| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ines Wanke, Michael Schwarz, Albrecht Buchman. Insulin and dexamethasone inhibit TGF-beta-induced apoptosis of hepatoma cells upstream of the caspase activation cascade. Toxicology. vol 204. issue 2-3. 2004-11-08. PMID:15388240. |
inhibition of tgf-beta-induced apoptosis by insulin and dexamethasone was paralleled by a strong reduction of caspase-3-like activity. |
2004-11-08 |
2023-08-12 |
rat |
| Cristina D'Alessandris, Francesco Andreozzi, Massimo Federici, Marina Cardellini, Antonio Brunetti, Marco Ranalli, Silvia Del Guerra, Davide Lauro, Stefano Del Prato, Piero Marchetti, Renato Lauro, Giorgio Sest. Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 9. 2004-11-02. PMID:15059979. |
increased o-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells. |
2004-11-02 |
2023-08-12 |
human |
| Víctor Navarro-Tableros, M Carmen Sánchez-Soto, Santiago García, Marcia Hiriar. Autocrine regulation of single pancreatic beta-cell survival. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277381. |
when ngf or insulin signaling were blocked in culture media, cell survival decreased compared with control cells, with apoptosis being the main mechanism of cell death. |
2004-09-17 |
2023-08-12 |
rat |
| Víctor Navarro-Tableros, M Carmen Sánchez-Soto, Santiago García, Marcia Hiriar. Autocrine regulation of single pancreatic beta-cell survival. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277381. |
to further explore the role of glucose in beta-cell survival, we cultured the cells for 16 h in 2.6 mmol/l glucose and observed that nearly 17% of the cells developed apoptosis; this effect was partially prevented by ngf and almost completely inhibited by insulin treatment. |
2004-09-17 |
2023-08-12 |
rat |
| Kathrin Maedler, Joachim Størling, Jeppe Sturis, Richard A Zuellig, Giatgen A Spinas, Per O G Arkhammar, Thomas Mandrup-Poulsen, Marc Y Donat. Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. Diabetes. vol 53. issue 7. 2004-09-16. PMID:15220194. |
exposure of human islets for 4 days to 11.1 and 33.3 mmol/l glucose, 2 ng/ml il-1beta, or 10 and 100 micromol/l of the sulfonylurea tolbutamide induced beta-cell apoptosis and impaired glucose-stimulated insulin secretion. |
2004-09-16 |
2023-08-12 |
human |
| Linda Banaei-Bouchareb, Valerie Gouon-Evans, Dinane Samara-Boustani, Marie Claire Castellotti, Paul Czernichow, Jeffrey W Pollard, Michel Pola. Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice. Journal of leukocyte biology. vol 76. issue 2. 2004-09-03. PMID:15178709. |
the combined use of immunohistochemistry, morphometry, and cell quantification allows us to evaluate insulin and glucagon cell mass, total and insulin cell proliferation, and apoptosis in fetuses (e18.5), weanings (postnatal day 21), nonpregnant adults, and adults in late pregnancy (18.5 days). |
2004-09-03 |
2023-08-12 |
mouse |
| Axel Weber, Christine Huesken, Eckhard Bergmann, Wieland Kiess, Nina M Christiansen, Holger Christianse. Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 15. 2004-08-17. PMID:14654552. |
coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. |
2004-08-17 |
2023-08-12 |
human |
| Alexandra E Butler, Jennifer Jang, Tatyana Gurlo, Maynard D Carty, Walter C Soeller, Peter C Butle. Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes. vol 53. issue 6. 2004-08-04. PMID:15161755. |
the islet in type 2 diabetes is characterized by a deficit in beta-cell mass, increased beta-cell apoptosis, and impaired insulin secretion. |
2004-08-04 |
2023-08-12 |
mouse |
| G Bikopoulos, R B Ceddia, G Sweeney, A J Hillike. Insulin reduces apoptosis and increases DNA synthesis and cell size via distinct signalling pathways in Drosophila Kc cells. Cell proliferation. vol 37. issue 4. 2004-08-04. PMID:15245566. |
insulin reduces apoptosis and increases dna synthesis and cell size via distinct signalling pathways in drosophila kc cells. |
2004-08-04 |
2023-08-12 |
drosophila_melanogaster |
| G Bikopoulos, R B Ceddia, G Sweeney, A J Hillike. Insulin reduces apoptosis and increases DNA synthesis and cell size via distinct signalling pathways in Drosophila Kc cells. Cell proliferation. vol 37. issue 4. 2004-08-04. PMID:15245566. |
in summary, we show that derk plays an important role in mediating the effect of insulin to reduce apoptosis and increase dna synthesis whereas the dpi3k/dtor/dp70s6 kinase pathway mediates effects of insulin on cell size in drosophila kc cells. |
2004-08-04 |
2023-08-12 |
drosophila_melanogaster |
| Tomoshi Tsuchiya, Joseph M Dhahbi, Xinping Cui, Patricia L Mote, Andrzej Bartke, Stephen R Spindle. Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiological genomics. vol 17. issue 3. 2004-07-16. PMID:15039484. |
together, the interventions produced changes in gene expression consistent with increased insulin, glucagon and catecholamine sensitivity, gluconeogenesis, protein turnover, lipid beta-oxidation, apoptosis, and xenobiotic and oxidant metabolism; and decreased cell proliferation, lipid and cholesterol synthesis, and chaperone expression. |
2004-07-16 |
2023-08-12 |
mouse |
| Xiaohua Wu, Chad E N Reiter, David A Antonetti, Scot R Kimball, Leonard S Jefferson, Thomas W Gardne. Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. The Journal of biological chemistry. vol 279. issue 10. 2004-07-06. PMID:14660591. |
apoptosis, induced by serum deprivation and evaluated by hoechst staining, was inhibited by insulin treatment in r28 cells, but not in l6 muscle cells. |
2004-07-06 |
2023-08-12 |
rat |
| Yue-cheng Yu, Xiao-yan Xin, Feng Zhang, Xiang-dong Ma, De-tang Wang, Hui-ling Gu. [Effect of insulin on apoptosis of cultured human trophoblast cells and its mechanism]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 19. issue 5. 2004-06-30. PMID:15169668. |
[effect of insulin on apoptosis of cultured human trophoblast cells and its mechanism]. |
2004-06-30 |
2023-08-12 |
human |
| Yue-cheng Yu, Xiao-yan Xin, Feng Zhang, Xiang-dong Ma, De-tang Wang, Hui-ling Gu. [Effect of insulin on apoptosis of cultured human trophoblast cells and its mechanism]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 19. issue 5. 2004-06-30. PMID:15169668. |
to explore the effect of insulin on apoptosis of cultured human trophoblast cells and its possible mechanism. |
2004-06-30 |
2023-08-12 |
human |
| Amanda Hoehn Wyman, Maggie Chi, Joan Riley, Mary O Carayannopoulos, Chunmei Yang, Kenneth J Coker, Jeffrey E Pessin, Kelle H Mole. Syntaxin 4 expression affects glucose transporter 8 translocation and embryo survival. Molecular endocrinology (Baltimore, Md.). vol 17. issue 10. 2004-06-22. PMID:12829803. |
these data demonstrate that the lack of syntaxin 4 expression results in abnormal movement of glut8 in response to insulin, decreased insulin-stimulated glucose uptake, and increased apoptosis. |
2004-06-22 |
2023-08-12 |
mouse |
| Dharminder Chauhan, Guilan Li, Klaus Podar, Teru Hideshima, Reshma Shringarpure, Laurence Catley, Constantine Mitsiades, Nikhil Munshi, Yu Tzu Tai, Nanjoo Suh, Gordon W Gribble, Tadashi Honda, Robert Schlossman, Paul Richardson, Michael B Sporn, Kenneth C Anderso. The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance. Blood. vol 103. issue 8. 2004-05-27. PMID:15070698. |
moreover, cddo-im-induced apoptosis in mm cells is not blocked by il-6 or insulin growth factor-1 (igf-1). |
2004-05-27 |
2023-08-12 |
Not clear |
| John G Shelton, Fumin Chang, John T Lee, Richard A Franklin, Linda S Steelman, James A McCubre. B-raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells. Cell cycle (Georgetown, Tex.). vol 3. issue 2. 2004-05-21. PMID:14712088. |
b-raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells. |
2004-05-21 |
2023-08-12 |
Not clear |
| John G Shelton, Fumin Chang, John T Lee, Richard A Franklin, Linda S Steelman, James A McCubre. B-raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells. Cell cycle (Georgetown, Tex.). vol 3. issue 2. 2004-05-21. PMID:14712088. |
insulin by itself did not prevent apoptosis, however, upon db-raf:er or draf-1:er activation and addition of insulin, more than an additive effect was observed in both lines indicating that these path- ways synergized to prevent apoptosis. |
2004-05-21 |
2023-08-12 |
Not clear |
| Gordon Dixon, John Nolan, Neville H McClenaghan, Peter R Flatt, Philip Newsholm. Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity. Clinical science (London, England : 1979). vol 106. issue 2. 2004-05-10. PMID:14561212. |
conversely 24 h exposure to the saturated fatty acid palmitic acid (pa) was found to decrease beta-cell viability (by increasing apoptosis), increase the intracellular concentration of triacylglycerol (triglyceride), while inhibiting alanine-stimulated insulin secretion. |
2004-05-10 |
2023-08-12 |
Not clear |
| Matthias Bauer, Anne C Hamm, Melanie Bonaus, Andrea Jacob, Jens Jaekel, Hubert Schorle, Michael J Pankratz, Joerg D Katzenberge. Starvation response in mouse liver shows strong correlation with life-span-prolonging processes. Physiological genomics. vol 17. issue 2. 2004-05-10. PMID:14762175. |
striking changes in lipid signaling cascade, insulin and dehydroepiandrosterone (dhea) hormonal pathways, urea cycle and s-adenosylmethionine-based methyl transfer systems, and cell apoptosis regulators were observed. |
2004-05-10 |
2023-08-12 |
mouse |