Nakamura, A J Barber, D A Antonetti, K F LaNoue, K A Robinson, M G Buse, T W Gardne. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. The Journal of biological chemistry. vol 276. issue 47. 2001-12-20. PMID:11560942. |
we tested whether increased glucose flux through the hbp perturbs insulin action and induces apoptosis in retinal neuronal cells. |
2001-12-20 |
2023-08-12 |
Not clear |