| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen-Guo Li, Weixian Zhang, Anders A F Sim. The role of impaired insulin/IGF action in primary diabetic encephalopathy. Brain research. vol 1037. issue 1-2. 2005-06-16. PMID:15777748. |
to differentiate the contribution by insulin deficiency vs. that by hyperglycemia on neuronal apoptosis, we examined the activities of various apoptotic pathways in hippocampi from type 1 diabetic bb/wor rats (hyperglycemic and insulinopenic) and type 2 diabetic bbzdr/wor rats (hyperglycemic and hyperinsulinemic). |
2005-06-16 |
2023-08-12 |
rat |
| Zhen-Guo Li, Weixian Zhang, Anders A F Sim. The role of impaired insulin/IGF action in primary diabetic encephalopathy. Brain research. vol 1037. issue 1-2. 2005-06-16. PMID:15777748. |
the findings suggest that insulin deficiency plays a compounding role to that of hyperglycemia in neuronal apoptosis underpinning primary diabetic encephalopathy. |
2005-06-16 |
2023-08-12 |
rat |
| David R Garri. Cytochemical analysis of pancreatic islet lipoapoptosis: hyperlipidemia-induced cytoinvolution following expression of the diabetes (db/db) mutation. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 72. issue 3. 2005-06-13. PMID:15860929. |
diminished b-cell vesicular (insulin) granulation was pronounced in atrophic pancreatic islets, which were also characterized by hyperplasic acinar cellular intrusion and subsequent proteolytic b-cell dissolution coincident with 3'-dna fragmentation-indexed (tunel-labeled) nuclear apoptosis. |
2005-06-13 |
2023-08-12 |
mouse |
| Shanthi Srinivasan, Mitsuru Ohsugi, Zhonghao Liu, Szabolcs Fatrai, Ernesto Bernal-Mizrachi, M Alan Permut. Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793234. |
endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells. |
2005-06-03 |
2023-08-12 |
mouse |
| Silvia Del Guerra, Lorella Marselli, Roberto Lupi, Ugo Boggi, Franco Mosca, Luca Benzi, Stefano Del Prato, Piero Marchett. Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets. Journal of diabetes and its complications. vol 19. issue 1. 2005-05-31. PMID:15642492. |
this study assessed the insulin content, glucose-stimulated insulin release, islet cell apoptosis, and mrna expression of insulin and glut-1 in isolated human islets cultured in the presence of therapeutical concentrations of glimepiride (10 microm), glibenclamide (10 microm), or chlorpropamide (600 microm). |
2005-05-31 |
2023-08-12 |
human |
| Alexandra H Minn, Christian Hafele, Anath Shale. Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Endocrinology. vol 146. issue 5. 2005-05-24. PMID:15705778. |
thus, txnip is a novel proapoptotic beta-cell gene elevated in insulin resistance/diabetes and up-regulated by glucose through a unique chore and may link glucotoxicity and beta-cell apoptosis. |
2005-05-24 |
2023-08-12 |
mouse |
| Jeppe Sylvest Nielsen, Anders Larsson, Vibeke Brix-Christensen, Jens Randel Nyengaard, Thomas Ledet, Else Tønnese. Endotoxemia-induced lymphocyte apoptosis is augmented by a hyperinsulinemic-euglycemic clamp. Anesthesiology. vol 102. issue 4. 2005-05-16. PMID:15791106. |
because normalization of blood glucose improves outcome in critically ill patients, the authors hypothesized that one of the effects of insulin and normoglycemia would be inhibition of lymphocyte apoptosis. |
2005-05-16 |
2023-08-12 |
Not clear |
| B Ahrén, O Schmit. GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655721. |
glucagon-like peptide-1 (glp-1) is an incretin hormone with antidiabetic action through its ability to stimulate insulin secretion, increase beta cell neogenesis, inhibit beta cell apoptosis, inhibit glucagon secretion, delay gastric emptying and induce satiety. |
2005-05-12 |
2023-08-12 |
Not clear |
| H F Zhang, Q Fan, X X Qian, B L Lopez, T A Christopher, X L Ma, F Ga. Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion. Apoptosis : an international journal on programmed cell death. vol 9. issue 6. 2005-04-28. PMID:15505420. |
to study the effects of glucose-insulin-potassium (gik) cocktail on cardiac myocyte apoptosis and cardiac functional recovery following myocardial ischemia/reperfusion (mi/r), and to further determine the role of insulin in the gik-induced cardioprotective effect in vivo . |
2005-04-28 |
2023-08-12 |
Not clear |
| Helmut Walter, Georg Lübbe. Potential role of oral thiazolidinedione therapy in preserving beta-cell function in type 2 diabetes mellitus. Drugs. vol 65. issue 1. 2005-04-25. PMID:15610048. |
insulin resistance, the 'traditional' cornerstone defect of type 2 diabetes, leads to an array of adverse effects on beta cells, including hypertrophy, apoptosis and those caused by lipotoxicity and glucotoxicity. |
2005-04-25 |
2023-08-12 |
rat |
| Gianpaolo Papaccio, Antonio Graziano, Salvatore Valiante, Riccardo D'Aquino, Salvatore Travali, Ferdinando Nicolett. Interleukin (IL)-1beta toxicity to islet beta cells: Efaroxan exerts a complete protection. Journal of cellular physiology. vol 203. issue 1. 2005-04-21. PMID:15389634. |
our data have evidenced the following: (i) addition of efaroxan to islet cultures inhibited il-1beta activation of ice (cysteine protease il-1beta converting enzyme) while addition of 1400w did not; (ii) efaroxan completely inhibited il-1beta-induced suppression of insulin secretion and induction of inos mrna transcripts, and, in addition, counteracted islet beta-cell protein profile alterations, bax-cytochrome c translocation, caspase activation, and apoptosis; (iii) 1400w inhibited il-1beta induction of inos, but failed to completely counteract the other cytotoxic effects; (iv) the two compounds, moreover, exerted different effects on manganese superoxide dismutase (mnsod), in fact, while efaroxan inhibited the early stimulatory effect of il-1beta on mnsod, 1400w did not. |
2005-04-21 |
2023-08-12 |
rat |
| G Uçkaya, P Delagrange, A Chavanieu, G Grassy, M-F Berthault, A Ktorza, E Cerasi, G Leibowitz, N Kaise. Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue. The Journal of endocrinology. vol 184. issue 3. 2005-04-18. PMID:15749809. |
immunohistochemical analysis showed islet degranulation with disrupted morphology in untreated animals, whereas islets from s 23521-treated animals appeared intact and filled with insulin; beta-cell apoptosis was approximately 70% reduced, without a change in beta-cell proliferation. |
2005-04-18 |
2023-08-12 |
Not clear |
| M Bilodeau, J Tousignant, C Ethier, B Rocheleau, V-A Raymond, R Lapoint. Anti-apoptotic effect of insulin on normal hepatocytes in vitro and in vivo. Apoptosis : an international journal on programmed cell death. vol 9. issue 5. 2005-04-12. PMID:15314289. |
results show that insulin decreases apoptosis of tgf-beta-treated hepatocyte cultures by 43% (p < 0.002) and the alanine amino transferase (alt) release by 49% (p < 0.001). |
2005-04-12 |
2023-08-12 |
rat |
| Angela M Valverde, Cecilia Mur, Michael Brownlee, Manuel Benit. Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes. Molecular biology of the cell. vol 15. issue 11. 2005-04-08. PMID:15356271. |
finally, insulin treatment prevented apoptosis in both cell types. |
2005-04-08 |
2023-08-12 |
mouse |
| Joachim Størling, Nathalie Allaman-Pillet, Allan E Karlsen, Nils Billestrup, Christophe Bonny, Thomas Mandrup-Poulse. Antitumorigenic effect of proteasome inhibitors on insulinoma cells. Endocrinology. vol 146. issue 4. 2005-04-08. PMID:15618349. |
exposure of mouse betatc3 insulinoma cells to the proteasome inhibitor n-acetyl-leu-leu-nle-cho (alln) reduced cell viability, activated caspase-3, induced apoptosis, and suppressed insulin release. |
2005-04-08 |
2023-08-12 |
mouse |
| Satoshi Akiba, Takashi Sat. Cellular function of calcium-independent phospholipase A2. Biological & pharmaceutical bulletin. vol 27. issue 8. 2005-03-18. PMID:15305016. |
those include eicosanoid production, glucose-induced insulin secretion, fas-induced apoptosis, cellular proliferation, membrane traffic in fusion, contribution to myocardial ischemia, and others. |
2005-03-18 |
2023-08-12 |
Not clear |
| Claire Lagathu, Jean-Philippe Bastard, Martine Auclair, Mustapha Maachi, Michel Kornprobst, Jacqueline Capeau, Martine Caro. Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro. Antiviral therapy. vol 9. issue 6. 2005-03-01. PMID:15651750. |
proinflammatory cytokines and adiponectin, which are secreted by adipose tissue, regulate fat metabolism, insulin sensitivity and adipose cell apoptosis. |
2005-03-01 |
2023-08-12 |
Not clear |
| Kathrin Maedler, Richard D Carr, Domenico Bosco, Richard A Zuellig, Thierry Berney, Marc Y Donat. Sulfonylurea induced beta-cell apoptosis in cultured human islets. The Journal of clinical endocrinology and metabolism. vol 90. issue 1. 2005-02-10. PMID:15483097. |
therefore, we investigated the effect of the new insulin secretagogues, repaglinide and nateglinide, and the sulfonylurea, glibenclamide, on beta-cell apoptosis in human islets. |
2005-02-10 |
2023-08-12 |
human |
| Kathrin Maedler, Richard D Carr, Domenico Bosco, Richard A Zuellig, Thierry Berney, Marc Y Donat. Sulfonylurea induced beta-cell apoptosis in cultured human islets. The Journal of clinical endocrinology and metabolism. vol 90. issue 1. 2005-02-10. PMID:15483097. |
glibenclamide at 0.1-10 nm (doses that were less efficient on insulin secretion) did not induce beta-cell apoptosis after 4 h incubation as well as 0.1 nm after 4 d incubation. |
2005-02-10 |
2023-08-12 |
human |
| Laurent Meijer, Marc Flajolet, Paul Greengar. Pharmacological inhibitors of glycogen synthase kinase 3. Trends in pharmacological sciences. vol 25. issue 9. 2005-02-10. PMID:15559249. |
three closely related forms of glycogen synthase kinase 3 (gsk-3alpha, gsk-3beta and gsk-3beta2) have a major role in wnt and hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. |
2005-02-10 |
2023-08-12 |
Not clear |