| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Temitope O Keku, Pauline Kay Lund, Joseph Galanko, James G Simmons, John T Woosley, Robert S Sandle. Insulin resistance, apoptosis, and colorectal adenoma risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 14. issue 9. 2005-11-29. PMID:16172212. |
similarly, subjects in the highest two quartiles of insulin were more likely to be in the lowest two quartiles of apoptosis. |
2005-11-29 |
2023-08-12 |
human |
| Temitope O Keku, Pauline Kay Lund, Joseph Galanko, James G Simmons, John T Woosley, Robert S Sandle. Insulin resistance, apoptosis, and colorectal adenoma risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 14. issue 9. 2005-11-29. PMID:16172212. |
the results provide novel evidence that elevated insulin and glucose are associated with increased adenoma risk and decreased apoptosis in normal rectal mucosa. |
2005-11-29 |
2023-08-12 |
human |
| Temitope O Keku, Pauline Kay Lund, Joseph Galanko, James G Simmons, John T Woosley, Robert S Sandle. Insulin resistance, apoptosis, and colorectal adenoma risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 14. issue 9. 2005-11-29. PMID:16172212. |
these findings suggest that insulin may act early in the adenoma-carcinoma sequence to promote the development of colorectal adenoma by decreasing apoptosis in the normal mucosa. |
2005-11-29 |
2023-08-12 |
human |
| Won-Ho Kim, June Woo Lee, Young Ho Suh, Shin Hee Hong, Joo Sun Choi, Joo Hyun Lim, Ji Hyun Song, Bin Gao, Myeong Ho Jun. Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells. Diabetes. vol 54. issue 9. 2005-11-21. PMID:16123348. |
during apoptosis, glucokinase (gck) expression decreases in high-glucose-treated cells, concomitant with a decrease in cellular atp production and insulin secretion. |
2005-11-21 |
2023-08-12 |
mouse |
| Brian Schreibe. Levocarnitine and dialysis: a review. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. vol 20. issue 2. 2005-11-15. PMID:16207659. |
aberrant fatty-acid metabolism has been associated with the promotion of free-radical production, insulin resistance, and cellular apoptosis. |
2005-11-15 |
2023-08-12 |
human |
| Ming-En Xu, Shang-Zhi Xiao, Yong-Hong Sun, Xiao-Xiang Zheng, Yang Ou-Yang, Chen Gua. The study of anti-metabolic syndrome effect of puerarin in vitro. Life sciences. vol 77. issue 25. 2005-11-10. PMID:16005472. |
results of present study showed that puerarin could potentiate insulin-induced preadipocyte differentiation, promote glucose-uptake of adipocytes that have been induced insulin resistance by high glucose, and prevent tnf-a-induced apoptosis and viability loss of endothelial cells. |
2005-11-10 |
2023-08-12 |
Not clear |
| Zhanyou Yun, Mutsumi Takagi, Toshiomi Yoshid. Repeated addition of insulin for dynamic control of apoptosis in serum-free culture of Chinese hamster ovary cells. Journal of bioscience and bioengineering. vol 96. issue 1. 2005-11-07. PMID:16233483. |
repeated addition of insulin for dynamic control of apoptosis in serum-free culture of chinese hamster ovary cells. |
2005-11-07 |
2023-08-12 |
Not clear |
| Zhanyou Yun, Mutsumi Takagi, Toshiomi Yoshid. Repeated addition of insulin for dynamic control of apoptosis in serum-free culture of Chinese hamster ovary cells. Journal of bioscience and bioengineering. vol 96. issue 1. 2005-11-07. PMID:16233483. |
repeated addition of insulin, together with an initial addition of the reduced form of glutathione (gsh) and a chelator, aurintricarboxylic acid (ata), was proposed as a strategy for the dynamic control of apoptosis in serum-free culture of chinese hamster ovary (cho) cells. |
2005-11-07 |
2023-08-12 |
Not clear |
| Jichun Yang, Zhiyong Gao, Claudia E Robert, Brant R Burkhardt, Helena Gaweska, Amary Wagner, Jianmei Wu, Scott R Greene, Robert A Young, Bryan A Wol. Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells. Biochemistry. vol 44. issue 34. 2005-11-01. PMID:16114871. |
pander (pancreatic derived factor, fam3b) is a novel cytokine, present in insulin secretory granules, that induces apoptosis of alpha and beta cells of mouse, rat, and human islets in a dose- and time-dependent manner, and may be implicated in diabetes. |
2005-11-01 |
2023-08-12 |
mouse |
| T Nakazawa, T Chiba, E Kaneko, K Yui, M Yoshida, K Shimokad. Insulin signaling in arteries prevents smooth muscle apoptosis. Arteriosclerosis, thrombosis, and vascular biology. vol 25. issue 4. 2005-10-31. PMID:15692100. |
insulin signaling in arteries prevents smooth muscle apoptosis. |
2005-10-31 |
2023-08-12 |
rat |
| Hongxiang Hui, Xiaoning Zhao, Riccardo Perfett. Structure and function studies of glucagon-like peptide-1 (GLP-1): the designing of a novel pharmacological agent for the treatment of diabetes. Diabetes/metabolism research and reviews. vol 21. issue 4. 2005-10-04. PMID:15852457. |
the multifaceted actions of glp-1 include the following: (1) the stimulation of insulin secretion and of its gene expression, (2) the inhibition of glucagon secretion, (3) the inhibition of food intake, (4) the proliferation and differentiation of beta cells, and (5) the protection of beta-cells from apoptosis. |
2005-10-04 |
2023-08-12 |
Not clear |
| S Y Park, N Cho, I Chang, J-H Chung, Y-K Min, M-K Lee, K-W Kim, S J Kim, M-S Le. Effect of PK11195, a peripheral benzodiazepine receptor agonist, on insulinoma cell death and insulin secretion. Apoptosis : an international journal on programmed cell death. vol 10. issue 3. 2005-09-27. PMID:15909116. |
functional role of peripheral benzodiazepine receptor on mitochondrial membrane in apoptosis and insulin secretion from insulinoma cells was studied. |
2005-09-27 |
2023-08-12 |
Not clear |
| S Y Park, N Cho, I Chang, J-H Chung, Y-K Min, M-K Lee, K-W Kim, S J Kim, M-S Le. Effect of PK11195, a peripheral benzodiazepine receptor agonist, on insulinoma cell death and insulin secretion. Apoptosis : an international journal on programmed cell death. vol 10. issue 3. 2005-09-27. PMID:15909116. |
these results suggest that pk11195 induces mitochondrial potential loss, cytochrome c translocation, increased insulin secretion in conjunction with an increase in cytoplasmic [ca(2+)] and calpain activation, which collectively leads to apoptosis of insulinoma cells. |
2005-09-27 |
2023-08-12 |
Not clear |
| N Duenker, A I Valenciano, A Franke, C Hernández-Sánchez, R Dressel, M Behrendt, F De Pablo, K Krieglstein, E J de la Ros. Balance of pro-apoptotic transforming growth factor-beta and anti-apoptotic insulin effects in the control of cell death in the postnatal mouse retina. The European journal of neuroscience. vol 22. issue 1. 2005-09-19. PMID:16029193. |
transforming growth factor (tgf)-beta and insulin display opposite effects in regulating programmed cell death during vertebrate retina development; the former induces apoptosis while the latter prevents it. |
2005-09-19 |
2023-08-12 |
mouse |
| N Duenker, A I Valenciano, A Franke, C Hernández-Sánchez, R Dressel, M Behrendt, F De Pablo, K Krieglstein, E J de la Ros. Balance of pro-apoptotic transforming growth factor-beta and anti-apoptotic insulin effects in the control of cell death in the postnatal mouse retina. The European journal of neuroscience. vol 22. issue 1. 2005-09-19. PMID:16029193. |
addition of exogenous tgf-beta resulted in a significant increase in cell death whereas exogenous insulin attenuated apoptosis and was capable of blocking tgf-beta-induced apoptosis. |
2005-09-19 |
2023-08-12 |
mouse |
| Rennian Wang, Jinming Li, Kristina Lyte, Nina K Yashpal, Fraser Fellows, Cynthia G Goodye. Role for beta1 integrin and its associated alpha3, alpha5, and alpha6 subunits in development of the human fetal pancreas. Diabetes. vol 54. issue 7. 2005-09-13. PMID:15983209. |
when the beta1 integrin receptor was functionally blocked in cultured islet-epithelial clusters with a beta1 immunoneutralizing antibody or following transient beta1 integrin small interfering rna treatment, there was inhibition of cell adhesion to extracellular matrices, decreased expression of insulin, and increased cell apoptosis. |
2005-09-13 |
2023-08-12 |
human |
| Anita M Hennige, Umut Ozcan, Terumasa Okada, Ulupi S Jhala, Markus Schubert, Morris F White, Rohit N Kulkarn. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. American journal of physiology. Endocrinology and metabolism. vol 289. issue 2. 2005-09-08. PMID:15827066. |
we used a transplantation approach, as a means of separating host insulin resistance from islet function, to examine alterations in proteins in insulin/igf-i signaling pathways that may contribute to beta-cell proliferation and/or apoptosis in irs-1ko islets. |
2005-09-08 |
2023-08-12 |
mouse |
| Uma Kant Misra, Salvatore Vincent Pizz. Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845644. |
concomitantly, insulin also up-regulated prosurvival mechanisms by elevating gadd34 and elements of the antiapoptotic pathway including bcl-2, x-linked inhibitor of apoptosis, and phosphorylated forkhead transcription factor. |
2005-09-08 |
2023-08-12 |
Not clear |
| Robert E Schoen, Joel L Weissfeld, Lewis H Kuller, F Leland Thaete, Rhobert W Evans, Richard B Hayes, Clifford J Rose. Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterology. vol 129. issue 2. 2005-09-07. PMID:16083703. |
insulin and insulin-like growth factor-i (igf-i) affect proliferation, differentiation, and apoptosis and are potential risk factors for colorectal cancer (crc). |
2005-09-07 |
2023-08-12 |
human |
| Xian Liang Li, Kwan Man, Kevin T Ng, Chris K Sun, Chung Mau Lo, Sheung Tat Fa. The influence of phosphatidylinositol 3-kinase/Akt pathway on the ischemic injury during rat liver graft preservation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 5. issue 6. 2005-09-01. PMID:15888030. |
significant activation of caspase-12, -3 and -7 contributed to cell apoptosis and severe ischemic injury was shown after 7 h of preservation by uw solution with insulin. |
2005-09-01 |
2023-08-12 |
rat |