| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Almudena Porras, Susana Zuluaga, Amparo Valladares, Alberto M Alvarez, Blanca Herrera, Isabel Fabregat, Manuel Benit. Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:14500576. |
the effect of insulin on apoptosis and the mechanisms involved were assessed. |
2004-01-05 |
2023-08-12 |
rat |
| Almudena Porras, Susana Zuluaga, Amparo Valladares, Alberto M Alvarez, Blanca Herrera, Isabel Fabregat, Manuel Benit. Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:14500576. |
different from the known effects of insulin as a survival factor, we have found that long-term treatment (72 h) with insulin induces apoptosis in rat fetal brown adipocytes. |
2004-01-05 |
2023-08-12 |
rat |
| Eiichi Araki, Seiichi Oyadomari, Masataka Mor. Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus. Experimental biology and medicine (Maywood, N.J.). vol 228. issue 10. 2003-12-23. PMID:14610263. |
overexpression of the mutant insulin in mouse min6 beta-cells induced chop expression and led to apoptosis. |
2003-12-23 |
2023-08-12 |
mouse |
| Efrat Assa-Kunik, Daniel Fishman, Sigal Kellman-Pressman, Sylvia Tsory, Shira Elhyany, Ofer Baharir, Shraga Sega. Alterations in the expression of MHC class I glycoproteins by B16BL6 melanoma cells modulate insulin receptor-regulated signal transduction and augment [correction of augments] resistance to apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 171. issue 6. 2003-12-04. PMID:12960318. |
alterations in the expression of mhc class i glycoproteins by b16bl6 melanoma cells modulate insulin receptor-regulated signal transduction and augment [correction of augments] resistance to apoptosis. |
2003-12-04 |
2023-08-12 |
mouse |
| Mathew G Miller, Izabela Naruszewicz, Ashu S Kumar, Toolsie Ramlal, Gregory E Hanniga. Integrin-linked kinase is a positive mediator of L6 myoblast differentiation. Biochemical and biophysical research communications. vol 310. issue 3. 2003-12-02. PMID:14550274. |
cell cycle analysis of ilk(e359k) cells cultured in serum-free conditions indicates significant apoptosis (11-19% sub-diploid peak) which is not seen in insulin treated cells. |
2003-12-02 |
2023-08-12 |
Not clear |
| Irini Rakatzi, Gerhard Seipke, Jürgen Ecke. [LysB3, GluB29] insulin: a novel insulin analog with enhanced beta-cell protective action. Biochemical and biophysical research communications. vol 310. issue 3. 2003-12-02. PMID:14550282. |
the marked cytokine- and fatty acid-induced apoptosis was strongly (55-60%) inhibited by ig both at the level of caspase 3 activation and nucleosomal release, with only 15% inhibition of apoptosis by regular insulin. |
2003-12-02 |
2023-08-12 |
Not clear |
| Guanjun Cheng, Aurélia E Lewis, Judy L Meinkot. Ras stimulates aberrant cell cycle progression and apoptosis in rat thyroid cells. Molecular endocrinology (Baltimore, Md.). vol 17. issue 3. 2003-10-16. PMID:12554771. |
we report that apoptosis is a primary and general response of rat thyroid cells to acute expression of activated ras in the absence or presence of thyrotropin, insulin, and serum, survival factors for thyroid cells. |
2003-10-16 |
2023-08-12 |
rat |
| Marshall S Baker, Xiaojuan Chen, Alizah R Rotramel, Jeffrey J Nelson, Dixon B Kaufma. Interferon regulatory factor-1 down-regulates cytokine-induced IP-10 expression in pancreatic islets. Surgery. vol 134. issue 2. 2003-10-16. PMID:12947309. |
interferon (ifn)-gamma acts synergistically with interleukin (il)-1beta and tumor necrosis factor (tnf)-alpha to activate isoform of nitric oxide synthetase (inos) gene expression, induce apoptosis, and impair glucose-stimulated insulin release (gsir) in pancreatic islets. |
2003-10-16 |
2023-08-12 |
Not clear |
| Alexandra E Butler, Juliette Janson, Walter C Soeller, Peter C Butle. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes. vol 52. issue 9. 2003-10-07. PMID:12941770. |
recent studies in rodents reveal that beta-cell mass is regulated, increasing in response to insulin resistance through increased beta-cell supply (islet neogenesis and beta-cell replication) and/or decreased beta-cell loss (beta-cell apoptosis). |
2003-10-07 |
2023-08-12 |
mouse |
| R Augustin, P Pocar, C Wrenzycki, H Niemann, B Fische. Mitogenic and anti-apoptotic activity of insulin on bovine embryos produced in vitro. Reproduction (Cambridge, England). vol 126. issue 1. 2003-09-29. PMID:12814351. |
the various effects of insulin were unravelled by supplementing the in vitro culture medium with insulin (1.7 micromol l(-1)) and (i) the rates of cleavage and blastocyst development were recorded; (ii) mitogenic activity was studied by determining the total number of blastocyst cells and the ratio between trophectoderm and inner cell mass (icm) cells; (iii) the frequency of apoptosis in blastocysts was determined by the tdt-mediated dutp nick-end labelling (tunel) assay and by quantification of the relative amounts of mrna for bax and bcl-xl; and (iv) expression for glut1, glut3 and glut8 transcripts was compared between embryos cultured in the presence or absence of insulin. |
2003-09-29 |
2023-08-12 |
cattle |
| R Augustin, P Pocar, C Wrenzycki, H Niemann, B Fische. Mitogenic and anti-apoptotic activity of insulin on bovine embryos produced in vitro. Reproduction (Cambridge, England). vol 126. issue 1. 2003-09-29. PMID:12814351. |
blastocysts derived from cultures supplemented with insulin showed a significant decrease in apoptosis as determined by the tunel assay (14.8+/-0.9 to 12.2+/-0.7). |
2003-09-29 |
2023-08-12 |
cattle |
| Julia Xu, Jong Eun Yeon, Howard Chang, Geoffrey Tison, Guo Jun Chen, Jack Wands, Suzanne de la Mont. Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase. The Journal of biological chemistry. vol 278. issue 29. 2003-08-27. PMID:12700235. |
we examined insulin signaling in an experimental rat model of chronic gestational exposure to ethanol in which the pups exhibited striking cerebellar hypoplasia with increased apoptosis. |
2003-08-27 |
2023-08-12 |
rat |
| Louis Ragolia, Thomas Palaia, Enesa Paric, John K Maesak. Prostaglandin D2 synthase inhibits the exaggerated growth phenotype of spontaneously hypertensive rat vascular smooth muscle cells. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12684506. |
unexpectedly, we found that when wky cells were pretreated with l-pgds, insulin could actually induce apoptosis and failed to stimulate akt/gsk-3beta phosphorylation. |
2003-07-22 |
2023-08-12 |
rat |
| Hakan Akca, Selma Yenisoy, Atila Yanikoglu, Osman Nidai Oze. Tumor necrosis factor-alpha-induced accumulation of tumor suppressor protein p53 and cyclin-dependent protein kinase inhibitory protein p21 is inhibited by insulin in ME-180S cells. Clinical chemistry and laboratory medicine. vol 40. issue 8. 2003-07-10. PMID:12392301. |
since many tumors secrete growth factor(s) that inhibit apoptosis and support the growth of cancer cells, we wanted to know whether insulin would have an effect on antitumor and p53-inducing activities of human tumor necrosis factor-alpha (tnf-alpha). |
2003-07-10 |
2023-08-12 |
human |
| Hakan Akca, Selma Yenisoy, Atila Yanikoglu, Osman Nidai Oze. Tumor necrosis factor-alpha-induced accumulation of tumor suppressor protein p53 and cyclin-dependent protein kinase inhibitory protein p21 is inhibited by insulin in ME-180S cells. Clinical chemistry and laboratory medicine. vol 40. issue 8. 2003-07-10. PMID:12392301. |
however, pretreatment of these cells with insulin inhibits tnf-alpha-dependent cell killing, induction of p53, p21 and apoptosis. |
2003-07-10 |
2023-08-12 |
human |
| Masaki Yamanaka, Masato Shirai, Hiroaki Shiina, Yuichiro Tanaka, Akira Tsujimura, Kiyomi Matsumiya, Akihiko Okuyama, Rajvir Dahiy. Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats. The Journal of urology. vol 170. issue 1. 2003-07-09. PMID:12796708. |
diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats. |
2003-07-09 |
2023-08-12 |
rat |
| Masaki Yamanaka, Masato Shirai, Hiroaki Shiina, Yuichiro Tanaka, Akira Tsujimura, Kiyomi Matsumiya, Akihiko Okuyama, Rajvir Dahiy. Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats. The Journal of urology. vol 170. issue 1. 2003-07-09. PMID:12796708. |
molecular and immunohistochemical analyses for apoptosis were then performed in rat crura to assess their role in diabetes induced erectile dysfunction and insulin treatment. |
2003-07-09 |
2023-08-12 |
rat |
| G S Wang, J Karamchandani, O Pulido, L Rosenberg, F W Scot. Altered islet homeostasis before classic insulitis in BB rats. Diabetes & metabolism. vol 28. issue 6 Pt 2. 2003-07-07. PMID:12688639. |
pancreatic sections were fixed in bouin's solution and evaluated using immunohistochemistry and image analysis by staining with antibodies for islet hormones: insulin, glucagon; cell proliferation markers: pcna, brdu; markers of islet neogenesis: pdx-1, cytokeratin 20; apoptosis was assessed by morphological changes and tunel staining. |
2003-07-07 |
2023-08-12 |
rat |
| Marc-Estienne Roehrich, Vincent Mooser, Vincent Lenain, Joachim Herz, Johannes Nimpf, Salman Azhar, Martine Bideau, Alessandro Capponi, Pascal Nicod, Jacques-Antoine Haefliger, Gérard Waebe. Insulin-secreting beta-cell dysfunction induced by human lipoproteins. The Journal of biological chemistry. vol 278. issue 20. 2003-06-25. PMID:12594227. |
purified human very low density lipoprotein (vldl) and ldl particles reduced insulin mrna levels and beta-cell proliferation and induced a dose-dependent increase in the rate of apoptosis. |
2003-06-25 |
2023-08-12 |
mouse |
| Maria B Grant, Sergio Caballer. Somatostatin analogues as drug therapies for retinopathies. Drugs of today (Barcelona, Spain : 1998). vol 38. issue 11. 2003-06-09. PMID:12582462. |
sstr2 and sstr3 are the most important receptor subtypes mediating growth hormone secretion and endothelial cell cycle arrest, retinal endothelial cell apoptosis and release of insulin. |
2003-06-09 |
2023-08-12 |
Not clear |