| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dinender Kumar, Joseph Zimpelmann, Susan Robertson, Kevin D Burn. Tubular and interstitial cell apoptosis in the streptozotocin-diabetic rat kidney. Nephron. Experimental nephrology. vol 96. issue 3. 2004-05-10. PMID:15056984. |
we studied the extent of apoptosis in streptozotocin (stz) induced diabetic nephropathy in the rat and the effects of insulin and type 1 (at1) or type 2 (at2) ang ii receptor blockade with losartan or pd123319, respectively. |
2004-05-10 |
2023-08-12 |
rat |
| Masahito Hanada, Jianhua Feng, Brian A Hemming. Structure, regulation and function of PKB/AKT--a major therapeutic target. Biochimica et biophysica acta. vol 1697. issue 1-2. 2004-05-05. PMID:15023346. |
protein kinase b (pkb/akt) is a central player in the signal transduction pathways activated in response to growth factors or insulin and is thought to contribute to several cellular functions including nutrient metabolism, cell growth and apoptosis. |
2004-05-05 |
2023-08-12 |
human |
| Makoto Inoue, Takatoshi Maeno, Daijiro Miki, Sherif Embabi, Diane L Hatchel. Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats. Ophthalmic research. vol 36. issue 1. 2004-04-12. PMID:15007237. |
from 7 to 60 days after transplantation, immunoperoxidase staining for insulin, glucagon, cd4, cd8, and interleukin (il)-2, and evaluation of apoptosis using nick-end labeling (tunel) were performed. |
2004-04-12 |
2023-08-12 |
rat |
| Anne K Jonassen, Ole D Mjøs, Michael N Sac. p70s6 kinase is a functional target of insulin activated Akt cell-survival signaling. Biochemical and biophysical research communications. vol 315. issue 1. 2004-04-09. PMID:15013440. |
insulin administration attenuates cardiac ischemia-reperfusion apoptosis via activation of akt-mediated cell-survival signaling. |
2004-04-09 |
2023-08-12 |
human |
| Bernat Soria, Ivan Quesada, Ana B Ropero, José A Pertusa, Franz Martín, Angel Nada. Novel players in pancreatic islet signaling: from membrane receptors to nuclear channels. Diabetes. vol 53 Suppl 1. 2004-03-23. PMID:14749271. |
this includes not only insulin release, but also insulin synthesis and storage and other aspects of beta-cell biology, including cell proliferation, apoptosis, differentiation, and gene expression. |
2004-03-23 |
2023-08-12 |
Not clear |
| Mark Van de Casteele, Benjamin Ate Kefas, Ying Cai, Harry Heimberg, Donald K Scott, Jean Claude Henquin, Daniël Pipeleers, Jean Christophe Jona. Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochemical and biophysical research communications. vol 312. issue 4. 2004-03-18. PMID:14651961. |
in contrast, inhibition of ca(2+) influx and insulin secretion with diazoxide under control conditions did not stimulate islet c-myc expression nor beta-cell apoptosis. |
2004-03-18 |
2023-08-12 |
rat |
| Mark Van de Casteele, Benjamin Ate Kefas, Ying Cai, Harry Heimberg, Donald K Scott, Jean Claude Henquin, Daniël Pipeleers, Jean Christophe Jona. Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochemical and biophysical research communications. vol 312. issue 4. 2004-03-18. PMID:14651961. |
in the insulin producing min6 cell line, apoptosis induction by either low glucose or an activator of amp-activated protein kinase (ampk) was associated with c-myc mrna and protein upregulation. |
2004-03-18 |
2023-08-12 |
rat |
| Sunny Z Hussain, Tamara Sneddon, Xinping Tan, Amanda Micsenyi, George K Michalopoulos, Satdarshan P S Mong. Wnt impacts growth and differentiation in ex vivo liver development. Experimental cell research. vol 292. issue 1. 2004-02-27. PMID:14720515. |
livers from mouse embryos at day 10 were cultured in serum-free wnt-3a-conditioned media alone or with hgf and insulin for 72 h and analyzed for histology, proliferation, apoptosis and lineage. |
2004-02-27 |
2023-08-12 |
mouse |
| U Seybold, R Draenert, F D Goebe. [Adverse effects of antiretroviral therapy. Aspects of pathogenesis]. Der Internist. vol 44. issue 6. 2004-02-20. PMID:14567106. |
the pathogenesis is related to metabolic alterations of the adipocytes with cellular insulin resistance and enhanced apoptosis of these cells caused by adipocytic cytokines such as adiponectin, leptin, tnf-alpha and interleukin 2. |
2004-02-20 |
2023-08-12 |
Not clear |
| F Shi, P S LaPol. Relationship between FoxO1 protein levels and follicular development, atresia, and luteinization in the rat ovary. The Journal of endocrinology. vol 179. issue 2. 2004-01-27. PMID:14596671. |
foxo1 is a transcription factor implicated in a growing number of physiological processes, including apoptosis, cell cycle progression, and insulin signaling. |
2004-01-27 |
2023-08-12 |
human |
| R Jamali, M Bao, H J Arnqvis. IGF-I but not insulin inhibits apoptosis at a low concentration in vascular smooth muscle cells. The Journal of endocrinology. vol 179. issue 2. 2004-01-27. PMID:14596678. |
igf-i but not insulin inhibits apoptosis at a low concentration in vascular smooth muscle cells. |
2004-01-27 |
2023-08-12 |
rat |
| R Jamali, M Bao, H J Arnqvis. IGF-I but not insulin inhibits apoptosis at a low concentration in vascular smooth muscle cells. The Journal of endocrinology. vol 179. issue 2. 2004-01-27. PMID:14596678. |
our aim was to evaluate the effect of insulin and igf-i on apoptosis in vsmcs. |
2004-01-27 |
2023-08-12 |
rat |
| R Jamali, M Bao, H J Arnqvis. IGF-I but not insulin inhibits apoptosis at a low concentration in vascular smooth muscle cells. The Journal of endocrinology. vol 179. issue 2. 2004-01-27. PMID:14596678. |
igf-i dose-dependently reduced apoptosis evaluated by elisa, reaching a maximal effect at 10(-9) m. insulin reduced apoptosis but the effect was weaker and a higher concentration was needed. |
2004-01-27 |
2023-08-12 |
rat |
| Tadako Nakatsuj. Oncogene expression on the syngeneic beta-cells of long-term surviving pancreatic grafts and better effects of interleukin-1 receptor (IL-1R) and IL-2Rbeta on the grafted beta-cells in LEW/Sea strain rats. Transplant immunology. vol 11. issue 1. 2004-01-23. PMID:12727475. |
insulin secretion from the grafted beta-cells and il-1beta-induced fas-mediated apoptosis of the beta-cells were suspected to be present at the same time in the female with the best graft survival. |
2004-01-23 |
2023-08-12 |
rat |
| Kathleen L Wyn. Free fatty acids and type 2 diabetes mellitus. The American journal of medicine. vol 115 Suppl 8A. 2004-01-23. PMID:14678863. |
sustained elevation, however, leads to apoptosis of pancreatic beta-cells and is a major risk factor for cardiovascular disease and sudden death in patients with insulin resistance or a family history of diabetes mellitus, as well as in individuals with normal glucose tolerance. |
2004-01-23 |
2023-08-12 |
Not clear |
| E S Torres, C V Andrade, E C Fonseca, M A Mello, M E L Duart. Insulin impairs the maturation of chondrocytes in vitro. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 36. issue 9. 2004-01-22. PMID:12937784. |
while apoptosis increased in control cultures as a function of culture time, terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel)-labeled cells were markedly reduced in the presence of insulin. |
2004-01-22 |
2023-08-12 |
chicken |
| Undurti N Da. Insulin: an endogenous cardioprotector. Current opinion in critical care. vol 9. issue 5. 2004-01-22. PMID:14508150. |
several recent studies suggest that insulin not only is useful to control hyperglycemia and maintain glucose homeostasis but also may have the unique property to protect the myocardium from reperfusion injury and ischemia and prevent apoptosis of myocardial cells. |
2004-01-22 |
2023-08-12 |
Not clear |
| Ewan Bell, Xiaopei Cao, Jacob A Moibi, Scott R Greene, Robert Young, Matteo Trucco, Zhiyong Gao, Franz M Matschinsky, Shaoping Deng, James F Markman, Ali Naji, Bryan A Wol. Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets. Diabetes. vol 52. issue 11. 2004-01-14. PMID:14578291. |
a supra-therapeutic rapamycin concentration of 100 nmol/l significantly impaired glucose- and carbachol-stimulated insulin secretion in rat islets and had a deleterious effect on the viability of rat and human islets, causing apoptosis of both alpha- and beta-cells. |
2004-01-14 |
2023-08-12 |
human |
| Loredana Farilla, Angela Bulotta, Boaz Hirshberg, Sergio Li Calzi, Nasif Khoury, Houtan Noushmehr, Cristina Bertolotto, Umberto Di Mario, David M Harlan, Riccardo Perfett. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:12960095. |
the peptide hormone, glucagon-like peptide 1 (glp-1), has been shown to increase glucose-dependent insulin secretion, enhance insulin gene transcription, expand islet cell mass, and inhibit beta-cell apoptosis in animal models of diabetes. |
2004-01-05 |
2023-08-12 |
human |
| Almudena Porras, Susana Zuluaga, Amparo Valladares, Alberto M Alvarez, Blanca Herrera, Isabel Fabregat, Manuel Benit. Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:14500576. |
long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress. |
2004-01-05 |
2023-08-12 |
rat |