| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cedric Le May, Khoi Chu, Min Hu, Christina S Ortega, Evan R Simpson, Kenneth S Korach, Ming-Jer Tsai, Franck Mauvais-Jarvi. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 24. 2006-09-11. PMID:16754860. |
in these mice, estradiol treatment rescues streptozotocin-induced beta-cell apoptosis, helps sustain insulin production, and prevents diabetes. |
2006-09-11 |
2023-08-12 |
mouse |
| Cedric Le May, Khoi Chu, Min Hu, Christina S Ortega, Evan R Simpson, Kenneth S Korach, Ming-Jer Tsai, Franck Mauvais-Jarvi. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 24. 2006-09-11. PMID:16754860. |
in vitro, in mouse pancreatic islets and beta-cells exposed to oxidative stress, estradiol prevents apoptosis and protects insulin secretion. |
2006-09-11 |
2023-08-12 |
mouse |
| Natalie N Rizk, José A Rafols, Joseph C Dunba. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain research. vol 1096. issue 1. 2006-09-08. PMID:16729987. |
cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and c-peptide. |
2006-09-08 |
2023-08-12 |
rat |
| Natalie N Rizk, José A Rafols, Joseph C Dunba. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain research. vol 1096. issue 1. 2006-09-08. PMID:16729987. |
in this study, we evaluated both the acute and chronic effects of insulin and/or c-peptide on cns necrosis and apoptosis in non-diabetic and streptozotocin-induced diabetic rats following mcao with reperfusion. |
2006-09-08 |
2023-08-12 |
rat |
| Natalie N Rizk, José A Rafols, Joseph C Dunba. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain research. vol 1096. issue 1. 2006-09-08. PMID:16729987. |
the chronic administration of a low maintenance concentration of insulin (2 u/kg), or the acute administration of insulin (2 u/kg) with or without c-peptide, did not alter the lesion volume or basal levels of apoptosis or the apoptotic levels in animals subjected to 2-h mcao followed by 24-h reperfusion. |
2006-09-08 |
2023-08-12 |
rat |
| Natalie N Rizk, José A Rafols, Joseph C Dunba. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain research. vol 1096. issue 1. 2006-09-08. PMID:16729987. |
however, both the acute or chronic administration of a high concentration of insulin (12 u/kg) significantly decreased lesion volume and apoptosis subsequent to 2-h mcao followed by 24-h reperfusion. |
2006-09-08 |
2023-08-12 |
rat |
| Natalie N Rizk, José A Rafols, Joseph C Dunba. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain research. vol 1096. issue 1. 2006-09-08. PMID:16729987. |
high dose insulin treatment also decreased the basal level of apoptosis. |
2006-09-08 |
2023-08-12 |
rat |
| Natalie N Rizk, José A Rafols, Joseph C Dunba. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain research. vol 1096. issue 1. 2006-09-08. PMID:16729987. |
we conclude that in diabetic rats subjected to ischemia and reperfusion chronic insulin treatment decreased the basal apoptotic level, and both acute and chronic insulin decreased the mcao-induced lesion volume and apoptosis. |
2006-09-08 |
2023-08-12 |
rat |
| M N Pertsev. Involvement of adenylyl cyclase signaling mechanism in insulin and IGF-I coregulation of fundamental cell processes. Annals of the New York Academy of Sciences. vol 1040. 2006-08-29. PMID:15891080. |
the discovery of the adenylyl cyclase signaling mechanism (acsm) of insulin and related peptides allows for advancing the hypothesis of its participation in regulatory action on cell growth, apoptosis, and metabolism. |
2006-08-29 |
2023-08-12 |
Not clear |
| Christopher M Jenkins, Wei Yan, David J Mancuso, Richard W Gros. Highly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity. The Journal of biological chemistry. vol 281. issue 23. 2006-08-23. PMID:16595686. |
calcium-independent phospholipase a2beta (ipla2beta) participates in numerous diverse cellular processes, such as arachidonic acid release, insulin secretion, calcium signaling, and apoptosis. |
2006-08-23 |
2023-08-12 |
Not clear |
| V N Molodtsov, E V Senchenkov, E D Bazhanov. [Apoptosis and vasopressin, insulin and Bcl-2 expression in neurosecretory system of old mice]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 42. issue 3. 2006-08-16. PMID:16808289. |
[apoptosis and vasopressin, insulin and bcl-2 expression in neurosecretory system of old mice]. |
2006-08-16 |
2023-08-12 |
mouse |
| Hannah J Welters, Sabine Senkel, Ludger Klein-Hitpass, Silke Erdmann, Heike Thomas, Lorna W Harries, Ewan R Pearson, Coralie Bingham, Andrew T Hattersley, Gerhart U Ryffel, Noel G Morga. Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells. The Journal of endocrinology. vol 190. issue 1. 2006-08-16. PMID:16837621. |
the attenuation of insulin secretion was, however, dissociated from the inhibition of proliferation and loss of viability, since expression of the p328l329del mutant led to a reduced rate of cell proliferation, but failed to induce apoptosis or to alter insulin secretion. |
2006-08-16 |
2023-08-12 |
Not clear |
| Aleksey V Matveyenko, Peter C Butle. Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes. Diabetes. vol 55. issue 7. 2006-08-14. PMID:16804082. |
we report that increased beta-cell apoptosis and impaired first-phase insulin secretion precede the development of ifg, which coincides with an approximately 50% defect in beta-cell mass and onset of hepatic insulin resistance. |
2006-08-14 |
2023-08-12 |
human |
| Aleksey V Matveyenko, Peter C Butle. Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes. Diabetes. vol 55. issue 7. 2006-08-14. PMID:16804082. |
we conclude that iapp-induced beta-cell apoptosis causes defects in insulin secretion and beta-cell mass that lead first to hepatic insulin resistance and ifg and then to extrahepatic insulin resistance, hyperglucagonemia, and diabetes. |
2006-08-14 |
2023-08-12 |
human |
| Ryoji Yanai, Naoyuki Yamada, Makoto Inui, Teruo Nishid. Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells. Experimental eye research. vol 83. issue 1. 2006-08-07. PMID:16530761. |
the growth factors examined could be classified into three groups on the basis of their effects on the proliferation and apoptosis of human corneal epithelial cells: hepatocyte growth factor (hgf), insulin, insulin-like growth factor (igf)-1, igf-2, and epidermal growth factor (egf) each increased cell proliferation, inhibited the induction of apoptosis by sodium nitroprusside, and elicited the activation of akt; transforming growth factor-beta1 and -beta2 inhibited [3h]thymidine incorporation but had no effect on sodium nitroprusside-induced apoptosis or on akt activity; and platelet-derived growth factor-bb had no effects on the measured parameters. |
2006-08-07 |
2023-08-12 |
human |
| Eleazar Shafrir, Ehud Ziv, Rony Kalma. Nutritionally induced diabetes in desert rodents as models of type 2 diabetes: Acomys cahirinus (spiny mice) and Psammomys obesus (desert gerbil). ILAR journal. vol 47. issue 3. 2006-08-03. PMID:16804196. |
ultrastructural studies reveal gradual disappearance of beta-cell glucokinase, glut 2 transporter, and insulin, followed by apoptosis of beta-cells. |
2006-08-03 |
2023-08-12 |
mouse |
| Aleksey V Matveyenko, Peter C Butle. Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes. ILAR journal. vol 47. issue 3. 2006-08-03. PMID:16804197. |
specifically, increasing h-iapp transgene expression by breeding or induction of insulin resistance leads to increased beta-cell apoptosis and diabetes. |
2006-08-03 |
2023-08-12 |
mouse |
| Peng Cui, Timothy L Macdonald, Meng Chen, Jerry L Nadle. Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes. Bioorganic & medicinal chemistry letters. vol 16. issue 13. 2006-08-02. PMID:16650991. |
the lsf analogs were evaluated in a pancreatic beta-cell line for the effects on apoptosis protection and insulin release. |
2006-08-02 |
2023-08-12 |
mouse |
| S Savastio, S Bellone, R Baldelli, M Ferraris, A Lapidari, F Zanetta, S Sogni, A Petri, G Bon. Role of ghrelin in the regulation of appetite in children. Minerva pediatrica. vol 58. issue 1. 2006-08-01. PMID:16541004. |
ghrelin and ghss, acting on central and peripheral receptors, exert other actions such as stimulation of acth and prolactin secretion, influence on insulin secretion and glucose metabolism, orexigenic effect and modulatory activity on the neuroendocrine and metabolic response to starvation, influence on exocrine gastro-entero-pancreatic functions, cardiovascular activities and modulation of cell proliferation and apoptosis. |
2006-08-01 |
2023-08-12 |
Not clear |
| Marianna Pertseva, Alexander Shpakov, Ludmila Kuznetsova, Svetlana Plesneva, Evgeniya Omeljaniu. Adenylyl cyclase signaling mechanisms of relaxin and insulin action: similarities and differences. Cell biology international. vol 30. issue 6. 2006-07-31. PMID:16580233. |
according to our hypothesis, the regulatory action of the insulin superfamily peptides on cell processes (proliferation, apoptosis, and metabolism) is mediated via acsm. |
2006-07-31 |
2023-08-12 |
Not clear |