| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Curi, C J Lagranha, S Q Doi, D F Sellitti, J Procopio, T C Pithon-Curi, M Corless, P Newsholm. Molecular mechanisms of glutamine action. Journal of cellular physiology. vol 204. issue 2. 2005-08-25. PMID:15795900. |
glutamine is the most abundant free amino acid in the body and is known to play a regulatory role in several cell specific processes including metabolism (e.g., oxidative fuel, gluconeogenic precursor, and lipogenic precursor), cell integrity (apoptosis, cell proliferation), protein synthesis, and degradation, contractile protein mass, redox potential, respiratory burst, insulin resistance, insulin secretion, and extracellular matrix (ecm) synthesis. |
2005-08-25 |
2023-08-12 |
Not clear |
| B Ahré. Type 2 diabetes, insulin secretion and beta-cell mass. Current molecular medicine. vol 5. issue 3. 2005-08-08. PMID:15892647. |
this may possibly be achieved by stimulating insulin secretion, supporting islet stimulating mechanisms, removing toxic beta-cell insults and inhibiting beta cell apoptosis. |
2005-08-08 |
2023-08-12 |
human |
| N K Rai, Suryabhan, M Ansari, M Kumar, V K Shukla, K Tripath. Effect of glycaemic control on apoptosis in diabetic wounds. Journal of wound care. vol 14. issue 6. 2005-08-08. PMID:15974415. |
to study the effect of glycaemic control on apoptosis in chronic ulcers in diabetic patients and the differential roles of insulin and oral hypoglycaemic agents (ohas). |
2005-08-08 |
2023-08-12 |
Not clear |
| Tanya Hansotia, Daniel J Drucke. GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice. Regulatory peptides. vol 128. issue 2. 2005-08-04. PMID:15780432. |
both incretins potentiate glucose-dependent insulin secretion and enhance beta-cell mass through regulation of beta-cell proliferation, neogenesis and apoptosis. |
2005-08-04 |
2023-08-12 |
mouse |
| Michael A Nauck, Juris J Meie. Glucagon-like peptide 1 and its derivatives in the treatment of diabetes. Regulatory peptides. vol 128. issue 2. 2005-08-04. PMID:15780433. |
the actions of glp-1 include (a) a stimulation of insulin secretion in a glucose-dependent manner, (b) a suppression of glucagon, (c) a reduction in appetite and food intake, (d) a deceleration of gastric emptying, (e) a stimulation of beta-cell neogenesis, growth and differentiation in animal and tissue culture experiments, and (f) an in vitro inhibition of beta-cell apoptosis induced by different toxins. |
2005-08-04 |
2023-08-12 |
Not clear |
| S-J Kim, Y Ha. Insulin inhibits AMPA-induced neuronal damage via stimulation of protein kinase B (Akt). Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 2. 2005-07-29. PMID:15657639. |
flow cytometry and dna fragmentation assays showed that insulin inhibits ampa-induced apoptosis and dna fragmentation, respectively. |
2005-07-29 |
2023-08-12 |
rat |
| S-J Kim, Y Ha. Insulin inhibits AMPA-induced neuronal damage via stimulation of protein kinase B (Akt). Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 2. 2005-07-29. PMID:15657639. |
taken together, these results suggest that insulin exerts neuroprotective effects by inhibiting ampa-induced excitotoxicity and apoptosis, possibly by activating akt and blocking sapk/jnk. |
2005-07-29 |
2023-08-12 |
rat |
| Ravinder Kaur, Jatin K Nagpal, Bibhu R Da. Polymorphism in IGF-2 as a surrogate marker for predisposition towards tobacco chewing-mediated oral cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 26. issue 3. 2005-07-29. PMID:15970649. |
insulin and insulin-like growth factors (igfs) are major determinants of proliferation and apoptosis, thereby playing a significant role in carcinogenesis. |
2005-07-29 |
2023-08-12 |
Not clear |
| Andreas Barthel, Dieter Schmoll, Terry G Unterma. FoxO proteins in insulin action and metabolism. Trends in endocrinology and metabolism: TEM. vol 16. issue 4. 2005-07-27. PMID:15860415. |
there is increasing evidence that forkhead box 'other' (foxo) proteins, a subgroup of the forkhead transcription factor family, have an important role in mediating the effects of insulin and growth factors on diverse physiological functions, including cell proliferation, apoptosis and metabolism. |
2005-07-27 |
2023-08-12 |
caenorhabditis_elegans |
| Karin A M Jandeleit-Dahm, Christos Tikellis, Christopher M Reid, Colin I Johnston, Mark E Coope. Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes. Journal of hypertension. vol 23. issue 3. 2005-07-21. PMID:15716683. |
thus, ace inhibitors and arbs may act by attenuating the deleterious effect of angiotensin ii on vasoconstriction, fibrosis, inflammation, apoptosis and beta-cell death in the pancreas, thereby protecting a critical beta-cell mass essential for insulin production. |
2005-07-21 |
2023-08-12 |
Not clear |
| Igor Sukhotnik, Jorge Mogilner, Raanan Shamir, Naim Shehadeh, Jacob Bejar, Mark Hirsh, Arnold G Cora. Effect of subcutaneous insulin on intestinal adaptation in a rat model of short bowel syndrome. Pediatric surgery international. vol 21. issue 3. 2005-07-19. PMID:15756562. |
the purpose of the present study was to evaluate the effects of parenteral insulin on structural intestinal adaptation, cell proliferation, and apoptosis in a rat model of short bowel syndrome (sbs). |
2005-07-19 |
2023-08-12 |
rat |
| P Gerbe. [Diabetes]. Revue medicale suisse. vol 1. issue 2. 2005-07-19. PMID:15773212. |
we will end this short review discussing the future of the inhibitor of glp-1 degradation which in addition to a modest hypoglycaemic effect seems to be able to prevent apoptosis of insulin producing beta cells. |
2005-07-19 |
2023-08-12 |
Not clear |
| Leona Plum, Markus Schubert, Jens C Brünin. The role of insulin receptor signaling in the brain. Trends in endocrinology and metabolism: TEM. vol 16. issue 2. 2005-07-15. PMID:15734146. |
furthermore, insulin inhibits neuronal apoptosis via activation of protein kinase b in vitro, and it regulates phosphorylation of tau, metabolism of the amyloid precursor protein and clearance of beta-amyloid from the brain in vivo. |
2005-07-15 |
2023-08-12 |
Not clear |
| F Broglio, E Arvat, C Gottero, A Benso, F Prodam, S Destefanis, G Aimaretti, M Papotti, G Muccioli, R Deghenghi, E Ghig. Natural and synthetic growth hormone secretagogues: do they have therapeutic potential? Treatments in endocrinology. vol 2. issue 3. 2005-07-15. PMID:15966564. |
ghrelin and ghss also exert other actions mediated through central and peripheral receptors, including stimulation of adrenocorticotrophic hormone and prolactin secretion, influence on insulin secretion and glucose metabolism, orexigenic effects and modulatory activity on the neuroendocrine and metabolic response to starvation, influence on exocrine gastro-entero-pancreatic functions, cardiovascular effects and modulation of cell proliferation and apoptosis. |
2005-07-15 |
2023-08-12 |
Not clear |
| Zhen Y Jiang, Qiong L Zhou, John Holik, Shraddha Patel, John Leszyk, Kerri Coleman, My Chouinard, Michael P Czec. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. The Journal of biological chemistry. vol 280. issue 22. 2005-07-12. PMID:15799971. |
insulin signaling through protein kinase akt/protein kinase b (pkb), a downstream element of the phosphatidylinositol 3-kinase (pi3k) pathway, regulates diverse cellular functions including metabolic pathways, apoptosis, mitogenesis, and membrane trafficking. |
2005-07-12 |
2023-08-12 |
Not clear |
| Russell D Leek, Ian Stratford, Adrian L Harri. The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway. Cancer research. vol 65. issue 10. 2005-07-07. PMID:15899805. |
addition of insulin increased proliferation and apoptosis in both hepa-1 and c4 spheroids, demonstrating an hif-1-independent effect of insulin signaling in three-dimensional growth. |
2005-07-07 |
2023-08-12 |
mouse |
| Yubin Guo, Yarong Lu, Daniel Houle, Katie Robertson, Zhengyi Tang, John J Kopchick, Ye Lauren Liu, Jun-Li Li. Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice. Endocrinology. vol 146. issue 6. 2005-06-28. PMID:15731363. |
both gh and igf-i stimulate islet cell growth, inhibit cell apoptosis, and regulate insulin biosynthesis and secretion. |
2005-06-28 |
2023-08-12 |
mouse |
| Claire Lagathu, Minji Kim, Mustapha Maachi, Corinne Vigouroux, Pascale Cervera, Jacqueline Capeau, Martine Caron, Jean-Philippe Bastar. HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo. Biochimie. vol 87. issue 1. 2005-06-28. PMID:15733739. |
some antiretroviral molecules inhibit differentiation and induce insulin resistance and apoptosis in adipose cells both in vitro and in vivo. |
2005-06-28 |
2023-08-12 |
Not clear |
| Claire Lagathu, Minji Kim, Mustapha Maachi, Corinne Vigouroux, Pascale Cervera, Jacqueline Capeau, Martine Caron, Jean-Philippe Bastar. HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo. Biochimie. vol 87. issue 1. 2005-06-28. PMID:15733739. |
altered adipokine secretion could result from patients' exposure to pis and nrtis and lead to altered adipocyte differentiation, insulin resistance and apoptosis, ultimately resulting in lipoatrophy. |
2005-06-28 |
2023-08-12 |
Not clear |
| Shun-ichi Nihei, Kazuhito Yamashita, Hiromi Tasaki, Kiyoshi Ozumi, Yasuhide Nakashim. Oxidized low-density lipoprotein-induced apoptosis is attenuated by insulin-activated phosphatidylinositol 3-kinase/Akt through p38 mitogen-activated protein kinase. Clinical and experimental pharmacology & physiology. vol 32. issue 3. 2005-06-22. PMID:15743407. |
it was also demonstrated that insulin inhibited oxldl-induced apoptosis and may inhibit the activation of p38 mapk through the pi3k/akt pathway. |
2005-06-22 |
2023-08-12 |
human |