| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji-Eun Kim, Steven R Tannenbau. Insulin regulates cleavage of procaspase-9 via binding of X chromosome-linked inhibitor of apoptosis protein in HT-29 cells. Cancer research. vol 64. issue 24. 2005-02-03. PMID:15604274. |
insulin regulates cleavage of procaspase-9 via binding of x chromosome-linked inhibitor of apoptosis protein in ht-29 cells. |
2005-02-03 |
2023-08-12 |
Not clear |
| Ji-Eun Kim, Steven R Tannenbau. Insulin regulates cleavage of procaspase-9 via binding of X chromosome-linked inhibitor of apoptosis protein in HT-29 cells. Cancer research. vol 64. issue 24. 2005-02-03. PMID:15604274. |
our data suggest that insulin decreases the tnf-alpha-induced cleavage of procaspase-9 and subsequent apoptosis by regulating xiap via the pi3k/akt pathway. |
2005-02-03 |
2023-08-12 |
Not clear |
| Anne Navarrete Santos, Sarah Tonack, Michaela Kirstein, Marie Pantaleon, Peter Kaye, Bernd Fische. Insulin acts via mitogen-activated protein kinase phosphorylation in rabbit blastocysts. Reproduction (Cambridge, England). vol 128. issue 5. 2005-01-31. PMID:15509697. |
the addition of insulin during in vitro culture has beneficial effects on rabbit preimplantation embryos leading to increased cell proliferation and reduced apoptosis. |
2005-01-31 |
2023-08-12 |
rabbit |
| S Cellek, W Qu, A M Schmidt, S Moncad. Synergistic action of advanced glycation end products and endogenous nitric oxide leads to neuronal apoptosis in vitro: a new insight into selective nitrergic neuropathy in diabetes. Diabetologia. vol 47. issue 2. 2005-01-14. PMID:14676945. |
this comprises an initial insulin-reversible decrease in neuronal nitric oxide synthase (nnos) in the axons, followed by apoptosis of the nitrergic neurones, a process that is not reversible by insulin. |
2005-01-14 |
2023-08-12 |
human |
| Angela M Valverde, Isabel Fabregat, Deborah J Burks, Morris F White, Manuel Benit. IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology (Baltimore, Md.). vol 40. issue 6. 2004-12-29. PMID:15565601. |
infection of irs-2(-/-) hepatocytes with adenovirus encoding irs-2 reconstituted phosphatidylinositol 3-kinase (pi 3-kinase)/akt/foxo1 signaling, restored pro- and antiapoptotic gene expression, and decreased caspase-3 activity in response to insulin, thereby blocking apoptosis. |
2004-12-29 |
2023-08-12 |
mouse |
| Maximilian G Posch, Chuanbing Zang, Wolf Mueller, Ulrike Lass, Andreas von Deimling, Elena Elstne. Somatic mutations in peroxisome proliferator-activated receptor-gamma are rare events in human cancer cells. Medical science monitor : international medical journal of experimental and clinical research. vol 10. issue 8. 2004-12-21. PMID:15277984. |
there is striking evidence that ppar-gamma activation leads not only to an increase in insulin sensitivity, but also to tumor cell apoptosis and cell cycle arrest. |
2004-12-21 |
2023-08-12 |
human |
| Rudolf Kaak. Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence. Novartis Foundation symposium. vol 262. 2004-12-21. PMID:15562834. |
the anabolic signals by insulin or igf-1 can promote tumour development by inhibiting apoptosis, and by stimulating cell proliferation. |
2004-12-21 |
2023-08-12 |
Not clear |
| Rohit N Kulkarni, Ulupi S Jhala, Jonathon N Winnay, Stan Krajewski, Marc Montminy, C Ronald Kah. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. The Journal of clinical investigation. vol 114. issue 6. 2004-12-14. PMID:15372107. |
in both models, superimposition of pdx-1 haploinsufficiency upon the background of insulin resistance completely abrogated the adaptive islet hyperplastic response, and instead the beta cells showed apoptosis resulting in premature death of the mice. |
2004-12-14 |
2023-08-12 |
mouse |
| Masahiro Oka, Akiko Kageyama, Mizuho Fukunaga, Toshinori Bito, Hiroshi Nagai, Chikako Nishigor. Phosphatidylinositol 3-kinase/Akt-dependent and -independent protection against apoptosis in normal human melanocytes. The Journal of investigative dermatology. vol 123. issue 5. 2004-12-07. PMID:15482482. |
the ability of four representative growth promoting agents including insulin, 12-o-tetradecanoylphorbol-13-acetate (tpa), basic fibroblast growth factor (bfgf), and 3-isobutyl-1-methylxanthine (ibmx), (itbi) to protect melanocytes against apoptosis was examined. |
2004-12-07 |
2023-08-12 |
human |
| Masahiro Oka, Akiko Kageyama, Mizuho Fukunaga, Toshinori Bito, Hiroshi Nagai, Chikako Nishigor. Phosphatidylinositol 3-kinase/Akt-dependent and -independent protection against apoptosis in normal human melanocytes. The Journal of investigative dermatology. vol 123. issue 5. 2004-12-07. PMID:15482482. |
insulin and tpa protected against apoptosis almost completely, whereas bfgf and ibmx rescued melanocytes from apoptosis to a lesser extent. |
2004-12-07 |
2023-08-12 |
human |
| Masahiro Oka, Akiko Kageyama, Mizuho Fukunaga, Toshinori Bito, Hiroshi Nagai, Chikako Nishigor. Phosphatidylinositol 3-kinase/Akt-dependent and -independent protection against apoptosis in normal human melanocytes. The Journal of investigative dermatology. vol 123. issue 5. 2004-12-07. PMID:15482482. |
wortmannin, an inhibitor of pi 3-kinase, potently inhibited the protective effect of insulin on melanocytes, whereas it did not block the ability of tpa, bfgf, or ibmx to rescue the cells from apoptosis. |
2004-12-07 |
2023-08-12 |
human |
| A Roll. The pathophysiological basis for intensive insulin replacement. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 28 Suppl 2. 2004-12-06. PMID:15306831. |
with the progression of the disease and glucotoxicity there is continuous decrease in beta-cell mass due to increased apoptosis that results in absolute insulin deficiency. |
2004-12-06 |
2023-08-12 |
Not clear |
| Piero Marchetti, Silvia Del Guerra, Lorella Marselli, Roberto Lupi, Matilde Masini, Maria Pollera, Marco Bugliani, Ugo Boggi, Fabio Vistoli, Franco Mosca, Stefano Del Prat. Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. The Journal of clinical endocrinology and metabolism. vol 89. issue 11. 2004-12-02. PMID:15531508. |
diabetic islets were characterized by reduced insulin content, decreased amount of mature insulin granules, impaired glucose-induced insulin secretion, reduced insulin mrna expression, and increased apoptosis with enhanced caspase-3 and -8 activity. |
2004-12-02 |
2023-08-12 |
human |
| Robert C Cooksey, Hani A Jouihan, Richard S Ajioka, Mark W Hazel, Deborah L Jones, James P Kushner, Donald A McClai. Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology. vol 145. issue 11. 2004-11-30. PMID:15308612. |
oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. |
2004-11-30 |
2023-08-12 |
mouse |
| Robert C Cooksey, Hani A Jouihan, Richard S Ajioka, Mark W Hazel, Deborah L Jones, James P Kushner, Donald A McClai. Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology. vol 145. issue 11. 2004-11-30. PMID:15308612. |
we conclude that iron excess results in beta-cell oxidant stress and decreased insulin secretory capacity secondary to beta-cell apoptosis and desensitization of glucose-induced insulin secretion. |
2004-11-30 |
2023-08-12 |
mouse |
| E Zeender, K Maedler, D Bosco, T Berney, M Y Donath, P A Halba. Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta. The Journal of clinical endocrinology and metabolism. vol 89. issue 10. 2004-11-19. PMID:15472206. |
il-1beta and 600 mg/dl glucose increased beta-cell apoptosis and abolished short-term glucose-stimulated insulin secretion. |
2004-11-19 |
2023-08-12 |
human |
| E Zeender, K Maedler, D Bosco, T Berney, M Y Donath, P A Halba. Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta. The Journal of clinical endocrinology and metabolism. vol 89. issue 10. 2004-11-19. PMID:15472206. |
both drugs protected partially against loss of glucose-stimulated insulin secretion and prevented completely increased apoptosis caused by il-1beta or 600 mg/dl glucose. |
2004-11-19 |
2023-08-12 |
human |
| Feng Gao, Dong-wei Shi, Xiao-ming Wang, Ling Dong, Yue-min Wang, Xin-liang M. [Effects of glucose-insulin-potassium cocktail on cardiac myocyte death and post-ischemic recovery cardiac functional recovery: the critical role of insulin]. Zhonghua nei ke za zhi. vol 42. issue 3. 2004-11-16. PMID:12816693. |
to study the effect of glucose-insulin-potassium (gik) cocktail on cardiac myocyte death (i.e., necrosis and apoptosis) and cardiac functional recovery following myocardial ischemia/reperfusion (mi/r), and to further investigate the role of insulin in the gik-induced cardioprotective effect. |
2004-11-16 |
2023-08-12 |
Not clear |
| Ines Wanke, Michael Schwarz, Albrecht Buchman. Insulin and dexamethasone inhibit TGF-beta-induced apoptosis of hepatoma cells upstream of the caspase activation cascade. Toxicology. vol 204. issue 2-3. 2004-11-08. PMID:15388240. |
insulin and dexamethasone inhibit tgf-beta-induced apoptosis of hepatoma cells upstream of the caspase activation cascade. |
2004-11-08 |
2023-08-12 |
rat |
| Ines Wanke, Michael Schwarz, Albrecht Buchman. Insulin and dexamethasone inhibit TGF-beta-induced apoptosis of hepatoma cells upstream of the caspase activation cascade. Toxicology. vol 204. issue 2-3. 2004-11-08. PMID:15388240. |
insulin and dexamethasone are potent inhibitors of apoptosis induced by transforming growth factor-beta1 (tgf-beta) in hepatoma cells. |
2004-11-08 |
2023-08-12 |
rat |