| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth M Sale, Conrad P Hodgkinson, Neil P Jones, Graham J Sal. A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. Biochemistry. vol 45. issue 1. 2006-04-13. PMID:16388597. |
protein kinase b appears to play a key role in insulin signaling and in the control of apoptosis, although the precise targets of pkb are incompletely understood. |
2006-04-13 |
2023-08-12 |
Not clear |
| Seung Yoon Park, Sanghyun Lee, Kyong Soo Park, Hong Kyu Lee, Wan Le. Proteomic analysis of cellular change involved in mitochondria-to-nucleus communication in L6 GLUT4myc myocytes. Proteomics. vol 6. issue 4. 2006-04-11. PMID:16402357. |
it is suggested that the insulin resistance developed in mtdna-depleted myocytes may be associated with disorganization of cytoskeleton assembly, and that cellular mtdna depletion might promote the ability to evade apoptosis or other death effectors. |
2006-04-11 |
2023-08-12 |
Not clear |
| Brian D Schreibe. Debate forum: levocarnitine therapy is rational and justified in selected dialysis patients. Blood purification. vol 24. issue 1. 2006-03-23. PMID:16361853. |
aberrant fatty acid metabolism has been associated with a number of cellular abnormalities such as increased mitochondrial permeability (a promoter of apoptosis), insulin resistance, and enhanced generation of free radicals. |
2006-03-23 |
2023-08-12 |
human |
| Nadia Hedhli, Michel Pelat, Christophe Depr. Protein turnover in cardiac cell growth and survival. Cardiovascular research. vol 68. issue 2. 2006-03-10. PMID:16061215. |
we highlight the critical role played by such interaction in different cellular functions, including insulin signaling, stress response to hypoxia, adaptation to variations in workload, regulation of protein phosphatase activity, apoptosis and post-ischemic recovery. |
2006-03-10 |
2023-08-12 |
Not clear |
| G Calvaruso, R Vento, E Gerbino, M Lauricella, M Carabillò, H Main, G Tesorier. Insulin and IGFs induce apoptosis in chick embryo retinas deprived of L-glutamine. Cell death and differentiation. vol 4. issue 3. 2006-03-02. PMID:16465230. |
insulin and igfs induce apoptosis in chick embryo retinas deprived of l-glutamine. |
2006-03-02 |
2023-08-12 |
chicken |
| M M Sailaja Devi, U N Da. Effect of prostaglandins against alloxan-induced diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids. vol 74. issue 1. 2006-02-27. PMID:16297610. |
previously, we observed that alloxan-induced in vitro cytotoxicity and apoptosis in an insulin secreting rat insulinoma, rin, cells was prevented by prior exposure to prostaglandin (pg) e(1), pge(2), pgi(2), pgf(1)(alpha), and pgf(3)(alpha) (p<0.05 compared to alloxan), whereas thromboxane b(2) (txb(2)) and 6-keto-pgf(1)(alpha) were ineffective. |
2006-02-27 |
2023-08-12 |
rat |
| Eric P K Mensah-Brown, Allen Shahin, Mariam Al-Shamisi, Xiaoging Wei, Miodrag L Luki. IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin. European journal of immunology. vol 36. issue 1. 2006-02-17. PMID:16358360. |
ten daily injections of 400 ng il-23, starting on the first day of mld-stz administration led to significant and sustained hyperglycemia along with weight loss compared with controls (no il-23), and a significant increase in the number of infiltrating cells, a lower insulin content, enhanced apoptosis, expression of ifn-gamma and il-17 (not seen in the controls) and a significant increase in the expression of tnf-alpha and il-18 in the pancreatic islets. |
2006-02-17 |
2023-08-12 |
mouse |
| K Staiger, H Staiger, M A Schweitzer, E Metzinger, B Balletshofer, H-U Häring, M Kellere. Insulin and its analogue glargine do not affect viability and proliferation of human coronary artery endothelial and smooth muscle cells. Diabetologia. vol 48. issue 9. 2006-02-03. PMID:16078017. |
we therefore investigated the modulatory effects of regular human insulin and its analogue glargine on proliferation and apoptosis of human coronary artery endothelial cells (hcaecs) and human coronary artery smooth muscle cells (hcasmcs). |
2006-02-03 |
2023-08-12 |
human |
| Grainne A Cunningham, Neville H McClenaghan, Peter R Flatt, Philip Newsholm. L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis. Clinical science (London, England : 1979). vol 109. issue 5. 2006-01-13. PMID:16045439. |
in the present study, the effects of prolonged exposure (24 h) to the amino acid l-alanine on insulin secretory function, gene expression and pro-inflammatory cytokine-induced apoptosis were studied using clonal brin-bd11 cells. |
2006-01-13 |
2023-08-12 |
rat |
| Essam Refai, Nancy Dekki, Shao-Nian Yang, Gabriela Imreh, Over Cabrera, Lina Yu, Guang Yang, Svante Norgren, Sophia M Rössner, Luca Inverardi, Camillo Ricordi, Gunilla Olivecrona, Mats Andersson, Hans Jörnvall, Per-Olof Berggren, Lisa Juntti-Berggre. Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16286652. |
the monomer was without effect on glucose-induced insulin release and apoptosis. |
2006-01-12 |
2023-08-12 |
Not clear |
| K Staiger, N Stefan, H Staiger, M D Brendel, D Brandhorst, R G Bretzel, F Machicao, M Kellerer, M Stumvoll, A Fritsche, H-U Härin. Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis. The Journal of clinical endocrinology and metabolism. vol 90. issue 12. 2006-01-10. PMID:16204361. |
whether adiponectin affects insulin secretion and beta-cell apoptosis and whether plasma adiponectin is associated with beta-cell function in humans is under investigation. |
2006-01-10 |
2023-08-12 |
mouse |
| Gang Liu, Cristina M Rondinon. JNK: bridging the insulin signaling and inflammatory pathway. Current opinion in investigational drugs (London, England : 2000). vol 6. issue 10. 2006-01-06. PMID:16259218. |
c-jun n-terminal kinases (jnk) are activated by inflammatory cytokines and have a key role in beta-cell apoptosis and in negative regulation of insulin signaling. |
2006-01-06 |
2023-08-12 |
mouse |
| Jennifer M Dyson, Anne M Kong, Fenny Wiradjaja, Megan V Astle, Rajendra Gurung, Christina A Mitchel. The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2. The international journal of biochemistry & cell biology. vol 37. issue 11. 2005-12-29. PMID:15964236. |
phosphoinositides are membrane-bound signaling molecules that recruit, activate and localize target effectors to intracellular membranes regulating apoptosis, cell proliferation, insulin signaling and membrane trafficking. |
2005-12-29 |
2023-08-12 |
mouse |
| Jai Parkash, Muhammad A Chaudhry, William B Rhote. Tumor necrosis factor-alpha-induced changes in insulin-producing beta-cells. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. vol 286. issue 2. 2005-12-20. PMID:16114068. |
we used rinr1046-38 (rin) insulin-producing beta-cells, which constitutively express calbindin-d(28k), to characterize the effect of tnf-alpha on apoptosis, replication, insulin release, and gene and protein expression. |
2005-12-20 |
2023-08-12 |
Not clear |
| Haiyan Wang, Georgia Kouri, Claes B Wollhei. ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity. Journal of cell science. vol 118. issue Pt 17. 2005-12-14. PMID:16091421. |
both high-glucose treatment and srebp-1c activation in ins-1 cells resulted in lipid accumulation, impaired glucose-stimulated insulin secretion, apoptosis, and strikingly similar gene expression patterns, including upregulation of lipogenic and pro-apoptotic genes and downregulation of irs2, bclxl and pdx1. |
2005-12-14 |
2023-08-12 |
human |
| Robert Z Spaczynski, Jonathan L Tilly, Ali Mansour, Antoni J Duleb. Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis. Molecular human reproduction. vol 11. issue 5. 2005-12-01. PMID:15833775. |
insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis. |
2005-12-01 |
2023-08-12 |
rat |
| Robert Z Spaczynski, Jonathan L Tilly, Ali Mansour, Antoni J Duleb. Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis. Molecular human reproduction. vol 11. issue 5. 2005-12-01. PMID:15833775. |
in an in vitro model of apoptosis, purified rat t-i cells were cultured for 24 h with serum and subsequently for up to an additional 24 h with serum or in serum-free medium with or without insulin, insulin-like growth factors (igf-i and igf-ii) and lh or 8-bromo-cyclic amp (8br-camp). |
2005-12-01 |
2023-08-12 |
rat |
| Robert Z Spaczynski, Jonathan L Tilly, Ali Mansour, Antoni J Duleb. Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis. Molecular human reproduction. vol 11. issue 5. 2005-12-01. PMID:15833775. |
insulin (10 nm) protected t-i cells from apoptosis, reducing dna fragmentation by 39 +/- 8% compared to serum-free controls. |
2005-12-01 |
2023-08-12 |
rat |
| Temitope O Keku, Pauline Kay Lund, Joseph Galanko, James G Simmons, John T Woosley, Robert S Sandle. Insulin resistance, apoptosis, and colorectal adenoma risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 14. issue 9. 2005-11-29. PMID:16172212. |
insulin resistance, apoptosis, and colorectal adenoma risk. |
2005-11-29 |
2023-08-12 |
human |
| Temitope O Keku, Pauline Kay Lund, Joseph Galanko, James G Simmons, John T Woosley, Robert S Sandle. Insulin resistance, apoptosis, and colorectal adenoma risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 14. issue 9. 2005-11-29. PMID:16172212. |
we evaluated the relationship between plasma insulin, glucose, igf-i, igf-ii, igf-binding protein-3 (igfbp-3), apoptosis, and colorectal adenomas in a case-control study. |
2005-11-29 |
2023-08-12 |
human |